Jen Ren Wang

Summary

Affiliation: National Cheng Kung University
Country: Taiwan

Publications

  1. pmc Mutations in the non-structural protein region contribute to intra-genotypic evolution of enterovirus 71
    Sheng Wen Huang
    Center of Infectious Disease and Signaling Research, National Cheng Kung University Hospital, Tainan, Taiwan
    J Biomed Sci 21:33. 2014
  2. pmc A single nucleotide in stem loop II of 5'-untranslated region contributes to virulence of enterovirus 71 in mice
    Ming Te Yeh
    The Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan
    PLoS ONE 6:e27082. 2011
  3. ncbi request reprint An outbreak of enterovirus 71 infection in Taiwan, 1998. II. Laboratory diagnosis and genetic analysis
    J R Wang
    Department of Medical Technology, National Cheng Kung University, Tainan, Taiwan, ROC
    J Clin Virol 17:91-9. 2000
  4. pmc Change of major genotype of enterovirus 71 in outbreaks of hand-foot-and-mouth disease in Taiwan between 1998 and 2000
    Jen Ren Wang
    Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    J Clin Microbiol 40:10-5. 2002
  5. pmc Laboratory diagnosis and genetic analysis of an echovirus 30-associated outbreak of aseptic meningitis in Taiwan in 2001
    Jen Ren Wang
    Department of Medical Technology, National Cheng Kung University, Tainan, Taiwan
    J Clin Microbiol 40:4439-44. 2002
  6. pmc Reemergence of enterovirus 71 in 2008 in taiwan: dynamics of genetic and antigenic evolution from 1998 to 2008
    Sheng Wen Huang
    Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, One University Road, Tainan, 701, Taiwan
    J Clin Microbiol 47:3653-62. 2009
  7. pmc Increasing appearance of reassortant influenza B virus in Taiwan from 2002 to 2005
    Huey Pin Tsai
    Department of Pathology, National Cheng Kung University Hospital, Tainan, Taiwan
    J Clin Microbiol 44:2705-13. 2006
  8. ncbi request reprint An echovirus 18-associated outbreak of aseptic meningitis in Taiwan: epidemiology and diagnostic and genetic aspects
    Huey Pin Tsai
    Department of Pathology, National Cheng Kung University Medical Center, Tainan, Taiwan, ROC
    J Med Microbiol 60:1360-5. 2011
  9. pmc Immunological and biochemical characterization of coxsackie virus A16 viral particles
    Pele Chong
    Vaccine R and D Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan Town, Miaoli County, Taiwan
    PLoS ONE 7:e49973. 2012
  10. doi request reprint Clinical features of children infected with different strains of influenza B in southern Taiwan
    Chia Yu Chi
    Division of Clinical Research, National Health Research Institutes, Chunan, Miaoli, Taiwan
    Pediatr Infect Dis J 27:640-5. 2008

Collaborators

Detail Information

Publications46

  1. pmc Mutations in the non-structural protein region contribute to intra-genotypic evolution of enterovirus 71
    Sheng Wen Huang
    Center of Infectious Disease and Signaling Research, National Cheng Kung University Hospital, Tainan, Taiwan
    J Biomed Sci 21:33. 2014
    ..To investigate genetic changes in viral evolution, complete EV71 genome sequences were used to analyze the intra-genotypic evolution pattern in Taiwan, China, and the Netherlands...
  2. pmc A single nucleotide in stem loop II of 5'-untranslated region contributes to virulence of enterovirus 71 in mice
    Ming Te Yeh
    The Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan
    PLoS ONE 6:e27082. 2011
    ..Enterovirus 71 (EV71) has emerged as a neuroinvasive virus responsible for several large outbreaks in the Asia-Pacific region while virulence determinant remains unexplored...
  3. ncbi request reprint An outbreak of enterovirus 71 infection in Taiwan, 1998. II. Laboratory diagnosis and genetic analysis
    J R Wang
    Department of Medical Technology, National Cheng Kung University, Tainan, Taiwan, ROC
    J Clin Virol 17:91-9. 2000
    ..Many enteroviruses were isolated in our laboratory from 258 cases during this outbreak. Approximately half of the enteroviruses isolated were EV71 and one fifth were coxsackievirus A16...
