Hwai Shi Wang

Summary

Affiliation: National Yang-Ming University
Country: Taiwan

Publications

  1. pmc Matrix metalloproteases and tissue inhibitors of metalloproteinases in medial plica and pannus-like tissue contribute to knee osteoarthritis progression
    Chih Chang Yang
    Department of Anatomy, National Yang Ming University, Taipei, Taiwan, R O C
    PLoS ONE 8:e79662. 2013
  2. ncbi request reprint Mesenchymal stem cells in the Wharton's jelly of the human umbilical cord
    Hwai Shi Wang
    Institute of Anatomy and Cell Biology, Yang Ming University, Taipei, Taiwan, Republic of China
    Stem Cells 22:1330-7. 2004
  3. ncbi request reprint CD44 cross-linking induces integrin-mediated adhesion and transendothelial migration in breast cancer cell line by up-regulation of LFA-1 (alpha L beta2) and VLA-4 (alpha4beta1)
    Hwai Shi Wang
    Institute of Anatomy and Cell Biology, School of Medicine, Yang Ming University, 155, Sec 2, Lih Nong Street, Shih Pai, 112, Peitou, Taipei 112, Taiwan, ROC
    Exp Cell Res 304:116-26. 2005
  4. ncbi request reprint TGF-beta induced hyaluronan synthesis in orbital fibroblasts involves protein kinase C betaII activation in vitro
    Hwai Shi Wang
    Institute of Anatomy and Cell Biology, School of Medicine, Yang Ming University, Taipei, Taiwan
    J Cell Biochem 95:256-67. 2005
  5. doi request reprint Enhanced membrane-type 1 matrix metalloproteinase expression by hyaluronan oligosaccharides in breast cancer cells facilitates CD44 cleavage and tumor cell migration
    Chang I Kung
    Institute of Anatomy and Cell Biology, School of Medicine, National Yang Ming University, Taipei, Taiwan, ROC
    Oncol Rep 28:1808-14. 2012
  6. doi request reprint Transplantation of insulin-producing cells derived from umbilical cord stromal mesenchymal stem cells to treat NOD mice
    Hwai Shi Wang
    Institute of Anatomy and Cell Biology, School of Medicine, National Yang Ming University, Taipei, Taiwan, ROC
    Cell Transplant 20:455-66. 2011
  7. pmc Transplantation of insulin-producing cells from umbilical cord mesenchymal stem cells for the treatment of streptozotocin-induced diabetic rats
    Pei Jiun Tsai
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Republic of China
    J Biomed Sci 19:47. 2012
  8. doi request reprint Transforming growth factor-beta induces CD44 cleavage that promotes migration of MDA-MB-435s cells through the up-regulation of membrane type 1-matrix metalloproteinase
    Yi Chih Kuo
    Institute of Anatomy and Cell Biology, School of Medicine, Yang Ming University, Taipei, Taiwan
    Int J Cancer 124:2568-76. 2009
  9. doi request reprint Intraportal injection of insulin-producing cells generated from human bone marrow mesenchymal stem cells decreases blood glucose level in diabetic rats
    Pei Jiun Tsai
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan, R O C
    Endocr Res 39:26-33. 2014
  10. ncbi request reprint CD44 crosslinking-mediated matrix metalloproteinase-9 relocation in breast tumor cells leads to enhanced metastasis
    Shu Tine Peng
    Institute of Anatomy and Cell Biology, School of Medicine, Yang Ming University, Taipei, Taiwan, R O C
    Int J Oncol 31:1119-26. 2007

