Research Topics
Genomes and GenesSpecies | Chien An SunSummaryAffiliation: National Defense Medical Center Country: Taiwan Publications
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Detail Information
Publications
The MTHFR C677T polymorphism, estrogen exposure and breast cancer risk: a nested case-control study in TaiwanWei Yu Lin
School of Public Health, National Defense Medical Center, Taipei, Taiwan, Republic of China
Anticancer Res 24:3863-8. 2004..We evaluated the effects of the MTHFR C677T polymorphism and its interaction with estrogen exposure on breast cancer risk in a nested case-control study conducted in Taiwan...- Genetic polymorphisms of glutathione S-transferases M1 and T1 associated with susceptibility to aflatoxin-related hepatocarcinogenesis among chronic hepatitis B carriers: a nested case-control study in TaiwanC A Sun
School of Public Health, National Defense Medical Center, Taipei, Taiwan
Carcinogenesis 22:1289-94. 2001..These results demonstrate the importance of gene-environment interactions in the multifactorial development of HCC... - Viral load of high-risk human papillomavirus in cervical squamous intraepithelial lesionsC A Sun
School of Public Health, National Defense Medical Center, Taipei, Taiwan
Int J Gynaecol Obstet 76:41-7. 2002..This case-control study was conducted to investigate the role of viral load of high-risk human papillomaviruses (HPVs) in the development of cervical squamous intraepithelial lesions (SILs) and invasive cancers... 
Determinants of formation of aflatoxin-albumin adducts: a seven-township study in TaiwanC A Sun
School of Public Health, National Defense Medical Center, School of Public Health, No 161, Section 6, Min Chuan East Road, Taipei 114, Taiwan, Republic of China
Br J Cancer 87:966-70. 2002..This study further emphasises the necessity to reduce aflatoxin exposure in people living in an area endemic for chronic hepatitis B virus infection...- Incidence and cofactors of hepatitis C virus-related hepatocellular carcinoma: a prospective study of 12,008 men in TaiwanChien An Sun
School of Public Health, National Defense Medical Center, Taipei, Taiwan
Am J Epidemiol 157:674-82. 2003..The results of this study suggest that HCV plays a significant role in hepatocarcinogenesis in an area endemic for chronic HBV infection... 
Carriers of inactive hepatitis B virus are still at risk for hepatocellular carcinoma and liver-related deathJin De Chen
Department of Internal Medicine, Bei Hu Branch, National Taiwan University Hospital, Taipei, Taiwan
Gastroenterology 138:1747-54. 2010..The risk and the predictors of liver disease progression in carriers of inactive hepatitis B virus (HBV) are unclear...- Single nucleotide polymorphism at Fas promoter is associated with cervical carcinogenesisHung Cheng Lai
Graduate Institutes of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China
Int J Cancer 103:221-5. 2003..033). The present study demonstrated an association between Fas polymorphism and cervical carcinogenesis. We deduced a possible effect of apoptosis of immune cells in this virus-induced cancer... - The methylenetetrahydrofolate reductase 677C-->T polymorphism and lung cancer risk in a Chinese populationYi Lin Jeng
School of Public Health, National Defense Medical Center, No 161, Section 6 Min Chuan East Road, Taipei 114, Taiwan, Republic of China
Anticancer Res 23:5149-52. 2003..We examined the relationship of the MTHFR C677T genotype with the risk of lung cancer in a nested case-control study conducted in a cancer screening follow-up study in Taiwan... - Polymorphic catechol-O-methyltransferase gene, duration of estrogen exposure, and breast cancer risk: a nested case-control study in TaiwanWei Yu Lin
School of Public Health, National Defense Medical Center, Taipei 114, Taiwan, Republic of China
Cancer Detect Prev 29:427-32. 2005..Polymorphic catechol-O-methyltransferase (COMT) catalyzes the O-methylation of catechol estrogens, which are hypothesized to participate in estrogen-induced carcinogenesis... - Breast cancer risk associated with multigenotypic polymorphisms in folate-metabolizing genes: a nested case-control study in TaiwanCheng Ping Yu
Department of Pathology, Tri Service General Hospital, Taipei, Taiwan, ROC
Anticancer Res 27:1727-32. 2007..The purpose of this study was to test the hypothesis that multigenotypic polymorphisms in the folate metabolic pathway, which may result in genomic instability and inbalance of estrogen metabolism, were associated with breast cancer risk... - Adipocytokine resistin and breast cancer riskChien An Sun
Department of Public Health, College of Medicine, Fu Jen Catholic University, No 510, Jhongjheng Road, Sinjhuang 242, Taipei, Taiwan, ROC
Breast Cancer Res Treat 123:869-76. 2010..Adipocytokine resistin may have an adiposity-independent role in breast carcinogenesis. Mechanistic studies to fully elucidate the mechanisms underlying resistin's effects should be pursued in future investigations... - Dietary intake of vitamin B(6) and risk of breast cancer in Taiwanese womenYu Ching Chou
School of Public Health, National Defense Medical Center, Taipei, Taiwan
J Epidemiol 21:329-36. 2011..B vitamins, including vitamin B(6), are coenzymes that are important for DNA integrity and stability. Deficiencies in B vitamins may promote tumor carcinogenesis... - Relationships between critical period of estrogen exposure and circulating levels of insulin-like growth factor-I (IGF-I) in breast cancer: evidence from a case-control studyMei Hsuan Wu
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
Int J Cancer 126:508-14. 2010..42, 95% CI, 1.33-4.38). These results suggest that the joint effect of IGF-I and estrogens may provide novel methods of breast cancer risk reduction among women... - Androgen receptor gene CAG repeats, estrogen exposure status, and breast cancer susceptibilityMei Hsuan Wu
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
