Yau Sheng Tsai

Summary

Affiliation: National Cheng Kung University
Country: Taiwan

Publications

  1. pmc ENU mutagenesis identifies mice with morbid obesity and severe hyperinsulinemia caused by a novel mutation in leptin
    Chen Jee Hong
    Institute of Brain Science, School of Medicine, National Yang Ming University, Taipei, Taiwan
    PLoS ONE 5:e15333. 2010
  2. pmc Decreased PPAR gamma expression compromises perigonadal-specific fat deposition and insulin sensitivity
    Yau Sheng Tsai
    Institute of Clinical Medicine, National Cheng Kung University, Tainan 701, Taiwan, Republic of China
    Mol Endocrinol 23:1787-98. 2009
  3. pmc Overweight worsens apoptosis, neuroinflammation and blood-brain barrier damage after hypoxic ischemia in neonatal brain through JNK hyperactivation
    Yi Fang Tu
    Institute of Clinical Medicine, National Cheng Kung University College of Medicine, Tainan, Taiwan
    J Neuroinflammation 8:40. 2011
  4. pmc Diuretics prevent thiazolidinedione-induced cardiac hypertrophy without compromising insulin-sensitizing effects in mice
    Cherng Shyang Chang
    Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan Cardiovascular Research Center, National Cheng Kung University, Tainan, Taiwan
    Am J Pathol 184:442-53. 2014
  5. pmc Effects of PPARγ and RBP4 gene variants on metabolic syndrome in HIV-infected patients with anti-retroviral therapy
    Yuan Pin Hung
    Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan
    PLoS ONE 7:e49102. 2012
  6. doi request reprint Increased aortic stiffness and attenuated lysyl oxidase activity in obesity
    Ju Yi Chen
    Institute of Clinical Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Arterioscler Thromb Vasc Biol 33:839-46. 2013
  7. pmc Shorter daily dwelling time in peritoneal dialysis attenuates the epithelial-to-mesenchymal transition of mesothelial cells
    Yi Che Lee
    Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan
    BMC Nephrol 15:35. 2014
  8. doi request reprint Polymorphisms of INSIG2, MC4R, and LEP are associated with obesity- and metabolic-related traits in schizophrenic patients
    Po Hsiu Kuo
    Department of Public Health and Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
    J Clin Psychopharmacol 31:705-11. 2011
  9. pmc Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle
    Huei Fen Jheng
    Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Republic of China
    Mol Cell Biol 32:309-19. 2012
  10. pmc Ligand-activated peroxisome proliferator-activated receptor-gamma protects against ischemic cerebral infarction and neuronal apoptosis by 14-3-3 epsilon upregulation
    Jui Sheng Wu
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Circulation 119:1124-34. 2009

Collaborators

  • Nobuyo Maeda
  • Yi Heng Li
  • Wei Chuan Tsai
  • Yuan Yow Chiou
  • Shih Jen Tsai
  • Po Hsiu Kuo
  • Y Eugene Chen
  • Jun Yang Liou
  • Kenneth K Wu
  • Hyung Suk Kim
  • Chen Jee Hong
  • Tsun Mei Lin
  • Ju Yi Chen
  • Pei Jane Tsai
  • Cherng Shyang Chang
  • Yi Che Lee
  • Li chun Ho
  • Sheng Hsiang Lin
  • Chang Hua Chou
  • Huei Fen Jheng
  • Yuan Pin Hung
  • Yi Fang Tu
  • Jui Sheng Wu
  • Hsi Hao Wang
  • Junne Ming Sung
  • Min Yu Chang
  • Yung Tang Kung
  • Hsiang Chun Liu
  • Kumar Pandya
  • Hung Hsiang Liou
  • Kuang Wen Liu
  • Shih Yuan Hung
  • Hsin Pao Chen
  • Hao Kuang Wang
  • Hong Arh Fan
  • Shu Chu Shiesh
  • Ming Long Yeh
  • Hua Lin Wu
  • Mei Chung Wang
  • Li Jen Lin
  • Ruei Lan Tsai
  • Chen Fuh Lam
  • Yu Tzu Chang
  • Haw Chih Tai
  • Ming Jer Tang
  • Ho Ching Chang
  • Ih Jen Su
  • Hsiao Ju Lin
  • Yi Hui Wu
  • Chuang Rung Chang
  • Po Lin Chen
  • Chin Shan Ho
  • Li Hua Kuo
  • Chi Jung Wu
  • Ming Cheng Wang
  • Nan Yao Lee
  • Wen Chien Ko
  • Syue Maio Guo
  • Liang Miin Tsai
  • Chia Ming Chang
  • Hsin Chieh Wu
  • Chien Jung Ho
  • Lan Wan Wang
  • Chao Ching Huang
  • Song Kun Shyue
  • Jin Jer Chen
  • Wen Hsuan Fong
  • Hsin Da Tsai
  • Wai Mui Cheung

