Hsing Wen Wang

Summary

Affiliation: National Yang-Ming University
Country: Taiwan

Publications

  1. ncbi request reprint Diffuse reflectance spectroscopy detects increased hemoglobin concentration and decreased oxygenation during colon carcinogenesis from normal to malignant tumors
    Hsing Wen Wang
    Institute of Biophotonics, National Yang Ming University, Taipei, 11221, Taiwan
    Opt Express 17:2805-17. 2009
  2. doi request reprint Differentiation of apoptosis from necrosis by dynamic changes of reduced nicotinamide adenine dinucleotide fluorescence lifetime in live cells
    Hsing Wen Wang
    National Yang Ming University, Institute of Biophotonics, Taipei, Taiwan
    J Biomed Opt 13:054011. 2008
  3. ncbi request reprint Reduced nicotinamide adenine dinucleotide (NADH) fluorescence for the detection of cell death
    Hsing Wen Wang
    Institute of Biophotonics, National Yang Ming University, 155 Li Nong St, Sec 2, Taipei 11221, Taiwan
    Anticancer Agents Med Chem 9:1012-7. 2009
  4. ncbi request reprint Quantitative comparison of tissue oxygen and motexafin lutetium uptake by ex vivo and noninvasive in vivo techniques in patients with intraperitoneal carcinomatosis
    Hsing Wen Wang
    University of Pennsylvania, Department of Physics, Philadelphia, Pennsylvania, USA
    J Biomed Opt 12:034023. 2007
  5. doi request reprint Reduced nicotinamide adenine dinucleotide fluorescence lifetime detected poly(adenosine-5'-diphosphate-ribose) polymerase-1-mediated cell death and therapeutic effect of pyruvate
    Han Wen Guo
    National Yang Ming University, Institute of Biophotonics, Taipei 112, Taiwan
    J Biomed Opt 16:068001. 2011
  6. pmc Fluence rate-dependent intratumor heterogeneity in physiologic and cytotoxic responses to Photofrin photodynamic therapy
    Theresa M Busch
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania, B13 Anatomy and Chemistry, 3620 Hamilton Walk, Philadelphia, PA 19104 6072, USA
    Photochem Photobiol Sci 8:1683-93. 2009
  7. ncbi request reprint Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcome
    Hsing Wen Wang
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Cancer Res 64:7553-61. 2004
  8. ncbi request reprint In vivo reflectance measurement of optical properties, blood oxygenation and motexafin lutetium uptake in canine large bowels, kidneys and prostates
    Michael Solonenko
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia 19104, USA
    Phys Med Biol 47:857-73. 2002
  9. ncbi request reprint A phase II trial of intraperitoneal photodynamic therapy for patients with peritoneal carcinomatosis and sarcomatosis
    Stephen M Hahn
    Department of Radiation Oncology, Division of Gynecologic Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Clin Cancer Res 12:2517-25. 2006
  10. ncbi request reprint Broadband reflectance measurements of light penetration, blood oxygenation, hemoglobin concentration, and drug concentration in human intraperitoneal tissues before and after photodynamic therapy
    Hsing Wen Wang
    University of Pennsylvania, Department of Physics and Astronomy, 209 South 33rd Street, Philadelphia, Pennsylvania 19104 6396, USA
    J Biomed Opt 10:14004. 2005