  4. pmc Change of major genotype of enterovirus 71 in outbreaks of hand-foot-and-mouth disease in Taiwan between 1998 and 2000
    Jen Ren Wang
    Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    J Clin Microbiol 40:10-5. 2002
    ..Furthermore, the predominant EV71 genotypes responsible for each of the two major HFMD outbreaks within the 3-year period in Taiwan were different...
  5. pmc Laboratory diagnosis and genetic analysis of an echovirus 30-associated outbreak of aseptic meningitis in Taiwan in 2001
    Jen Ren Wang
    Department of Medical Technology, National Cheng Kung University, Tainan, Taiwan
    J Clin Microbiol 40:4439-44. 2002
    ..1 to 25.2%, suggesting that this outbreak was caused by a new variant strain of E30 introduced into Taiwan in 2000 that resulted in the widespread aseptic meningitis epidemic in 2001...
  6. pmc Reemergence of enterovirus 71 in 2008 in taiwan: dynamics of genetic and antigenic evolution from 1998 to 2008
    Sheng Wen Huang
    Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, One University Road, Tainan, 701, Taiwan
    J Clin Microbiol 47:3653-62. 2009
    ..Therefore, continuous surveillance of EV71 including the monitoring of genetic evolution and antigenic changes is recommended and may contribute to the development of a vaccine for EV71...
  7. pmc Increasing appearance of reassortant influenza B virus in Taiwan from 2002 to 2005
    Huey Pin Tsai
    Department of Pathology, National Cheng Kung University Hospital, Tainan, Taiwan
    J Clin Microbiol 44:2705-13. 2006
    ....
  8. ncbi request reprint An echovirus 18-associated outbreak of aseptic meningitis in Taiwan: epidemiology and diagnostic and genetic aspects
    Huey Pin Tsai
    Department of Pathology, National Cheng Kung University Medical Center, Tainan, Taiwan, ROC
    J Med Microbiol 60:1360-5. 2011
    ..These results indicate that a genetic variant of E18 was circulating and caused an outbreak of aseptic meningitis in Taiwan in 2006...
  9. pmc Immunological and biochemical characterization of coxsackie virus A16 viral particles
    Pele Chong
    Vaccine R and D Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan Town, Miaoli County, Taiwan
    PLoS ONE 7:e49973. 2012
    ..It manifests most often in childhood exanthema, commonly known as hand-foot-and-mouth disease (HFMD). There are currently no vaccine or effective medical treatments available...
  10. doi request reprint Clinical features of children infected with different strains of influenza B in southern Taiwan
    Chia Yu Chi
    Division of Clinical Research, National Health Research Institutes, Chunan, Miaoli, Taiwan
    Pediatr Infect Dis J 27:640-5. 2008
    ..The clinical features were compared with influenza A infection occurring in the same period...
  11. ncbi request reprint Appearance of intratypic recombination of enterovirus 71 in Taiwan from 2002 to 2005
    Shih Chen Huang
    Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Virus Res 131:250-9. 2008
    ..This intratypic recombination was identified among naturally circulating EV71 isolates in Taiwan, therefore, it suggests that nonstructural genes may recombine to produce new EV71 variants...
  12. pmc High-incidence of human adenoviral co-infections in taiwan
    Shan Li Wang
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Tainan, Taiwan
    PLoS ONE 8:e75208. 2013
    ..Respiratory infections caused by adenovirus (HAdV) are common year round. Recently, a significant increase of adenoviral infections was observed in Taiwan...
  13. doi request reprint Introduction of a strong temperature-sensitive phenotype into enterovirus 71 by altering an amino acid of virus 3D polymerase
    Yen Hua Kung
    Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, Tainan, 701, Taiwan
    Virology 396:1-9. 2010
    ..p. infection model. Therefore, these results suggested that the threonine at position 251 results in a temperature sensitivity phenotype of EV71 which may contribute to the attenuation of circulating strains...
  14. ncbi request reprint Lactoferrin inhibits enterovirus 71 infection by binding to VP1 protein and host cells
    Tsui Ying Weng
    Department of Medical Laboratory Sciences and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC
    Antiviral Res 67:31-7. 2005
    ..Finally, LF protected mice against lethal EV71 challenge. Taken together, these results suggest that LF can inhibit EV71 infection by interacting with both EV71 and host cells...
