Yen Hsuan Ni

Summary

Affiliation: National Taiwan University
Country: Taiwan

Publications

  1. pmc Significant social events and increasing use of life-sustaining treatment: trend analysis using extracorporeal membrane oxygenation as an example
    Yen Yuan Chen
    Department of Pediatrics, National Taiwan University College of Medicine, NO, 1, Road Ren Ai sec, 1, Taipei 100, Taiwan
    BMC Med Ethics 15:21. 2014
  2. doi request reprint Minimization of hepatitis B infection by a 25-year universal vaccination program
    Yen Hsuan Ni
    Department of Pediatrics, Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
    J Hepatol 57:730-5. 2012
  3. ncbi request reprint Hepatitis B vaccination in children: the Taiwan experience
    Y H Ni
    Department of Pediatrics, National Taiwan University Children s Hospital, Taipei, Taiwan
    Pathol Biol (Paris) 58:296-300. 2010
  4. doi request reprint Natural history of hepatitis B virus infection: pediatric perspective
    Yen Hsuan Ni
    Department of Pediatrics, College of Medicine and Children s Hospital, National Taiwan University, 8 Chung Shan South Road, Taipei, Taiwan
    J Gastroenterol 46:1-8. 2011
  5. ncbi request reprint Long-term follow-up of children with postnatal immunoprophylaxis failure who were infected with hepatitis B virus surface antigen gene mutant
    Hong Yuan Hsu
    Department of Pediatrics, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan
    J Infect Dis 207:1047-57. 2013
  6. doi request reprint Clinical course of de novo hepatitis B infection after pediatric liver transplantation
    Wei Ju Su
    Department of Pediatrics, National Taiwan University College of Medicine and Hospital, Taipei 100, Taiwan
    Liver Transpl 16:215-21. 2010
  7. doi request reprint Toll-like receptor and hepatitis B virus clearance in chronic infected patients: a long-term prospective cohort study in Taiwan
    Jia Feng Wu
    Department of Pediatrics, National Taiwan University Hospital, Taipei
    J Infect Dis 206:662-8. 2012
  8. ncbi request reprint Factors affecting the mortality of pediatric fulminant hepatic failure in relation to hepatitis B virus infection
    Pei Chun Chan
    Department of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
    J Gastroenterol Hepatol 20:1223-7. 2005
  9. ncbi request reprint Lamivudine treatment in maternally transmitted chronic hepatitis B virus infection patients
    Yen Hsuan Ni
    Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan
    Pediatr Int 47:372-7. 2005
  10. doi request reprint Long-term effect of maternal HBeAg on delayed HBeAg seroconversion in offspring with chronic hepatitis B infection
    Yu Ru Tseng
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Liver Int 31:1373-80. 2011

Collaborators

Detail Information

Publications97

  1. pmc Significant social events and increasing use of life-sustaining treatment: trend analysis using extracorporeal membrane oxygenation as an example
    Yen Yuan Chen
    Department of Pediatrics, National Taiwan University College of Medicine, NO, 1, Road Ren Ai sec, 1, Taipei 100, Taiwan
    BMC Med Ethics 15:21. 2014
    ....
  2. doi request reprint Minimization of hepatitis B infection by a 25-year universal vaccination program
    Yen Hsuan Ni
    Department of Pediatrics, Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
    J Hepatol 57:730-5. 2012
    ..Five previous seroepidemiologic surveys were conducted at 0, 5, 10, 15, and 20 years after the launch of the vaccination program...
  3. ncbi request reprint Hepatitis B vaccination in children: the Taiwan experience
    Y H Ni
    Department of Pediatrics, National Taiwan University Children s Hospital, Taipei, Taiwan
    Pathol Biol (Paris) 58:296-300. 2010
    ..The emergence of escape mutant did not impose increased risk of chronic infection at present. Nevertheless, development of new vaccines may overcome the vaccine failure...
  4. doi request reprint Natural history of hepatitis B virus infection: pediatric perspective
    Yen Hsuan Ni
    Department of Pediatrics, College of Medicine and Children s Hospital, National Taiwan University, 8 Chung Shan South Road, Taipei, Taiwan
    J Gastroenterol 46:1-8. 2011
    ..The achievement of our ultimate goal of HBV elimination depends on a globally effective universal vaccination program, as well as the application of some novel successful medications to control those who are already infected...
  5. ncbi request reprint Long-term follow-up of children with postnatal immunoprophylaxis failure who were infected with hepatitis B virus surface antigen gene mutant
    Hong Yuan Hsu
    Department of Pediatrics, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan
    J Infect Dis 207:1047-57. 2013
    ..The long-term evolution and outcomes of infection with a hepatitis B virus (HBV) surface antigen (HBsAg) gene mutant (hereafter, "HBsAg-mutant HBV") among immunized children remain unclear...
  6. doi request reprint Clinical course of de novo hepatitis B infection after pediatric liver transplantation
    Wei Ju Su
    Department of Pediatrics, National Taiwan University College of Medicine and Hospital, Taipei 100, Taiwan
    Liver Transpl 16:215-21. 2010
    ..In conclusion, surface mutants are frequent among pediatric liver transplant recipients with de novo HBV infections, but their clinical relevance requires further study...
