Yune Fang Ueng

Summary

Affiliation: National Research Institute of Chinese Medicine
Country: Taiwan

Publications

  1. ncbi request reprint Inhibition of human cytochrome P450 enzymes by the natural hepatotoxin safrole
    Yune Fang Ueng
    National Research Institute of Chinese Medicine, 155 1, Li Nong Street, Sec 2, Taipei 112, Taiwan, ROC
    Food Chem Toxicol 43:707-12. 2005
  2. ncbi request reprint Mechanism-based inhibition of CYP1A1 and CYP3A4 by the furanocoumarin chalepensin
    Yune Fang Ueng
    Laboratory of Drug Metabolism, National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC
    Drug Metab Pharmacokinet 28:229-38. 2013
  3. ncbi request reprint Oxidative metabolism of the alkaloid rutaecarpine by human cytochrome P450
    Yune Fang Ueng
    National Research Institute of Chinese Medicine, 155 1, Li Nong Street, Sec 2, Taipei 112, Taiwan, ROC
    Drug Metab Dispos 34:821-7. 2006
  4. doi request reprint Differential inductive profiles of hepatic cytochrome P450s by the extracts of Sophora flavescens in male and female C57BL/6JNarl mice
    Yune Fang Ueng
    National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC
    J Ethnopharmacol 126:437-46. 2009
  5. pmc Mechanism-based inhibition of cytochrome P450 (CYP)2A6 by chalepensin in recombinant systems, in human liver microsomes and in mice in vivo
    Yune Fang Ueng
    National Research Institute of Chinese Medicine, Taipei, Taiwan
    Br J Pharmacol 163:1250-62. 2011
  6. ncbi request reprint Alteration of the pharmacokinetics of theophylline by rutaecarpine, an alkaloid of the medicinal herb Evodia rutaecarpa, in rats
    Yune Fang Ueng
    National Research Institute of Chinese Medicine, Taipei, Taiwan, R O C
    J Pharm Pharmacol 57:227-32. 2005
  7. ncbi request reprint The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes
    Yune Fang Ueng
    National Research Institute of Chinese Medicine, Taipei, Taiwan, Republic of China
    Drug Metab Dispos 30:349-53. 2002
  8. ncbi request reprint Modulation of drug-metabolizing enzymes by extracts of a herbal medicine Evodia rutaecarpa in C57BL/6J mice
    Yune Fang Ueng
    National Research Institute of Chinese Medicine, 155 1, Li Nong Street, Sec 2, Taipei 11211, Taiwan, ROC
    Life Sci 71:1267-77. 2002
  9. ncbi request reprint Diterpene quinone tanshinone IIA selectively inhibits mouse and human cytochrome p4501A2
    Yune Fang Ueng
    National Research Institute of Chinese Medicine, Taipei 112, Taiwan, ROC
    Xenobiotica 33:603-13. 2003
  10. ncbi request reprint Effects of Wu-chu-yu-tang and its component herbs on drug-metabolizing enzymes
    Yune Fang Ueng
    National Research Institute of Chinese Medicine, Taipei, Taiwan
    Jpn J Pharmacol 89:267-73. 2002

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Inhibition of human cytochrome P450 enzymes by the natural hepatotoxin safrole
    Yune Fang Ueng
    National Research Institute of Chinese Medicine, 155 1, Li Nong Street, Sec 2, Taipei 112, Taiwan, ROC
    Food Chem Toxicol 43:707-12. 2005
    ..These results revealed that safrole was a potent inhibitor of human CYP1A2, CYP2A6, and CYP2E1. With relatively less potency, CYP2D6 and CYP3A4 were also inhibited...
  2. ncbi request reprint Mechanism-based inhibition of CYP1A1 and CYP3A4 by the furanocoumarin chalepensin
    Yune Fang Ueng
    Laboratory of Drug Metabolism, National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC
    Drug Metab Pharmacokinet 28:229-38. 2013
    ..These results demonstrate that chalepensin inhibits multiple P450s and that epoxidation activity is crucial for the potential drug interaction through mechanism-based inhibition...
  3. ncbi request reprint Oxidative metabolism of the alkaloid rutaecarpine by human cytochrome P450
    Yune Fang Ueng
    National Research Institute of Chinese Medicine, 155 1, Li Nong Street, Sec 2, Taipei 112, Taiwan, ROC
    Drug Metab Dispos 34:821-7. 2006
    ..The metabolite profile and kinetic properties of rutaecarpine hydroxylation by human P450s provide important information relevant to the clinical application of rutaecarpine and E. rutaecarpa...