  15. doi request reprint Co-circulating genetically divergent A2 human metapneumovirus strains among children in southern Taiwan
    Hsuan Chen Wang
    Division of Clinical Research, National Health Research Institutes, No 137, Shengli Rd, Tainan, Taiwan
    Arch Virol 153:2207-13. 2008
    ..This study indicated that genetically divergent strains of hMPV which caused respiratory disease and hospitalization were circulating among children in Taiwan...
  16. doi request reprint Milrinone therapy for enterovirus 71-induced pulmonary edema and/or neurogenic shock in children: a randomized controlled trial
    Chia Yu Chi
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli County, Taiwan
    Crit Care Med 41:1754-60. 2013
    ..This prospective, randomized control trial was designed to provide more definitive evidence of the ability of milrinone to reduce the 1-week mortality of stage 3B enterovirus 71 infections...
  17. ncbi request reprint Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: roles of cytokines and cellular immune activation in patients with pulmonary edema
    Shih Min Wang
    Department of Emergency Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
    J Infect Dis 188:564-70. 2003
    ..An extensive peripheral and central nervous system inflammatory response with abnormal IL-10, IL-13, and IFN-gamma cytokine production and lymphocyte depletion appears to be responsible for the pathogenesis of EV71-associated PE...
  18. pmc Retrograde axonal transport: a major transmission route of enterovirus 71 in mice
    Che Szu Chen
    Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan 70101, Republic of China
    J Virol 81:8996-9003. 2007
    ..m. inoculated in the forelimb. Colchicine, a fast axonal transport inhibitor, but not sciatic nerve transection reduced EV71 neuroinvasion in a dose-dependent manner, indicating a neuronal transmission of the virus...
  19. doi request reprint Mutations in VP2 and VP1 capsid proteins increase infectivity and mouse lethality of enterovirus 71 by virus binding and RNA accumulation enhancement
    Sheng Wen Huang
    The Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan
    Virology 422:132-43. 2012
    ..In sum, VP2(149M) and VP1(145E) mutations cooperatively promote viral binding and RNA accumulation of EV71, contributing to viral infectivity in vitro and mouse lethality in vivo...
  20. doi request reprint Characterization of glycan binding specificities of influenza B viruses with correlation with hemagglutinin genotypes and clinical features
    Ya fang Wang
    National Institute of Infectious Disease and Vaccinology, National Health Research Institutes, Tainan, Taiwan
    J Med Virol 84:679-85. 2012
    ..05). Glycan binding analyses provide additional information to monitor the antigenic shift, tissue tropism, and transmission capability of influenza B viruses, and will contribute to virus surveillance and vaccine strain selection...
  21. pmc Immunity to avirulent enterovirus 71 and coxsackie A16 virus protects against enterovirus 71 infection in mice
    Te Chia Wu
    Department of Microbiology, Institute of Basic Medical Sciences, Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China
    J Virol 81:10310-5. 2007
    ..These results illustrated that live vaccine is feasible for EV71 and that intertypic cross-reactivity of enteroviruses may provide a way to determine the prevalence of EV71...
  22. pmc Challenges to licensure of enterovirus 71 vaccines
    Min Shi Lee
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Taiwan
    PLoS Negl Trop Dis 6:e1737. 2012
    ..Prospective cohort studies are warranted to clarify clinical and epidemiological significances of the antigenic and genetic variations between different EV71 genogroups, which is critical for vaccine design...
  23. doi request reprint Investigations of clinical isolations of oral poliovirus vaccine strains between 2000 and 2005 in southern Taiwan
    Chia Yu Chi
    Division of Infectious Diseases, National Health Research Institutes, 367 Sheng Li Road, Tainan 704, Taiwan
    J Clin Virol 45:129-34. 2009
    ..In Taiwan, trivalent oral poliovirus vaccine (tOPV) is in the routine immunization schedule, but its association with illnesses had not been examined...
  24. pmc Cell surface sialylation affects binding of enterovirus 71 to rhabdomyosarcoma and neuroblastoma cells
    Pei Yi Su
    Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, Tainan, Taiwan
    BMC Microbiol 12:162. 2012
    ..Although there are two highly glycosylated membrane proteins, SCARB2 and PSGL-1, which have been identified as the cellular and functional receptors of EV71, the role of glycosylation in EV71 infection is still unclear...
  25. doi request reprint Echovirus 18 meningitis in southern Taiwan
    Shih Min Wang
    Department of Emergency Medicine, College of Medicine, National Cheng Kung University and Hospital, Tainan City, Taiwan, Republic of China
    Pediatr Infect Dis J 30:259-60. 2011
    ..The case-fatality rate among the children with meningitis was 4%. Echovirus 18 was isolated from the cerebrospinal fluid of 68% of the children...