  7. doi request reprint Toll-like receptor and hepatitis B virus clearance in chronic infected patients: a long-term prospective cohort study in Taiwan
    Jia Feng Wu
    Department of Pediatrics, National Taiwan University Hospital, Taipei
    J Infect Dis 206:662-8. 2012
    ..We sought to elucidate the impacts of the Toll-like receptors (TLRs) on spontaneous hepatitis B virus (HBV) e antigen (HBeAg) and hepatitis B s antigen (HBsAg) seroconversion in chronic HBV-infected patients...
  8. ncbi request reprint Factors affecting the mortality of pediatric fulminant hepatic failure in relation to hepatitis B virus infection
    Pei Chun Chan
    Department of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
    J Gastroenterol Hepatol 20:1223-7. 2005
    ..To investigate the factors affecting the outcome of fulminant hepatic failure (FHF) in children in relation to hepatitis B virus (HBV) infection...
  9. ncbi request reprint Lamivudine treatment in maternally transmitted chronic hepatitis B virus infection patients
    Yen Hsuan Ni
    Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan
    Pediatr Int 47:372-7. 2005
    ..Lamivudine treatment in chronic carriers who acquired hepatitis B virus through maternal transmission were investigated...
  10. doi request reprint Long-term effect of maternal HBeAg on delayed HBeAg seroconversion in offspring with chronic hepatitis B infection
    Yu Ru Tseng
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Liver Int 31:1373-80. 2011
    ..This cohort study investigated the long-term effect of maternal hepatitis B virus (HBV) sero-status on the spontaneous HBeAg seroconversion in offspring with chronic HBV infection...
  11. doi request reprint Human interleukin-10 genotypes are associated with different precore/core gene mutation patterns in children with chronic hepatitis B virus infection
    Jia Feng Wu
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    J Pediatr 158:808-13. 2011
    ..To elucidate the association between human interleukin-10 (IL-10) genotypes and hepatitis B virus (HBV) precore/core gene mutation in children with chronic HBV infection...
  12. ncbi request reprint Genetic variants in GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals
    Yu Cheng Lin
    Department of Pediatrics, Far Eastern Memorial Hospital, Taipei, Taiwan Y CL and P FC the Departments of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan M HC and Y HN and the Oriental Institute of Technology, New Taipei City, Taiwan Y CL
    Am J Clin Nutr 99:869-74. 2014
    ....
  13. ncbi request reprint Two decades of universal hepatitis B vaccination in taiwan: impact and implication for future strategies
    Yen Hsuan Ni
    Department of Pediatrics, Hospital and College of Medicine, National Taiwan University, Genomics Research Center, Taipei, Taiwan
    Gastroenterology 132:1287-93. 2007
    ....
  14. ncbi request reprint Differential integration rates of hepatitis B virus DNA in the liver of children with chronic hepatitis B virus infection and hepatocellular carcinoma
    Hsiang Po Huang
    Department of Pediatrics, College of Medicine, National Taiwan University, 10016 Taipei, Taiwan
    J Gastroenterol Hepatol 20:1206-14. 2005
    ..The aim of the present study was to determine the prevalence of HBV integration more accurately and to decide whether the integration rate varies at different stages of chronic HBV infection in children...
  15. ncbi request reprint Hepatic steatosis and neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) in Taiwanese infants
    Jiun Nan Yeh
    Department of Pediatrics, Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan
    J Pediatr 148:642-6. 2006
    ..To explore the prevalence of hepatic steatosis and neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) in Taiwanese infants with idiopathic intrahepatic cholestasis...
  16. ncbi request reprint Clinical relevance of hepatitis B virus genotype in children with chronic infection and hepatocellular carcinoma
    Yen Hsuan Ni
    Department of Pediatrics, College of Medicine, National Taiwan University, Taipei 100 Taiwan
    Gastroenterology 127:1733-8. 2004
    ..The aim of this study was to investigate the influence of hepatitis B virus (HBV) genotypes on the clinical outcome of chronic childhood HBV infection and hepatocellular carcinoma (HCC)...
  17. doi request reprint Effect of puberty onset on spontaneous hepatitis B virus e antigen seroconversion in men
    Jia Feng Wu
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Gastroenterology 138:942-8.e1. 2010
    ..Male predominance is a remarkable phenomenon in hepatitis B virus (HBV)-related liver disease. This study elucidated the effects of puberty on spontaneous hepatitis B virus e antigen (HBeAg) seroconversion in boys...
  18. ncbi request reprint Transmission of occult hepatitis B virus by transfusion to adult and pediatric recipients in Taiwan
    Chun Jen Liu
    Division of Gastroenterology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, 1 Chang Te Street, Taipei 100, Taiwan
    J Hepatol 44:39-46. 2006
    ..To address this, we investigated the incidence of post-transfusion HBV infection after receiving screened blood units in Taiwan...
  19. ncbi request reprint FIC1 and BSEP defects in Taiwanese patients with chronic intrahepatic cholestasis with low gamma-glutamyltranspeptidase levels
    Huey Ling Chen
    Department of Pediatrics, Pathology, and Clinical Medicine, National Taiwan University Hospital, Taipei
    J Pediatr 140:119-24. 2002
    ..BSEP mutations were found in 2 of the 3 patients in group 2, including 2 missense mutations and a 1-bp deletion. Phenotypic characterization is useful to differentiate FIC1- from BSEP-related disease...
