Guei Jane Wang

Summary

Affiliation: National Research Institute of Chinese Medicine
Country: Taiwan

Publications

  1. doi request reprint Cellular calcium regulatory machinery of vasorelaxation elicited by petasin
    Guei Jane Wang
    National Research Institute of Chinese Medicine, National Yang Ming University, Taipei, Taiwan
    Clin Exp Pharmacol Physiol 37:309-15. 2010
  2. ncbi request reprint The vasorelaxation of Antrodia camphorata mycelia: involvement of endothelial Ca(2+)-NO-cGMP pathway
    Guei Jane Wang
    National Research Institute of Chinese Medicine, Room 739, 155 1, Section 2, Li Nong Street, Pei tou District 112, Taipei, Taiwan, ROC
    Life Sci 73:2769-83. 2003
  3. ncbi request reprint Inhibitory effects of glycosides from the leaves of Melaleuca quinquenervia on vascular contraction of rats
    Tzong Huei Lee
    Institute of Botany, Academia Sinica, Nankang, Taipei, Taiwan, ROC
    Planta Med 68:492-6. 2002
  4. ncbi request reprint Ca2+ channel blocking effect of iso-S-petasin in rat aortic smooth muscle cells
    Guei Jane Wang
    National Research Institute of Chinese Medicine, Room 355, 155 1, Section 2, Li Nong Street, Pei tou District 112, Taipei, Taiwan, ROC
    Eur J Pharmacol 445:239-45. 2002
  5. doi request reprint Lanostanes from Phellinus igniarius and their iNOS inhibitory activities
    Guei Jane Wang
    National Research Institute of Chinese Medicine, Taipei 112, Taiwan
    Planta Med 75:1602-7. 2009
  6. doi request reprint Flavonoids with iNOS inhibitory activity from Pogonatherum crinitum
    Guei Jane Wang
    National Research Institute of Chinese Medicine, Taipei, Taiwan
    J Ethnopharmacol 118:71-8. 2008
  7. doi request reprint Anemonin, from Clematis crassifolia, potent and selective inducible nitric oxide synthase inhibitor
    Tzong Huei Lee
    Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, Taiwan, Republic of China
    J Ethnopharmacol 116:518-27. 2008
  8. doi request reprint Vasorelaxing alkaloids and flavonoids from Cassytha filiformis
    Tung Hu Tsai
    Institute of Traditional Medicine, National Yang Ming University, Taipei, Taiwan, Republic of China
    J Nat Prod 71:289-91. 2008
  9. ncbi request reprint Calcium-antagonizing activity of S-petasin, a hypotensive sesquiterpene from Petasites formosanus, on inotropic and chronotropic responses in isolated rat atria and cardiac myocytes
    Guei Jane Wang
    National Research Institute of Chinese Medicine, Taipei, Taiwan, Republic of China
    Naunyn Schmiedebergs Arch Pharmacol 369:322-9. 2004
  10. ncbi request reprint Inhibitory effects of L-arginine derivatives on endothelium-dependent vasorelaxing response to acetylcholine of the rat aorta
    Guei Jane Wang
    National Research Institute of Chinese Medicine, Taipei 112, Taiwan, ROC
    Eur J Med Chem 39:611-7. 2004