  26. ncbi request reprint Evolution of re-emergent virus and its impact on enterovirus 71 epidemics
    Sheng Wen Huang
    The Institute of Basic Medical Sciences, National Cheng Kung University, Tainan 701, Taiwan
    Exp Biol Med (Maywood) 236:899-908. 2011
    ....
  27. pmc Immunophenotype Expressions and Cytokine Profiles of Influenza A H1N1 Virus Infection in Pediatric Patients in 2009
    Shih Min Wang
    Department of Emergency Medicine, College of Medicine, National Cheng Kung University and Hospital, Tainan 70428, Taiwan Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan 70428, Taiwan
    Dis Markers 2014:195453. 2014
    ..Acute phase cytokine profiles of the 2009 S-OIV infection might have contributed to the pathogenesis of the pulmonary complications. ..
  28. doi request reprint Enterovirus 71 blocks selectively type I interferon production through the 3C viral protein in mice
    Yi Ping Lee
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan City, Taiwan
    J Med Virol 84:1779-89. 2012
    ..These findings indicate that EV 71 can hamper the host innate defense by blocking selectively type I IFN synthesis through the 3C viral protein...
  29. pmc Galectin-1 binds to influenza virus and ameliorates influenza virus pathogenesis
    Mei Lin Yang
    Institute of Basic Medical Science, National Cheng Kung University Medical College, Tainan, Taiwan
    J Virol 85:10010-20. 2011
    ..Collectively, our results indicate that galectin-1 has anti-influenza virus activity by binding to viral surface and inhibiting its infectivity. Thus, galectin-1 may be further explored as a novel therapeutic agent for influenza...
  30. pmc Preexisting antibody response against 2009 pandemic influenza H1N1 viruses in the Taiwanese population
    Chia Yu Chi
    Division of Infectious Diseases, National Health Research Institutes, Tainan, Taiwan
    Clin Vaccine Immunol 17:1958-62. 2010
    ..Our data also indicate that natural infection with the Taiwan 2006 and 2008 seasonal H1N1 viruses may induce a cross-reactive antibody response to the 2009 pH1N1 virus...
  31. pmc Immunological evaluation and comparison of different EV71 vaccine candidates
    Ai Hsiang Chou
    Vaccine R and D Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan Township, Miaoli County, Taiwan
    Clin Dev Immunol 2012:831282. 2012
    ..Therefore, the best formulation for producing cost-effective HFMD vaccine is a combination of formalin-inactivated EV71 and CAV16 virions...
  32. pmc The regulatory T cells in anti-influenza antibody response post influenza vaccination
    Shih Min Wang
    Department of Emergency Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Hum Vaccin Immunother 8:1243-9. 2012
    ..Treg cells and TGF-β seem to participate in the downregulation of the anti-influenza antibody response post influenza vaccination. Alteration of Treg activity might enhance influenza vaccine antibody responses and efficacy...
  33. ncbi request reprint Decreased leukocytes and other characteristics of laboratory findings of influenza virus infections in children
    Ching Fen Shen
    Department of Pediatrics, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan
    J Microbiol Immunol Infect 41:294-300. 2008
    ..An outbreak of influenza A and influenza B appeared at the beginning and end of 2006 in southern Taiwan. We conducted this study to test whether laboratory findings could differentiate influenza A from influenza B infection...
  34. ncbi request reprint Epidemiological survey of enterovirus infections occurring in Taiwan between 2000 and 2005: analysis of sentinel physician surveillance data
    Fan Chen Tseng
    Division of Clinical Research, National Health Research Institutes, Tainan, Taiwan
    J Med Virol 79:1850-60. 2007
    ..Surveying the epidemic pattern, disease spectra, and severity associated with each EV serotype provided important information for public health and medical personnel...
  35. ncbi request reprint Therapeutic efficacy of milrinone in the management of enterovirus 71-induced pulmonary edema
    Shih Min Wang
    Department of Emergency Medicine, College of Medicine, National Cheng Kung University and Hospital, Tainan, Taiwan
    Pediatr Pulmonol 39:219-23. 2005
    ..These results were associated with improvement in sympathetic regulation and decrease in IL-13 production. Milrinone therapy may provide a useful therapeutic approach for this highly lethal disorder...