  20. ncbi request reprint Inadequate humoral immunogenicity to recombinant hepatitis B virus vaccine in biliary atresia children
    Jia Feng Wu
    Department of Pediatrics, National Taiwan University, Taipei 100, Taiwan, China
    Pediatr Res 64:100-4. 2008
    ..538). In conclusion, adequate primary humoral immunity after the standard doses of recombinant HBV vaccine in BA infants is hard to establish. However, once immunity is acquired, BA children have adequate anti-HBs titer in the long run...
  21. ncbi request reprint Development of autoantibodies after pediatric liver transplantation
    Ching Yi Chen
    Department of Pediatrics, College of Medicine and Children s Hospital, Taipei, Taiwan
    Pediatr Transplant 17:144-8. 2013
    ..The incidence of the development of autoantibodies was 75.0% in pediatric LT cases in this study. ASMA was the most commonly found autoantibody. Autoantibodies may not play a sentinel role for dn-AIH after LT...
  22. doi request reprint A common variant in the peroxisome proliferator-activated receptor-γ coactivator-1α gene is associated with nonalcoholic fatty liver disease in obese children
    Yu Cheng Lin
    Department of Pediatrics, Far Eastern Memorial Hospital and Oriental Institute of Technology, New Taipei City, Taiwan
    Am J Clin Nutr 97:326-31. 2013
    ..The PPARGC1A gene encodes PGC-1α, which regulates cellular energy metabolism...
  23. doi request reprint No increase in prevalence of hepatitis B surface antigen mutant in a population of children and adolescents who were fully covered by universal infant immunization
    Hong Yuan Hsu
    Department of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
    J Infect Dis 201:1192-200. 2010
    ..Mutants of the a determinant of hepatitis B surface antigen (HBsAg) can escape neutralization by vaccine-induced antibodies and prevail in an immunized population...
  24. doi request reprint Tumour necrosis factor-α promoter region polymorphisms affect the course of spontaneous HBsAg clearance
    Pei Chi Kao
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Liver Int 30:1448-53. 2010
    ..This study aimed to investigate the roles of tumour necrosis factor-α (TNF-α) gene polymorphisms in the spontaneous clearance of HBsAg after a hepatitis B virus (HBV) infection...
  25. doi request reprint Pre-S2 deletions of hepatitis B virus and hepatocellular carcinoma in children
    Hsiang Po Huang
    Department of Medical Research, National Taiwan University Hospital, Taipei 100, Taiwan
    Pediatr Res 67:90-4. 2010
    ....
  26. ncbi request reprint Waning immunity to plasma-derived hepatitis B vaccine and the need for boosters 15 years after neonatal vaccination
    Chun Yi Lu
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Hepatology 40:1415-20. 2004
    ..In conclusion, our findings suggest that one or more booster immunizations are needed in seronegative subjects by at least 15 years following neonatal immunization with plasma-derived HB vaccine...
  27. ncbi request reprint Post-transplantation lymphoproliferative disorders localizing to the gastrointestinal tract after liver transplantation: report of five pediatric cases
    Yi Chun Lai
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Pediatr Transplant 10:390-4. 2006
    ..In our series, each PTLD involved the GI tract. The mechanism of this phenomenon is unclear, but these five cases indicate the high incidence of PTLD in pediatric solid organ transplantation...
  28. doi request reprint Secular trend of the viral genotype distribution in children with chronic hepatitis B virus infection after universal infant immunization
    Wan Hsin Wen
    Department of Pediatrics, College of Medicine and Hospital, National Taiwan University, Taipei, Taiwan
    Hepatology 53:429-36. 2011
    ..03, 95% CI = 1.62-5.65, P = 0.001). However, the increased genotype C to genotype B ratio was not seen in the HBsAg-carrier mother pool in the postimmunization era...
  29. ncbi request reprint Viremia profiles in children with chronic hepatitis B virus infection and spontaneous e antigen seroconversion
    Yen Hsuan Ni
    Department of Pediatrics, Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
    Gastroenterology 132:2340-5. 2007
    ..This study investigated the viremia profiles in children with chronic hepatitis B virus (HBV) infection and spontaneous hepatitis B e antigen (HBeAg) seroconversion...
  30. ncbi request reprint Expression of hepatocyte transporters and nuclear receptors in children with early and late-stage biliary atresia
    Huey Ling Chen
    Department of Pediatrics, National Taiwan University College of Medicine and Hospital, Taipei, 10002 Taiwan
    Pediatr Res 63:667-73. 2008
    ..In conclusion, at long-term cholestasis, hepatocyte bile efflux was through sinusoidal and canalicular transporters, with FXR-BSEP levels maintained and PXR downregulated. Low PXR and CAR levels were associated with poor prognosis...
  31. ncbi request reprint Pediatric fulminant hepatic failure in endemic areas of hepatitis B infection: 15 years after universal hepatitis B vaccination
    Huey Ling Chen
    Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei
    Hepatology 39:58-63. 2004
    ..HBV-positive FHF was prone to develop in infants born to HBeAg-negative, HBsAg-carrier mothers; these infants had not received hepatitis B immunoglobulin according to the vaccination program in place...