Detail Information

Publications11

  1. pmc ENU mutagenesis identifies mice with morbid obesity and severe hyperinsulinemia caused by a novel mutation in leptin
    Chen Jee Hong
    Institute of Brain Science, School of Medicine, National Yang Ming University, Taipei, Taiwan
    PLoS ONE 5:e15333. 2010
    ..Obesity is a multifactorial disease that arises from complex interactions between genetic predisposition and environmental factors. Leptin is central to the regulation of energy metabolism and control of body weight in mammals...
  2. pmc Decreased PPAR gamma expression compromises perigonadal-specific fat deposition and insulin sensitivity
    Yau Sheng Tsai
    Institute of Clinical Medicine, National Cheng Kung University, Tainan 701, Taiwan, Republic of China
    Mol Endocrinol 23:1787-98. 2009
    ..Together, these results underscore the differential sensitivity of the individual fat depots on PPAR gamma availability as an underlying mechanism of partial lipodystrophy...
  3. pmc Overweight worsens apoptosis, neuroinflammation and blood-brain barrier damage after hypoxic ischemia in neonatal brain through JNK hyperactivation
    Yi Fang Tu
    Institute of Clinical Medicine, National Cheng Kung University College of Medicine, Tainan, Taiwan
    J Neuroinflammation 8:40. 2011
    ..We hypothesized that neonatal overweight aggravates HI brain damage through JNK hyperactivation-mediated upregulation of neuronal apoptosis, neuroinflammation and BBB leakage in rat pups...
  4. pmc Diuretics prevent thiazolidinedione-induced cardiac hypertrophy without compromising insulin-sensitizing effects in mice
    Cherng Shyang Chang
    Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan Cardiovascular Research Center, National Cheng Kung University, Tainan, Taiwan
    Am J Pathol 184:442-53. 2014
    ..We conclude that releasing plasma volume reduces adverse effects of TZD-induced volume expansion and cardiac events without compromising TZD actions in metabolic switch in the heart and whole-body insulin sensitivity. ..
  5. pmc Effects of PPARγ and RBP4 gene variants on metabolic syndrome in HIV-infected patients with anti-retroviral therapy
    Yuan Pin Hung
    Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan
    PLoS ONE 7:e49102. 2012
    ..The influences of PPARγ (C1431T and Pro12Ala) and RBP4 (-803GA) polymorphisms on metabolic syndrome in HIV-infected patients receiving anti-retroviral therapy were examined in this study...
  6. doi request reprint Increased aortic stiffness and attenuated lysyl oxidase activity in obesity
    Ju Yi Chen
    Institute of Clinical Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Arterioscler Thromb Vasc Biol 33:839-46. 2013
    ..The aim of this study was to investigate the pathophysiology that links obesity to aortic stiffening...
  7. pmc Shorter daily dwelling time in peritoneal dialysis attenuates the epithelial-to-mesenchymal transition of mesothelial cells
    Yi Che Lee
    Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan
    BMC Nephrol 15:35. 2014
    ..The epithelial-to-mesenchymal transition (EMT) of mesothelial cells (MCs) plays an important role during the above process; however, the clinical parameters associated with the EMT process of MCs remain to be explored...
  8. doi request reprint Polymorphisms of INSIG2, MC4R, and LEP are associated with obesity- and metabolic-related traits in schizophrenic patients
    Po Hsiu Kuo
    Department of Public Health and Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
    J Clin Psychopharmacol 31:705-11. 2011
    ..We aimed to investigate the associations between these genes and metabolic disturbances in patients with schizophrenia in Taiwan...
  9. pmc Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle
    Huei Fen Jheng
    Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Republic of China
    Mol Cell Biol 32:309-19. 2012
    ..Thus, disruption of mitochondrial dynamics may underlie the pathogenesis of muscle insulin resistance in obesity and type 2 diabetes...
  10. pmc Ligand-activated peroxisome proliferator-activated receptor-gamma protects against ischemic cerebral infarction and neuronal apoptosis by 14-3-3 epsilon upregulation
    Jui Sheng Wu
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Circulation 119:1124-34. 2009
    ..Their protective actions are considered to be peroxisome proliferator-activated receptor-gamma (PPAR-gamma)-dependent; however, it is unclear how PPAR-gamma activation confers resistance to ischemia-reperfusion injury...
  11. doi request reprint Effects of increased systemic inflammation and central obesity on arterial stiffness in patients with nonalcoholic fatty liver disease
    Ju Yi Chen
    Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    J Am Soc Hypertens 6:253-60. 2012
    ..01-1.13; P < .05) was the only independent factor that predicted low CI (<median value) in patients with NAFLD. Central obesity was an important determinant both for increased arterial stiffness and hs-CRP in Patients with NAFLD...