Che Ming Teng

Summary

Affiliation: National Taiwan University
Country: Taiwan

Publications

  1. pmc Aciculatin induces p53-dependent apoptosis via MDM2 depletion in human cancer cells in vitro and in vivo
    Chin Yu Lai
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    PLoS ONE 7:e42192. 2012
  2. pmc Physalin F induces cell apoptosis in human renal carcinoma cells by targeting NF-kappaB and generating reactive oxygen species
    Szu Ying Wu
    Department of Pharmacology, National Taiwan University, Taipei, Taiwan
    PLoS ONE 7:e40727. 2012
  3. pmc Apoptosis signal-regulating kinase 1 mediates denbinobin-induced apoptosis in human lung adenocarcinoma cells
    Chen Tzu Kuo
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan, ROC
    J Biomed Sci 16:43. 2009
  4. ncbi request reprint YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] inhibits endothelial cell functions induced by angiogenic factors in vitro and angiogenesis in vivo models
    Shiow Lin Pan
    Pharmacological Institute, College of Medicine, National Taiwan University, 1 Jen Ai Road, Section 1, Taipei, Taiwan
    J Pharmacol Exp Ther 314:35-42. 2005
  5. ncbi request reprint CIL-102 interacts with microtubule polymerization and causes mitotic arrest following apoptosis in the human prostate cancer PC-3 cell line
    Yao Ting Huang
    Pharmacological Institute and School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan
    J Biol Chem 280:2771-9. 2005
  6. ncbi request reprint Antitumor mechanism of evodiamine, a constituent from Chinese herb Evodiae fructus, in human multiple-drug resistant breast cancer NCI/ADR-RES cells in vitro and in vivo
    Cho Hwa Liao
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei 100, Taiwan
    Carcinogenesis 26:968-75. 2005
  7. ncbi request reprint YC-1 [3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl Indazole] exhibits a novel antiproliferative effect and arrests the cell cycle in G0-G1 in human hepatocellular carcinoma cells
    Shih Wei Wang
    Pharmacological Institutes, College of Medicine, National Taiwan University, 1 Jen Ai Road, sect 1, Taipei, Taiwan
    J Pharmacol Exp Ther 312:917-25. 2005
  8. doi request reprint Moscatilin, a bibenzyl derivative from the India orchid Dendrobrium loddigesii, suppresses tumor angiogenesis and growth in vitro and in vivo
    An Chi Tsai
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    Cancer Lett 292:163-70. 2010
  9. ncbi request reprint YC-1 suppresses constitutive nuclear factor-kappaB activation and induces apoptosis in human prostate cancer cells
    Yao Ting Huang
    Pharmacological Institute, College of Medicine, National Taiwan University, No 1, Jen Ai Road, Taipei 100, Taiwan
    Mol Cancer Ther 4:1628-35. 2005
  10. ncbi request reprint Investigation of extrinsic and intrinsic apoptosis pathways of new clerodane diterpenoids in human prostate cancer PC-3 cells
    Dong Ming Huang
    Pharmacological Institute, College of Medicine, National Taiwan University, No 1, Jen Ai Road, sect 1, Taipei, Taiwan
    Eur J Pharmacol 503:17-24. 2004

Collaborators

Detail Information

Publications63

  1. pmc Aciculatin induces p53-dependent apoptosis via MDM2 depletion in human cancer cells in vitro and in vivo
    Chin Yu Lai
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    PLoS ONE 7:e42192. 2012
    ..Collectively, these results indicate that aciculatin treatment induces cell cycle arrest and apoptosis via inhibition of MDM2 expression, thereby inducing p53 accumulation without significant DNA damage and genome toxicity...
  2. pmc Physalin F induces cell apoptosis in human renal carcinoma cells by targeting NF-kappaB and generating reactive oxygen species
    Szu Ying Wu
    Department of Pharmacology, National Taiwan University, Taipei, Taiwan
    PLoS ONE 7:e40727. 2012
    ..The aim of this study was to determine the molecular mechanisms of physalin F, an effective purified extract of Physalis angulata L. (Solanacae), in renal carcinoma A498 cells...
