Po Nien Tsao
Affiliation: National Taiwan University
Tsao P, Matsuoka C, Wei S, Sato A, Sato S, Hasegawa K, et al
. Epithelial Notch signaling regulates lung alveolar morphogenesis and airway epithelial integrity. Proc Natl Acad Sci U S A. 2016;113:8242-7 pubmed publisher
..Our data suggest that epithelial Notch signaling regulates multiple aspects of postnatal development in the distal lung and may represent a potential target for intervention in pulmonary diseases. ..
Tsao P, Chan F, Wei S, Hsieh W, Chou H, Su Y, et al
. Soluble vascular endothelial growth factor receptor-1 protects mice in sepsis. Crit Care Med. 2007;35:1955-60 pubmed
..These findings support a critical protective role of sFlt-1 in endotoxic shock and sepsis. sFlt-1 may therefore have utility as an adjunctive agent for the treatment of sepsis syndrome. ..
Hou H, Cheng S, Chung K, Wei S, Tsao P, Lu H, et al
. PlGF mediates neutrophil elastase-induced airway epithelial cell apoptosis and emphysema. Respir Res. 2014;15:106 pubmed publisher
..The NE-PlGF-JNK/PKCÎ´ pathway contributes to the pathogenesis of LE cell apoptosis and emphysema. PlGF and its downstream signaling molecules may be potential therapeutic targets for COPD. ..
Yang W, Chen C, Chou H, Hsieh W, Tsao P. Angiogenic Factors in Cord Blood of Preterm Infants Predicts Subsequently Developing Bronchopulmonary Dysplasia. Pediatr neonatol. 2015;56:382-5 pubmed publisher
..Consistent with our previous report, cord blood level of PlGF may be considered as a biomarker to predict subsequently developing BPD in preterm infants. ..
Tsao P, Wei S, Huang M, Lee M, Chou H, Chen C, et al
. Lipopolysaccharide-induced Notch signaling activation through JNK-dependent pathway regulates inflammatory response. J Biomed Sci. 2011;18:56 pubmed publisher
..Therefore, in the future Notch inhibitors may be utilized as adjunctive agents for the treatment of sepsis syndrome. ..
Wang S, Liou J, Chen C, Chou H, Hsieh W, Tsao P. Risk Factors for Extubation Failure in Extremely Low Birth Weight Infants. Pediatr neonatol. 2017;58:145-150 pubmed publisher
..Among ELBW infants who require invasive ventilator support, those who have lower postextubation arterial pH and bicarbonate levels are at high risk of extubation failure. ..