Chien An Sun

Summary

Affiliation: National Defense Medical Center
Country: Taiwan

Publications

  1. ncbi request reprint The MTHFR C677T polymorphism, estrogen exposure and breast cancer risk: a nested case-control study in Taiwan
    Wei Yu Lin
    School of Public Health, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Anticancer Res 24:3863-8. 2004
  2. ncbi request reprint Genetic polymorphisms of glutathione S-transferases M1 and T1 associated with susceptibility to aflatoxin-related hepatocarcinogenesis among chronic hepatitis B carriers: a nested case-control study in Taiwan
    C A Sun
    School of Public Health, National Defense Medical Center, Taipei, Taiwan
    Carcinogenesis 22:1289-94. 2001
  3. ncbi request reprint Viral load of high-risk human papillomavirus in cervical squamous intraepithelial lesions
    C A Sun
    School of Public Health, National Defense Medical Center, Taipei, Taiwan
    Int J Gynaecol Obstet 76:41-7. 2002
  4. pmc Determinants of formation of aflatoxin-albumin adducts: a seven-township study in Taiwan
    C A Sun
    School of Public Health, National Defense Medical Center, School of Public Health, No 161, Section 6, Min Chuan East Road, Taipei 114, Taiwan, Republic of China
    Br J Cancer 87:966-70. 2002
  5. ncbi request reprint Incidence and cofactors of hepatitis C virus-related hepatocellular carcinoma: a prospective study of 12,008 men in Taiwan
    Chien An Sun
    School of Public Health, National Defense Medical Center, Taipei, Taiwan
    Am J Epidemiol 157:674-82. 2003
  6. doi request reprint Carriers of inactive hepatitis B virus are still at risk for hepatocellular carcinoma and liver-related death
    Jin De Chen
    Department of Internal Medicine, Bei Hu Branch, National Taiwan University Hospital, Taipei, Taiwan
    Gastroenterology 138:1747-54. 2010
  7. ncbi request reprint Hormonal and body-size factors in relation to breast cancer risk: a prospective study of 11,889 women in a low-incidence area
    Mei Hsuan Wu
    School of Public Health, National Defense Medical Center, Taipei 114, Taiwan, Republic of China
    Ann Epidemiol 16:223-9. 2006
  8. ncbi request reprint Polymorphic catechol-O-methyltransferase gene, duration of estrogen exposure, and breast cancer risk: a nested case-control study in Taiwan
    Wei Yu Lin
    School of Public Health, National Defense Medical Center, Taipei 114, Taiwan, Republic of China
    Cancer Detect Prev 29:427-32. 2005
  9. ncbi request reprint The methylenetetrahydrofolate reductase 677C-->T polymorphism and lung cancer risk in a Chinese population
    Yi Lin Jeng
    School of Public Health, National Defense Medical Center, No 161, Section 6 Min Chuan East Road, Taipei 114, Taiwan, Republic of China
    Anticancer Res 23:5149-52. 2003
  10. doi request reprint Dietary intake of vitamin B(6) and risk of breast cancer in Taiwanese women
    Yu Ching Chou
    School of Public Health, National Defense Medical Center, Taipei, Taiwan
    J Epidemiol 21:329-36. 2011