Eur J Cancer Prev 17:317-22. 2008..25-1.59) was detected. These data suggest that longer AR (CAG)n repeat alleles may confer an increased risk of breast cancer among particular subsets of individuals, although these findings need replication in other populations... - Plasma homocysteine as a metabolic risk factor for breast cancer: findings from a case-control study in TaiwanYu Ching Chou
Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China
Breast Cancer Res Treat 101:199-205. 2007..Future studies are needed to prove causality and provide insight on the mechanism of action of Hcy in breast tumorigenesis... - Vitamin D decreases risk of breast cancer in premenopausal women of normal weight in subtropical taiwanMeei Shyuan Lee
School of Public Health, National Defense Medical Center, Taipei, Taiwan, Republic of China
J Epidemiol 21:87-94. 2011..This hospital-based case-control study examined the relationship of breast cancer with vitamin D intake and sunlight exposure... - Tumor susceptibility and prognosis of breast cancer associated with the G870A polymorphism of CCND1Cheng Ping Yu
Department of Pathology, Tri Service General Hospital, Taipei, Taiwan, Republic of China
Breast Cancer Res Treat 107:95-102. 2008..The role of G870A polymorphism in alternative transcript was not only implicated in CCND1 alternative splicing but also correlated with immunohistochemistry markers... - Prevalence of metabolically healthy obesity and its impacts on incidences of hypertension, diabetes and the metabolic syndrome in TaiwanLee Ching Hwang
Department of Family Medicine, Mackay Memorial Hospital, Taipei, Taiwan, Republic of China
Asia Pac J Clin Nutr 21:227-33. 2012..Our data provide further evidence that opposes the notion of metabolically healthy obese as harmless conditions... - Identification of novel DNA methylation markers in cervical cancerHung Cheng Lai
Department of Obstetrics and Gynecology, Tri Service General Hospital, Taipei, Taiwan, Republic of China
Int J Cancer 123:161-7. 2008..64%) for HSIL/SCC. Testing PAX1 methylation marker alone, the specificity for HSIL/SCC is 99%. The analysis of these novel DNA methylations may be a promising approach for the screening of cervical cancers... - Ultrasound screening and risk factors for death from hepatocellular carcinoma in a high risk group in TaiwanTony Hsiu-Hsi Chen
Institute of Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
Int J Cancer 98:257-61. 2002..A randomized controlled trial would yield definitive evidence. Within the protocol of such a trial, a shorter interscreening interval for patients with liver cirrhosis is suggested... - Hepatitis B e antigen and the risk of hepatocellular carcinomaHwai-I Yang
Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei
N Engl J Med 347:168-74. 2002..5 to 102.1) among those who were positive for both HBsAg and HBeAg, as compared with men who were negative for both. CONCLUSIONS: Positivity for HBeAg is associated with an increased risk of hepatocellular carcinoma... - Risk of hepatocellular carcinoma and habits of alcohol drinking, betel quid chewing and cigarette smoking: a cohort of 2416 HBsAg-seropositive and 9421 HBsAg-seronegative male residents in TaiwanLi-Yu Wang
Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan, ROC
Cancer Causes Control 14:241-50. 2003..Abstinence from substance use is important for the prevention of HCC in areas where chronic HBV infection is endemic... - Epidemiologic correlates of cervical human papillomavirus prevalence in women with abnormal Pap smear tests: a Taiwan Cooperative Oncology Group (TCOG) studyChien-An Sun
School of Public Health, National Defense Medical Center, Taipei, Taiwan, ROC
J Med Virol 77:273-81. 2005..85-2.15). The results of this study provide further evidence of the role of HPV in cervical carcinogenesis. The data also indicate the main areas of risk for the prevalence of HPV in cervical neoplasia in Chinese women living in Taiwan... - Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C infection: a follow-up study in TaiwanChi Ling Chen
Graduate Institute of Clinical Medicine, College of Medicine, College of Public Health, National Taiwan University, Taipei
Gastroenterology 135:111-21. 2008.... - Genetic polymorphisms of the methylenetetrahydrofolate reductase gene, plasma folate levels and breast cancer susceptibility: a case-control study in TaiwanYu Ching Chou
Graduate Institute of Medical Sciences, National Defense Medical Center Taipei, Taiwan
Carcinogenesis 27:2295-300. 2006..These results provide support for the important role of folate metabolism in breast tumorigenesis. Further mechanistic studies are warranted to investigate how MTHFR combined genotypes exert their effect on cancer susceptibility... - Seroprevalence of human papillomaviruses and Chlamydia trachomatis and cervical cancer risk: nested case-control studyPontus Naucler
Lund University, University Hospital at Malmö, SE 20502 Malmo, Sweden
J Gen Virol 88:814-22. 2007..trachomatis is associated with cervical cancer in prospective studies, and support the notion that HPV-16 seropositivity is strongly associated with cervical cancer... - Hormonal and body-size factors in relation to breast cancer risk: a prospective study of 11,889 women in a low-incidence areaMei-Hsuan Wu
School of Public Health, National Defense Medical Center, Taipei 114, Taiwan, Republic of China
Ann Epidemiol 16:223-9. 2006..CONCLUSIONS: The findings of this study indicated common mechanisms responsible for the higher incidence of breast cancer in Western populations may also explain the risk of breast cancer development in Taiwan, a low-incidence area... - Anthropometric measures, plasma adiponectin, and breast cancer riskYu Feng Tian
Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan
Endocr Relat Cancer 14:669-77. 2007..These results suggest that adiponectin may have an independent role in breast carcinogenesis, particularly in the postmenopausal and ER-positive breast cancer risk...