Collaborators

Detail Information

Publications25

  1. doi request reprint Cellular calcium regulatory machinery of vasorelaxation elicited by petasin
    Guei Jane Wang
    National Research Institute of Chinese Medicine, National Yang Ming University, Taipei, Taiwan
    Clin Exp Pharmacol Physiol 37:309-15. 2010
    ..The more pronounced effect of the sesquiterpene in blood vessels from SHR suggests its possible therapeutic potential in the mangement of hypertension...
  2. ncbi request reprint The vasorelaxation of Antrodia camphorata mycelia: involvement of endothelial Ca(2+)-NO-cGMP pathway
    Guei Jane Wang
    National Research Institute of Chinese Medicine, Room 739, 155 1, Section 2, Li Nong Street, Pei tou District 112, Taipei, Taiwan, ROC
    Life Sci 73:2769-83. 2003
    ..However, K+ channels had no apparent roles. Adenosine could possibly be involved in the endothelium-dependent pathway of B85-induced vasorelaxation...
  3. ncbi request reprint Inhibitory effects of glycosides from the leaves of Melaleuca quinquenervia on vascular contraction of rats
    Tzong Huei Lee
    Institute of Botany, Academia Sinica, Nankang, Taipei, Taiwan, ROC
    Planta Med 68:492-6. 2002
    ..The rank-order potency (EC 50 value) of vasorelaxing activities of these compounds is 4 > 2 > 2a > 3 > 1...
  4. ncbi request reprint Ca2+ channel blocking effect of iso-S-petasin in rat aortic smooth muscle cells
    Guei Jane Wang
    National Research Institute of Chinese Medicine, Room 355, 155 1, Section 2, Li Nong Street, Pei tou District 112, Taipei, Taiwan, ROC
    Eur J Pharmacol 445:239-45. 2002
    ..In conclusion, these results suggest that Ca(2+) antagonism of the L-type VDCC in vascular smooth muscle cells might largely account for the hypotensive action of iso-S-petasin...
  5. doi request reprint Lanostanes from Phellinus igniarius and their iNOS inhibitory activities
    Guei Jane Wang
    National Research Institute of Chinese Medicine, Taipei 112, Taiwan
    Planta Med 75:1602-7. 2009
    ..57 +/- 1.38 microM...
  6. doi request reprint Flavonoids with iNOS inhibitory activity from Pogonatherum crinitum
    Guei Jane Wang
    National Research Institute of Chinese Medicine, Taipei, Taiwan
    J Ethnopharmacol 118:71-8. 2008
    ....
  7. doi request reprint Anemonin, from Clematis crassifolia, potent and selective inducible nitric oxide synthase inhibitor
    Tzong Huei Lee
    Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, Taiwan, Republic of China
    J Ethnopharmacol 116:518-27. 2008
    ..These results indicated that the potential anti-inflammatory effect of anemonin, the naturally occurring selective iNOS inhibitor, may provide a rationale for the medical use of Clematis crassifolia...
  8. doi request reprint Vasorelaxing alkaloids and flavonoids from Cassytha filiformis
    Tung Hu Tsai
    Institute of Traditional Medicine, National Yang Ming University, Taipei, Taiwan, Republic of China
    J Nat Prod 71:289-91. 2008
    ..50 to 32.81 microM at the test concentrations...
  9. ncbi request reprint Calcium-antagonizing activity of S-petasin, a hypotensive sesquiterpene from Petasites formosanus, on inotropic and chronotropic responses in isolated rat atria and cardiac myocytes
    Guei Jane Wang
    National Research Institute of Chinese Medicine, Taipei, Taiwan, Republic of China
    Naunyn Schmiedebergs Arch Pharmacol 369:322-9. 2004
    ....
  10. ncbi request reprint Inhibitory effects of L-arginine derivatives on endothelium-dependent vasorelaxing response to acetylcholine of the rat aorta
    Guei Jane Wang
    National Research Institute of Chinese Medicine, Taipei 112, Taiwan, ROC
    Eur J Med Chem 39:611-7. 2004
    ..These compounds revealed that the nitro group is an essential inhibiting group of these inhibitors, and that hydrophobic functional groups can fine-tune the binding effects. Among them, A-3 is the most potent inhibitor...
  11. doi request reprint New constituents with iNOS inhibitory activity from mycelium of Antrodia camphorata
    Sien Sing Yang
    Department of Internal Medicine, Cathy General Hospital, Taipei, Taiwan
    Planta Med 75:512-6. 2009
    ..7 +/- 2.8 microg/mL, respectively, but displayed cytotoxicity at considerably higher concentrations. Compound 3 showed the lowest percent cell viability of 45.5 +/- 1.8 % as observed in treated cells at a concentration of 16.8 microg/mL...
  12. doi request reprint Bioactive γ-lactones from the fermented broth of Neosartorya sp
    Sien Sing Yang
    Department of Internal Medicine, Cathay General Hospital, Taipei, Taiwan
    Planta Med 76:1701-5. 2010
    ..Compounds 1 and 2 significantly inhibited NO production with the IC(50) values of 12.2 ± 1.5 and 11.4 ± 1.0 µM, respectively; but displayed cytotoxicity at considerably higher concentrations than 50 µM...
  13. ncbi request reprint Prenylflavonol, acylated flavonol glycosides and related compounds from Epimedium sagittatum
    Guei Jane Wang
    National Research Institute of Chinese Medicine, 155 1, Li Nong Street Section 2, Taipei 112, Taiwan
    Phytochemistry 68:2455-64. 2007
    ..16+/-0.03 mg/ml. However, the 13 compounds tested, generated only a mild or moderate relaxation, and did not possess significant vasorelaxing effect individually...