  32. ncbi request reprint Response to booster hepatitis B vaccines in liver-transplanted children primarily vaccinated in infancy
    Yen Hsuan Ni
    Department of Pediatrics, College of Medicine and Hospital, National Taiwan University, Taipei, Taiwan
    Transplantation 86:1531-5. 2008
    ..Most of the children who received organ transplantation were primarily vaccinated before transplantation. This study investigated the efficacy of HBV vaccination and booster responses in children after liver transplantation (LT)...
  33. ncbi request reprint Long-term immunogenicity and efficacy of universal hepatitis B virus vaccination in Taiwan
    Yu Cheng Lin
    Department of Pediatrics, National Taiwan University Hospital and National Taiwan University, College of Medicine, Taipei, Taiwan
    J Infect Dis 187:134-8. 2003
    ..The results suggest that routine booster vaccination may not be required to provide protection against chronic HBV infection before age 15 years...
  34. doi request reprint Oral absorbable fat-soluble vitamin formulation in pediatric patients with cholestasis
    Yu Mei Shen
    Department of Pediatrics, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan
    J Pediatr Gastroenterol Nutr 55:587-91. 2012
    ..The aim of the present study was to evaluate the status of FSV deficiencies in patients under present practice and to test the effect of an oral, absorbable, fat-soluble vitamin formulation (OAFSV) in these patients...
  35. ncbi request reprint Fecal elastase 1, serum amylase and lipase levels in children with cholestasis
    Wan Hsin Wen
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Pancreatology 5:432-7. 2005
    ..The aim of the study was to evaluate the exocrine pancreatic function and common pancreatic function tests in children with cholestatic disorders...
  36. ncbi request reprint Time course of acylcarnitine elevation in neonatal intrahepatic cholestasis caused by citrin deficiency
    Ni Chung Lee
    Department of Medical Genetics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    J Inherit Metab Dis 29:551-5. 2006
    ..Although the rise of free carnitine and acylcarnitines seems to be a benign condition, the sequential changes of these metabolic derangements may give clues to the pathogenesis of this interesting disorder...
  37. ncbi request reprint Long-term prognosis of patients with biliary atresia: a 25 year summary
    Pei Yin Hung
    Department of Pediatrics, National Taiwan University Hospital, No 7 Chung Shan South Road, Taipei, Taiwan
    J Pediatr Gastroenterol Nutr 42:190-5. 2006
    ..The purpose of this study was to delineate the long-term prognosis of biliary atresia (BA) in Taiwan...
  38. doi request reprint A common variant in the PNPLA3 gene is a risk factor for non-alcoholic fatty liver disease in obese Taiwanese children
    Yu Cheng Lin
    Department of Pediatrics, Far Eastern Memorial Hospital, Banqiao City, Taipei County, Taiwan
    J Pediatr 158:740-4. 2011
    ..To test the hypothesis that the presence of the PNPLA3 rs738409 G allele would increase the susceptibility of non-alcoholic fatty liver disease (NAFLD) in obese Taiwanese children...
  39. pmc Predictive effect of serial serum alanine aminotransferase levels on spontaneous HBeAg seroconversion in chronic genotype B and C HBV-infected children
    Jia Feng Wu
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    J Pediatr Gastroenterol Nutr 54:97-100. 2012
    ..The present study aimed to investigate the association between serial serum alanine aminotransferase (ALT) and spontaneous hepatitis B e antigen (HBeAg) seroconversion age in chronic hepatitis B virus (HBV)-infected children...
  40. doi request reprint Mother-to-infant transmission of hepatitis B virus infection: significance of maternal viral load and strategies for intervention
    Wan Hsin Wen
    Department of Pediatrics, Cardinal Tien Hospital, New Taipei City, Taiwan
    J Hepatol 59:24-30. 2013
    ..Immunoprophylaxis reduces but does not completely eradicate hepatitis B virus (HBV) transmission. This prospective study aims at assessing the rate and risk factors of maternally transmitted HBV infection...
  41. ncbi request reprint TT virus infection in healthy children, children after blood transfusion, and children with non-A to E hepatitis or other liver diseases in Taiwan
    Hong Yuan Hsu
    Department of Pediatrics, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan
    J Med Virol 69:66-71. 2003
    ..These results indicate that TTV infection in children was significantly associated with transfusion. TTV infection is highly prevalent in early childhood in Taiwan but plays a minimal role in the induction of hepatitis in children...
  42. ncbi request reprint Longitudinal study on mutation profiles of core promoter and precore regions of the hepatitis B virus genome in children
    Yen Hsuan Ni
    Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taiwan
    Pediatr Res 56:396-9. 2004
    ....
  43. ncbi request reprint Prophylactic oral antibiotics in prevention of recurrent cholangitis after the Kasai portoenterostomy
    Ling Nan Bu
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    J Pediatr Surg 38:590-3. 2003
    ....
  44. pmc Long-term follow-up of Hepatitis B Surface antibody levels in subjects receiving universal Hepatitis B vaccination in infancy in an area of hyperendemicity: correlation between radioimmunoassay and enzyme immunoassay
    Ching Wen Wang
    Department of Pediatrics, Hepatitus Research Center, National Taiwan University Hospital, College of Medicine, Taipei 100, Taiwan
    Clin Diagn Lab Immunol 12:1442-7. 2005
    ..The anti-HBs titers measured by EIA correlate well with the S/N assayed by RIA. The annual decay rate of the log anti-HBs level may help in planning booster immunizations for hypo-responders or individuals at risk in adolescence...