Collaborators

Detail Information

Publications16

  1. pmc Matrix metalloproteases and tissue inhibitors of metalloproteinases in medial plica and pannus-like tissue contribute to knee osteoarthritis progression
    Chih Chang Yang
    Department of Anatomy, National Yang Ming University, Taipei, Taiwan, R O C
    PLoS ONE 8:e79662. 2013
    ..The results suggest that medial plica and pannus-like tissue may be involved in the process of cartilage degradation in medial compartment OA of the knee. ..
  2. ncbi request reprint Mesenchymal stem cells in the Wharton's jelly of the human umbilical cord
    Hwai Shi Wang
    Institute of Anatomy and Cell Biology, Yang Ming University, Taipei, Taiwan, Republic of China
    Stem Cells 22:1330-7. 2004
    ....
  3. ncbi request reprint CD44 cross-linking induces integrin-mediated adhesion and transendothelial migration in breast cancer cell line by up-regulation of LFA-1 (alpha L beta2) and VLA-4 (alpha4beta1)
    Hwai Shi Wang
    Institute of Anatomy and Cell Biology, School of Medicine, Yang Ming University, 155, Sec 2, Lih Nong Street, Shih Pai, 112, Peitou, Taipei 112, Taiwan, ROC
    Exp Cell Res 304:116-26. 2005
    ..Because these induced integrins promote tumor cell migration into the target tissue, it may be possible to suppress this by pharmacological means, and thus potentially cause a reduction in invasive capability and metastasis...
  4. ncbi request reprint TGF-beta induced hyaluronan synthesis in orbital fibroblasts involves protein kinase C betaII activation in vitro
    Hwai Shi Wang
    Institute of Anatomy and Cell Biology, School of Medicine, Yang Ming University, Taipei, Taiwan
    J Cell Biochem 95:256-67. 2005
    ..PKCbetaII, a key enzyme in the regulation of HA synthesis by TGF-beta, might be an appropriate target for therapeutic compounds to be used to treat Graves' ophthalmopathy accompanied by inflammation...
  5. doi request reprint Enhanced membrane-type 1 matrix metalloproteinase expression by hyaluronan oligosaccharides in breast cancer cells facilitates CD44 cleavage and tumor cell migration
    Chang I Kung
    Institute of Anatomy and Cell Biology, School of Medicine, National Yang Ming University, Taipei, Taiwan, ROC
    Oncol Rep 28:1808-14. 2012
    ..The HA oligosaccharide-induced MT1-MMP expression in breast cancer cells may be a critical step in the formation of metastatic colonies...
  6. doi request reprint Transplantation of insulin-producing cells derived from umbilical cord stromal mesenchymal stem cells to treat NOD mice
    Hwai Shi Wang
    Institute of Anatomy and Cell Biology, School of Medicine, National Yang Ming University, Taipei, Taiwan, ROC
    Cell Transplant 20:455-66. 2011
    ..Thus, we demonstrated that differentiated insulin-producing cells from human umbilical cord stromal MSCs transplanted into NOD mice could alleviate hyperglycemia in diabetic mice...
  7. pmc Transplantation of insulin-producing cells from umbilical cord mesenchymal stem cells for the treatment of streptozotocin-induced diabetic rats
    Pei Jiun Tsai
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Republic of China
    J Biomed Sci 19:47. 2012
    ..Secondly, we evaluated the effect of portal vein transplantation of these differentiated cells in the treatment of streptozotocin-induced diabetes in rats...
  8. doi request reprint Transforming growth factor-beta induces CD44 cleavage that promotes migration of MDA-MB-435s cells through the up-regulation of membrane type 1-matrix metalloproteinase
    Yi Chih Kuo
    Institute of Anatomy and Cell Biology, School of Medicine, Yang Ming University, Taipei, Taiwan
    Int J Cancer 124:2568-76. 2009
    ..MT1-MMP siRNA transfection-inhibited TGF-beta-induced cancer cell transendothelial migration. Thus, this study contributes to our understanding of molecular mechanisms that play a critical role in tumor cell invasion and metastasis...
  9. doi request reprint Intraportal injection of insulin-producing cells generated from human bone marrow mesenchymal stem cells decreases blood glucose level in diabetic rats
    Pei Jiun Tsai
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan, R O C
    Endocr Res 39:26-33. 2014
    ..We concluded that hBM-MSCs could be trans-differentiated into insulin-producing cells in vitro. Portal vein transplantation of insulin-producing cells alleviated hyperglycemia in diabetic rats...
  10. ncbi request reprint CD44 crosslinking-mediated matrix metalloproteinase-9 relocation in breast tumor cells leads to enhanced metastasis
    Shu Tine Peng
    Institute of Anatomy and Cell Biology, School of Medicine, Yang Ming University, Taipei, Taiwan, R O C
    Int J Oncol 31:1119-26. 2007
    ..This study demonstrates for the first time that CD44 crosslinking leads to an enhanced level and relocation of MMP-9 in human breast tumor cells accompanied by increased tumor invasion and metastasis...
  11. doi request reprint Antofine-induced connexin43 gap junction disassembly in rat astrocytes involves protein kinase Cβ
    Yu fang Huang
    Institute of Anatomy and Cell Biology, School of Medicine, National Yang Ming University, Taipei 11221, Taiwan
    Neurotoxicology 35:169-79. 2013
    ..Taken together, these findings indicate that antofine induces Cx43 gap junction disassembly by the PKCβ signaling pathway. Inhibition of GJIC by antofine may undermine the neuroprotective effect of astrocytes in CNS...
  12. doi request reprint Matrix metalloprotease-3 expression in the medial plica and pannus-like tissue in knees from patients with medial compartment osteoarthritis
    Hwai Shi Wang
    Department of Anatomy and Cell Biology, National Yang Ming University, Taipei, Taiwan
    Histopathology 58:593-600. 2011
    ..The aim of the present study was therefore to investigate matrix metalloprotease-3 (MMP-3) expression in the plica isolated from patients with medial compartment osteoarthritis of the knee...
  13. pmc Lipopolysaccharide induces degradation of connexin43 in rat astrocytes via the ubiquitin-proteasome proteolytic pathway
    Chih Kai Liao
    Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    PLoS ONE 8:e79350. 2013
    ..Taken together, these results suggest that LPS stimulation leads to downregulation of Cx43 expression and GJIC in rat astrocytes by activation of SAPK/JNK and the ubiquitin-proteasome proteolytic pathway. ..
  14. ncbi request reprint CDK5 regulates cell adhesion and migration in corneal epithelial cells
    Chun Gao
    National Eye Institute, NIH, Bethesda, MD Yang Ming University, Taipei, Taiwan
    Mol Cancer Res 1:12-24. 2002
    ..These findings indicate that CDK5 may be an important regulator of adhesion and migration of corneal epithelial cells...
  15. doi request reprint Alleviation of hyperglycemia in diabetic rats by intraportal injection of insulin-producing cells generated from surgically resected human pancreatic tissue
    Jia Fwu Shyu
    Department of Biology and Anatomy, National Defense Medical Center, Taipei 11490, Taiwan, ROC
    J Endocrinol 208:233-44. 2011
    ..Thus, surgically resected pancreatic tissue may represent an alternative source of functional insulin-producing cells...
  16. ncbi request reprint Cdk5 regulates cell-matrix and cell-cell adhesion in lens epithelial cells
    Sewite Negash
    National Eye Institute, NIH, Bethesda, MD 20892, USA
    J Cell Sci 115:2109-17. 2002
    ..In addition, Cdk5 overexpression decreased cell-cell adhesion as measured by a cell aggregation assay. These findings suggest that Cdk5 plays a role in regulating both cell-matrix and cell-cell interactions in the lens...