  3. pmc Apoptosis signal-regulating kinase 1 mediates denbinobin-induced apoptosis in human lung adenocarcinoma cells
    Chen Tzu Kuo
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan, ROC
    J Biomed Sci 16:43. 2009
    ..These results suggest that denbinobin might activate ASK1 through ROS production to cause JNK/AP-1 activation, which in turn induces Bim expression, and ultimately results in A549 cell apoptosis...
  4. ncbi request reprint YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] inhibits endothelial cell functions induced by angiogenic factors in vitro and angiogenesis in vivo models
    Shiow Lin Pan
    Pharmacological Institute, College of Medicine, National Taiwan University, 1 Jen Ai Road, Section 1, Taipei, Taiwan
    J Pharmacol Exp Ther 314:35-42. 2005
    ..YC-1 may be useful for treating angiogenesis-dependent human diseases such as cancer...
  5. ncbi request reprint CIL-102 interacts with microtubule polymerization and causes mitotic arrest following apoptosis in the human prostate cancer PC-3 cell line
    Yao Ting Huang
    Pharmacological Institute and School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan
    J Biol Chem 280:2771-9. 2005
    ..CIL-102 causes mitotic arrest, at least partly, by modulating cyclin-dependent kinases and then apoptosis executed by caspase and noncaspase pathways...
  6. ncbi request reprint Antitumor mechanism of evodiamine, a constituent from Chinese herb Evodiae fructus, in human multiple-drug resistant breast cancer NCI/ADR-RES cells in vitro and in vivo
    Cho Hwa Liao
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei 100, Taiwan
    Carcinogenesis 26:968-75. 2005
    ..Evodiamine therefore represents a highly promising chemotherapeutic agent in the treatment of human multiple-drug resistant cancer cells...
  7. ncbi request reprint YC-1 [3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl Indazole] exhibits a novel antiproliferative effect and arrests the cell cycle in G0-G1 in human hepatocellular carcinoma cells
    Shih Wei Wang
    Pharmacological Institutes, College of Medicine, National Taiwan University, 1 Jen Ai Road, sect 1, Taipei, Taiwan
    J Pharmacol Exp Ther 312:917-25. 2005
    ..Because of this, YC-1 is a potential antitumor agent worthy of further investigation...
  8. doi request reprint Moscatilin, a bibenzyl derivative from the India orchid Dendrobrium loddigesii, suppresses tumor angiogenesis and growth in vitro and in vivo
    An Chi Tsai
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    Cancer Lett 292:163-70. 2010
    ..These results suggest that inhibition of angiogenesis by moscatilin may be a major mechanism in cancer therapy...
  9. ncbi request reprint YC-1 suppresses constitutive nuclear factor-kappaB activation and induces apoptosis in human prostate cancer cells
    Yao Ting Huang
    Pharmacological Institute, College of Medicine, National Taiwan University, No 1, Jen Ai Road, Taipei 100, Taiwan
    Mol Cancer Ther 4:1628-35. 2005
    ..Given these unique actions, further investigations of the effects of YC-1 against hormone-refractory prostate cancer are warranted...
  10. ncbi request reprint Investigation of extrinsic and intrinsic apoptosis pathways of new clerodane diterpenoids in human prostate cancer PC-3 cells
    Dong Ming Huang
    Pharmacological Institute, College of Medicine, National Taiwan University, No 1, Jen Ai Road, sect 1, Taipei, Taiwan
    Eur J Pharmacol 503:17-24. 2004
    ....
  11. pmc CHM-1, a new vascular targeting agent, induces apoptosis of human umbilical vein endothelial cells via p53-mediated death receptor 5 up-regulation
    An Chi Tsai
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei 10051, Taiwan
    J Biol Chem 285:5497-506. 2010
    ....
  12. ncbi request reprint A potential role of YC-1 on the inhibition of cytokine release in peripheral blood mononuclear leukocytes and endotoxemic mouse models
    Shiow Lin Pan
    Pharmacological Institutes, College of Medicine, National Taiwan University, Taipei
    Thromb Haemost 93:940-8. 2005
    ..It is suggested that YC-1 may be a potential agent for the therapeutic treatment of sepsis...
  13. ncbi request reprint The indazole derivative YD-3 inhibits thrombin-induced vascular smooth muscle cell proliferation and attenuates intimal thickening after balloon injury
    Chieh Yu Peng
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    Thromb Haemost 92:1232-9. 2004
    ..Moreover, YD-3 also shows a developmental potential in the treatment of atherosclerosis and restenosis after vascular injury...