  45. ncbi request reprint Multiple intrahepatic biliary cysts in children with biliary atresia
    Ling Nan Bu
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    J Pediatr Surg 37:1183-7. 2002
    ..The aim of this study was to investigate the incidence, clinical course, and outcome of multiple intrahepatic biliary cysts in patients with biliary atresia...
  46. doi request reprint A high serum interleukin-12p40 level prior to Kasai surgery predict a favourable outcome in children with biliary atresia
    Jia Feng Wu
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Liver Int 32:1557-63. 2012
    ..Biliary atresia (BA) is a paediatric cholestatic disease characterized by a progressive fibro-inflammation of the biliary tree. Current treatment of choice is to establish good bile flow via the Kasai operation...
  47. doi request reprint Suppression of furin by interferon-γ and the impact on hepatitis B virus antigen biosynthesis in human hepatocytes
    Jia Feng Wu
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Am J Pathol 181:19-25. 2012
    ....
  48. doi request reprint Effects of maternal screening and universal immunization to prevent mother-to-infant transmission of HBV
    Huey Ling Chen
    Department of Pediatrics, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan
    Gastroenterology 142:773-781.e2. 2012
    ..We analyzed the rate of HBV infection among children born to hepatitis B surface antigen (HBsAg)-positive mothers and whether HBIG administration reduces transmission...
  49. doi request reprint Prenatal diagnosis of progressive familial intrahepatic cholestasis type 2
    Szu Ta Chen
    Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    J Gastroenterol Hepatol 23:1390-3. 2008
    ..Mutations in ABCB11 are also associated with benign recurrent intrahepatic cholestasis type 2 and intrahepatic cholestasis of pregnancy in adult patients. We aimed to make the prenatal diagnosis of PFIC2...
  50. ncbi request reprint Pancreaticobiliary anomalies is the leading cause of childhood recurrent pancreatitis
    Wei Ju Su
    Department of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
    J Formos Med Assoc 106:119-25. 2007
    ..To explore the etiology, age and gender distribution, complications, and prognosis of recurrent pediatric pancreatitis...
  51. ncbi request reprint Serum levels of interleukin-10 and interleukin-12 predict early, spontaneous hepatitis B virus e antigen seroconversion
    Jia Feng Wu
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Gastroenterology 138:165-72.e1-3. 2010
    ..This prospective cohort study aimed to determine the effect of cytokines on spontaneous hepatitis B e antigen (HBeAg) seroconversion in patients with chronic hepatitis B virus (HBV) infection...
  52. ncbi request reprint SEN virus infection in children in Taiwan: transmission route and role in blood transfusion and liver diseases
    Hong Yuan Hsu
    Department of Pediatrics, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei
    Pediatr Infect Dis J 25:390-4. 2006
    ..SEN virus (SENV) is a newly discovered DNA virus. We conducted this study to evaluate potential modes of SENV transmission and the pathogenic effect of SENV on liver diseases in children...
  53. doi request reprint Diagnosis of neonatal intrahepatic cholestasis caused by citrin deficiency using high-resolution melting analysis and a clinical scoring system
    Szu Ta Chen
    Department of Pediatrics, National Taiwan University Hospital Yun Lin Branch, Yun Lin County, Taiwan
    J Pediatr 161:626-31.e2. 2012
    ..To assess the diagnosis of neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) by using high-resolution melting (HRM) analysis and a clinical scoring system...
  54. ncbi request reprint HLA typing associated with hepatitis B E antigen seroconversion in children with chronic hepatitis B virus infection: a long-term prospective sibling cohort study in Taiwan
    Jia Feng Wu
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    J Pediatr 148:647-651. 2006
    ..To conduct a prospective cohort study to clarify the relationship between human leukocyte antigen (HLA) polymorphisms and the seroconversion of hepatitis B e antigen (HBeAg)...
  55. ncbi request reprint Viral infections and prolonged fever after liver transplantation in young children with inborn errors of metabolism
    Hsiang Po Huang
    Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    J Formos Med Assoc 104:623-9. 2005
    ..Liver transplantation could be a useful treatment for selected inborn errors of metabolism. This study evaluated the outcome and viral infections after liver transplantation in young children and infants with these diseases...
  56. doi request reprint Interferon-alpha treatment in children and young adults with chronic hepatitis B: a long-term follow-up study in Taiwan
    Hong Yuan Hsu
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Liver Int 28:1288-97. 2008
    ..The short- and long-term benefits of interferon (IFN)-alpha therapy in young patients with chronic hepatitis B (CHB) acquiring infection perinatally or during early childhood have been questioned...
  57. ncbi request reprint Stable seroepidemiology of hepatitis B after universal immunization in Taiwan: A 3-year study of national surveillance of primary school students
    Ching Yi Chen
    Department of Pediatrics, College of Medicine and Children s Hospital, National Taiwan University, Taipei 100, Taiwan
    Vaccine 28:5605-8. 2010
    ..This study is aimed to investigate if there was increased risk of HBV acquisition among first graders in Taiwan during a 3-year follow-up period...