  14. ncbi request reprint Lipopolysaccharide-stimulated responses in rat aortic endothelial cells by a systems biology approach
    Hsiang Wen Tseng
    Department and Institute of Pharmacology, National Yang Ming University, Taipei, Taiwan
    Proteomics 6:5915-28. 2006
    ..Moreover, the expressions of altered genes, proteins, and their involvement in the hypothetical signaling pathway can provide further understanding of inflammation associated responses in ECs...
  15. doi request reprint Ligusticum chuanxiong as a potential neuroprotectant for preventing serum deprivation-induced apoptosis in rat pheochromocytoma cells: functional roles of mitogen-activated protein kinases
    Yun Lian Lin
    National Research Institute of Chinese Medicine, Taipei, Taiwan
    J Ethnopharmacol 122:417-23. 2009
    ..Ligusticum chuanxiong (LC) as a common component in many traditional Chinese medicinal formulas and decoctions has been used to treat different central nervous diseases, suggesting a neuroprotective function...
  16. ncbi request reprint Long-term administration of Salvia miltiorrhiza ameliorates carbon tetrachloride-induced hepatic fibrosis in rats
    Tzung Yan Lee
    Institute of Traditional Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan
    J Pharm Pharmacol 55:1561-8. 2003
    ..In conclusion, long-term administration of Salvia miltiorrhiza in rats ameliorated the CCl4-induced hepatic injury that probably related to a reduced oxidant stress and degree of hepatic fibrosis...
  17. ncbi request reprint Improving abnormal hemorheological parameters in aging guinea pigs by water-soluble extracts of Salvia miltiorrhiza Bunge
    Wen Chi Hou
    Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, Taiwan
    J Ethnopharmacol 111:483-9. 2007
    ..Blood viscosity and viscoelasticity exhibited significant improvement in oscillatory measurements. Also, we found that the oxygen transport efficiency of whole blood increased...
  18. doi request reprint Ganoderma lucidum extract attenuates the proliferation of hepatic stellate cells by blocking the PDGF receptor
    Guei Jane Wang
    National Research Institute of Chinese Medicine, Taipei, Taiwan
    Phytother Res 23:833-9. 2009
    ..These results indicated that G. lucidum inhibits PDGF-BB-activated HSC proliferation possibly through blocking PDGFbetaR phosphorylation, thereby indicating its efficacy for preventing and treating hepatic fibrosis...
  19. ncbi request reprint DPPH radical scavenging and semicarbazide-sensitive amine oxidase inhibitory and cytotoxic activities of Taiwanofungus camphoratus (Chang-chih)
    Guei Jane Wang
    National Research Institute of Chinese Medicine, Taipei, Taiwan
    Biosci Biotechnol Biochem 71:1873-8. 2007
    ..It was found that extracted fractions from three Chang-chih exhibited the different levels of biological activities...
  20. pmc Anti-inflammatory and anti-infectious effects of Evodia rutaecarpa (Wuzhuyu) and its major bioactive components
    Jyh Fei Liao
    Institute of Pharmacology, National Yang Ming University, No 155, Sec 2, Linong Road, Taipei 112, Taiwan
    Chin Med 6:6. 2011
    ..Stimulation of calcitonin gene-related peptide release may partially explain the analgesic, cardiovascular and gastrointestinal protective, anti-obese activities of Evodia rutaecarpa and its major bioactive components...
  21. doi request reprint Ethanolic extracts and isolated compounds from small-leaf grape (Vitis thunbergii var. taiwaniana) with antihypertensive activities
    Yin Shiou Lin
    School of Pharmacy, Taipei Medical University, Taipei, Taiwan
    J Agric Food Chem 60:7435-41. 2012
    ..These results suggest that the development of functional foods with VTT extracts may be beneficial for regulating blood pressure. ..
  22. ncbi request reprint Chemical and biological comparisons on Evodia with two related species of different locations and conditions
    Han Chieh Ko
    Department of Medicinal Chemistry, School of Pharmacy, Taipei Medical University, Taipei, Taiwan, ROC
    J Ethnopharmacol 108:257-63. 2006
    ..This strongly supports our assumption that biological function evaluations, instead of chemical standardization, is the more adequate way of showing meaningful consistency of natural preparations...
  23. ncbi request reprint Selective inducible nitric oxide synthase suppression by new bracteanolides from Murdannia bracteata
    Guei Jane Wang
    National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC
    J Ethnopharmacol 112:221-7. 2007
    ..The selective inhibition on iNOS provides a possible explanation for the anti-inflammatory use of M. bracteata...
  24. doi request reprint Sepsis worsening vascular hyporeactivity of the superior mesenteric artery in portal vein-ligated rats
    Wei Chih Liao
    National Yang Ming University School of Medicine, 201 Section 2 Shih Pai Road, Taipei, Taiwan, R O C
    J Chin Med Assoc 73:462-70. 2010
    ..The objective of this study was to investigate whether impairment of superior mesenteric artery vascular contractility in the portal hypertensive rat was further impaired after sepsis...
  25. pmc Arctigenin from Arctium lappa inhibits interleukin-2 and interferon gene expression in primary human T lymphocytes
    Wei Jern Tsai
    Institute of Life Science, Fu Jen University, Taipei, 24205, Taiwan
    Chin Med 6:12. 2011
    ..abstract:..