Collaborators

Detail Information

Publications29

  1. ncbi request reprint The MTHFR C677T polymorphism, estrogen exposure and breast cancer risk: a nested case-control study in Taiwan
    Wei Yu Lin
    School of Public Health, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Anticancer Res 24:3863-8. 2004
    ..We evaluated the effects of the MTHFR C677T polymorphism and its interaction with estrogen exposure on breast cancer risk in a nested case-control study conducted in Taiwan...
  2. ncbi request reprint Genetic polymorphisms of glutathione S-transferases M1 and T1 associated with susceptibility to aflatoxin-related hepatocarcinogenesis among chronic hepatitis B carriers: a nested case-control study in Taiwan
    C A Sun
    School of Public Health, National Defense Medical Center, Taipei, Taiwan
    Carcinogenesis 22:1289-94. 2001
    ..These results demonstrate the importance of gene-environment interactions in the multifactorial development of HCC...
  3. ncbi request reprint Viral load of high-risk human papillomavirus in cervical squamous intraepithelial lesions
    C A Sun
    School of Public Health, National Defense Medical Center, Taipei, Taiwan
    Int J Gynaecol Obstet 76:41-7. 2002
    ..This case-control study was conducted to investigate the role of viral load of high-risk human papillomaviruses (HPVs) in the development of cervical squamous intraepithelial lesions (SILs) and invasive cancers...
  4. pmc Determinants of formation of aflatoxin-albumin adducts: a seven-township study in Taiwan
    C A Sun
    School of Public Health, National Defense Medical Center, School of Public Health, No 161, Section 6, Min Chuan East Road, Taipei 114, Taiwan, Republic of China
    Br J Cancer 87:966-70. 2002
    ..This study further emphasises the necessity to reduce aflatoxin exposure in people living in an area endemic for chronic hepatitis B virus infection...
  5. ncbi request reprint Incidence and cofactors of hepatitis C virus-related hepatocellular carcinoma: a prospective study of 12,008 men in Taiwan
    Chien An Sun
    School of Public Health, National Defense Medical Center, Taipei, Taiwan
    Am J Epidemiol 157:674-82. 2003
    ..The results of this study suggest that HCV plays a significant role in hepatocarcinogenesis in an area endemic for chronic HBV infection...
  6. doi request reprint Carriers of inactive hepatitis B virus are still at risk for hepatocellular carcinoma and liver-related death
    Jin De Chen
    Department of Internal Medicine, Bei Hu Branch, National Taiwan University Hospital, Taipei, Taiwan
    Gastroenterology 138:1747-54. 2010
    ..The risk and the predictors of liver disease progression in carriers of inactive hepatitis B virus (HBV) are unclear...
  7. ncbi request reprint Hormonal and body-size factors in relation to breast cancer risk: a prospective study of 11,889 women in a low-incidence area
    Mei Hsuan Wu
    School of Public Health, National Defense Medical Center, Taipei 114, Taiwan, Republic of China
    Ann Epidemiol 16:223-9. 2006
    ..This prospective cohort study of 11,889 women was conducted to determine significant factors associated with the risk of breast cancer among Chinese women in Taiwan, a low-incidence area...
  8. ncbi request reprint Polymorphic catechol-O-methyltransferase gene, duration of estrogen exposure, and breast cancer risk: a nested case-control study in Taiwan
    Wei Yu Lin
    School of Public Health, National Defense Medical Center, Taipei 114, Taiwan, Republic of China
    Cancer Detect Prev 29:427-32. 2005
    ..Polymorphic catechol-O-methyltransferase (COMT) catalyzes the O-methylation of catechol estrogens, which are hypothesized to participate in estrogen-induced carcinogenesis...
  9. ncbi request reprint The methylenetetrahydrofolate reductase 677C-->T polymorphism and lung cancer risk in a Chinese population
    Yi Lin Jeng
    School of Public Health, National Defense Medical Center, No 161, Section 6 Min Chuan East Road, Taipei 114, Taiwan, Republic of China
    Anticancer Res 23:5149-52. 2003
    ..We examined the relationship of the MTHFR C677T genotype with the risk of lung cancer in a nested case-control study conducted in a cancer screening follow-up study in Taiwan...
  10. doi request reprint Dietary intake of vitamin B(6) and risk of breast cancer in Taiwanese women
    Yu Ching Chou
    School of Public Health, National Defense Medical Center, Taipei, Taiwan