  58. ncbi request reprint Variants in the UGT1A1 gene and the risk of pediatric nonalcoholic fatty liver disease
    Yu Cheng Lin
    Department of Pediatrics, Far Eastern Memorial Hospital, Taipei, Taiwan
    Pediatrics 124:e1221-7. 2009
    ..Variants in the UGT1A1 gene contribute to increased bilirubin levels, and bilirubin can act as an antioxidant. We hypothesize that variant UGT1A1 genotypes reduce the risk for NAFLD development...
  59. ncbi request reprint Humoral and cellular immune responses to a hepatitis B vaccine booster 15-18 years after neonatal immunization
    Chun Yi Lu
    Department of Pediatrics, National Taiwan University Hospital, Taiwan
    J Infect Dis 197:1419-26. 2008
    ..Whether hepatitis B (HB) vaccine-conferred immunity persists into adulthood is unknown. We aimed to investigate long-term HB immunity in adolescents...
  60. ncbi request reprint Characterization of integration patterns and flanking cellular sequences of hepatitis B virus in childhood hepatocellular carcinomas
    Daw Jen Tsuei
    Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Med Virol 68:513-21. 2002
    ..The results indicate that HBV integration and activation of RBMY gene expression in liver cells may be associated with the development of childhood HCC...
  61. ncbi request reprint The development of hepatocellular carcinoma among prospectively followed children with chronic hepatitis B virus infection
    Wan Hsin Wen
    Department of Pediatrics, National Taiwan University Hospital, and the Department of Pediatrics, Cardinal Tien Hospital, Taipei, Taiwan
    J Pediatr 144:397-9. 2004
    ..Both had e antigen seroconversion in early childhood and cirrhosis. Early e antigen seroconversion and/or cirrhosis may be risk factors for hepatocellular carcinoma...
  62. ncbi request reprint Outcome predictors of fulminant hepatic failure in children
    Pei Chun Chan
    Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    J Formos Med Assoc 103:432-6. 2004
    ..It is crucial to identify patients with poor prognosis for timely referral to liver transplantation. This study aimed to assess the clinical and laboratory characteristics of children with FHF and evaluate their correlation with outcome...
  63. ncbi request reprint Neonatal Dubin-Johnson syndrome: long-term follow-up and MRP2 mutations study
    Jyh Hong Lee
    Department of Pediatrics, National Taiwan University College of Medicine, Taipei, Taiwan
    Pediatr Res 59:584-9. 2006
    ....
  64. doi request reprint Mutations of T-cell epitopes in the hepatitis B virus surface gene in children with chronic infection and hepatocellular carcinoma
    Yen Hsuan Ni
    Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Am J Gastroenterol 103:1004-9. 2008
    ..In this study, we aimed to investigate mutations of the human leukocyte antigen-A2-restricted T-cell epitope (TCE) in chronic HBV-infected children...
  65. doi request reprint Timing of Epstein-Barr virus acquisition and the course of posttransplantation lymphoproliferative disorder in children
    Jia Feng Wu
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Transplantation 87:758-62. 2009
    ....
  66. doi request reprint Decreasing rate of biliary atresia in Taiwan: a survey, 2004-2009
    Yi Chun Lin
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Pediatrics 128:e530-6. 2011
    ..The goals of this study were to identify BA incidence changes in Taiwan in 2004-2009 and to survey the factors that might influence incidence changes to elucidate the possible causes of BA...
  67. doi request reprint Risk of hyperbilirubinemia in breast-fed infants
    Pi Feng Chang
    Department of Pediatrics, Far Eastern Memorial Hospital, Pan Chiao, Taipei, Taiwan
    J Pediatr 159:561-5. 2011
    ..To investigate the risk factors for hyperbilirubinemia in infants who are exclusively breast-fed...
  68. doi request reprint High-titer antibody to hepatitis B surface antigen before liver transplantation can prevent de novo hepatitis B infection
    Wei Ju Su
    Department of Pediatrics, College of Medicine and Hospital, National Taiwan University, Taipei
    J Pediatr Gastroenterol Nutr 48:203-8. 2009
    ..We assessed the incidence and risk factors of de novo HBV infection in pediatric liver transplant recipients...
  69. doi request reprint Characteristics and incidences of pediatric Crohn's disease in the decades before and after 2000
    Yu Mei Shen
    Department of Pediatrics, National Taiwan University Children s Hospital, National Taiwan University, Taipei, Taiwan
    Pediatr neonatol 52:317-20. 2011
    ..This study was conducted to delineate the trends of incidence during this period and clinical patterns of pediatric CD in Taiwan...
  70. ncbi request reprint Cytomegalovirus-associated immune thrombocytopenic purpura after liver transplantation
    Shu Hao Wei
    Department of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
    J Formos Med Assoc 106:327-9. 2007
    ..He recovered from thrombocytopenia 4 weeks later. An inadequate immunosuppression, as evident by the low serum tacrolimus level (5.8 ng/mL before the episode of ITP) in this patient, may allow the development of ITP after CMV infection...
  71. pmc Male germ cell-specific RNA binding protein RBMY: a new oncogene explaining male predominance in liver cancer
    Daw Jen Tsuei
    Department of Pediatrics, College of Medicine, National Taiwan University, National Taiwan University Hospital, Taipei, Taiwan
    PLoS ONE 6:e26948. 2011
    ..Collectively, these findings suggest that Y chromosome-specific RBMY is likely involved in the regulation of androgen receptor activity and contributes to male predominance of HCC...