  14. ncbi request reprint YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] inhibits neointima formation in balloon-injured rat carotid through suppression of expressions and activities of matrix metalloproteinases 2 and 9
    Yi Nan Liu
    Pharmacological Institute, College of Medicine, National Taiwan University, 1 Jen Ai Road, sect 1, Taipei, Taiwan
    J Pharmacol Exp Ther 316:35-41. 2006
    ..YC-1 shows therapeutic potential for treatment of restenosis after angioplasty...
  15. ncbi request reprint Induction of mitotic arrest and apoptosis by evodiamine in human leukemic T-lymphocytes
    Yu Chun Huang
    Pharmacological Institute, College of Medicine, National Taiwan University, No 1, Jen Ai Road, Sec 1, Taipei, Taiwan
    Life Sci 75:35-49. 2004
    ..Furthermore, several biological events including the Bcl-2 phosphorylation, Bax up-regulation and increase of caspase-3 activity could explain evodiamine-induced cell apoptosis...
  16. ncbi request reprint CHM-1 inhibits hepatocyte growth factor-induced invasion of SK-Hep-1 human hepatocellular carcinoma cells by suppressing matrix metalloproteinase-9 expression
    Shih Wei Wang
    Pharmacological Institute, College of Medicine, National Taiwan University, No 1, Jen Ai Road, sect 1, Taipei, Taiwan
    Cancer Lett 257:87-96. 2007
    ..Thus, we suggest that CHM-1 is a potential therapeutic agent against tumor invasion...
  17. ncbi request reprint Genistein inversely affects tubulin-binding agent-induced apoptosis in human breast cancer cells
    Cho Hwa Liao
    Pharmacological Institute, College of Medicine, National Taiwan University, No 1, Jen Ai Road, Section 1, Taipei 100, Taiwan
    Biochem Pharmacol 67:2031-8. 2004
    ..In conclusion, genistein inversely affected tubulin-binding agent-induced apoptosis via down-regulation of cyclin B1/CDC2 kinase expression resulting in reduced Bcl-2 phosphorylation...
  18. ncbi request reprint Investigation of anticancer mechanism of clavulone II, a coral cyclopentenone prostaglandin analog, in human acute promyelocytic leukemia
    Yu Chun Huang
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Biomed Sci 12:335-45. 2005
    ....
  19. ncbi request reprint Induction of mitotic arrest and apoptosis in human prostate cancer pc-3 cells by evodiamine
    Dong Ming Huang
    Department of Pharmacology, School of Pharmacy and Department of Urology, College of Medicine, National Taiwan University, No 1 Jen Ai Road, Taipei 100, Taiwan, Republic of China
    J Urol 173:256-61. 2005
    ..We examined the anticancer activities and action mechanism of evodiamine...
  20. ncbi request reprint Moscatilin inhibits migration and metastasis of human breast cancer MDA-MB-231 cells through inhibition of Akt and Twist signaling pathway
    Hui Chen Pai
    Phamacological Institute, College of Medicine, National Taiwan University, No 1, Jen Ai Road, Sec 1, Taipei, Taiwan
    J Mol Med (Berl) 91:347-56. 2013
    ..Therefore, moscatilin may be an effective compound for the prevention of human breast cancer metastasis...
  21. ncbi request reprint Quinolone analogue inhibits tubulin polymerization and induces apoptosis via Cdk1-involved signaling pathways
    Ying Cheng Chen
    School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan
    Biochem Pharmacol 74:10-9. 2007
    ..Furthermore, participation of cell-cycle regulators, Bcl-2 family of proteins, activation of caspases and release of AIF may mutually cross-regulate the apoptotic signaling cascades induced by 2-phenyl-4-quinolone...
  22. doi request reprint Denbinobin induces apoptosis in human lung adenocarcinoma cells via Akt inactivation, Bad activation, and mitochondrial dysfunction
    Chen Tzu Kuo
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Toxicol Lett 177:48-58. 2008
    ..These results suggest that Akt inactivation, followed by Bad activation, mitochondrial dysfunction, caspase 3 activation, and AIF release, contributes to denbinobin-induced cell apoptosis...
