Research Topics
| Jen Ren WangSummaryAffiliation: National Cheng Kung University Country: Taiwan Publications
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Publications
An outbreak of enterovirus 71 infection in Taiwan, 1998. II. Laboratory diagnosis and genetic analysisJ R Wang
Department of Medical Technology, National Cheng Kung University, Tainan, Taiwan, ROC
J Clin Virol 17:91-9. 2000..Many enteroviruses were isolated in our laboratory from 258 cases during this outbreak. Approximately half of the enteroviruses isolated were EV71 and one fifth were coxsackievirus A16...
Change of major genotype of enterovirus 71 in outbreaks of hand-foot-and-mouth disease in Taiwan between 1998 and 2000Jen Ren Wang
Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
J Clin Microbiol 40:10-5. 2002..Furthermore, the predominant EV71 genotypes responsible for each of the two major HFMD outbreaks within the 3-year period in Taiwan were different...- Laboratory diagnosis and genetic analysis of an echovirus 30-associated outbreak of aseptic meningitis in Taiwan in 2001Jen Ren Wang
Department of Medical Technology, National Cheng Kung University, Tainan, Taiwan
J Clin Microbiol 40:4439-44. 2002..1 to 25.2%, suggesting that this outbreak was caused by a new variant strain of E30 introduced into Taiwan in 2000 that resulted in the widespread aseptic meningitis epidemic in 2001... - Reemergence of enterovirus 71 in 2008 in taiwan: dynamics of genetic and antigenic evolution from 1998 to 2008Sheng Wen Huang
Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, One University Road, Tainan, 701, Taiwan
J Clin Microbiol 47:3653-62. 2009..Therefore, continuous surveillance of EV71 including the monitoring of genetic evolution and antigenic changes is recommended and may contribute to the development of a vaccine for EV71... 
An echovirus 18-associated outbreak of aseptic meningitis in Taiwan: epidemiology and diagnostic and genetic aspectsHuey Pin Tsai
Department of Pathology, National Cheng Kung University Medical Center, Tainan, Taiwan, ROC
J Med Microbiol 60:1360-5. 2011..These results indicate that a genetic variant of E18 was circulating and caused an outbreak of aseptic meningitis in Taiwan in 2006...- A single nucleotide in stem loop II of 5'-untranslated region contributes to virulence of enterovirus 71 in miceMing Te Yeh
The Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan
PLoS ONE 6:e27082. 2011..Enterovirus 71 (EV71) has emerged as a neuroinvasive virus responsible for several large outbreaks in the Asia-Pacific region while virulence determinant remains unexplored... - Mutations in VP2 and VP1 capsid proteins increase infectivity and mouse lethality of enterovirus 71 by virus binding and RNA accumulation enhancementSheng Wen Huang
The Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan
Virology 422:132-43. 2012..In sum, VP2(149M) and VP1(145E) mutations cooperatively promote viral binding and RNA accumulation of EV71, contributing to viral infectivity in vitro and mouse lethality in vivo... - Retrograde axonal transport: a major transmission route of enterovirus 71 in miceChe Szu Chen
Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan 70101, Republic of China
J Virol 81:8996-9003. 2007..m. inoculated in the forelimb. Colchicine, a fast axonal transport inhibitor, but not sciatic nerve transection reduced EV71 neuroinvasion in a dose-dependent manner, indicating a neuronal transmission of the virus... - Appearance of intratypic recombination of enterovirus 71 in Taiwan from 2002 to 2005Shih Chen Huang
Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Virus Res 131:250-9. 2008..This intratypic recombination was identified among naturally circulating EV71 isolates in Taiwan, therefore, it suggests that nonstructural genes may recombine to produce new EV71 variants... - Characterization of glycan binding specificities of influenza B viruses with correlation with hemagglutinin genotypes and clinical featuresYa fang Wang
National Institute of Infectious Disease and Vaccinology, National Health Research Institutes, Tainan, Taiwan
J Med Virol 84:679-85. 2012..05). Glycan binding analyses provide additional information to monitor the antigenic shift, tissue tropism, and transmission capability of influenza B viruses, and will contribute to virus surveillance and vaccine strain selection... - Introduction of a strong temperature-sensitive phenotype into enterovirus 71 by altering an amino acid of virus 3D polymeraseYen Hua Kung
Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, Tainan, 701, Taiwan
Virology 396:1-9. 2010..p. infection model. Therefore, these results suggested that the threonine at position 251 results in a temperature sensitivity phenotype of EV71 which may contribute to the attenuation of circulating strains... - Cell surface sialylation affects binding of enterovirus 71 to rhabdomyosarcoma and neuroblastoma cellsPei Yi Su
Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, Tainan, Taiwan
