Tung Hu Tsai


Affiliation: National Yang-Ming University
Country: Taiwan


  1. Hou M, Chang L, Lin C, Lin L, Tsai T. Determination of bioactive components in Chinese herbal formulae and pharmacokinetics of rhein in rats by UPLC-MS/MS. Molecules. 2014;19:4058-75 pubmed publisher
    ..In conclusion, the herbal formulae (SHXXT) are more efficient than the single herb (rhubarb) or the pure compound (rhein) in rhein absorption. ..
  2. Su N, Wu S, Chi C, Tsai T, Chen Y. Cordycepin, isolated from medicinal fungus Cordyceps sinensis, enhances radiosensitivity of oral cancer associated with modulation of DNA damage repair. Food Chem Toxicol. 2019;124:400-410 pubmed publisher
    ..In conclusion, cordycepin increased the radiosensitivity of OSCC cells, which is associated with the modulation of RT-induced DNA damage repair machinery. ..
  3. Hsueh T, Tsai T. Preclinical Pharmacokinetics of Scoparone, Geniposide and Rhein in an Herbal Medicine Using a Validated LC-MS/MS Method. Molecules. 2018;23: pubmed publisher
    ..This pharmacokinetic study reveals that an increased dose of this herbal formula would largely increase the maximum concentration and bioavailability of scoparone, geniposide and rhein. ..
  4. Tsai Y, Jan W, Chien C, Lee W, Lin L, Tsai T. Optimised nano-formulation on the bioavailability of hydrophobic polyphenol, curcumin, in freely-moving rats. Food Chem. 2011;127:918-25 pubmed publisher
    ..These findings demonstrate that PLGA nano-formulation could potentially be applied to increase bioavailability of hydrophobic polyphenols. ..
  5. Huang A, Yeh K, Cheng Y, Dubey N, Chiu A, Tsai T. Investigation of Interactive Activity of Electro-Acupuncture on Pharmacokinetics of Sildenafil and Their Synergistic Effect on Penile Blood Flow in Rats. Int J Mol Sci. 2018;19: pubmed publisher
    ..These data indicate a synergistic therapeutic effect of EA and sildenafil for the treatment of ED. ..
  6. Huang W, Kuo K, Adebayo B, Wang C, Chen Y, Jin K, et al. Garcinol inhibits cancer stem cell-like phenotype via suppression of the Wnt/β-catenin/STAT3 axis signalling pathway in human non-small cell lung carcinomas. J Nutr Biochem. 2018;54:140-150 pubmed publisher
    ..Taken together, we demonstrated herein that garcinol modulates the LCSC phenotype via regulation of Wnt/β-catenin signaling and inactivation of STAT3, thus showing that garcinol may be a putative novel anti-LCSC therapeutic agent. ..
  7. Chen J, Kuo H, Lee K, Tsai T. Global proteomic analysis of brain tissues in transient ischemia brain damage in rats. Int J Mol Sci. 2015;16:11873-91 pubmed publisher
    ..Based on these results, we also provide the molecular evidence supporting the ischemia-reperfusion-related neuronal injury. ..
  8. Lai K, Cheng Y, Tsai T. Integrated LC-MS/MS Analytical Systems and Physical Inspection for the Analysis of a Botanical Herbal Preparation. Molecules. 2015;20:10641-56 pubmed publisher
    ..In conclusion, a rigorous examination should be performed to certify the quality of the herbal products. ..
  9. Lu C, Lin L, Tsai T. Determination and pharmacokinetic study of gentiopicroside, geniposide, baicalin, and swertiamarin in Chinese herbal formulae after oral administration in rats by LC-MS/MS. Molecules. 2014;19:21560-78 pubmed publisher
    ..1 min µg/mL. The pharmacokinetic profiles provide constructive information for the dosage regimen of herbal medicine and also contribute to elucidate the absorption mechanism in herbal applications and pharmacological experiments. ..

More Information


  1. Hou M, Lin C, Lin L, Tsai T. The Drug-Drug Effects of Rhein on the Pharmacokinetics and Pharmacodynamics of Clozapine in Rat Brain Extracellular Fluid by In Vivo Microdialysis. J Pharmacol Exp Ther. 2015;355:125-34 pubmed publisher
    ..These findings suggest that a detailed clinical study for drug-drug interactions is recommended. ..