  4. doi request reprint Differential inductive profiles of hepatic cytochrome P450s by the extracts of Sophora flavescens in male and female C57BL/6JNarl mice
    Yune Fang Ueng
    National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC
    J Ethnopharmacol 126:437-46. 2009
    ..Sophora flavescens has been used as an antipyretic and analgesic agent. To assess the possible herb-drug interaction, effects of S. flavescens extracts on hepatic cytochrome P450 (P450, CYP) enzymes were studied...
  5. pmc Mechanism-based inhibition of cytochrome P450 (CYP)2A6 by chalepensin in recombinant systems, in human liver microsomes and in mice in vivo
    Yune Fang Ueng
    National Research Institute of Chinese Medicine, Taipei, Taiwan
    Br J Pharmacol 163:1250-62. 2011
    ..Chalepensin is a pharmacologically active furanocoumarin compound found in rue, a medicinal herb. Here we have investigated the inhibitory effects of chalepensin on cytochrome P450 (CYP) 2A6 in vitro and in vivo...
  6. ncbi request reprint Alteration of the pharmacokinetics of theophylline by rutaecarpine, an alkaloid of the medicinal herb Evodia rutaecarpa, in rats
    Yune Fang Ueng
    National Research Institute of Chinese Medicine, Taipei, Taiwan, R O C
    J Pharm Pharmacol 57:227-32. 2005
    ..In patients taking theophylline, adverse effects might be noticed when a rutaecarpine-containing herbal preparation is used concomitantly...
  7. ncbi request reprint The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes
    Yune Fang Ueng
    National Research Institute of Chinese Medicine, Taipei, Taiwan, Republic of China
    Drug Metab Dispos 30:349-53. 2002
    ..These results indicated that rutaecarpine was a potent inhibitor of CYP1A2 in both mouse and human liver microsomes...
  8. ncbi request reprint Modulation of drug-metabolizing enzymes by extracts of a herbal medicine Evodia rutaecarpa in C57BL/6J mice
    Yune Fang Ueng
    National Research Institute of Chinese Medicine, 155 1, Li Nong Street, Sec 2, Taipei 11211, Taiwan, ROC
    Life Sci 71:1267-77. 2002
    ..rutaecarpa. Thus, caution should be paid to the possible drug interactions of E. rutaecarpa and CYP substrates...
  9. ncbi request reprint Diterpene quinone tanshinone IIA selectively inhibits mouse and human cytochrome p4501A2
    Yune Fang Ueng
    National Research Institute of Chinese Medicine, Taipei 112, Taiwan, ROC
    Xenobiotica 33:603-13. 2003
    ..Tanshinone I and cryptotanshinone had the same IC(50) ratio (1A1/1A2) of 4. 5. The results indicate that tanshinone represents a new group of CYP1A inhibitors, and tanshinone IIA had the highest selectivity in inhibition of CYP1A2...
  10. ncbi request reprint Effects of Wu-chu-yu-tang and its component herbs on drug-metabolizing enzymes
    Yune Fang Ueng
    National Research Institute of Chinese Medicine, Taipei, Taiwan
    Jpn J Pharmacol 89:267-73. 2002
    ..E. Fructus and rutaecarpine contributed at least in part to the CYP1a2 induction by Wu-chu-yu-tang. Patients should be cautioned about the drug interaction of Wu-chu-yu-tang and CYP1A2 substrates...
  11. doi request reprint The oxidative metabolism of dimemorfan by human cytochrome P450 enzymes
    Yueh Ching Chou
    Pharmacy Department, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    J Pharm Sci 99:1063-77. 2010
    ..02 mM in forming M1. CYP2B6, CYP2C9, and CYP2C19 had the K(m) or S(50) values smaller than those (1 mM) of CYP2D6 and CYP3A4 in forming M2. These results indicated the participation of multiple P450 forms in DFO...
  12. doi request reprint A dual function of the furanocoumarin chalepensin in inhibiting Cyp2a and inducing Cyp2b in mice: the protein stabilization and receptor-mediated activation
    Wei Sheng Lo
    National Research Institute of Chinese Medicine, NO 155 1, Li Nong Street, Sec 2, Taipei, 112, Taiwan, ROC
    Arch Toxicol 86:1927-38. 2012
    ..These findings revealed that suicidal inhibition of Cyp2a5 and the CAR-mediated Cyp2b9/10 induction concurrently occurred in chalepensin-treated mice...