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Diffuse reflectance spectroscopy detects increased hemoglobin concentration and decreased oxygenation during colon carcinogenesis from normal to malignant tumors
    Hsing Wen Wang
    Institute of Biophotonics, National Yang Ming University, Taipei, 11221, Taiwan
    Opt Express 17:2805-17. 2009
    ....
  2. doi request reprint Differentiation of apoptosis from necrosis by dynamic changes of reduced nicotinamide adenine dinucleotide fluorescence lifetime in live cells
    Hsing Wen Wang
    National Yang Ming University, Institute of Biophotonics, Taipei, Taiwan
    J Biomed Opt 13:054011. 2008
    ....
  3. ncbi request reprint Reduced nicotinamide adenine dinucleotide (NADH) fluorescence for the detection of cell death
    Hsing Wen Wang
    Institute of Biophotonics, National Yang Ming University, 155 Li Nong St, Sec 2, Taipei 11221, Taiwan
    Anticancer Agents Med Chem 9:1012-7. 2009
    ..Further studies are required to understand the actual site and mechanism of NADH binding of a specific death pathway for future successful in vivo detection of cell death using the NADH fluorescence lifetime...
  4. ncbi request reprint Quantitative comparison of tissue oxygen and motexafin lutetium uptake by ex vivo and noninvasive in vivo techniques in patients with intraperitoneal carcinomatosis
    Hsing Wen Wang
    University of Pennsylvania, Department of Physics, Philadelphia, Pennsylvania, USA
    J Biomed Opt 12:034023. 2007
    ..These results further demonstrate the potential of in vivo DRS measurements in clinical PDT...
  5. doi request reprint Reduced nicotinamide adenine dinucleotide fluorescence lifetime detected poly(adenosine-5'-diphosphate-ribose) polymerase-1-mediated cell death and therapeutic effect of pyruvate
    Han Wen Guo
    National Yang Ming University, Institute of Biophotonics, Taipei 112, Taiwan
    J Biomed Opt 16:068001. 2011
    ....
  6. pmc Fluence rate-dependent intratumor heterogeneity in physiologic and cytotoxic responses to Photofrin photodynamic therapy
    Theresa M Busch
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania, B13 Anatomy and Chemistry, 3620 Hamilton Walk, Philadelphia, PA 19104 6072, USA
    Photochem Photobiol Sci 8:1683-93. 2009
    ..This research suggests that the benefits of low-fluence-rate PDT are mediated in part by a reduction in intratumor heterogeneity in hypoxic, vascular and cytotoxic responses...
  7. ncbi request reprint Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcome
    Hsing Wen Wang
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Cancer Res 64:7553-61. 2004
    ..These data suggest that monitoring of PDT-induced changes in tumor oxygenation may be a valuable prognostic indicator...
  8. ncbi request reprint In vivo reflectance measurement of optical properties, blood oxygenation and motexafin lutetium uptake in canine large bowels, kidneys and prostates
    Michael Solonenko
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia 19104, USA
    Phys Med Biol 47:857-73. 2002
    ..This class of in situ optical property measurement may be desirable to individualize PDT drug and light delivery...
  9. ncbi request reprint A phase II trial of intraperitoneal photodynamic therapy for patients with peritoneal carcinomatosis and sarcomatosis
    Stephen M Hahn
    Department of Radiation Oncology, Division of Gynecologic Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Clin Cancer Res 12:2517-25. 2006
    ..The primary objectives of this phase II study were to determine the efficacy and toxicities of i.p. photodynamic therapy in patients with peritoneal carcinomatosis and sarcomatosis...
  10. ncbi request reprint Broadband reflectance measurements of light penetration, blood oxygenation, hemoglobin concentration, and drug concentration in human intraperitoneal tissues before and after photodynamic therapy
    Hsing Wen Wang
    University of Pennsylvania, Department of Physics and Astronomy, 209 South 33rd Street, Philadelphia, Pennsylvania 19104 6396, USA
    J Biomed Opt 10:14004. 2005
    ..These results provide benchmark in-vivo tissue optical property data, and demonstrate the feasibility of in-situ measurements during clinical PDT treatments...
  11. doi request reprint NADH fluorescence as a photobiological metric in 5-aminolevlinic acid (ALA)-photodynamic therapy
    Guan Chin Su
    Institute of Biophotonics, National Yang Ming University, 155 Li Nong St, Sec 2, Taipei 112, Taiwan
    Opt Express 19:21145-54. 2011
    ..This feature will be unique in the use of optimizing apoptosis-favored treatments such as metronomic PDT...
  12. doi request reprint Increase of reduced nicotinamide adenine dinucleotide fluorescence lifetime precedes mitochondrial dysfunction in staurosporine-induced apoptosis of HeLa cells
    Jia Sin Yu
    National Yang Ming University, Institute of Biophotonics, Taipei, Taiwan
    J Biomed Opt 16:036008. 2011
    ..Furthermore, the NADH fluorescence lifetime change is associated with the pace of apoptosis...
  13. ncbi request reprint Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy
    Guoqiang Yu
    Department of Physics and Astronomy, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Clin Cancer Res 11:3543-52. 2005
    ..To monitor tumor blood flow noninvasively during photodynamic therapy (PDT) and to correlate flow responses with therapeutic efficacy...
  14. doi request reprint Reduced nicotinamide adenine dinucleotide fluorescence lifetime separates human mesenchymal stem cells from differentiated progenies
    Han Wen Guo
    Institute of Biophotonics, National Yang Ming University, 155 Li Nong Street, Section 2, Taipei 11221, Taiwan
    J Biomed Opt 13:050505. 2008
    ..These findings suggest that NADH fluorescence lifetime may serve as a new optical biomarker for noninvasive selection of stem cells from differentiated progenies...
  15. ncbi request reprint Effect of photosensitizer dose on fluence rate responses to photodynamic therapy
    Hsing Wen Wang
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Photochem Photobiol 83:1040-8. 2007
    ..Clinical confirmation and application of these results will be possible through use of minimally invasive oxygen and photosensitizer monitoring technologies, which are currently under development...