    J Epidemiol 21:329-36. 2011
    ..B vitamins, including vitamin B(6), are coenzymes that are important for DNA integrity and stability. Deficiencies in B vitamins may promote tumor carcinogenesis...
  11. doi request reprint Adipocytokine resistin and breast cancer risk
    Chien An Sun
    Department of Public Health, College of Medicine, Fu Jen Catholic University, No 510, Jhongjheng Road, Sinjhuang 242, Taipei, Taiwan, ROC
    Breast Cancer Res Treat 123:869-76. 2010
    ..Adipocytokine resistin may have an adiposity-independent role in breast carcinogenesis. Mechanistic studies to fully elucidate the mechanisms underlying resistin's effects should be pursued in future investigations...
  12. ncbi request reprint Single nucleotide polymorphism at Fas promoter is associated with cervical carcinogenesis
    Hung Cheng Lai
    Graduate Institutes of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Int J Cancer 103:221-5. 2003
    ..033). The present study demonstrated an association between Fas polymorphism and cervical carcinogenesis. We deduced a possible effect of apoptosis of immune cells in this virus-induced cancer...
  13. ncbi request reprint Breast cancer risk associated with multigenotypic polymorphisms in folate-metabolizing genes: a nested case-control study in Taiwan
    Cheng Ping Yu
    Department of Pathology, Tri Service General Hospital, Taipei, Taiwan, ROC
    Anticancer Res 27:1727-32. 2007
    ..The purpose of this study was to test the hypothesis that multigenotypic polymorphisms in the folate metabolic pathway, which may result in genomic instability and inbalance of estrogen metabolism, were associated with breast cancer risk...
  14. doi request reprint Relationships between critical period of estrogen exposure and circulating levels of insulin-like growth factor-I (IGF-I) in breast cancer: evidence from a case-control study
    Mei Hsuan Wu
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    Int J Cancer 126:508-14. 2010
    ..42, 95% CI, 1.33-4.38). These results suggest that the joint effect of IGF-I and estrogens may provide novel methods of breast cancer risk reduction among women...
  15. ncbi request reprint Risk of hepatocellular carcinoma and habits of alcohol drinking, betel quid chewing and cigarette smoking: a cohort of 2416 HBsAg-seropositive and 9421 HBsAg-seronegative male residents in Taiwan
    Li Yu Wang
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan, ROC
    Cancer Causes Control 14:241-50. 2003
    ..The specific aim of this study is to assess the associations between the risk of HCC and habits of alcohol drinking, betel quid chewing and cigarette smoking among subjects with and without chronic HBV infection...
  16. ncbi request reprint Epidemiologic correlates of cervical human papillomavirus prevalence in women with abnormal Pap smear tests: a Taiwan Cooperative Oncology Group (TCOG) study
    Chien An Sun
    School of Public Health, National Defense Medical Center, Taipei, Taiwan, ROC
    J Med Virol 77:273-81. 2005
    ..85-2.15). The results of this study provide further evidence of the role of HPV in cervical carcinogenesis. The data also indicate the main areas of risk for the prevalence of HPV in cervical neoplasia in Chinese women living in Taiwan...
  17. ncbi request reprint Ultrasound screening and risk factors for death from hepatocellular carcinoma in a high risk group in Taiwan
    Tony Hsiu Hsi Chen
    Institute of Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
    Int J Cancer 98:257-61. 2002
    ..A randomized controlled trial would yield definitive evidence. Within the protocol of such a trial, a shorter interscreening interval for patients with liver cirrhosis is suggested...
  18. ncbi request reprint Plasma homocysteine as a metabolic risk factor for breast cancer: findings from a case-control study in Taiwan
    Yu Ching Chou
    Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Breast Cancer Res Treat 101:199-205. 2007
    ..Future studies are needed to prove causality and provide insight on the mechanism of action of Hcy in breast tumorigenesis...
  19. doi request reprint Androgen receptor gene CAG repeats, estrogen exposure status, and breast cancer susceptibility
    Mei Hsuan Wu
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    Eur J Cancer Prev 17:317-22. 2008
