Chang Yi Wu


Affiliation: National Sun Yat-Sen University
Country: Taiwan


  1. Chou H, Lin Y, Liu W, Wu C, Li R, Huang H, et al. Combination Therapy of Chloroquine and C₂-Ceramide Enhances Cytotoxicity in Lung Cancer H460 and H1299 Cells. Cancers (Basel). 2019;11: pubmed publisher
    ..Accumulated and non-degraded autophagosomes increased NSCLC cell stress, eventually leading to cell death. This study sheds light on improvements to NSCLC chemotherapy to reduce the chemotherapy dose and NSCLC patient burden. ..
  2. Weng W, Wu C, Wang F, Wu C, Ma Y, Chan H, et al. α-Melanocyte-Stimulating Hormone Attenuates Neovascularization by Inducing Nitric Oxide Deficiency via MC-Rs/PKA/NF-κB Signaling. Int J Mol Sci. 2018;19: pubmed publisher
    ..Therefore, α-MSH exerts anti-angiogenic function by perturbing NO bioavailability and eNOS/iNOS expression in endothelial cells. ..
  3. Chang Y, Fong Y, Tsai E, Chang Y, Chou H, Wu C, et al. Exogenous C₈-Ceramide Induces Apoptosis by Overproduction of ROS and the Switch of Superoxide Dismutases SOD1 to SOD2 in Human Lung Cancer Cells. Int J Mol Sci. 2018;19: pubmed publisher
    ..Accordingly, our works may give a promising strategy for lung cancer treatment in the future. ..
  4. Weng W, Huang S, Ma Y, Chan H, Lin S, Wu J, et al. ?-Melanocyte-stimulating hormone inhibits angiogenesis through attenuation of VEGF/VEGFR2 signaling pathway. Biochim Biophys Acta. 2014;1840:1850-60 pubmed publisher
    ..MSH is a potent angiogenesis inhibitor targeting at endothelial VEGF/VEGFR2 signaling, which may have potential for therapeutic application. ..
  5. Ma Y, Lin S, Fang H, Chou K, Bee Y, Chu T, et al. A novel poly-naphthol compound ST104P suppresses angiogenesis by attenuating matrix metalloproteinase-2 expression in endothelial cells. Int J Mol Sci. 2014;15:16611-27 pubmed publisher
    ..Together, these results suggest that ST104P is a potent angiogenesis inhibitor and may hold potential for treatment of diseases due to excessive angiogenesis including cancer. ..
  6. Lin S, Huang S, Kuo H, Chen C, Ma Y, Chu T, et al. Coral-derived compound WA-25 inhibits angiogenesis by attenuating the VEGF/VEGFR2 signaling pathway. Mar Drugs. 2015;13:861-78 pubmed publisher
    ..WA-25 is a potent angiogenesis inhibitor that acts through the down-regulation of VEGF and VEGFR2 in endothelial cells. WA-25 may constitute a novel anti-angiogenic drug that acts by targeting endothelial VEGF/VEGFR2 signaling. ..
  7. Chou C, Wu C, Chen J, Ng M, Wang H, Chen J, et al. BubR1 Acts as a Promoter in Cellular Motility of Human Oral Squamous Cancer Cells through Regulating MMP-2 and MMP-9. Int J Mol Sci. 2015;16:15104-17 pubmed publisher
    ..Our present study defines an alternative pathway in promoting metastasis of OSCC cells, and the expression of BubR1 could be a prognostic index in OSCC patients. ..
  8. Li R, Wu T, Mou Y, Wang Y, Chen C, Wu C. Nr2f1b control venous specification and angiogenic patterning during zebrafish vascular development. J Biomed Sci. 2015;22:104 pubmed publisher
    ..We show nr2f1b control venous specification and angiogenic patterning during zebrafish vascular development, which is mediated by Notch signalings. ..
  9. Chiu C, Chou H, Chen B, Chang K, Tseng C, Fong Y, et al. BPIQ, a novel synthetic quinoline derivative, inhibits growth and induces mitochondrial apoptosis of lung cancer cells in vitro and in zebrafish xenograft model. BMC Cancer. 2015;15:962 pubmed publisher
    ..BPIQ-induced anti-lung cancer is involved in mitochondrial apoptosis. BPIQ could be a promising anti-lung cancer drug for further applications. ..

More Information


  1. Wang W, Hsu H, Li Y, Wu C. Retinoic Acid Protects and Rescues the Development of Zebrafish Embryonic Retinal Photoreceptor Cells from Exposure to Paclobutrazol. Int J Mol Sci. 2017;18: pubmed publisher
    ..PBZ has strong embryonic toxicity to retinal photoreceptors, probably via suppressing the production of RA, with effects including impaired retinal cell division. ..
  2. Chang H, Wang W, Chiu C, Chen C, Wang Y, Chen Z, et al. Ftr82 Is Critical for Vascular Patterning during Zebrafish Development. Int J Mol Sci. 2017;18: pubmed publisher
    ..Together, we identify teleost-specific ftr82 as a vascular gene that plays an important role for vascular development in zebrafish. ..
  3. Song Y, Wu B, Chiu C, Chen C, Zhou J, Liang S, et al. Coral-Derived Natural Marine Compound GB9 Impairs Vascular Development in Zebrafish. Int J Mol Sci. 2017;18: pubmed publisher
    ..Moreover, exogenous N-acetyl-cysteine (NAC) treatment rescued the vascular defects in GB9 treated embryos. Our results showed that GB9 exposure causes vascular defects likely mediated by the imbalance of redox homeostasis. ..
  4. Yen Y, Farooqi A, Li K, Butt G, Tang J, Wu C, et al. Methanolic extracts of Solieria robusta inhibits proliferation of oral cancer Ca9-22 cells via apoptosis and oxidative stress. Molecules. 2014;19:18721-32 pubmed publisher
    ..001). Taken together, MESR showed inhibitory effects on oral cancer proliferation coupled with apoptosis and oxidative stress. ..
  5. Wu T, Wang Y, Song Y, Chen Z, Chen Y, Chiu C, et al. Fine-tune regulation of carboxypeptidase N1 controls vascular patterning during zebrafish development. Sci Rep. 2017;7:1852 pubmed publisher
    ..In conclusion, we demonstrate that cpn1 has a critical role in the vascular development of zebrafish. We also reveal a fine-tune regulation of cpn1 that controls vascular patterning mediated by multiple signals. ..
  6. Chang H, Tang J, Yen C, Huang H, Wu C, Chung Y, et al. Antiproliferation of Cryptocarya concinna-derived cryptocaryone against oral cancer cells involving apoptosis, oxidative stress, and DNA damage. BMC Complement Altern Med. 2016;16:94 pubmed publisher
    ..CPC is a potential ROS-mediated natural product for anti-oral cancer therapy. ..