Research Topics
Genomes and GenesSpecies | Chi Kuang SunSummaryAffiliation: National Taiwan University Country: Taiwan Publications
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Detail Information
Publications
Multiharmonic-generation biopsy of skinChi Kuang Sun
Department of Electrical Engineering and Graduate Institute of Electro Optical Engineering, National Taiwan University, Taipei 10617, Taiwan
Opt Lett 28:2488-90. 2003..Our preliminary study suggests that this technique could provide submicrometer-resolution deep-tissue noninvasive biopsy images in skin without the use of fluorescence and exogenous markers...- Higher harmonic generation microscopy for developmental biologyChi Kuang Sun
Graduate Institute of Electro Optical Engineering and Department of Electrical Engineering, National Taiwan University, Taipei 10617, Taiwan, ROC
J Struct Biol 147:19-30. 2004.... - Higher harmonic generation microscopyChi Kuang Sun
Graduate Institute of Electro Optical Engineering and Department of Electrical Engineering, National Taiwan University, Taipei 10617, Taiwan, ROC
Adv Biochem Eng Biotechnol 95:17-56. 2005.... 
Terahertz pipe-waveguide-based directional couplersJen Tang Lu
Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei, Taiwan
Opt Express 19:26883-90. 2011..Rectangular pipe-waveguide-based directional couplers and the issue of insertion loss are also discussed. It is found that the THz directional coupler works most efficiently in the minimal-attenuation wavelength regime...- High-sensitivity in vivo THz transmission imaging of early human breast cancer in a subcutaneous xenograft mouse modelHua Chen
Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei, 10617, Taiwan
Opt Express 19:21552-62. 2011..Our in vivo study on the subcutaneous xenograft mouse model will encourage broad and further investigations for future early cancer screening by using THz imaging system... - Quantitative and qualitative investigation into the impact of focused ultrasound with microbubbles on the triggered release of nanoparticles from vasculature in mouse tumorsChung Yin Lin
Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan Division of Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan
J Control Release 146:291-8. 2010.... - A sub-100 fs self-starting Cr:forsterite laser generating 1.4 W output powerShih Hsuan Chia
Graduate Institute of Photonics and Optoelectronics and Department of Electrical Engineering, Natl Taiwan University, Taipei 10617, Taiwan
Opt Express 18:24085-91. 2010..This intense femtosecond Cr:forsterite laser is ideal to pump varieties of high power fiber light sources and could be thus ideal for many biological and spectroscopy applications... - Molecular third-harmonic-generation microscopy through resonance enhancement with absorbing dyeChe Hang Yu
Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei 10617, Taiwan
Opt Lett 33:387-9. 2008..It is concluded that combining THG microscopy with the mature staining technique can readily achieve 3D molecular imaging without using fluorescence... - Miniaturized video-rate epi-third-harmonic-generation fiber-microscopeShih Hsuan Chia
Department of Electrical Engineering, Graduate Inst of Photonics and Optoelectronics, Natl Taiwan Univ, Taipei 10617, Taiwan
Opt Express 18:17382-91. 2010..In vivo real time virtual biopsy of the Asian skin with a video rate (31 Hz) and a sub-micron resolution was obtained. The result indicates that this miniaturized system was compact enough for the least invasive hand-held clinical use... - Terahertz polarization-sensitive rectangular pipe waveguidesJen Tang Lu
Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei, 10617, Taiwan
Opt Express 19:21532-9. 2011..By measuring the attenuation spectra, we find that the polarization sensitivity depends on the structure of the pipe waveguides. With butt coupling method, it is easy to combine circular pipe waveguides and the rectangular ones... - Bending loss of terahertz pipe waveguidesJen Tang Lu
Graduate Institute of Photonics and Optoelectronics and Department of Electrical Engineering, National Taiwan University, Taipei 10617, Taiwan
Opt Express 18:26332-8. 2010..The unexpected low bending loss in the investigated simple leaky waveguide structure promises variety of flexible applications... - Imaging polyhedral inclusion bodies of nuclear polyhedrosis viruses with second harmonic generation microscopyTzu Ming Liu
Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei 10617, Taiwan, ROC
Opt Express 16:5602-8. 2008..With multimodal harmonic generation microscopy, we also demonstrated 3D imaging on PIBs of NPV in living cells. The distribution and the number of PIBs in intact infected cells can be revealed without the help of fluorescent labeling... - Epi-third and second harmonic generation microscopic imaging of abnormal enamelSzu Yu Chen
Department of Electrical Engineering, Graduate Institute of Photonics and Optoelectronics, National TaiwanUniversity, Taipei, Taiwan, ROC
Opt Express 16:11670-9. 2008.... 