  13. ncbi request reprint Identification of the main human cytochrome P450 enzymes involved in safrole 1'-hydroxylation
    Yune Fang Ueng
    National Research Institute of Chinese Medicine, 155 1, Department of Pharmacology, National Yang Ming University, 155, Li Nong Street, Section 2, Taipei, Republic of China
    Chem Res Toxicol 17:1151-6. 2004
    ..CYP2E1 showed an intrinsic clearance 3-fold greater than CYP2C9. These results demonstrated that CYP2C9 and CYP2E1 were the main P450s involved in human hepatic SOH...
  14. ncbi request reprint Identification of the microsomal oxidation metabolites of rutaecarpine, a main active alkaloid of the medicinal herb Evodia rutaecarpa
    Yune Fang Ueng
    National Research Institute of Chinese Medicine, 155 1 Li Nong Street, Sec 2, Taipei 112, Taiwan, ROC
    J Chromatogr A 1076:103-9. 2005
    ..Rutaecarpine was metabolized by microsomal enzymes to form 3-, 10-, 11-, and 12-hydroxyrutaecarpine. The formation of 10-hydroxyrutaecarpine was highly induced by a cytochrome P450 1A inducer, 3-methylcholanthrene...
  15. ncbi request reprint Induction of cytochrome P450-dependent monooxygenase by extracts of the medicinal herb Salvia miltiorrhiza
    Ya Hui Kuo
    National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC
    J Pharm Pharmacol 58:521-7. 2006
    ..miltiorrhiza. The CYP induction by the ethyl acetate extract and pharmaceutical product suggested that possible drug interactions between S. miltiorrhiza and CYP substrates should be noticed...
  16. ncbi request reprint Effect of structural modification on the inhibitory selectivity of rutaecarpine derivatives on human CYP1A1, CYP1A2, and CYP1B1
    Ming Jaw Don
    National Research Institute of Chinese Medicine, 155 1 Li Nong Street, Sec 2, Taipei 112, Taiwan, ROC
    Bioorg Med Chem Lett 13:2535-8. 2003
    ..Among the derivatives, 10- and 11-methoxyrutaecarpine are the most selective CYP1B1 inhibitors. 1-Methoxyrutaecarpine and 1,2-dimethoxyrutaecarpine are the most selective CYP1A2 inhibitors...
  17. ncbi request reprint Induction of CYP1A by a diterpene quinone tanshinone IIA isolated from a medicinal herb Salvia miltiorrhiza in C57BL/6J but not in DBA/2J mice
    Yune Fang Ueng
    National Research Institute of Chinese Medicine, 155 1, Li Nong Street, Sec 2, Taipei 112, Taiwan, ROC
    Life Sci 74:885-96. 2004
    ..Tanshinone IIA had no effects on UGT and GST activities in both B6 and D2 mice. These results demonstrated that induction of CYP1A2 by tanshinone IIA depended on the Ah-responsiveness and occurred at pre-translational level...
  18. doi request reprint Ketamine inhibits tumor necrosis factor-alpha and interleukin-6 gene expressions in lipopolysaccharide-stimulated macrophages through suppression of toll-like receptor 4-mediated c-Jun N-terminal kinase phosphorylation and activator protein-1 activation
    Gone Jhe Wu
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Toxicol Appl Pharmacol 228:105-13. 2008
    ..The suppressive mechanisms occur through suppression of TLR4-mediated sequential activations of c-Jun N-terminal kinase and activator protein-1...
  19. ncbi request reprint Induction of hepatic cytochrome P450s by the herbal medicine Sophora flavescens extract in rats: impact on the elimination of theophylline
    Yune Fang Ueng
    National Research Institute of Chinese Medicine, Taipei, Taiwan ueng nricm edu tw
    Drug Metab Pharmacokinet 25:560-7. 2010
    ..In patients taking Sf, possible P450 induction-induced drug interaction should be noted to decrease the risk of therapeutic failure or adverse effects resulting from the use of additional therapeutic agents...