  2. Cheng Y, Hsieh C, Tsai T. Concurrent administration of anticancer chemotherapy drug and herbal medicine on the perspective of pharmacokinetics. J Food Drug Anal. 2018;26:S88-S95 pubmed publisher
  3. Hsueh T, Ho J, Lin L, Chiu A, Lin C, Tsai T. Herb-drug interaction of Epimedium extract on the pharmacokinetic of dapoxetine in rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;1014:64-9 pubmed publisher
    ..The oral bioavailability of dapoxetine was about 75% in rats. ..
  4. Cheng Y, Tsai T. Analysis of Sheng-Mai-San, a Ginseng-Containing Multiple Components Traditional Chinese Herbal Medicine Using Liquid Chromatography Tandem Mass Spectrometry and Physical Examination by Electron and Light Microscopies. Molecules. 2016;21: pubmed publisher
    ..This study provides a reference standard operating procedure guide for the quality control of the Chinese herbal pharmaceutical products of Sheng-Mai-San. ..
  5. Liu Y, Liu Y, Huang P, Tsai T, Chen Y. Antrodia cinnamomea mycelial fermentation broth inhibits the epithelial-mesenchymal transition of human esophageal adenocarcinoma cancer cells. Food Chem Toxicol. 2018;119:380-386 pubmed publisher
    ..Furthermore, AC-MFB treatment was able to inhibit the expression levels of both Twist and Twist1. Overall, AC-MFB was able to inhibit the EMT of esophageal cancer BE3 cells, which was accompanied by Twist and Twist1 downregulation. ..
  6. Liu J, Cheng Y, Hsieh C, Tsai T. The Herb-Drug Pharmacokinetic Interaction of 5-Fluorouracil and Its Metabolite 5-Fluoro-5,6-Dihydrouracil with a Traditional Chinese Medicine in Rats. Int J Mol Sci. 2017;19: pubmed publisher
    ..Overall, the pharmacokinetic results confirm the safety of coadministering 5-FU with XSLJZT, and provide practical dosage information for clinical practice. ..
  7. Hsueh T, Lin W, Tsai T. Using Light Microscopy and Liquid Chromatography Tandem Mass Spectrometry for Qualitative and Quantitative Control of a Combined Three-Herb Formulation in Different Preparations. Molecules. 2016;21: pubmed
    ..The results provide a reference for clinical herbal product preparations and further pharmacokinetic research. ..
  8. Chen S, Lee T, Tsai T, Lin Y, Lin C, Shieh H, et al. The Traditional Chinese Medicine DangguiBuxue Tang Sensitizes Colorectal Cancer Cells to Chemoradiotherapy. Molecules. 2016;21: pubmed
    ..We conclude that DBT-PD induces autophagy-associated cell death in CT26 cells, and may have potential as a chemotherapy or radiotherapy sensitizer in colorectal cancer treatment. ..
  9. Chen C, Chiang C, Wu L, Yang C, Kuo Y, Tsuang Y, et al. Time course investigation of intervertebral disc degeneration in a rat-tail puncture model. Life Sci. 2016;156:15-20 pubmed publisher
    ..The degenerative changes observed in this rat-tail puncture model are similar to human disc degeneration and that this model may be valuable for elucidating the molecular mechanisms and pathways underlying disc degeneration. ..
  10. Cheng Y, Tsai T, Jhan Y, Chiu A, Tsai K, Chien C, et al. Thermosensitive chitosan-based hydrogel as a topical ocular drug delivery system of latanoprost for glaucoma treatment. Carbohydr Polym. 2016;144:390-9 pubmed publisher
    ..This newly developed chitosan-based hydrogel may provide a non-invasive alternative to traditional anti-glaucoma eye drops for glaucoma treatment. ..
  11. Hou M, Lu C, Lin C, Lin L, Tsai T. Pharmacokinetics of Maleic Acid as a Food Adulterant Determined by Microdialysis in Rat Blood and Kidney Cortex. Molecules. 2016;21:367 pubmed publisher
    ..v., respectively), indicating that greater accumulation of maleic acid occurred in the rat kidney. ..