Glycogen synthase kinase 3 alpha and 3 beta have distinct functions during cardiogenesis of zebrafish embryoHuang Chieh Lee
Institute of Molecular and Cellular Biology, National Taiwan University, NO, 1, Roosevelt Road, Sec, 4, Taipei 106, Taiwan
BMC Dev Biol 7:93. 2007..At this study, we attempt to specifically inhibit either GSK3alpha or GSK3beta and uncover the isoform-specific roles that GSK3 plays during cardiogenesis...- Infrared-based third and second harmonic generation imaging of corneaSzu Yu Chen
National Taiwan University, Graduate Institute of Photonics and Optoelectronics, Department of Electrical Engineering, No 1 Roosevelt Road Section 4, Taipei 10617, Taiwan
J Biomed Opt 14:044012. 2009..This study provides a critical reference for future development of infrared-based corneal imaging... - In vivo long-term continuous observation of gene expression in zebrafish embryo nerve systems by using harmonic generation microscopy and morphant technologyCho Shuen Hsieh
National Taiwan University, Department of Electrical Engineering, and, Graduate Institute of Photonics and Optoelectronics, Taipei 10617, Taiwan
J Biomed Opt 13:064041. 2008..e., SHG microscopy and THG microscopy, successfully revealed the weak cell adhesion, cell apoptosis, nerve formation reduction, and neural tube distortion in the morphant zebrafish embryos... - Virtual biopsy of rat tympanic membrane using higher harmonic generation microscopyWen Jeng Lee
National Taiwan University, Department of Electrical Engineering, Taipei, Taiwan
J Biomed Opt 15:046012. 2010..Our study demonstrates the feasibility of using a noninvasive optical imaging system for comprehensive evaluation of the tympanic membrane... - Cell tracking and detection of molecular expression in live cells using lipid-enclosed CdSe quantum dots as contrast agents for epi-third harmonic generation microscopyChieh Feng Chang
Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei 10617, Taiwan
Opt Express 16:9534-48. 2008..Combined with a high penetration 1230 nm laser, these novel features make LEQDs excellent THG contrast agents for in vivo deep-tissue imaging in the future... - Cr:Forsterite-laser-based fiber-optic nonlinear endoscope with higher efficienciesMing Che Chan
Department of Electrical Engineering and Graduate Institute of Electro Optical Engineering, National Taiwan University, Taipei 10617, Taiwan, Republic of China
Microsc Res Tech 71:559-63. 2008..The system resolution has been characterized to be 5.4 microm in the two-photon fluorescence endoscope, limited by the sampling theory. Finally, several image examples have been given... - Performance of THz fiber-scanning near-field microscopy to diagnose breast tumorsHua Chen
Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei, 10617, Taiwan
Opt Express 19:19523-31. 2011.... - Direct backward third-harmonic generation in nanostructuresChieh Feng Chang
Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei 10617, Taiwan
Opt Express 18:7397-406. 2010..An integral equation was also derived for fast computation of DBTHG in nano films. Our investigation suggests that DBTHG can be a potentially powerful tool in nano-science research, especially when combined with FTHG measurements... - Noninvasive harmonics optical microscopy for long-term observation of embryonic nervous system development in vivoSzu-Yu Chen
Department of Electrical Engineering and Graduate Institute of Electro-Optical Engineering, National Taiwan University, Taipei 10617, Taiwan
J Biomed Opt 11:054022. 2006.... - Multi-photon resonance enhancement of third harmonic generation in human oxyhemoglobin and deoxyhemoglobinChieh Feng Chang
Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei 10617, Taiwan
J Biophotonics 3:678-85. 2010..Our spectroscopic results thus indicate the high potential of THG spectroscopic microscopy for oxygen depletion level measurement of a single red blood cell in vivo... - Modal characteristics of antiresonant reflecting pipe waveguides for terahertz waveguidingChih Hsien Lai
Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei, 10617, Taiwan
Opt Express 18:309-22. 2010..Experiments using time-domain spectroscopy with PMMA pipes also confirm the antiresonant reflecting guiding mechanism... - Selective imaging in second-harmonic-generation microscopy with anisotropic radiationShi Wei Chu
Department of Physics, National Taiwan University, Taipei 10617, Taiwan
J Biomed Opt 14:010504. 2009..Moreover, we find that well-formed collagen fibrils are highlighted by forward SHG, while loosely arranged collagen matrix is outlined by backward signal... - Transverse-junction superluminescent diodes at the 1.1 microm wavelength regimeShi Hao Guol
Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei 10617, Taiwan
Opt Express 16:16860-6. 2008..In contrast with a VJ SLD, the EL spectrum of our device is determined by QWs that have a larger differential gain than the positions of QWs neighbored with a p side layer... - Compact fiber-delivered Cr:forsterite laser for nonlinear light microscopyMing-Che Chan
National Taiwan University, Department of Electrical Engineering and Graduate Institute of Electro-Optical Engineering, Taipei 10617, Taiwan
J Biomed Opt 10:054006. 2005..2-nJ fiber-output pulse energy. Based on this fiber-delivered Cr:forsterite laser source, a compact and reliable two-photon fluorescence microscopy system can thus be realized... - Characterization of oral squamous cell carcinoma based on higher-harmonic generation microscopyMing Rung Tsai
Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei, Taiwan
J Biophotonics 5:415-24. 2012..In addition, distinct patterns of collagen fibers and increased distribution area of actin filaments in tumor cells were noted. These results indicate HGM holds great potential for the optical biopsy screening of oral cancer lesions... 
