Yune Fang Ueng
Affiliation: National Research Institute of Chinese Medicine
Wang H, Lu C, Chen W, Chen A, Ueng Y. Shenmai-Yin decreased the clearance of nifedipine in rats: The involvement of time-dependent inhibition of nifedipine oxidation. J Food Drug Anal. 2019;27:284-294 pubmed publisher
..The decreased nifedipine clearance by SY in rats warrants further human study to examine the clinical impact of this decrease. ..
Ueng Y, Chen C, Yamazaki H, Kiyotani K, Chang Y, Lo W, et al
. Mechanism-based inhibition of CYP1A1 and CYP3A4 by the furanocoumarin chalepensin. Drug Metab Pharmacokinet. 2013;28:229-38 pubmed
..These results demonstrate that chalepensin inhibits multiple P450s and that epoxidation activity is crucial for the potential drug interaction through mechanism-based inhibition. ..
Lo S, Shen C, Chang C, Tsai K, Huang C, Wu T, et al
. The Effect of Oxidation on Berberine-Mediated CYP1 Inhibition: Oxidation Behavior and Metabolite-Mediated Inhibition. Drug Metab Dispos. 2015;43:1100-7 pubmed publisher
..These results demonstrated that berberine was not efficiently oxidized by CYP1B1, and metabolism-dependent irreversible inactivation was minimal. Metabolites of berberine caused a relatively weak inhibition of CYP1. ..
Chang Y, Huang C, Shen C, Tsai K, Ueng Y. Differential inhibition of CYP1-catalyzed regioselective hydroxylation of estradiol by berberine and its oxidative metabolites. Drug Metab Pharmacokinet. 2015;30:374-83 pubmed publisher
Ueng Y, Lu C, Yang S, Wang H, Huang C. Potentiation of the anticoagulation effect of warfarin by the herbal remedy Shu-Jing-Hwo-Shiee-Tang in rats: The dosing regimen and pharmacokinetic interaction. Drug Metab Pharmacokinet. 2017;32:85-91 pubmed publisher
..These results demonstrate that a 2-h post-treatment of rats with SJHST caused pharmacokinetic interaction with warfarin, resulting in prothrombin time prolongation. ..
Yang J, Liu Y, Huang C, Ueng Y. The time-dependent effects of St John's wort on cytochrome P450, uridine diphosphate-glucuronosyltransferase, glutathione S-transferase, and NAD(P)H-quinone oxidoreductase in mice. J Food Drug Anal. 2018;26:422-431 pubmed publisher
..The induction of hepatic Cyp2c requires repeated treatment for a period longer than the initial induction of Cyp3a. ..
Ueng Y, Tsai T, Don M, Chen R, Chen T. Alteration of the pharmacokinetics of theophylline by rutaecarpine, an alkaloid of the medicinal herb Evodia rutaecarpa, in rats. J Pharm Pharmacol. 2005;57:227-32 pubmed
..In patients taking theophylline, adverse effects might be noticed when a rutaecarpine-containing herbal preparation is used concomitantly...
Ueng Y, Chen C, Tsai C, Soucek P. Differential inductive profiles of hepatic cytochrome P450s by the extracts of Sophora flavescens in male and female C57BL/6JNarl mice. J Ethnopharmacol. 2009;126:437-46 pubmed publisher
..Sophora flavescens has been used as an antipyretic and analgesic agent. To assess the possible herb-drug interaction, effects of S. flavescens extracts on hepatic cytochrome P450 (P450, CYP) enzymes were studied...
Ueng Y, Chen C, Chung Y, Liu T, Chang Y, Lo W, et al
. Mechanism-based inhibition of cytochrome P450 (CYP)2A6 by chalepensin in recombinant systems, in human liver microsomes and in mice in vivo. Br J Pharmacol. 2011;163:1250-62 pubmed publisher
..Formation of an epoxide could be a key step in this inactivation. 'Poor metabolizers' carrying CYP2A6*7 or *10 may be less susceptible to inhibition by chalepensin. Given in vivo, chalepensin decreased CYP2A activity in mice. ..