Chi Kuang Sun

Summary

Affiliation: National Taiwan University
Country: Taiwan

Publications

  1. doi request reprint A sub-100 fs self-starting Cr:forsterite laser generating 1.4 W output power
    Shih Hsuan Chia
    Graduate Institute of Photonics and Optoelectronics and Department of Electrical Engineering, Natl Taiwan University, Taipei 10617, Taiwan
    Opt Express 18:24085-91. 2010
  2. ncbi request reprint Multiharmonic-generation biopsy of skin
    Chi Kuang Sun
    Department of Electrical Engineering and Graduate Institute of Electro Optical Engineering, National Taiwan University, Taipei 10617, Taiwan
    Opt Lett 28:2488-90. 2003
  3. ncbi request reprint Higher harmonic generation microscopy for developmental biology
    Chi Kuang Sun
    Graduate Institute of Electro Optical Engineering and Department of Electrical Engineering, National Taiwan University, Taipei 10617, Taiwan, ROC
    J Struct Biol 147:19-30. 2004
  4. ncbi request reprint Higher harmonic generation microscopy
    Chi Kuang Sun
    Graduate Institute of Electro Optical Engineering and Department of Electrical Engineering, National Taiwan University, Taipei 10617, Taiwan, ROC
    Adv Biochem Eng Biotechnol 95:17-56. 2005
  5. pmc Studies of chi(2)/chi(3) tensors in submicron-scaled bio-tissues by polarization harmonics optical microscopy
    Shi Wei Chu
    Department of Electrical Engineering and Graduate Institute of Electro Optical Engineering, National Taiwan University, Taipei, Taiwan, Republic of China
    Biophys J 86:3914-22. 2004
  6. ncbi request reprint Noninvasive harmonics optical microscopy for long-term observation of embryonic nervous system development in vivo
    Szu Yu Chen
    Department of Electrical Engineering and Graduate Institute of Electro Optical Engineering, National Taiwan University, Taipei 10617, Taiwan
    J Biomed Opt 11:054022. 2006
  7. ncbi request reprint Compact fiber-delivered Cr:forsterite laser for nonlinear light microscopy
    Ming Che Chan
    National Taiwan University, Department of Electrical Engineering and Graduate Institute of Electro Optical Engineering, Taipei 10617, Taiwan
    J Biomed Opt 10:054006. 2005
  8. doi request reprint Terahertz pipe-waveguide-based directional couplers
    Jen Tang Lu
    Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei, Taiwan
    Opt Express 19:26883-90. 2011
  9. doi request reprint High-sensitivity in vivo THz transmission imaging of early human breast cancer in a subcutaneous xenograft mouse model
    Hua Chen
    Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei, 10617, Taiwan
    Opt Express 19:21552-62. 2011
  10. doi request reprint Quantitative and qualitative investigation into the impact of focused ultrasound with microbubbles on the triggered release of nanoparticles from vasculature in mouse tumors
    Chung Yin Lin
    Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan Division of Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan
    J Control Release 146:291-8. 2010

Collaborators

  • Shi Wei Chu
  • Tsung Han Tsai
  • Hua Chen
  • Huai Jen Tsai
  • Chi Hung Lin
  • Wei Chen
  • Guo Dung John Su
  • Win Li Lin
  • Sheng Wen Huang
  • Eric Y Chuang
  • Dar Bin Shieh
  • Huang Chieh Lee
  • Yi You Huang
  • Tze An Liu
  • Wen Chang Chang
  • Ming Rung Tsai
  • Szu Yu Chen
  • Che Hang Yu
  • Jen Tang Lu
  • Chieh Feng Chang
  • Ming Che Chan
  • Yi Hua Liao
  • Tzu Fang Tseng
  • Cho Shuen Hsieh
  • Chih Hsien Lai
  • Shih Hsuan Chia
  • Yuh Jing Hwang
  • Hung chun Chang
  • Wen Jeng Lee
  • Ja Yu Lu
  • Shih Peng Tai
  • Pierre Adrien Mante
  • Yuan Fu Tsai
  • Yu Chieh Wen
  • Jin Wei Shi
  • Chao Yu Chen
  • Fu Hsiung Chang
  • Shi Hao Guol
  • Ching Yi Ko
  • Chin Hwa Hu
  • Kung Hsuan Lin
  • Yu Hsiang Cheng
  • Yi Shuan Sheen
  • Jau Shiuh Chen
  • Sui Wei Peng
  • Jinn Kong Sheu
  • Pei Hsun Wang
  • Sin Yo Chou
  • Jhih Min Wun
  • Chien Cheng Chen
  • Pei Jen Lou
  • I Ju Chen
  • Chia Fone Lee
  • I Hsiu Chen
  • Yu Chun Hsueh
  • Borwen You
  • Andrey B Fedotov
  • Wei Rein Liu
  • Yuh Shyang Chen
  • Anatoly A Ivanov
  • Wen Feng Hsieh
  • Aleksey M Zheltikov
  • Nai Chia Cheng
  • Miin Jang Chen
  • Chia Hung Hsu
  • Jin Long Peng
  • I Jong Wang
  • Han Chieh Yu
  • Yi Bing Tseng
  • Chui Min Chiu
  • Chung Chiu Kuo
  • I Shuo Liu
  • Yu Shih Yang
  • Yen Wei Lee
  • Chien Hung Tseng
  • Hsiang Lin Liu
  • Shee Uan Chen
  • Yi Hsien Chen
  • Jiun Yi Lyu
  • Yi Fan Chan
  • Yu Huei Wu
  • Chun Ta Kung
  • Jian Shiung Wu
  • Cheng Ying Chen
  • Ci Ling Pan
  • Jr Hung Wang
  • Ying Jay Yang
  • Chin Ying S Hsu
  • Wei Fang Su
  • Yi Chung Chen

Detail Information

Publications41

  1. doi request reprint A sub-100 fs self-starting Cr:forsterite laser generating 1.4 W output power
    Shih Hsuan Chia
    Graduate Institute of Photonics and Optoelectronics and Department of Electrical Engineering, Natl Taiwan University, Taipei 10617, Taiwan
    Opt Express 18:24085-91. 2010
    ..This intense femtosecond Cr:forsterite laser is ideal to pump varieties of high power fiber light sources and could be thus ideal for many biological and spectroscopy applications...
  2. ncbi request reprint Multiharmonic-generation biopsy of skin
    Chi Kuang Sun
    Department of Electrical Engineering and Graduate Institute of Electro Optical Engineering, National Taiwan University, Taipei 10617, Taiwan
    Opt Lett 28:2488-90. 2003
    ..Our preliminary study suggests that this technique could provide submicrometer-resolution deep-tissue noninvasive biopsy images in skin without the use of fluorescence and exogenous markers...
  3. ncbi request reprint Higher harmonic generation microscopy for developmental biology
    Chi Kuang Sun
    Graduate Institute of Electro Optical Engineering and Department of Electrical Engineering, National Taiwan University, Taipei 10617, Taiwan, ROC
    J Struct Biol 147:19-30. 2004
    ....
  4. ncbi request reprint Higher harmonic generation microscopy
    Chi Kuang Sun
    Graduate Institute of Electro Optical Engineering and Department of Electrical Engineering, National Taiwan University, Taipei 10617, Taiwan, ROC
    Adv Biochem Eng Biotechnol 95:17-56. 2005
    ....
  5. pmc Studies of chi(2)/chi(3) tensors in submicron-scaled bio-tissues by polarization harmonics optical microscopy
    Shi Wei Chu
    Department of Electrical Engineering and Graduate Institute of Electro Optical Engineering, National Taiwan University, Taipei, Taiwan, Republic of China
    Biophys J 86:3914-22. 2004
    ....
  6. ncbi request reprint Noninvasive harmonics optical microscopy for long-term observation of embryonic nervous system development in vivo
    Szu Yu Chen
    Department of Electrical Engineering and Graduate Institute of Electro Optical Engineering, National Taiwan University, Taipei 10617, Taiwan
    J Biomed Opt 11:054022. 2006
    ....
  7. ncbi request reprint Compact fiber-delivered Cr:forsterite laser for nonlinear light microscopy
    Ming Che Chan
    National Taiwan University, Department of Electrical Engineering and Graduate Institute of Electro Optical Engineering, Taipei 10617, Taiwan
    J Biomed Opt 10:054006. 2005
    ..2-nJ fiber-output pulse energy. Based on this fiber-delivered Cr:forsterite laser source, a compact and reliable two-photon fluorescence microscopy system can thus be realized...
  8. doi request reprint Terahertz pipe-waveguide-based directional couplers
    Jen Tang Lu
    Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei, Taiwan
    Opt Express 19:26883-90. 2011
    ..Rectangular pipe-waveguide-based directional couplers and the issue of insertion loss are also discussed. It is found that the THz directional coupler works most efficiently in the minimal-attenuation wavelength regime...
  9. doi request reprint High-sensitivity in vivo THz transmission imaging of early human breast cancer in a subcutaneous xenograft mouse model
    Hua Chen
    Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei, 10617, Taiwan
    Opt Express 19:21552-62. 2011
    ..Our in vivo study on the subcutaneous xenograft mouse model will encourage broad and further investigations for future early cancer screening by using THz imaging system...
  10. doi request reprint Quantitative and qualitative investigation into the impact of focused ultrasound with microbubbles on the triggered release of nanoparticles from vasculature in mouse tumors
    Chung Yin Lin
    Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan Division of Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan
    J Control Release 146:291-8. 2010
    ....
  11. ncbi request reprint Biomolecular imaging based on far-red fluorescent protein with a high two-photon excitation action cross section
    Tsung Han Tsai
    Graduate Institute of Electro optical Engineering, National Taiwan University, Taipei 10617, Taiwan
    Opt Lett 31:930-2. 2006
    ..In vivo 2PFM of the developing heart deep inside a transgenic zebrafish embryo tagged by Hc-RFP is also successfully demonstrated...
  12. ncbi request reprint Optical piezoelectric transducer for nano-ultrasonics
    Kung Hsuan Lin
    Graduate Institute of Electro optical Engineering, National Taiwan University, Taipei 10617, Taiwan
    IEEE Trans Ultrason Ferroelectr Freq Control 52:1404-14. 2005
    ..This nano-structured OPT technique will provide the key toward the realization of nano-ultrasonics, which is analogous to the typical ultrasonic techniques but in a nanometer scale...
  13. doi request reprint Miniaturized video-rate epi-third-harmonic-generation fiber-microscope
    Shih Hsuan Chia
    Department of Electrical Engineering, Graduate Inst of Photonics and Optoelectronics, Natl Taiwan Univ, Taipei 10617, Taiwan
    Opt Express 18:17382-91. 2010
    ..In vivo real time virtual biopsy of the Asian skin with a video rate (31 Hz) and a sub-micron resolution was obtained. The result indicates that this miniaturized system was compact enough for the least invasive hand-held clinical use...
  14. doi request reprint Terahertz polarization-sensitive rectangular pipe waveguides
    Jen Tang Lu
    Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei, 10617, Taiwan
    Opt Express 19:21532-9. 2011
    ..By measuring the attenuation spectra, we find that the polarization sensitivity depends on the structure of the pipe waveguides. With butt coupling method, it is easy to combine circular pipe waveguides and the rectangular ones...
  15. ncbi request reprint Molecular third-harmonic-generation microscopy through resonance enhancement with absorbing dye
    Che Hang Yu
    Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei 10617, Taiwan
    Opt Lett 33:387-9. 2008
    ..It is concluded that combining THG microscopy with the mature staining technique can readily achieve 3D molecular imaging without using fluorescence...
  16. ncbi request reprint High-resolution simultaneous three-photon fluorescence and third-harmonic-generation microscopy
    Shi Wei Chu
    Graduate Institute of Electro Optical Engineering and Department of Electrical Engineering, National Taiwan University, Taipei 10617, Taiwan
    Microsc Res Tech 66:193-7. 2005
    ....
  17. doi request reprint Direct backward third-harmonic generation in nanostructures
    Chieh Feng Chang
    Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei 10617, Taiwan
    Opt Express 18:7397-406. 2010
    ..An integral equation was also derived for fast computation of DBTHG in nano films. Our investigation suggests that DBTHG can be a potentially powerful tool in nano-science research, especially when combined with FTHG measurements...
  18. doi request reprint Applying tattoo dye as a third-harmonic generation contrast agent for in vivo optical virtual biopsy of human skin
    Ming Rung Tsai
    National Taiwan University, Graduate Institute of Photonics and Optoelectronics and Department of Electrical Engineering, Taipei, 10617, Taiwan
    J Biomed Opt 18:26012. 2013
    ..Combined with the demonstrated THG enhancement effect, tattoo dyes show their promise for future clinical imaging applications...
  19. doi request reprint Bending loss of terahertz pipe waveguides
    Jen Tang Lu
    Graduate Institute of Photonics and Optoelectronics and Department of Electrical Engineering, National Taiwan University, Taipei 10617, Taiwan
    Opt Express 18:26332-8. 2010
    ..The unexpected low bending loss in the investigated simple leaky waveguide structure promises variety of flexible applications...
  20. doi request reprint Virtual biopsy of rat tympanic membrane using higher harmonic generation microscopy
    Wen Jeng Lee
    National Taiwan University, Department of Electrical Engineering, Taipei, Taiwan
    J Biomed Opt 15:046012. 2010
    ..Our study demonstrates the feasibility of using a noninvasive optical imaging system for comprehensive evaluation of the tympanic membrane...
  21. ncbi request reprint Imaging polyhedral inclusion bodies of nuclear polyhedrosis viruses with second harmonic generation microscopy
    Tzu Ming Liu
    Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei 10617, Taiwan, ROC
    Opt Express 16:5602-8. 2008
    ..With multimodal harmonic generation microscopy, we also demonstrated 3D imaging on PIBs of NPV in living cells. The distribution and the number of PIBs in intact infected cells can be revealed without the help of fluorescent labeling...
  22. doi request reprint High-depth-resolution 3-dimensional radar-imaging system based on a few-cycle W-band photonic millimeter-wave pulse generator
    Tzu Fang Tseng
    Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei, 10617, Taiwan
    Opt Express 21:14109-19. 2013
    ..A preliminary study indicates that 3-D radar images with a state-of-the-art ranging resolution of around 1.2 cm at the W-band can be achieved. ..
  23. ncbi request reprint Selective imaging in second-harmonic-generation microscopy with anisotropic radiation
    Shi Wei Chu
    Department of Physics, National Taiwan University, Taipei 10617, Taiwan
    J Biomed Opt 14:010504. 2009
    ..Moreover, we find that well-formed collagen fibrils are highlighted by forward SHG, while loosely arranged collagen matrix is outlined by backward signal...
  24. ncbi request reprint Epi-third and second harmonic generation microscopic imaging of abnormal enamel
    Szu Yu Chen
    Department of Electrical Engineering, Graduate Institute of Photonics and Optoelectronics, National TaiwanUniversity, Taipei, Taiwan, ROC
    Opt Express 16:11670-9. 2008
    ....
  25. pmc Glycogen synthase kinase 3 alpha and 3 beta have distinct functions during cardiogenesis of zebrafish embryo
    Huang Chieh Lee
    Institute of Molecular and Cellular Biology, National Taiwan University, NO, 1, Roosevelt Road, Sec, 4, Taipei 106, Taiwan
    BMC Dev Biol 7:93. 2007
    ..At this study, we attempt to specifically inhibit either GSK3alpha or GSK3beta and uncover the isoform-specific roles that GSK3 plays during cardiogenesis...
  26. doi request reprint Infrared-based third and second harmonic generation imaging of cornea
    Szu Yu Chen
    National Taiwan University, Graduate Institute of Photonics and Optoelectronics, Department of Electrical Engineering, No 1 Roosevelt Road Section 4, Taipei 10617, Taiwan
    J Biomed Opt 14:044012. 2009
    ..This study provides a critical reference for future development of infrared-based corneal imaging...
  27. doi request reprint Performance of THz fiber-scanning near-field microscopy to diagnose breast tumors
    Hua Chen
    Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei, 10617, Taiwan
    Opt Express 19:19523-31. 2011
    ....
  28. doi request reprint In vivo long-term continuous observation of gene expression in zebrafish embryo nerve systems by using harmonic generation microscopy and morphant technology
    Cho Shuen Hsieh
    National Taiwan University, Department of Electrical Engineering, and, Graduate Institute of Photonics and Optoelectronics, Taipei 10617, Taiwan
    J Biomed Opt 13:064041. 2008
    ..e., SHG microscopy and THG microscopy, successfully revealed the weak cell adhesion, cell apoptosis, nerve formation reduction, and neural tube distortion in the morphant zebrafish embryos...
  29. ncbi request reprint Cell tracking and detection of molecular expression in live cells using lipid-enclosed CdSe quantum dots as contrast agents for epi-third harmonic generation microscopy
    Chieh Feng Chang
    Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei 10617, Taiwan
    Opt Express 16:9534-48. 2008
    ..Combined with a high penetration 1230 nm laser, these novel features make LEQDs excellent THG contrast agents for in vivo deep-tissue imaging in the future...
  30. doi request reprint Cr:Forsterite-laser-based fiber-optic nonlinear endoscope with higher efficiencies
    Ming Che Chan
    Department of Electrical Engineering and Graduate Institute of Electro Optical Engineering, National Taiwan University, Taipei 10617, Taiwan, Republic of China
    Microsc Res Tech 71:559-63. 2008
    ..The system resolution has been characterized to be 5.4 microm in the two-photon fluorescence endoscope, limited by the sampling theory. Finally, several image examples have been given...
  31. doi request reprint Modal characteristics of antiresonant reflecting pipe waveguides for terahertz waveguiding
    Chih Hsien Lai
    Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei, 10617, Taiwan
    Opt Express 18:309-22. 2010
    ..Experiments using time-domain spectroscopy with PMMA pipes also confirm the antiresonant reflecting guiding mechanism...
  32. doi request reprint Multi-photon resonance enhancement of third harmonic generation in human oxyhemoglobin and deoxyhemoglobin
    Chieh Feng Chang
    Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei 10617, Taiwan
    J Biophotonics 3:678-85. 2010
    ..Our spectroscopic results thus indicate the high potential of THG spectroscopic microscopy for oxygen depletion level measurement of a single red blood cell in vivo...
  33. ncbi request reprint Transverse-junction superluminescent diodes at the 1.1 microm wavelength regime
    Shi Hao Guol
    Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei 10617, Taiwan
    Opt Express 16:16860-6. 2008
    ..In contrast with a VJ SLD, the EL spectrum of our device is determined by QWs that have a larger differential gain than the positions of QWs neighbored with a p side layer...
  34. ncbi request reprint Differential diagnosis of nonmelanoma pigmented skin lesions based on harmonic generation microscopy
    Ming Rung Tsai
    National Taiwan University, Graduate Institute of Photonics and Optoelectronics and Department of Electrical Engineering, Taipei 10617, TaiwanbNational Taiwan University, Molecular Imaging Center, Taipei 10617, Taiwan
    J Biomed Opt 19:36001. 2014
    ..Our study indicates that HGM serves as a promising histopathological examination tool for noninvasive differential diagnostics of nonmelanoma pigmented skin tumors...
  35. doi request reprint Fiber-based swept-source terahertz radar
    Yu Wei Huang
    Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei 10617, Taiwan
    Opt Lett 35:1344-6. 2010
    ..Our experiment showed that this fiber-based swept-source terahertz radar could be used in real time to locate concealed moving live objects with high stability...
  36. pmc Determination of chronological aging parameters in epidermal keratinocytes by in vivo harmonic generation microscopy
    Yi Hua Liao
    Department of Dermatology, National Taiwan University Hospital and College of Medicine, National Taiwan University, No 7, Chung Shan South Road, Taipei 10002, Taiwan Molecular Imaging Center, National Taiwan University, No 1, Sec 4, Roosevelt Road, Taipei 10617, Taiwan
    Biomed Opt Express 4:77-88. 2013
    ..The cellular and nuclear areas, which have an increase of 0.51 μm(2) and 0.15 μm(2) per year, respectively, can serve as scoring indices for intrinsic skin aging...
  37. doi request reprint Characterization of oral squamous cell carcinoma based on higher-harmonic generation microscopy
    Ming Rung Tsai
    Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei, Taiwan
    J Biophotonics 5:415-24. 2012
    ..In addition, distinct patterns of collagen fibers and increased distribution area of actin filaments in tumor cells were noted. These results indicate HGM holds great potential for the optical biopsy screening of oral cancer lesions...
  38. ncbi request reprint THz interferometric imaging using subwavelength plastic fiber based THz endoscopes
    Ja Yu Lu
    Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei, 10617, Taiwan
    Opt Express 16:2494-501. 2008
    ..By analyzing the axial-position dependent THz signals backward collected by the subwavelength plastic fiber, the THz reflection amplitudes and phases on the sample surface can be successfully reconstructed...
  39. ncbi request reprint Thermal Boundary Resistance between GaN and Cubic Ice and THz Acoustic Attenuation Spectrum of Cubic Ice from Complex Acoustic Impedance Measurements
    Pierre Adrien Mante
    Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei 10617, Taiwan
    Phys Rev Lett 111:225901. 2013
    ..This method is then applied to cubic ice, and the measurements of the elastic properties, the phonon anharmonic decay spectrum up to 1 THz, as well as the measurements of the thermal phonon lifetime at 150 K are all achieved...
  40. ncbi request reprint Higher harmonic generation microscopy of in vitro cultured mammal oocytes and embryos
    Cho Shuen Hsieh
    Department of Electrical Engineering, Graduate Institute of Photonics and Optoelectronics, National TaiwanUniversity, Taipei, Taiwan
    Opt Express 16:11574-88. 2008
    ..Combining two different higher-harmonic generation modalities, SHG and THG, HGM successfully revealed the sub-cellular structures of the whole mouse embryos with a high 3D spatial resolution...
  41. ncbi request reprint Miniaturized multiphoton microscope with a 24Hz frame-rate
    Tzu Ming Liu
    Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics, National TaiwanUniversity, Taipei, ROC
    Opt Express 16:10501-6. 2008
    ..Through a two-dimensional asynchronous scanning of the MEMS mirror, 24Hz frame rate can be realized. With a high numerical aperture objective, sub-micron resolution can also be achieved at the same time...