Determination of chronological aging parameters in epidermal keratinocytes by in vivo harmonic generation microscopyYi Hua Liao
Department of Dermatology, National Taiwan University Hospital and College of Medicine, National Taiwan University, No 7, Chung Shan South Road, Taipei 10002, Taiwan Molecular Imaging Center, National Taiwan University, No 1, Sec 4, Roosevelt Road, Taipei 10617, Taiwan
Biomed Opt Express 4:77-88. 2013..The cellular and nuclear areas, which have an increase of 0.51 μm(2) and 0.15 μm(2) per year, respectively, can serve as scoring indices for intrinsic skin aging...- THz interferometric imaging using subwavelength plastic fiber based THz endoscopesJa Yu Lu
Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei, 10617, Taiwan
Opt Express 16:2494-501. 2008..By analyzing the axial-position dependent THz signals backward collected by the subwavelength plastic fiber, the THz reflection amplitudes and phases on the sample surface can be successfully reconstructed... - Fiber-based swept-source terahertz radarYu Wei Huang
Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei 10617, Taiwan
Opt Lett 35:1344-6. 2010..Our experiment showed that this fiber-based swept-source terahertz radar could be used in real time to locate concealed moving live objects with high stability... - Optical piezoelectric transducer for nano-ultrasonicsKung-Hsuan Lin
Graduate Institute of Electro-Optical Engineering, National Taiwan University, Taipei 10617, Taiwan
IEEE Trans Ultrason Ferroelectr Freq Control 52:1404-14. 2005..This nano-structured OPT technique will provide the key toward the realization of nano-ultrasonics, which is analogous to the typical ultrasonic techniques but in a nanometer scale... - High-resolution simultaneous three-photon fluorescence and third-harmonic-generation microscopyShi-Wei Chu
Graduate Institute of Electro-Optical Engineering and Department of Electrical Engineering, National Taiwan University, Taipei 10617, Taiwan
Microsc Res Tech 66:193-7. 2005.... - Studies of chi(2)/chi(3) tensors in submicron-scaled bio-tissues by polarization harmonics optical microscopyShi-Wei Chu
Department of Electrical Engineering and Graduate Institute of Electro-Optical Engineering, National Taiwan University, Taipei, Taiwan, Republic of China
Biophys J 86:3914-22. 2004.... - Biomolecular imaging based on far-red fluorescent protein with a high two-photon excitation action cross sectionTsung-Han Tsai
Graduate Institute of Electro-Optical Engineering, National Taiwan University, Taipei 10617, Taiwan
Opt Lett 31:930-2. 2006..In vivo 2PFM of the developing heart deep inside a transgenic zebrafish embryo tagged by Hc-RFP is also successfully demonstrated... - Miniaturized multiphoton microscope with a 24Hz frame-rateTzu Ming Liu
Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics, National TaiwanUniversity, Taipei, ROC
Opt Express 16:10501-6. 2008..Through a two-dimensional asynchronous scanning of the MEMS mirror, 24Hz frame rate can be realized. With a high numerical aperture objective, sub-micron resolution can also be achieved at the same time... - Higher harmonic generation microscopy of in vitro cultured mammal oocytes and embryosCho Shuen Hsieh
Department of Electrical Engineering, Graduate Institute of Photonics and Optoelectronics, National TaiwanUniversity, Taipei, Taiwan
Opt Express 16:11574-88. 2008..Combining two different higher-harmonic generation modalities, SHG and THG, HGM successfully revealed the sub-cellular structures of the whole mouse embryos with a high 3D spatial resolution...