  23. ncbi request reprint Cardiac glycosides induce resistance to tubulin-dependent anticancer drugs in androgen-independent human prostate cancer
    Dong Ming Huang
    Pharmacological Institute, College of Medicine, National Taiwan University, Taiwan, ROC
    J Biomed Sci 9:443-52. 2002
    ..The decline in transport of these drugs into the nucleus may partly explain the action of cardiac glycosides...
  24. doi request reprint Moscatilin repressed lipopolysaccharide-induced HIF-1alpha accumulation and NF-kappaB activation in murine RAW264.7 cells
    Yi Nan Liu
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    Shock 33:70-5. 2010
    ..7. Furthermore, the inhibition of moscatilin seemed to be dependent on the repression of HIF-1alpha accumulation and NF-kappaB activation...
  25. ncbi request reprint Alisol B acetate, a triterpene from Alismatis rhizoma, induces Bax nuclear translocation and apoptosis in human hormone-resistant prostate cancer PC-3 cells
    Yao Ting Huang
    Pharmacological Institute, College of Medicine, National Taiwan University, No 1, Jen Ai Road, sect 1, Taipei, Taiwan, ROC
    Cancer Lett 231:270-8. 2006
    ..Furthermore, the Bax activation and translocation from the cytosol to nucleus might be a crucial response to the apoptotic effect...
  26. ncbi request reprint Investigation of ouabain-induced anticancer effect in human androgen-independent prostate cancer PC-3 cells
    Yao Ting Huang
    Pharmacological Institute, College of Medicine, National Taiwan University, No 1, Jen Ai Road, sect 1, Taipei, Taiwan, ROC
    Biochem Pharmacol 67:727-33. 2004
    ..Low concentrations of ouabain induce the increase of Par-4 expression and sensitize the cytotoxicity; while high concentrations of ouabain induce a loss of Deltapsim, a sustained ROS production and a severe apoptosis in PC-3 cells...
  27. doi request reprint The indazole derivative YD-3 specifically inhibits thrombin-induced angiogenesis in vitro and in vivo
    Chieh Yu Peng
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    Shock 34:580-5. 2010
    ..YD-3 may have benefit in elucidating pathophysiology induced by thrombin-induced angiogenesis...
  28. ncbi request reprint Enhancement of long-term potentiation by a potent nitric oxide-guanylyl cyclase activator, 3-(5-hydroxymethyl-2-furyl)-1-benzyl-indazole
    Wei Lin Chien
    Pharmacological Institute, College of Medicine, National Taiwan University, 1, Sec 1, Jen Ai Road, Taipei, Taiwan
    Mol Pharmacol 63:1322-8. 2003
    ..The NO-cGMP-PKG-ERK signaling pathway thus plays important role in the potentiation of LTP by YC-1...
  29. doi request reprint Depletion of 4E-BP1 and regulation of autophagy lead to YXM110-induced anticancer effects
    Chin Yu Lai
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei 10051, Taiwan
    Carcinogenesis 34:2050-60. 2013
    ..These data reveal key mechanisms that support the further development of YXM110 as a promising anticancer agent. ..
  30. ncbi request reprint Modulation of anti-adhesion molecule MUC-1 is associated with arctiin-induced growth inhibition in PC-3 cells
    Dong Ming Huang
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    Prostate 59:260-7. 2004
    ..We postulated that arctiin modulates the attachment/detachment of PC-3 cells and we investigated the role of arctiin on MUC-1 expression...
  31. ncbi request reprint Denbinobin-mediated anticancer effect in human K562 leukemia cells: role in tubulin polymerization and Bcr-Abl activity
    Yu Chun Huang
    Pharmacological Institute, No 1, Jen Ai Road, sect 1, Taipei, Taiwan
    J Biomed Sci 12:113-21. 2005
    ..Our data demonstrate that denbinobin could be a potential anticancer lead compound for further development...
  32. doi request reprint Denbinobin induces human glioblastoma multiforme cell apoptosis through the IKKα-Akt-FKHR signaling cascade
    Hsing Yu Weng
    Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, No 250, Wu Hsing Street, Taipei 11031, Taiwan
    Eur J Pharmacol 698:103-9. 2013
    ..These results suggest that IKKα inactivation, followed by Akt and FKHR dephosphorylation and caspase-3 activation, contributes to denbinobin-induced GBM cell apoptosis...