  72. doi request reprint Clinical features and treatment responses of children with eosinophilic gastroenteritis
    Fu Mien Tien
    Department of Pediatrics, National Taiwan University Children s Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Pediatr neonatol 52:272-8. 2011
    ..This study aimed to evaluate the clinical manifestations and outcome of eosinophilic gastroenteritis in children of Asian background...
  73. doi request reprint Effects of the infant stool color card screening program on 5-year outcome of biliary atresia in Taiwan
    Tien Hau Lien
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Hepatology 53:202-8. 2011
    ..2%, respectively (P < 0.001). The 5-year jaundice-free survival rate with native liver was 27.3% in cohort A and 64.3% in cohort B (P < 0.001), and the 5-year overall survival rates were 55.7% and 89.3%, respectively (P < 0.001)...
  74. ncbi request reprint RBMY, a male germ cell-specific RNA-binding protein, activated in human liver cancers and transforms rodent fibroblasts
    Daw Jen Tsuei
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taiwan
    Oncogene 23:5815-22. 2004
    ..The RBMY variant protein with deletion of C-terminal exons 9-12 was trapped in the cytoplasm and showed decreased tumorigenicity. Our results suggest that RBMY is a new candidate oncogene specific for male liver cancer...
  75. ncbi request reprint Pediatric Crohn disease: clinical and genetic characteristics in Taiwan
    Cheng Hui Hsiao
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    J Pediatr Gastroenterol Nutr 44:342-6. 2007
    ..Because clinical and genetic data in Asian children with CD are lacking, the aim of this study was to elucidate the clinical and genetic characteristics of Taiwanese children with CD...
  76. ncbi request reprint Lactobacillus casei rhamnosus Lcr35 in children with chronic constipation
    Ling Nan Bu
    Department of Pediatrics, Keelung Hospital, Department of Health, The Executive Yuan, Keelung, Taiwan
    Pediatr Int 49:485-90. 2007
    ..The purpose of the present paper was to evaluate the efficacy of probiotics (Lactobacillus casei rhamnosus, Lcr35) for treating children with chronic constipation and to compare its effect with magnesium oxide (MgO) and placebo...
  77. doi request reprint Humoral immunogenicity to measles, rubella, and varicella-zoster vaccines in biliary atresia children
    Jia Feng Wu
    Department of Pediatrics, National Taiwan University Hospital, National Taiwan University, No 7, Chung Shan S Rd, Taipei 100, Taiwan
    Vaccine 27:2812-5. 2009
    ..This study indicated that humoral immunity to rubella, measles and VZV vaccines are significantly lower in BA children than the normal population by standard vaccine schedule...
  78. ncbi request reprint X-linked liver glycogenosis in a Taiwanese family: transmission from undiagnosed males
    Szu Ta Chen
    Department of Pediatrics, National Taiwan University Children s Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Pediatr neonatol 50:230-3. 2009
    ..This is the first report of XLG-I in the ethnic-Chinese population in Taiwan. This report indicates that XLG may be undiagnosed or underestimated. A correct diagnosis is necessary for proper management and genetic counseling...
  79. doi request reprint Implication of early-onset biliary atresia and extrahepatic congenital anomalies
    Ming Chun Yang
    Children s Hospital, National Taiwan University, Taipei, Taiwan
    Pediatr Int 52:569-72. 2010
    ..The relationship between the timing of disease onset and congenital extrahepatic anomalies was also identified...
  80. doi request reprint Diagnosis of BSEP/ABCB11 mutations in Asian patients with cholestasis using denaturing high performance liquid chromatography
    Huey Ling Chen
    Department of Pediatrics, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan
    J Pediatr 153:825-32. 2008
    ..To determine if specific mutations were present in Asian patients with progressive familial intrahepatic cholestasis (PFIC) type 2 caused by defects in bile salt export pump (BSEP), encoded by ABCB11...
  81. ncbi request reprint Nephromegaly and elevated plasma hepatocyte growth factor-transforming growth factor-beta1 ratio in infants with fulminant hepatitis or biliary atresia
    Y K Tsau
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Am J Kidney Dis 38:279-85. 2001
    ..Nephromegaly in patients with severe or chronic liver dysfunction may provide a new in vivo model to study the mechanisms of renal growth...
  82. ncbi request reprint Precore stop codon mutant in chronic hepatitis B virus infection in children: its relation to hepatitis B e seroconversion and maternal hepatitis B surface antigen
    M H Chang
    Department of Pediatrics, College of Medicine, National Taiwan University, Taipei
    J Hepatol 28:915-22. 1998
    ..The aims of this study were to investigate the significance of the precore stop codon mutant in the natural course of hepatitis B virus infection in children, and the influence of maternal transmission...
  83. ncbi request reprint In vivo hepatic gene therapy
    Y H Ni
    Department of Pediatrics, College of Medicine, National Taiwan University Hospital, 7, Chung Shan South Road, Taipei, Taiwan 100
    Acta Paediatr Taiwan 42:191-200. 2001
    ..Up to now, neither viral nor non-viral vector is perfect. A further modification of the current vectors may improve a new generation of liver-directed gene transfer...
