Research Topics
Genomes and Genes | Shun Fen TzengSummaryAffiliation: National Cheng Kung University Country: Taiwan Publications
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Detail Information
Publications
Neural progenitors isolated from newborn rat spinal cords differentiate into neurons and astrogliaShun Fen Tzeng
Department of Biology, National Cheng Kung University, Tainan, Taiwan, ROC
J Biomed Sci 9:10-6. 2002..Thus, the neural progenitors isolated from newborn rat spinal cords in combination with neurotrophic factors may provide a tool for cell therapy in SCI patients...- Prostaglandins and cyclooxygenases in glial cells during brain inflammationShun Fen Tzeng
Department of Life Sciences, National Cheng Kung University, Tainan, Taiwan
Curr Drug Targets Inflamm Allergy 4:335-40. 2005..In addition, the mechanism by which PGs mediate signaling is discussed... - Inhibitors of DNA binding in neural cell proliferation and differentiationShun Fen Tzeng
Department of Biology, National Cheng Kung University, 1 Ta Hsiueh Road, Tainan City, Taiwan 70101
Neurochem Res 28:45-52. 2003..Here we summarize recent findings regarding the regulation of Id proteins in neural cells and discuss the possible mechanisms of Id-regulated neurogenesis... - Downregulation of inducible nitric oxide synthetase by neurotrophin-3 in microgliaShun Fen Tzeng
Department of Biology, National Cheng Kung University, Tainan City, Taiwan
J Cell Biochem 90:227-33. 2003..These findings indicate that NT-3 may serve as an anti-inflammatory factor to suppress microglial activation... 
Ca(2+)-dependent reduction of glutamate aspartate transporter GLAST expression in astrocytes by P2X(7) receptor-mediated phosphoinositide 3-kinase signalingYu Peng Liu
Department of Life Sciences, National Cheng Kung University, Tainan, Taiwan
J Neurochem 113:213-27. 2010....- Inhibition of lipopolysaccharide-induced microglial activation by preexposure to neurotrophin-3Shun Fen Tzeng
Department of Life Sciences, National Cheng Kung University, Tainan, Taiwan
J Neurosci Res 81:666-76. 2005..This suggests that an NT-enriched microenvironment may be favorable for preventing the inflammatory reaction of microglia... - TNF-alpha/IFN-gamma-induced iNOS expression increased by prostaglandin E2 in rat primary astrocytes via EP2-evoked cAMP/PKA and intracellular calcium signalingHan Yun Hsiao
Department of Life Sciences, National Cheng Kung University, Tainan, Taiwan
Glia 55:214-23. 2007..Collectively, PGE(2) may enhance T/I-induced astrocytic activation by augmenting iNOS/NO production through EP2-mediated cross-talk between cAMP/PKA and IP3/Ca(2+) signaling pathways... - Effects of malonate C60 derivatives on activated microgliaShun Fen Tzeng
Department of Biology, National Cheng Kung University, Tainan City, Taiwan
Brain Res 940:61-8. 2002..Therefore, our results suggest that the C60 derivatives might increase microglial SOD enzymatic activity which causes microglial morphological transformation from the activated amoeboid phenotype to the resting ramified form... 
Reduction in antioxidant enzyme expression and sustained inflammation enhance tissue damage in the subacute phase of spinal cord contusive injuryChih Yen Wang
Department of Life Sciences, National Cheng Kung University, Tainan, Taiwan
J Biomed Sci 18:13. 2011..To consider an appropriate time window for giving a promising therapeutic treatment for subacute and chronic SCI, global changes of proteins in the injured center at the longer survival time points after SCI remains to be elucidated...- Effects of combinatorial treatment with pituitary adenylate cyclase activating peptide and human mesenchymal stem cells on spinal cord tissue repairKuan Min Fang
Department of Life Sciences, National Cheng Kung University, Tainan, Taiwan
PLoS ONE 5:e15299. 2010.... - Inhibition of cadmium-induced oxidative injury in rat primary astrocytes by the addition of antioxidants and the reduction of intracellular calciumChung Shi Yang
Center for Nanomedicine Research, National Health Research Institutes, Zhunan, Taiwan, ROC
J Cell Biochem 103:825-34. 2008..This information provides a useful approach for treating Cd(2+)-induced CNS neurological disorders... - Retinoic acid mediates the expression of glutamate transporter-1 in rat astrocytes through genomic RXR action and non-genomic protein kinase C signaling pathwayTi Ju Chan
Department of Life Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan
J Neurochem 121:537-50. 2012..These results suggest that RA reduces astrocytic GLT-1 levels through both RXR-mediated inhibition at the transcriptional level and triggering activation of protein kinase C which reduces cell surface GLT-1 levels... - Microglial phagocytosis attenuated by short-term exposure to exogenous ATP through P2X receptor actionKuan Min Fang
Department of Life Sciences, National Cheng Kung University, Tainan, Taiwan
J Neurochem 111:1225-37. 2009.... - Expression of macrophage inflammatory protein-1α and monocyte chemoattractant protein-1 in glioma-infiltrating microglia: involvement of ATP and P2X₇ receptorKuan Min Fang
Department of Life Sciences, National Cheng Kung University, Tainan, Taiwan
J Neurosci Res 89:199-211. 2011.... - Mps one binder 2 gene upregulation in the stellation of astrocytes induced by cAMP-dependent pathwayKuan Min Fang