  33. pmc Anticancer activity of MPT0E028, a novel potent histone deacetylase inhibitor, in human colorectal cancer HCT116 cells in vitro and in vivo
    Han Li Huang
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    PLoS ONE 7:e43645. 2012
    ..Taken together, our results demonstrate that MPT0E028 has several properties and is potential as a promising anti-cancer therapeutic drug...
  34. pmc α-Tomatine-mediated anti-cancer activity in vitro and in vivo through cell cycle- and caspase-independent pathways
    Min Wu Chao
    Phamacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    PLoS ONE 7:e44093. 2012
    ..These results suggest that α-tomatine may be a candidate for leukemia treatment...
  35. doi request reprint CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo
    Shih Wei Wang
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Cancer Ther 7:350-60. 2008
    ..CHM-1 is a promising chemotherapeutic agent worthy of further development into a clinical trial candidate for treating cancer, especially hepatocellular carcinoma...
  36. ncbi request reprint Identification of apoptotic and antiangiogenic activities of terazosin in human prostate cancer and endothelial cells
    Shiow Lin Pan
    Pharmacological Institutes, School of Pharmacy and Department of Urology, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
    J Urol 169:724-9. 2003
    ..It has been suggested that terazosin has an inhibitory effect on prostate tumor growth. We determined if terazosin action contributes to direct suppression of the angiogenic effect...
  37. doi request reprint Denbinobin suppresses breast cancer metastasis through the inhibition of Src-mediated signaling pathways
    Pei Hsuan Chen
    School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Nutr Biochem 22:732-40. 2011
    ..Our findings provide evidences that denbinobin inhibits Src-mediated signaling pathways involved in controlling breast cancer migration and metastasis, suggesting that it has therapeutic potential in breast cancer treatment...
  38. pmc Aciculatin inhibits lipopolysaccharide-mediated inducible nitric oxide synthase and cyclooxygenase-2 expression via suppressing NF-κB and JNK/p38 MAPK activation pathways
    I Ni Hsieh
    School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Biomed Sci 18:28. 2011
    ....
  39. doi request reprint The inhibition of angiogenesis and tumor growth by denbinobin is associated with the blocking of insulin-like growth factor-1 receptor signaling
    An Chi Tsai
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei 100, Taiwan
    J Nutr Biochem 22:625-33. 2011
    ..Our findings suggest that denbinobin may be a novel IGF-1R kinase inhibitor and has potential therapeutic abilities for angiogenesis-related diseases such as cancer...
  40. ncbi request reprint Induction of endoplasmic reticulum stress and apoptosis by a marine prostanoid in human hepatocellular carcinoma
    Po Cheng Chiang
    School of Pharmacy, College of Medicine, National Taiwan University, No 1, Jen Ai Road, sect 1, Taipei, Taiwan, ROC
    J Hepatol 43:679-86. 2005
    ..We isolated a marine prostanoid, bromovulone III, from soft coral Clavularia viridis and found that it displayed effective anti-tumor activity in human hepatocellular carcinoma. The anti-tumor mechanism has been delineated in this study...
  41. doi request reprint Baicalein attenuates intimal hyperplasia after rat carotid balloon injury through arresting cell-cycle progression and inhibiting ERK, Akt, and NF-kappaB activity in vascular smooth-muscle cells
    Chieh Yu Peng
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    Naunyn Schmiedebergs Arch Pharmacol 378:579-88. 2008
    ..It also inhibits intimal hyperplasia after balloon vascular injury in the rat, indicating the therapeutic potential for treating restenosis after arterial injury...
  42. ncbi request reprint Soluble decoy receptor 3 induces angiogenesis by neutralization of TL1A, a cytokine belonging to tumor necrosis factor superfamily and exhibiting angiostatic action
    Chia Ron Yang
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Cancer Res 64:1122-9. 2004
    ..The pathological role of DcR3 in promoting cancer progress raises the possibility to target DcR3 for antiangiogenic therapy in the future...