  12. Wang J, Chiang M, Lu C, Tsai T. Determination the active compounds of herbal preparation by UHPLC-MS/MS and its application on the preclinical pharmacokinetics of pure ephedrine, single herbal extract of Ephedra, and a multiple herbal preparation in rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;1026:152-161 pubmed publisher
    ..These data suggest that the rest of the herbal ingredients in the Ephedra extract and the MXGST may provide a compensation effect that reduces the peak concentration of ephedrine and prolongs the elimination half-life. ..
  13. Hsieh C, Hou M, Wang L, Tai H, Tsai T, Chen Y. Local pelvic irradiation modulates Pharmacokinetics of 5-Fluorouracil in the plasma but not in the Lymphatic System. BMC Cancer. 2015;15:316 pubmed publisher
    ..The RT-PK phenomena in plasma provide references for adjustment of drug administration. Chemotherapy drugs entering the lymphatic system is worthy of further investigation. ..
  14. Li C, Cheng Y, Hsieh C, Tsai T. Pharmacokinetics of Schizandrin and Its Pharmaceutical Products Assessed Using a Validated LC-MS/MS Method. Molecules. 2018;23: pubmed publisher
    ..The method was successfully applied to the pharmacokinetic study of pure schizandrin after oral administration of its pharmaceutical industry products in rats. ..
  15. Cheng Y, Tsai T. A validated LC-MS/MS determination method for the illegal food additive rhodamine B: Applications of a pharmacokinetic study in rats. J Pharm Biomed Anal. 2016;125:394-9 pubmed publisher
    ..8±1.4h, with a clearance of 229.7±19.4mL/h/kg. These pharmacokinetic results provide a constructive contribution to our understanding of the absorption mechanism of rhodamine B and support additional food safety evaluations. ..
  16. Ting C, Kuo C, Hu H, Lee Y, Tsai T. Prescription frequency and patterns of Chinese herbal medicine for liver cancer patients in Taiwan: a cross-sectional analysis of the National Health Insurance Research Database. BMC Complement Altern Med. 2017;17:118 pubmed publisher
    ..We propose that these breakthrough findings may have important implications for HCC therapy, clinical trials and modernization of CHM. ..
  17. Su N, Wu S, Chi C, Liu C, Tsai T, Chen Y. Metronomic Cordycepin Therapy Prolongs Survival of Oral Cancer-Bearing Mice and Inhibits Epithelial-Mesenchymal Transition. Molecules. 2017;22: pubmed publisher
    ..In conclusion, metronomic cordycepin therapy showed effective tumor control, prolonged survival and low toxicities. Cytotoxicity against cancer cells with apoptotic features and EMT inhibition were observed. ..
  18. Ting C, Cheng Y, Tsai T. Herb-Drug Interaction between the Traditional Hepatoprotective Formulation and Sorafenib on Hepatotoxicity, Histopathology and Pharmacokinetics in Rats. Molecules. 2017;22: pubmed publisher
    ..A detailed clinical trial should be performed to further evaluate the efficacy or adverse effects of the LDXGT formulation in combination with sorafenib in humans. ..
  19. Hsueh T, Lin W, Tsai T. Pharmacokinetic interactions of herbal medicines for the treatment of chronic hepatitis. J Food Drug Anal. 2017;25:209-218 pubmed publisher
    ..In addition, the existing pharmacokinetic profiles were further linked with clinical practice to provide insight for the safety and specific use of traditional herbal medicines. ..
  20. Tsai Y, Chang Liao W, Chien C, Lin L, Tsai T. Effects of polymer molecular weight on relative oral bioavailability of curcumin. Int J Nanomedicine. 2012;7:2957-66 pubmed publisher
    ..The results of this study provide the rationale for design of a nanomedicine delivery system to enhance the bioavailability of water-insoluble pharmaceutical compounds and functional foods. ..
  21. request reprint
    Tsai T, Chang C, Lin L. Effects of Evodia rutaecarpa and rutaecarpine on the pharmacokinetics of caffeine in rats. Planta Med. 2005;71:640-5 pubmed
    ..This finding should be very important whenever herb-drug interactions would be possible for a herbal remedy...
  22. Liu J, Cheng Y, Hsieh C, Tsai T. Identification of a Multicomponent Traditional Herbal Medicine by HPLC-MS and Electron and Light Microscopy. Molecules. 2017;22: pubmed publisher
    ..The developed chemical and physical methods provide a standard operating procedure for the quantity control of the herbal pharmaceutical products of XSLJZT. ..