    ..25-1.59) was detected. These data suggest that longer AR (CAG)n repeat alleles may confer an increased risk of breast cancer among particular subsets of individuals, although these findings need replication in other populations...
  20. ncbi request reprint Vitamin D decreases risk of breast cancer in premenopausal women of normal weight in subtropical taiwan
    Meei Shyuan Lee
    School of Public Health, National Defense Medical Center, Taipei, Taiwan, Republic of China
    J Epidemiol 21:87-94. 2011
    ..This hospital-based case-control study examined the relationship of breast cancer with vitamin D intake and sunlight exposure...
  21. ncbi request reprint Tumor susceptibility and prognosis of breast cancer associated with the G870A polymorphism of CCND1
    Cheng Ping Yu
    Department of Pathology, Tri Service General Hospital, Taipei, Taiwan, Republic of China
    Breast Cancer Res Treat 107:95-102. 2008
    ..The role of G870A polymorphism in alternative transcript was not only implicated in CCND1 alternative splicing but also correlated with immunohistochemistry markers...
  22. pmc Description and prediction of the development of metabolic syndrome: a longitudinal analysis using a markov model approach
    Lee Ching Hwang
    Department of Family Medicine, Mackay Memorial Hospital, Taipei, Taiwan
    PLoS ONE 8:e67436. 2013
    ..This study aimed to build Markov models to simulate each component's progress and to test the effect of different initial states on the development of MetS...
  23. ncbi request reprint Prevalence of metabolically healthy obesity and its impacts on incidences of hypertension, diabetes and the metabolic syndrome in Taiwan
    Lee Ching Hwang
    Department of Family Medicine, Mackay Memorial Hospital, Taipei, Taiwan, Republic of China
    Asia Pac J Clin Nutr 21:227-33. 2012
    ..Our data provide further evidence that opposes the notion of metabolically healthy obese as harmless conditions...
  24. doi request reprint Identification of novel DNA methylation markers in cervical cancer
    Hung Cheng Lai
    Department of Obstetrics and Gynecology, Tri Service General Hospital, Taipei, Taiwan, Republic of China
    Int J Cancer 123:161-7. 2008
    ..64%) for HSIL/SCC. Testing PAX1 methylation marker alone, the specificity for HSIL/SCC is 99%. The analysis of these novel DNA methylations may be a promising approach for the screening of cervical cancers...
  25. ncbi request reprint Seroprevalence of human papillomaviruses and Chlamydia trachomatis and cervical cancer risk: nested case-control study
    Pontus Naucler
    Lund University, University Hospital at Malmö, SE 20502 Malmo, Sweden
    J Gen Virol 88:814-22. 2007
    ..trachomatis is associated with cervical cancer in prospective studies, and support the notion that HPV-16 seropositivity is strongly associated with cervical cancer...
  26. doi request reprint Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C infection: a follow-up study in Taiwan
    Chi Ling Chen
    Graduate Institute of Clinical Medicine, College of Medicine, College of Public Health, National Taiwan University, Taipei
    Gastroenterology 135:111-21. 2008
    ....
  27. ncbi request reprint Genetic polymorphisms of the methylenetetrahydrofolate reductase gene, plasma folate levels and breast cancer susceptibility: a case-control study in Taiwan
    Yu Ching Chou
    Graduate Institute of Medical Sciences, National Defense Medical Center Taipei, Taiwan
    Carcinogenesis 27:2295-300. 2006
    ..These results provide support for the important role of folate metabolism in breast tumorigenesis. Further mechanistic studies are warranted to investigate how MTHFR combined genotypes exert their effect on cancer susceptibility...
  28. ncbi request reprint Hepatitis B e antigen and the risk of hepatocellular carcinoma
    Hwai I Yang
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei
    N Engl J Med 347:168-74. 2002
    ..We conducted a prospective study to determine the relation between positivity for hepatitis B surface antigen (HBsAg) and HBeAg and the development of hepatocellular carcinoma...
  29. ncbi request reprint Anthropometric measures, plasma adiponectin, and breast cancer risk
    Yu Feng Tian
    Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan
    Endocr Relat Cancer 14:669-77. 2007
    ..These results suggest that adiponectin may have an independent role in breast carcinogenesis, particularly in the postmenopausal and ER-positive breast cancer risk...