Huai Jen Tsai
Affiliation: National Taiwan University
Chang H, Ko T, Chang Y, Huang K, Lin C, Chou H, et al
. Crystal structure of the blue fluorescent protein with a Leu-Leu-Gly tri-peptide chromophore derived from the purple chromoprotein of Stichodactyla haddoni. Int J Biol Macromol. 2019;130:675-684 pubmed publisher
..These observations provide new insights into the molecular basis that correlates chromophore conformation with light absorption and fluorescence emission for the development of improved biomarkers. ..
Lin C, Zhang P, Chen Y, Wu C, Tsai H. Conditional Overexpression of rtn4al in Muscle of Adult Zebrafish Displays Defects Similar to Human Amyotrophic Lateral Sclerosis. Mar Biotechnol (NY). 2019;21:52-64 pubmed publisher
..These results suggest that this zebrafish transgenic line, representing the inducible overexpression of Rtn4a1 in muscle, may provide an alternative animal model with which to study ALS because it exhibits ALS-like phenotype. ..
Lin C, Chiang C, Tsai H. Zebrafish and Medaka: new model organisms for modern biomedical research. J Biomed Sci. 2016;23:19 pubmed publisher
..Therefore, transgenic model fish possess a broad spectrum of applications in modern biomedical research, as exampled in the following review. ..
Chiang C, Lin C, Chen Y, Tsai H. Blue fluorescent protein derived from the mutated purple chromoprotein isolated from the sea anemone Stichodactyla haddoni. Protein Eng Des Sel. 2016;: pubmed
..Additionally, we found that the cDNA of shBFP is stably expressed in zebrafish embryos with fidelity, indicating the application of shBFP as a biomarker or selective marker. ..
Lin C, He J, Zeng C, Loo M, Chang W, Zhang P, et al
. microRNA-206 modulates an Rtn4a/Cxcr4a/Thbs3a axis in newly forming somites to maintain and stabilize the somite boundary formation of zebrafish embryos. Open Biol. 2017;7: pubmed publisher
..Collectively, we suggest that miR-206 mediates a novel pathway, the Rtn4a/Cxcr4a/Thbs3a axis, that allows boundary cells to undergo MET and form somite boundaries in the newly forming somites of zebrafish embryos. ..
Chen Y, Wang Y, Chang M, Lin C, Weng C, Westerfield M, et al
. Multiple upstream modules regulate zebrafish myf5 expression. BMC Dev Biol. 2007;7:1 pubmed
..This study provides an insight to understand the molecular control of myf5 and myogenesis in the zebrafish. ..
Lee H, Tsai J, Liao P, Tsai W, Lin K, Chuang C, et al
. Glycogen synthase kinase 3 alpha and 3 beta have distinct functions during cardiogenesis of zebrafish embryo. BMC Dev Biol. 2007;7:93 pubmed