Wan Wan Lin


Affiliation: National Taiwan University
Country: Taiwan


  1. Lin Y, Huang D, Wang J, Lin Y, Hsieh S, Huang K, et al. Syk is involved in NLRP3 inflammasome-mediated caspase-1 activation through adaptor ASC phosphorylation and enhanced oligomerization. J Leukoc Biol. 2015;97:825-835 pubmed publisher
    ..Thus, the control of Syk activity might be effective to modulate NLRP3 inflammasome activation and treat NLRP3-related immune diseases. ..
  2. Sekar P, Huang D, Hsieh S, Chang S, Lin W. AMPK-dependent and independent actions of P2X7 in regulation of mitochondrial and lysosomal functions in microglia. Cell Commun Signal. 2018;16:83 pubmed publisher
  3. Chang H, Huang D, Wu N, Kannagi R, Wang L, Lin W. BLIMP1 transcriptionally induced by EGFR activation and post-translationally regulated by proteasome and lysosome is involved in keratinocyte differentiation, migration and inflammation. J Dermatol Sci. 2018;92:151-161 pubmed publisher
    ..Functionally, BLIMP1 is a negative regulator of EGF-induced inflammation and migration in keratinocytes, and exerts a gene-specific regulation on keratinocyte differentiation. ..
  4. Cheng C, Yang A, Ekambaranellore P, Huang K, Lin W. Anti-obesity action of INDUS810, a natural compound from Trigonella foenum-graecum: AMPK-dependent lipolysis effect in adipocytes. Obes Res Clin Pract. 2018;12:562-569 pubmed publisher
    ..Our in vitro and in vivo studies suggest that INDUS810 is a potential anti-obesity agent, and this action depends on activate adenosine monophosphate-activated protein kinase activation. ..
  5. Chen K, Huang D, Chiu C, Lin W, Liang P, Cheng W. Synthesis of Diverse N-Substituted Muramyl Dipeptide Derivatives and Their Use in a Study of Human NOD2 Stimulation Activity. Chemistry. 2015;21:11984-8 pubmed publisher
    ..It was found that addition of the methyl group at the C1 position of N-glycolyl MDP significantly enhanced the NOD2 stimulating activity. ..
  6. Mohanraj M, Sekar P, Liou H, Chang S, Lin W. The Mycobacterial Adjuvant Analogue TDB Attenuates Neuroinflammation via Mincle-Independent PLC-?1/PKC/ERK Signaling and Microglial Polarization. Mol Neurobiol. 2018;: pubmed publisher
    ..Thus, TDB may be a promising therapeutic agent for the treatment of neuroinflammatory diseases. ..
  7. Wang J, Wu D, Huang D, Lin W. TAK1 inhibition-induced RIP1-dependent apoptosis in murine macrophages relies on constitutive TNF-α signaling and ROS production. J Biomed Sci. 2015;22:76 pubmed publisher
    ..TAKI-induced cytotoxicity is cell context specific, and apoptosis observed in macrophages is dependent on the constitutive autocrine action of TNF-α for RIP1 activation and ROS production. ..
  8. Wu N, Huang D, Wang L, Kannagi R, Fan Y, Lin W. Spleen Tyrosine Kinase Mediates EGFR Signaling to Regulate Keratinocyte Terminal Differentiation. J Invest Dermatol. 2016;136:192-201 pubmed publisher
  9. Lin K, Huang D, Huang D, Tzeng S, Lin W. Inhibition of AMPK through Lyn-Syk-Akt enhances FcεRI signal pathways for allergic response. J Mol Med (Berl). 2016;94:183-94 pubmed publisher
    ..AMPK is inhibited by FcεRI via Lyn-Syk-Akt signaling in RBL-2H3 cells. AMPK inhibition supports FcεRI-mediated Lyn signaling and allergic response. Metformin has inhibitory effect on passive cutaneous anaphylaxis. ..

More Information


  1. Chang H, Huang D, Wu M, Chu C, Tzeng S, Lin W. Spleen tyrosine kinase mediates the actions of EPO and GM-CSF and coordinates with TGF-? in erythropoiesis. Biochim Biophys Acta Mol Cell Res. 2017;1864:687-696 pubmed publisher
    ..Taken together, Syk is a novel upstream signaling molecule of EPOR, and contributes to erythroblast proliferation, survival and differentiation. ..
  2. Hsieh S, Lin W. Decoy receptor 3: an endogenous immunomodulator in cancer growth and inflammatory reactions. J Biomed Sci. 2017;24:39 pubmed publisher
    ..Thus, 'switch-on' of DcR3 expression may be feasible for the treatment of inflammatory diseases and enhance tissue repairing, while 'switch-off' of DcR3 expression can enhance tumor apoptosis and suppress tumor growth in vivo. ..
  3. Wu N, Huang D, Tsou H, Lin Y, Lin W. Syk mediates IL-17-induced CCL20 expression by targeting Act1-dependent K63-linked ubiquitination of TRAF6. J Invest Dermatol. 2015;135:490-498 pubmed publisher