  43. doi request reprint Moscatilin induces apoptosis in human colorectal cancer cells: a crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage
    Tzu Hsuan Chen
    Pharmacological Institute and School of Pharmacy, College of Medicine, National Taiwan University, Taiwan, Republic of China
    Clin Cancer Res 14:4250-8. 2008
    ..To study the effect of moscatilin (purified from the stem of orchid Dendrobrium loddigesii) on the proliferation of human colorectal cancer HCT-116 cells in vitro and in vivo...
  44. ncbi request reprint Inhibition of Ras-mediated cell proliferation by benzyloxybenzaldehyde
    Shiow Lin Pan
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC
    J Biomed Sci 9:622-30. 2002
    ....
  45. pmc YC-1 increases cyclo-oxygenase-2 expression through protein kinase G- and p44/42 mitogen-activated protein kinase-dependent pathways in A549 cells
    Ming Shyan Chang
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    Br J Pharmacol 136:558-67. 2002
    ....
  46. ncbi request reprint Potentiation of tumor necrosis factor-alpha expression by YC-1 in alveolar macrophages through a cyclic GMP-independent pathway
    Tsong Long Hwang
    Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Tao Yuan, Taiwan, ROC
    Biochem Pharmacol 66:149-56. 2003
    ..Thus, caution needs to be used in attributing the YC-1-mediated response to the activation of sGC...
  47. doi request reprint TW01001, a novel piperazinedione compound, induces mitotic arrest and autophagy in non-small cell lung cancer A549 cells
    Mei Chuan Chen
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    Cancer Lett 336:370-8. 2013
    ....
  48. pmc Dehydrocostuslactone suppresses angiogenesis in vitro and in vivo through inhibition of Akt/GSK-3β and mTOR signaling pathways
    Chih Ya Wang
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    PLoS ONE 7:e31195. 2012
    ..Taken together, our study has identified Akt/GSK-3β and mTOR as important targets of DHC and has thus highlighted its potential application in angiogenesis-related diseases, such as cancer...
  49. ncbi request reprint Esculetin inhibits Ras-mediated cell proliferation and attenuates vascular restenosis following angioplasty in rats
    Shiow Lin Pan
    Pharmacological Institute, College of Medicine, National Taiwan University, No 1 Jen Ai Road, sect 1, Taipei, Taiwan, ROC
    Biochem Pharmacol 65:1897-905. 2003
    ..It also inhibits intimal hyperplasia after balloon vascular injury in the rat, indicating the therapeutic potential for treating restenosis after arterial injury...
  50. doi request reprint Activated PAR-2 regulates pancreatic cancer progression through ILK/HIF-α-induced TGF-α expression and MEK/VEGF-A-mediated angiogenesis
    Li Hsun Chang
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    Am J Pathol 183:566-75. 2013
    ....
  51. doi request reprint Thrombin induces expression of twist and cell motility via the hypoxia-inducible factor-1α translational pathway in colorectal cancer cells
    Li Hsun Chang
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Cell Physiol 226:1060-8. 2011
    ..These findings show that thrombin upregulates Twist via HIF-1α to make tumor cells malignant and also establish a link between the coagulation disorder and cancer metastasis...
  52. doi request reprint Potent anti-inflammatory effects of denbinobin mediated by dual inhibition of expression of inducible no synthase and cyclooxygenase 2
    Hsiang Erh Liu
    School of Pharmacy, Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Shock 35:191-7. 2011
    ..Our results demonstrate that denbinobin exerts potent anti-inflammatory activity, suggesting that it might provide a new therapeutic approach to inflammatory diseases...
  53. doi request reprint Denbinobin induces apoptosis by apoptosis-inducing factor releasing and DNA damage in human colorectal cancer HCT-116 cells
    Tzu Hsuan Chen
    Pharmacological Institute, College of Medicine, National Taiwan University, No 1, Jen Ai Road, sect 1, Taipei, Taiwan
    Naunyn Schmiedebergs Arch Pharmacol 378:447-57. 2008
    ..Taken together, our findings suggest that denbinobin induces apoptosis of human colorectal cancer HCT-116 cells via DNA damage and an AIF-mediated pathway. These results indicate that denbinobin has potential as a novel anticancer agent...
  54. doi request reprint DYZ-2-90, a novel neo-tanshinlactone ring-opened compound, induces ERK-mediated mitotic arrest and subsequent apoptosis by activating JNK in human colorectal cancer cells
    Li Ting Wang
    Pharmacological Institute, College of Medicine, National Taiwan University, No 1, Jen Ai Road, Sec 1, Taipei 10051, Taiwan
    Chembiochem 13:1663-72. 2012
    ..This paper provides a new insight into the model of mitotic cell death, which was proposed in order to elucidate how cancer cells respond to microtubule-interfering agents and prolonged cell cycle delay...
  55. doi request reprint Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines
    Chun Han Chen
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, ROC
    Cancer Lett 315:1-11. 2012
    ..In conclusion, the data suggest that protopine is a novel microtubule stabilizer with anticancer activity in HRPC cells through apoptotic pathway by modulating Cdk1 activity and Bcl-2 family of proteins...
  56. ncbi request reprint Characterization of some novel alpha 1-adrenoceptor antagonists in human hyperplastic prostate
    Shih Chieh Chueh
    Department of Urology, College of Medicine, National Taiwan University, No 1, Jen Ai Road, sect 1, Taipei, Taiwan
    Eur J Pharmacol 445:125-31. 2002
    ..These data show FH-71 to be a potent and selective alpha(1A)-adrenoceptor antagonist with activity in human hyperplastic prostate...
  57. doi request reprint QS-ZYX-1-61 induces apoptosis through topoisomerase II in human non-small-cell lung cancer A549 cells
    Mei Chuan Chen
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    Cancer Sci 103:80-7. 2012
    ..Taken together, our results indicate that QS-ZYX-1-61 is a novel DNA damaging agent and displays an outstanding activity that could be worthy of further investigation...
  58. ncbi request reprint The inhibitory mechanism of YC-1, a benzyl indazole, on smooth muscle cell proliferation: an in vitro and in vivo study
    Chieh Hsi Wu
    Department of Pharmacology, China Medical University, Taichung, Taiwan
    J Pharmacol Sci 94:252-60. 2004
    ..This study provides insights into the pharmacological mechanisms of YC-1 in preventing abnormal smooth muscle cell proliferation and thus supports the use of YC-1 as an adjuvant therapy for balloon injury-induced restenosis...
  59. doi request reprint YC-1 induces heat shock protein 70 expression and prevents oxidized LDL-mediated apoptosis in vascular smooth muscle cells
    Yi Nan Liu
    Phamacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    Shock 30:274-9. 2008
    ..According to our observations, YC-1 would be an effectively pharmacological hsp70 inducer that can be used as a cytoprotective agent in vascular diseases...
  60. ncbi request reprint Enhancement of learning behaviour by a potent nitric oxide-guanylate cyclase activator YC-1
    Wei Lin Chien
    Pharmacological Institute, College of Medicine, National Taiwan University, No 1, Sec 1, Jen Ai Road, Taipei, Taiwan
    Eur J Neurosci 21:1679-88. 2005
    ..YC-1 is thus a good drug candidate for the improvement of learning and memory...
  61. doi request reprint Molecular mechanism of the inhibitory effect of KS-5 on bFGF-induced angiogenesis in vitro and in vivo
    Chieh Yu Peng
    Pharmacological Institute, College of Medicine, National Taiwan University, No 1, Jen Ai Road, Section 1, Taipei, Taiwan
    Cancer Lett 263:114-21. 2008
    ..In conclusion, the present study suggests that KS-5 has potential anti-angiogenetic effect for cancer therapy and other angiogenesis-dependent diseases...
  62. pmc In vitro and in vivo anti-tumour effects of MPT0B014, a novel derivative aroylquinoline, and in combination with erlotinib in human non-small-cell lung cancer cells
    An Chi Tsai
    School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan
    Br J Pharmacol 171:122-33. 2014
    ....
  63. ncbi request reprint Synergistic interaction between the HDAC inhibitor, MPT0E028, and sorafenib in liver cancer cells in vitro and in vivo
    Chun Han Chen
    Authors Affiliations Pharmacological Institute, College of Medicine, National Taiwan University School of Pharmacy, College of Pharmacy The Ph D program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan and Division of Medicinal Chemistry, College of Pharmacy, The Ohio State University, Columbus, Ohio
    Clin Cancer Res 20:1274-87. 2014
    ..To investigate the antitumor activities of a histone deacetylase (HDAC) inhibitor, MPT0E028, plus sorafenib in liver cancer cells in vitro and in vivo...