Wan Wan Lin
Affiliation: National Taiwan University
Lin Y, Huang D, Wang J, Lin Y, Hsieh S, Huang K, et al
. Syk is involved in NLRP3 inflammasome-mediated caspase-1 activation through adaptor ASC phosphorylation and enhanced oligomerization. J Leukoc Biol. 2015;97:825-835 pubmed publisher
..Thus, the control of Syk activity might be effective to modulate NLRP3 inflammasome activation and treat NLRP3-related immune diseases. ..
Sekar P, Huang D, Hsieh S, Chang S, Lin W. AMPK-dependent and independent actions of P2X7 in regulation of mitochondrial and lysosomal functions in microglia. Cell Commun Signal. 2018;16:83 pubmed publisher
Chang H, Huang D, Wu N, Kannagi R, Wang L, Lin W. BLIMP1 transcriptionally induced by EGFR activation and post-translationally regulated by proteasome and lysosome is involved in keratinocyte differentiation, migration and inflammation. J Dermatol Sci. 2018;92:151-161 pubmed publisher
..Functionally, BLIMP1 is a negative regulator of EGF-induced inflammation and migration in keratinocytes, and exerts a gene-specific regulation on keratinocyte differentiation. ..
Cheng C, Yang A, Ekambaranellore P, Huang K, Lin W. Anti-obesity action of INDUS810, a natural compound from Trigonella foenum-graecum: AMPK-dependent lipolysis effect in adipocytes. Obes Res Clin Pract. 2018;12:562-569 pubmed publisher
..Our in vitro and in vivo studies suggest that INDUS810 is a potential anti-obesity agent, and this action depends on activate adenosine monophosphate-activated protein kinase activation. ..
Chen K, Huang D, Chiu C, Lin W, Liang P, Cheng W. Synthesis of Diverse N-Substituted Muramyl Dipeptide Derivatives and Their Use in a Study of Human NOD2 Stimulation Activity. Chemistry. 2015;21:11984-8 pubmed publisher
..It was found that addition of the methyl group at the C1 position of N-glycolyl MDP significantly enhanced the NOD2 stimulating activity. ..
Mohanraj M, Sekar P, Liou H, Chang S, Lin W. The Mycobacterial Adjuvant Analogue TDB Attenuates Neuroinflammation via Mincle-Independent PLC-?1/PKC/ERK Signaling and Microglial Polarization. Mol Neurobiol. 2018;: pubmed publisher
..Thus, TDB may be a promising therapeutic agent for the treatment of neuroinflammatory diseases. ..
Wang J, Wu D, Huang D, Lin W. TAK1 inhibition-induced RIP1-dependent apoptosis in murine macrophages relies on constitutive TNF-Î± signaling and ROS production. J Biomed Sci. 2015;22:76 pubmed publisher
..TAKI-induced cytotoxicity is cell context specific, and apoptosis observed in macrophages is dependent on the constitutive autocrine action of TNF-Î± for RIP1 activation and ROS production. ..
Wu N, Huang D, Wang L, Kannagi R, Fan Y, Lin W. Spleen Tyrosine Kinase Mediates EGFR Signaling to Regulate Keratinocyte Terminal Differentiation. J Invest Dermatol. 2016;136:192-201 pubmed publisher
Lin K, Huang D, Huang D, Tzeng S, