Li Heng Pao

Summary

Affiliation: National Defense Medical Center
Country: Taiwan

Publications

  1. ncbi request reprint Herb-drug interaction of 50 Chinese herbal medicines on CYP3A4 activity in vitro and in vivo
    Li Heng Pao
    School of Pharmacy, National Defense Medical Center, 161 MinchuanEast Road Section 6, Taipei, Taiwan
    Am J Chin Med 40:57-73. 2012
  2. doi request reprint Validated liquid chromatography-tandem mass spectrometry method for determination of totally nine probe metabolites of cytochrome P450 enzymes and UDP-glucuronosyltransferases
    Jr Ting Lee
    Graduate Institute of Medical Sciences, National Defense Medical Center, No 161, Sec 6, Minquan East Road, Neihu District, Taipei City 114, Taiwan, ROC
    Talanta 106:220-8. 2013
  3. ncbi request reprint In vitro and in vivo evaluation of the metabolism and pharmacokinetics of sebacoyl dinalbuphine
    Li Heng Pao
    Department of Research, Development and Continuing Education, National Defense Medical Center, 161 Minchuan East Road, Sec 6, Taipei, Taiwan, R O C
    Drug Metab Dispos 33:395-402. 2005
  4. doi request reprint Simultaneous determination of nalbuphine and its prodrug sebacoly dinalbuphine ester in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic study in humans
    Pei Wei Huang
    School of Pharmacy, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Biomed Chromatogr 27:831-7. 2013
  5. ncbi request reprint Single-point plasma or urine dextromethorphan method for determining CYP3A activity
    Benjamin Pei Chung Kuo
    Graduate Institute of Life Sciences, National Defense Medical Center and Academy Sinica, Taipei, Taiwan, ROC
    Biopharm Drug Dispos 24:367-73. 2003
  6. pmc Dietary Flavonoids Modulate CYP2C to Improve Drug Oral Bioavailability and Their Qualitative/Quantitative Structure-Activity Relationship
    Hong Jaan Wang
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China
    AAPS J 16:258-68. 2014
  7. ncbi request reprint Novel inhibition of cis/trans retinoic acid interconversion in biological fluids--an accurate method for determination of trans and 13-cis retinoic acid in biological fluids
    Chao Jih Wang
    Graduate Institute of Life Science, National Defense Medical Center, Taipei, Taiwan, ROC
    J Chromatogr B Analyt Technol Biomed Life Sci 796:283-91. 2003
  8. ncbi request reprint Simultaneous quantification of triazolam and its metabolites in human urine by liquid chromatography-tandem mass spectrometry
    Ryh Nan Pan
    Department of Disaster Management, Taiwan Police College, 153 Shing Lung Rd, Section 3, Taipei, Taiwan
    J Anal Toxicol 35:170-5. 2011
  9. pmc Evaluation of chinese-herbal-medicine-induced herb-drug interactions: focusing on organic anion transporter 1
    Chang Ching Lin
    School of Pharmacy, National Defense Medical Center, Taipei 114, Taiwan
    Evid Based Complement Alternat Med 2012:967182. 2012
  10. doi request reprint Validated LC-MS-MS method for the determination of quetiapine in human plasma: application to a pharmacokinetic study
    Ryh Nan Pan
    Department of Disaster Management, Taiwan Police College, Taipei, Taiwan, Republic of China
    J Chromatogr Sci 50:277-82. 2012

Collaborators

  • Meei Shyuan Lee
  • Shung Tai Ho
  • Jr Ting Lee
  • Teh Ia Huo
  • Wen Huang Peng
  • Ryh Nan Pan
  • Chang Ching Lin
  • Cheng Huei Hsiong
  • Pei Wei Huang
  • Oliver Yoa Pu Hu
  • Hsien Yuan Fan
  • Jung Chao
  • Benjamin Pei Chung Kuo
  • Hong Jaan Wang
  • Chien Wen Kuo
  • Chao Jih Wang
  • Tung Yuan Shih
  • Hao Yuan Cheng
  • Jiunn Wang Liao
  • Jen Chieh Tsai
  • Ming Tsuen Hsieh
  • Xue Mei Qin
  • Hung Ta Liu
  • Chih Cherng Lu
  • Wen Yi Li
  • Wei Shiuan Tsai
  • Ting Shien Chen
  • Chi Feng Hung
  • Jacqueline Jia Kang Whang-Peng
  • Chih Yuan Wu

Detail Information

Publications15

  1. ncbi request reprint Herb-drug interaction of 50 Chinese herbal medicines on CYP3A4 activity in vitro and in vivo
    Li Heng Pao
    School of Pharmacy, National Defense Medical Center, 161 MinchuanEast Road Section 6, Taipei, Taiwan
    Am J Chin Med 40:57-73. 2012
    ..Mu Dan Pi, Ji Shiee Terng and Huang Qi were observed to have greatly increased in the C(max) and AUC of midazolam. This study provides evidence of possible herb-drug interactions involved with certain single herbs...
  2. doi request reprint Validated liquid chromatography-tandem mass spectrometry method for determination of totally nine probe metabolites of cytochrome P450 enzymes and UDP-glucuronosyltransferases
    Jr Ting Lee
    Graduate Institute of Medical Sciences, National Defense Medical Center, No 161, Sec 6, Minquan East Road, Neihu District, Taipei City 114, Taiwan, ROC
    Talanta 106:220-8. 2013
    ..By the end of the eighth week, the CD-fed induced fatty liver rats showed a significant decrease in the activities of CYP1A2 and UGT2B7 as compared to the standard diet group...
  3. ncbi request reprint In vitro and in vivo evaluation of the metabolism and pharmacokinetics of sebacoyl dinalbuphine
    Li Heng Pao
    Department of Research, Development and Continuing Education, National Defense Medical Center, 161 Minchuan East Road, Sec 6, Taipei, Taiwan, R O C
    Drug Metab Dispos 33:395-402. 2005
    ..Overall, these results suggest that SDN fulfilled the original pro-soft drug design in which the prodrug can rapidly metabolize to nalbuphine, and no other unexpected compounds were apparent in the blood...
  4. doi request reprint Simultaneous determination of nalbuphine and its prodrug sebacoly dinalbuphine ester in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic study in humans
    Pei Wei Huang
    School of Pharmacy, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Biomed Chromatogr 27:831-7. 2013
    ..The method is sensitive, selective and directly applicable to human pharmacokinetic studies involving nalbuphine...
  5. ncbi request reprint Single-point plasma or urine dextromethorphan method for determining CYP3A activity
    Benjamin Pei Chung Kuo
    Graduate Institute of Life Sciences, National Defense Medical Center and Academy Sinica, Taipei, Taiwan, ROC
    Biopharm Drug Dispos 24:367-73. 2003
    ..5-12 h could be used as the dextromethorphan MR for determining the CYP3A activity...
  6. pmc Dietary Flavonoids Modulate CYP2C to Improve Drug Oral Bioavailability and Their Qualitative/Quantitative Structure-Activity Relationship
    Hong Jaan Wang
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China
    AAPS J 16:258-68. 2014
    ..In the present study, tamarixetin significantly inhibited CYP2C activity in vitro and in vivo. Thus, the use of tamarixetin could improve the therapeutic efficacy of drugs with low bioavailability. ..
  7. ncbi request reprint Novel inhibition of cis/trans retinoic acid interconversion in biological fluids--an accurate method for determination of trans and 13-cis retinoic acid in biological fluids
    Chao Jih Wang
    Graduate Institute of Life Science, National Defense Medical Center, Taipei, Taiwan, ROC
    J Chromatogr B Analyt Technol Biomed Life Sci 796:283-91. 2003
    ..Thus, our results suggest that the HPLC method for analyzing tRA and 13-cRA in plasma with the addition of NEM and Vit. C is a simple, sensitive and accurate method...
  8. ncbi request reprint Simultaneous quantification of triazolam and its metabolites in human urine by liquid chromatography-tandem mass spectrometry
    Ryh Nan Pan
    Department of Disaster Management, Taiwan Police College, 153 Shing Lung Rd, Section 3, Taipei, Taiwan
    J Anal Toxicol 35:170-5. 2011
    ..The within- and between-run precisions were less than 15%, and accuracy was -12.33% to 9.76%. The method was proved to be accurate and specific, and it was applied to a urinary excretion study of triazolam in healthy Chinese volunteers...
  9. pmc Evaluation of chinese-herbal-medicine-induced herb-drug interactions: focusing on organic anion transporter 1
    Chang Ching Lin
    School of Pharmacy, National Defense Medical Center, Taipei 114, Taiwan
    Evid Based Complement Alternat Med 2012:967182. 2012
    ..Moreover, GZ showed concentration-dependent manners both in vitro and in vivo, and the decrease of rOAT1 mRNA expression indicated that GZ not only inhibited function of OAT1 but also suppressed expression of OAT1...
  10. doi request reprint Validated LC-MS-MS method for the determination of quetiapine in human plasma: application to a pharmacokinetic study
    Ryh Nan Pan
    Department of Disaster Management, Taiwan Police College, Taipei, Taiwan, Republic of China
    J Chromatogr Sci 50:277-82. 2012
    ..2%. The lower limit of quantification was 1 ng/mL. The extraction recoveries of quetiapine were over 90%. The method is proved to be accurate and specific, and was applied to the pharmacokinetic study in healthy Chinese volunteers...
  11. doi request reprint Determination of p-aminohippuric acid in rat plasma by liquid chromatography-tandem mass spectrometry
    Hsien Yuan Fan
    School of Pharmacy, National Defense Medical Center, Taipei, Taiwan, ROC
    J Chromatogr B Analyt Technol Biomed Life Sci 878:1643-6. 2010
    ..1-->110.1 for PAH and acetaminophen, respectively. Good linearity is observed over the concentration range of 0.1-500 microg/ml. The method was proved to be accurate and reliable and was applied to a pharmacokinetic study in rat...
  12. doi request reprint A new approach to facilitate diagnosis of nonalcoholic fatty liver disease through a galactose single point method in rats with fatty liver
    Jr Ting Lee
    Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, ROC
    Dig Liver Dis 45:134-41. 2013
    ..Liver biopsy reliably diagnoses nonalcoholic fatty liver disease, but its invasiveness and inter- and intra-observer errors limit its usefulness in monitoring...
  13. pmc Gallic Acid Ameliorated Impaired Glucose and Lipid Homeostasis in High Fat Diet-Induced NAFLD Mice
    Jung Chao
    Institute of Pharmacology, College of Medicine, National Yang Ming University, Taipei, Taiwan
    PLoS ONE 9:e96969. 2014
    ..The selected metabolites are potentially useful as preventive action biomarkers and could also be used to help our further understanding of the effect of GA in hepatosteatosis mice. ..
  14. doi request reprint Development and validation of a liquid chromatography-tandem mass spectrometry method for simultaneous quantification of p-aminohippuric acid and inulin in rat plasma for renal function study
    Chang Ching Lin
    School of Pharmacy, National Defense Medical Center, 9F, 161 Minchuan East Road, Section 6, Taipei, Taiwan, 114, Republic of China
    Anal Bioanal Chem 398:857-65. 2010
    ..This application was proven to be reliable and accurate and was successfully applied to a renal function study...
  15. ncbi request reprint Simultaneous determination of triazolam and its metabolites in human plasma by liquid chromatography-tandem mass spectrometry
    Ryh Nan Pan
    Department of Disaster Management, Taiwan Police College, Taipei, Taiwan, ROC
    J Chromatogr B Analyt Technol Biomed Life Sci 872:58-62. 2008
    ..The within- and between-run precisions were less than 15.26% and accuracy was -8.08% to 13.33%. The method proved to be accurate and specific, and was applied to the pharmacokinetic study of triazolam in healthy Chinese volunteers...