Institute of Life Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan
J Cell Biochem 113:3019-28. 2012..Based on our findings, we suggest that Mob2 is involved in PKA signaling-mediated astrocytic stellation... - Inhibitory regulation of glutamate aspartate transporter (GLAST) expression in astrocytes by cadmium-induced calcium influxYu Peng Liu
Department of Life Sciences, National Cheng Kung University, Tainan City, Taiwan
J Neurochem 105:137-50. 2008.... - Regulation of microglial activities by glial cell line derived neurotrophic factorYu-Ping Chang
Department of Life Sciences, National Cheng Kung University, No. 1 Ta-Hsueh Road, Tainan, Taiwan 70101
J Cell Biochem 97:501-11. 2006..Taken together, our results indicate that GDNF has a positive regulatory effect on microglial activities, such as phagocytosis and the upregulation of adhesion molecules... - Tumor necrosis factor-alpha and interleukin-18 modulate neuronal cell fate in embryonic neural progenitor cultureYu-Peng Liu
Department of Life Sciences, National Cheng Kung University, 1 Ta-Hsueh Rd, Tainan 70101, Taiwan
Brain Res 1054:152-8. 2005.... - Delayed granulocyte colony-stimulating factor treatment promotes functional recovery in rats with severe contusive spinal cord injuryJung Shun Lee
Department of Surgery Division of Neurosurgery, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Spine (Phila Pa 1976) 37:10-7. 2012.... - Reactive oxygen species-induced cell death of rat primary astrocytes through mitochondria-mediated mechanismChia Chun Wang
Department of Life Sciences, National Cheng Kung University, Tainan City, Taiwan
J Cell Biochem 107:933-43. 2009..This mitochondria-mediated but caspase-3-independent apoptotic pathway may be involved in oxidative stress-induced astrocytic cell death in the injured CNS... - Pituitary adenylate cyclase-activating polypeptide prevents cell death in the spinal cord with traumatic injuryWen Hsin Chen
Department of Life Sciences, National Cheng Kung University, 1 Ta Hsueh Road, Tainan 70101, Taiwan
Neurosci Lett 384:117-21. 2005..Our findings indicate the beneficial effect of PACAP for the treatment of spinal cord injury (SCI)... - Role of ciliary neurotrophic factor in microglial phagocytosisTsung I Lee
Department of Life Sciences, National Cheng Kung University, Tainan City, 70101, Taiwan
Neurochem Res 34:109-17. 2009..Our results also suggest that the upregulation of alphav integrin by CNTF could be involved in the increased phagocytotic activity of microglia... - Neuronal morphological change of size-sieved stem cells induced by neurotrophic stimuliShun-Fen Tzeng
Department of Biology, National Cheng Kung University, Tainan City, Taiwan ROC
Neurosci Lett 367:23-8. 2004..The findings indicate that neurotrophic signaling and cAMP-dependent signaling might promote the neuronal differentiation of SSCs... - Characterization of surface modification on microelectrode arrays for in vitro cell cultureShu Ping Lin
Institute of Biomedical Engineering, National Cheng Kung University, No 1 Ta Hsueh Road, Tainan, Taiwan, Republic of China
Biomed Microdevices 10:99-111. 2008.... - Gene transfer of glial cell line-derived neurotrophic factor promotes functional recovery following spinal cord contusionMing Hong Tai
Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
Exp Neurol 183:508-15. 2003..This research should provide information for developing a clinical strategy for GDNF gene therapy... - Behavior, neurochemistry and histology after intranigral lipopolysaccharide injectionPeiyuan F Hsieh
Division of Neurology, 160 Chung-Kang Road Section 3, Taichung, Taiwan 40705, ROC
Neuroreport 13:277-80. 2002..Unilateral LPS decreased dopamineric neurons ipsilaterally but increased contralaterally. This study provides the first evidence of behavioral hyperactivity, epinephrine suppression and neuronal plasticity in the LPS model of PD... - Experimental spinal cord injury induced an increase of extracellular ascorbic acid concentration in anesthetized rats: a microdialysis studyPi-Ju Tsai
Department of Education and Research, Taichung Veterans General Hospital, Taiwan
Clin Chim Acta 362:94-100. 2005..This on-line, continuous and automatic monitoring system can be applied to future investigations on the roles of ascorbic acid in spinal cord injuries... - Neuroprotection of glial cell line-derived neurotrophic factor in damaged spinal cords following contusive injuryHenrich Cheng
Neural Regeneration Laboratory, Neurological Institute, Taipei Veterans General Hospital, Taiwan
J Neurosci Res 69:397-405. 2002..Together our results show that GDNF exerts behavioral and anatomic neuroprotection following SCI. Additionally, GDNF-activated MAP kinase and Bcl-2 signaling may contribute to neuronal survival after spinal cord contusion... - Early-life fluoxetine exposure reduced functional deficits after hypoxic-ischemia brain injury in rat pupsYing-Chao Chang
Department of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Guang University College of Medicine, Kaohsiung, Taiwan
Neurobiol Dis 24:101-13. 2006..These findings suggest that functional deficits after HI in the developing brain can be reduced by agents that enhance neural plasticity and neurogenesis through CREB activation...