  84. ncbi request reprint Use of cisapride with magnesium oxide in chronic pediatric constipation
    Y H Ni
    Department of Pediatrics, National Taiwan University Hospital, Taipei
    Acta Paediatr Taiwan 42:345-9. 2001
    ..In conclusion, it appears that cisapride in combination with MgO may have a synergistic effect and improves the frequency of stool passage in pediatric functional constipation...
  85. doi request reprint Clostridium difficile infection in a patient with Crohn disease
    Chien Hui Hsu
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    J Formos Med Assoc 111:347-9. 2012
    ..This case report aims to address the unusual presentation of a usual pathogen, C difficile, in a pediatric patient with Crohn disease...
  86. doi request reprint Prolonged unconjugated hyperbiliriubinemia in breast-fed male infants with a mutation of uridine diphosphate-glucuronosyl transferase
    Pi Feng Chang
    Department of Pediatrics, Far Eastern Memorial Hospital, Pan Chiao, Taipei, Taiwan
    J Pediatr 155:860-3. 2009
    ..To test the hypothesis that a mutation in uridine diphosphate-glucuronosyl transferase 1A1 (UGT1A1) gene of breast-fed infants is a contributory factor to prolonged unconjugated hyperbilirubinemia...
  87. ncbi request reprint Clinical and genetic analysis of Peutz-Jeghers syndrome patients in Taiwan
    Meng Tzu Weng
    Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan
    J Formos Med Assoc 109:354-61. 2010
    ..The gene that encodes this serine/threonine kinase is located at chromosome 19p13.3. The aim of this study was to investigate the clinical and genetic characteristics of PJS patients in Taiwan...
  88. doi request reprint Low seroprevalence of parvovirus B19 in Taiwanese children and young adults
    Wei Ju Su
    Centers for Disease Control, Department of Health, Taipei, Taiwan
    Pediatr neonatol 51:265-8. 2010
    ..This study aimed to evaluate the prevalence of parvovirus B19 antibodies in children and young adults aged=30 years old in Taiwan...
  89. ncbi request reprint Nephromegaly relates to hepatocyte growth factor dysregulation in biliary atresia
    Yong Kwei Tsau
    Department of Pediatrics, National Taiwan University Hospital, No 7 Chung Shan South Road, Taipei 100, Taiwan
    Pediatr Nephrol 17:554-9. 2002
    ..The detailed mechanisms for nephromegaly in these two conditions should be further clarified...
  90. doi request reprint Cyclic vomiting syndrome and migraine in children
    Yi Pei Lin
    Department of Pediatrics, National Taiwan University Hospital, Taipei
    J Formos Med Assoc 110:382-7. 2011
    ..This study aimed to investigate the clinical manifestations of pediatric CVS and its prognosis, and to clarify its relationship with the risk of migraine development in children...
  91. doi request reprint Emerging importance of autoimmune hepatitis in children in Taiwan, an endemic area for viral hepatitis
    Sheng Hsiung Yeh
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Pediatr neonatol 50:65-9. 2009
    ..We performed this retrospective study to characterize the clinical features of AIH in Taiwanese children...
  92. ncbi request reprint Hypocalcemia and tetany caused by vitamin D deficiency in a child with intestinal lymphangiectasia
    Ying Yi Lu
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Formos Med Assoc 108:814-8. 2009
    ..Vitamin D supplementation for 3 months improved her bone density, secondary hyperparathyroidism and frequent tetany. Vitamin D status should be monitored in patients with intestinal lymphangiectasia...
  93. ncbi request reprint Chubby face and the biochemical parameters for the early diagnosis of neonatal intrahepatic cholestasis caused by citrin deficiency
    Hung Wen Chen
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    J Pediatr Gastroenterol Nutr 47:187-92. 2008
    ..To identify facial and biochemical characteristics as early clinical features of neonatal intrahepatic cholestasis due to citrin deficiency (NICCD)...
  94. pmc Host-microbial interactions and regulation of intestinal epithelial barrier function: From physiology to pathology
    Linda Chia Hui Yu
    Linda Chia Hui Yu, Graduate Institute of Physiology, College of Medicine, National Taiwan University, Taipei 100, Taiwan, China
    World J Gastrointest Pathophysiol 3:27-43. 2012
    ..This review attempts to explain the dynamic interaction between the intestinal epithelium and commensal bacteria in disease and health status...
  95. ncbi request reprint Prevalence and rapid identification of clarithromycin-resistant Helicobacter pylori isolates in children
    Y J Yang
    Department of Pediatrics, National Taiwan University, College of Medicine and Hospital, Taipei
    Pediatr Infect Dis J 20:662-6. 2001
    ..The dominant mutation is A2144G. PCR-RFLP provides a rapid and accurate approach to detect clarithromycin-resistant strains within 24 h...
  96. ncbi request reprint Antibodies to E2 protein of hepatitis G virus in children: different responses according to age at infection
    H L Chen
    Department of Pediatrics, Hepatitis Research Center, National Taiwan University Hospital, Taipei
    J Pediatr 133:382-5. 1998
    ..To study viral persistence and antibody responses after hepatitis G virus (HGV) infection in children of various ages...
  97. ncbi request reprint Bacterial cholangitis in patients with biliary atresia: impact on short-term outcome
    E T Wu
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Republic of China
    Pediatr Surg Int 17:390-5. 2001
    ..It significantly affected early mortality. Aggressive and complete treatment with empirical ceftriaxone was appropriate...