  20. ncbi request reprint Propofol specifically inhibits mitochondrial membrane potential but not complex I NADH dehydrogenase activity, thus reducing cellular ATP biosynthesis and migration of macrophages
    Gong Jhe Wu
    Department of Anesthesiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Ann N Y Acad Sci 1042:168-76. 2005
    ..This study provides in vitro data to validate mitochondrial dysfunction as a possible critical cause for propofol-induced immunosuppression of macrophage functions...
  21. ncbi request reprint Dimemorfan N-demethylation by mouse liver microsomal cytochrome P450 enzymes
    Yueh Ching Chou
    Department of Pharmacy, Department of Internal Medicine, Taipei Veteran General Hospital, Taipei 112, Taiwan, R O C
    Life Sci 77:735-45. 2005
    ..These results revealed that CYP3A played a major role in hepatic demethylation in untreated mice. Both CYP3A and CYP2B were involved in this demethylation in PB- and Dex-treated mice...
  22. ncbi request reprint Cytochrome P3A4 inhibitors and other constituents of Fibraurea tinctoria
    Chung Ren Su
    Department of Chemistry, National Cheng Kung University, Tainan, Taiwan, ROC
    J Nat Prod 70:1930-3. 2007
    ..Among these compounds, palmatine ( 9) and jatrorrhizine ( 10) showed inhibitory effects against cytochrome P450 3A4 (CYP3A4) with IC 50 values of 0.9 and 2.1 microM, respectively...
  23. doi request reprint Sulfotransferase 1A1 haplotypes associated with oral squamous cell carcinoma susceptibility in male Taiwanese
    Yu Ting Chung
    Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Carcinogenesis 30:286-94. 2009
    ....
  24. doi request reprint 7-Ketocholesterol induces P-glycoprotein through PI3K/mTOR signaling in hepatoma cells
    Sheng Fan Wang
    National Research Institute of Chinese Medicine, No 155 1 Li Nong Street, Sec 2, Taipei 112, Taiwan, ROC
    Biochem Pharmacol 86:548-60. 2013
    ..These results demonstrate that 7-KC induces P-gp through PI3K/mTOR signaling and decreased the cell-killing efficacy of doxorubicin in hepatoma cells. ..
  25. doi request reprint Inhibition of CYP1 by berberine, palmatine, and jatrorrhizine: selectivity, kinetic characterization, and molecular modeling
    Sheng Nan Lo
    National Research Institute of Chinese Medicine, Taipei 112, Taiwan, ROC Institute of Biopharmaceutical Sciences, National Yang Ming University, Taipei 112, Taiwan, ROC
    Toxicol Appl Pharmacol 272:671-80. 2013
    ..These findings demonstrate that berberine causes a selective CYP1B1-inhibition, in which Asn228 appears to be crucial. The inhibitory effects of berberine on CYP1B1 activities toward structurally diverse substrates can be different...
  26. doi request reprint Suppressive effect of tobacco smoke extracts on oral P-glycoprotein function and its impact in smoke-induced insult to oral epidermal cells
    Wen Chi Pan
    National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC
    Toxicol Lett 185:116-23. 2009
    ..These results demonstrated that smoke and its constituent, naphthalene, diminished Pgp-mediated efflux. The reduction in Pgp function could be a stimulatory factor of TS-induced oral cell insult...
  27. ncbi request reprint Enhancements of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism and carcinogenic risk via NNK/arsenic interaction
    Hui Ling Lee
    Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Zhunan, Miaoli County, Taiwan, ROC
    Toxicol Appl Pharmacol 227:108-14. 2008
    ..These findings suggest that in the presence of arsenic, NNK could induce greater DNA adducts formation in hepatic tissues resulting in higher carcinogenic potential...
  28. doi request reprint Signal-transducing mechanisms of ketamine-caused inhibition of interleukin-1 beta gene expression in lipopolysaccharide-stimulated murine macrophage-like Raw 264.7 cells
    Ta Liang Chen
    Department of Anesthesiology, Taipei Medical University, Taipei, Taiwan
    Toxicol Appl Pharmacol 240:15-25. 2009
    ....
  29. ncbi request reprint Glycine N-methyltransferase affects the metabolism of aflatoxin B1 and blocks its carcinogenic effect
    Chia Hung Yen
    Division of Molecular Medicine, Institute of Public Health, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Toxicol Appl Pharmacol 235:296-304. 2009
    ..9 microM. Therefore, GNMT is a tumor suppressor for HCC and it exerts protective effects in hepatocytes via direct interaction with AFB(1), resulting in reduced AFB(1)-DNA adducts formation and cell death...