  36. ncbi request reprint Autophagic machinery activated by dengue virus enhances virus replication
    Ying Ray Lee
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Virology 374:240-8. 2008
    ..Moreover, our data show that ATG5 protein is required to execute DV2-induced autophagy. All together, we are the first to demonstrate that DV can activate autophagic machinery that is favorable for viral replication...
  37. doi request reprint Profiling of influenza viruses by high-throughput carbohydrate membrane array
    Weng I Lao
    Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, No 1, University Road, Tainan 70101, Taiwan
    Future Med Chem 3:283-96. 2011
    ..Carbohydrate-protein interactions participate in many biological functions. To characterize the binding interactions represents a longstanding challenge...
  38. doi request reprint Poor immune response to a standard single dose non-adjuvanted vaccination against 2009 pandemic H1N1 influenza virus A in the adult and elder hemodialysis patients
    Yu Tzu Chang
    Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
    Vaccine 30:5009-18. 2012
    ....
  39. ncbi request reprint Comparison of neutralizing and hemagglutination-inhibiting antibody responses for evaluating the seasonal influenza vaccine
    Li Wei Cheng
    Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, Tainan 701, Taiwan
    J Virol Methods 182:43-9. 2012
    ..These data suggest that the neutralizing antibody response is a better measurement of influenza vaccine efficacy...
  40. pmc Formalin-inactivated EV71 vaccine candidate induced cross-neutralizing antibody against subgenotypes B1, B4, B5 and C4A in adult volunteers
    Ai Hsiang Chou
    Vaccine Research and Development Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan Town, Miaoli County, Taiwan
    PLoS ONE 8:e79783. 2013
    ..In this study we report the cross-neutralizing antibody responses from each volunteer against different subgenotypes of EV71 and CVA16...
  41. doi request reprint Large B cell lymphoma presenting initially in bone marrow, liver and spleen: an aggressive entity associated frequently with haemophagocytic syndrome
    Yu Min Yeh
    Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Histopathology 57:785-95. 2010
    ..To describe diffuse large B cell lymphoma (DLBCL) presenting initially in bone marrow, liver and spleen (BLS-type) without lymphadenopathy...
  42. doi request reprint Molecular epidemiology of Echovirus 30 in Taiwan, 1988-2008
    Guan Ming Ke
    Department of Clinical Laboratory, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Virus Genes 42:178-88. 2011
    ..Taiwanese strains were classified into GVI-D (1988-1989), GVI-F (1993-2004), and GVI-G (1993-2008). The quiescence period of E-30 is longer in Taiwan (5-8 years) than in other countries (3-5 years)...
  43. ncbi request reprint A role for chronic parvovirus B19 infection in liver dysfunction in renal transplant recipients?
    Po Chang Lee
    Department of Surgery, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Transplantation 73:1635-9. 2002
    ..Here we present the association of liver dysfunction with or without the coinfection of B19, HBV, and HCV after renal transplantation...
  44. pmc Laboratory-based surveillance and molecular epidemiology of influenza virus in Taiwan
    Shin Ru Shih
    Chang Gung Memorial Hospital and Chang Gung University, Taipei, Taiwan
    J Clin Microbiol 43:1651-61. 2005
    ..No clear seasonality of influenza reports in Taiwan occurred in contrast to other more continental regions...
  45. ncbi request reprint Evolution of EV71 genogroup in Taiwan from 1998 to 2005: an emerging of subgenogroup C4 of EV71
    Kuei Hsiang Lin
    Department of Clinical Laboratory, Kaohsiung Medical University, Kaohsiung City, Taiwan
    J Med Virol 78:254-62. 2006
    ..Nucleotide sequence alignment revealed 67 substitutions. Most of the substitutions (62/67) were silent mutations. This is the first report about the emergence of EV71 subgenogroup C4 in Taiwan...
  46. ncbi request reprint Acute chemokine response in the blood and cerebrospinal fluid of children with enterovirus 71-associated brainstem encephalitis
    Shih Min Wang
    Department of Emergency Medicine, National Cheng Kung University Medical College and Hospital, Taipei, Taiwan
    J Infect Dis 198:1002-6. 2008
    ..The present study was designed to determine the characteristics of the chemokine response in the blood and cerebrospinal fluid (CSF) of patients with EV71-associated BE...