BMC Microbiol 12:162. 2012..Although there are two highly glycosylated membrane proteins, SCARB2 and PSGL-1, which have been identified as the cellular and functional receptors of EV71, the role of glycosylation in EV71 infection is still unclear... - Echovirus 18 meningitis in southern TaiwanShih Min Wang
Department of Emergency Medicine, College of Medicine, National Cheng Kung University and Hospital, Tainan City, Taiwan, Republic of China
Pediatr Infect Dis J 30:259-60. 2011..The case-fatality rate among the children with meningitis was 4%. Echovirus 18 was isolated from the cerebrospinal fluid of 68% of the children... - Epidemiological survey of enterovirus infections occurring in Taiwan between 2000 and 2005: analysis of sentinel physician surveillance dataFan Chen Tseng
Division of Clinical Research, National Health Research Institutes, Tainan, Taiwan
J Med Virol 79:1850-60. 2007..Surveying the epidemic pattern, disease spectra, and severity associated with each EV serotype provided important information for public health and medical personnel... - Immunity to avirulent enterovirus 71 and coxsackie A16 virus protects against enterovirus 71 infection in miceTe Chia Wu
Department of Microbiology, Institute of Basic Medical Sciences, Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China
J Virol 81:10310-5. 2007..These results illustrated that live vaccine is feasible for EV71 and that intertypic cross-reactivity of enteroviruses may provide a way to determine the prevalence of EV71... - Evolution of re-emergent virus and its impact on enterovirus 71 epidemicsSheng Wen Huang
The Institute of Basic Medical Sciences, National Cheng Kung University, Tainan 701, Taiwan
Exp Biol Med (Maywood) 236:899-908. 2011.... - Galectin-1 binds to influenza virus and ameliorates influenza virus pathogenesisMei Lin Yang
Institute of Basic Medical Science, National Cheng Kung University Medical College, Tainan, Taiwan
J Virol 85:10010-20. 2011..Collectively, our results indicate that galectin-1 has anti-influenza virus activity by binding to viral surface and inhibiting its infectivity. Thus, galectin-1 may be further explored as a novel therapeutic agent for influenza... - Enterovirus 71 blocks selectively type I interferon production through the 3C viral protein in miceYi Ping Lee
Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan City, Taiwan
J Med Virol 84:1779-89. 2012..These findings indicate that EV 71 can hamper the host innate defense by blocking selectively type I IFN synthesis through the 3C viral protein... - Decreased leukocytes and other characteristics of laboratory findings of influenza virus infections in childrenChing Fen Shen
Department of Pediatrics, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan
J Microbiol Immunol Infect 41:294-300. 2008..An outbreak of influenza A and influenza B appeared at the beginning and end of 2006 in southern Taiwan. We conducted this study to test whether laboratory findings could differentiate influenza A from influenza B infection... - Co-circulating genetically divergent A2 human metapneumovirus strains among children in southern TaiwanHsuan Chen Wang
Division of Clinical Research, National Health Research Institutes, No 137, Shengli Rd, Tainan, Taiwan
Arch Virol 153:2207-13. 2008..This study indicated that genetically divergent strains of hMPV which caused respiratory disease and hospitalization were circulating among children in Taiwan... - The regulatory T cells in anti-influenza antibody response post influenza vaccinationShih Min Wang
Department of Emergency Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Hum Vaccin Immunother 8:1243-9. 2012..Treg cells and TGF-β seem to participate in the downregulation of the anti-influenza antibody response post influenza vaccination. Alteration of Treg activity might enhance influenza vaccine antibody responses and efficacy... - Poor immune response to a standard single dose non-adjuvanted vaccination against 2009 pandemic H1N1 influenza virus A in the adult and elder hemodialysis patientsYu Tzu Chang
Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
Vaccine 30:5009-18. 2012.... - Comparison of neutralizing and hemagglutination-inhibiting antibody responses for evaluating the seasonal influenza vaccineLi Wei Cheng
Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, Tainan 701, Taiwan
J Virol Methods 182:43-9. 2012..These data suggest that the neutralizing antibody response is a better measurement of influenza vaccine efficacy... - Preexisting antibody response against 2009 pandemic influenza H1N1 viruses in the Taiwanese populationChia Yu Chi
Division of Infectious Diseases, National Health Research Institutes, Tainan, Taiwan
Clin Vaccine Immunol 17:1958-62. 2010..Our data also indicate that natural infection with the Taiwan 2006 and 2008 seasonal H1N1 viruses may induce a cross-reactive antibody response to the 2009 pH1N1 virus... - Increasing appearance of reassortant influenza B virus in Taiwan from 2002 to 2005Huey-Pin Tsai
Department of Pathology, National Cheng Kung University Hospital, Tainan, Taiwan
J Clin Microbiol 44:2705-13. 2006.... - Profiling of influenza viruses by high-throughput carbohydrate membrane arrayWeng I Lao
Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, No 1, University Road, Tainan 70101, Taiwan
Future Med Chem 3:283-96. 2011..Carbohydrate-protein interactions participate in many biological functions. To characterize the binding interactions represents a longstanding challenge... - Molecular epidemiology of Echovirus 30 in Taiwan, 1988-2008Guan Ming Ke
Department of Clinical Laboratory, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Virus Genes 42:178-88. 2011..Taiwanese strains were classified into GVI-D (1988-1989), GVI-F (1993-2004), and GVI-G (1993-2008). The quiescence period of E-30 is longer in Taiwan (5-8 years) than in other countries (3-5 years)... - Large B cell lymphoma presenting initially in bone marrow, liver and spleen: an aggressive entity associated frequently with haemophagocytic syndromeYu Min Yeh
Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Histopathology 57:785-95. 2010..To describe diffuse large B cell lymphoma (DLBCL) presenting initially in bone marrow, liver and spleen (BLS-type) without lymphadenopathy... - A role for chronic parvovirus B19 infection in liver dysfunction in renal transplant recipients?Po Chang Lee
Department of Surgery, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Transplantation 73:1635-9. 2002..Here we present the association of liver dysfunction with or without the coinfection of B19, HBV, and HCV after renal transplantation... - Autophagic machinery activated by dengue virus enhances virus replicationYing Ray Lee
Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Virology 374:240-8. 2008..Moreover, our data show that ATG5 protein is required to execute DV2-induced autophagy. All together, we are the first to demonstrate that DV can activate autophagic machinery that is favorable for viral replication... - Therapeutic efficacy of milrinone in the management of enterovirus 71-induced pulmonary edemaShih Min Wang
Department of Emergency Medicine, College of Medicine, National Cheng Kung University and Hospital, Tainan, Taiwan
Pediatr Pulmonol 39:219-23. 2005..These results were associated with improvement in sympathetic regulation and decrease in IL-13 production. Milrinone therapy may provide a useful therapeutic approach for this highly lethal disorder... - Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: roles of cytokines and cellular immune activation in patients with pulmonary edemaShih-Min Wang
Department of Emergency Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
J Infect Dis 188:564-70. 2003..An extensive peripheral and central nervous system inflammatory response with abnormal IL-10, IL-13, and IFN-gamma cytokine production and lymphocyte depletion appears to be responsible for the pathogenesis of EV71-associated PE... - Lactoferrin inhibits enterovirus 71 infection by binding to VP1 protein and host cellsTsui-Ying Weng
Department of Medical Laboratory Sciences and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC
Antiviral Res 67:31-7. 2005..Finally, LF protected mice against lethal EV71 challenge. Taken together, these results suggest that LF can inhibit EV71 infection by interacting with both EV71 and host cells... - Laboratory-based surveillance and molecular epidemiology of influenza virus in TaiwanShin-Ru Shih
Chang Gung Memorial Hospital and Chang Gung University, Taipei, Taiwan
J Clin Microbiol 43:1651-61. 2005..No clear seasonality of influenza reports in Taiwan occurred in contrast to other more continental regions... - Clinical features of children infected with different strains of influenza B in southern TaiwanChia Yu Chi
Division of Clinical Research, National Health Research Institutes, Chunan, Miaoli, Taiwan
Pediatr Infect Dis J 27:640-5. 2008..The clinical features were compared with influenza A infection occurring in the same period... - Evolution of EV71 genogroup in Taiwan from 1998 to 2005: an emerging of subgenogroup C4 of EV71Kuei Hsiang Lin
Department of Clinical Laboratory, Kaohsiung Medical University, Kaohsiung City, Taiwan
J Med Virol 78:254-62. 2006..Nucleotide sequence alignment revealed 67 substitutions. Most of the substitutions (62/67) were silent mutations. This is the first report about the emergence of EV71 subgenogroup C4 in Taiwan... - Acute chemokine response in the blood and cerebrospinal fluid of children with enterovirus 71-associated brainstem encephalitisShih Min Wang
Department of Emergency Medicine, National Cheng Kung University Medical College and Hospital, Taipei, Taiwan
J Infect Dis 198:1002-6. 2008..The present study was designed to determine the characteristics of the chemokine response in the blood and cerebrospinal fluid (CSF) of patients with EV71-associated BE...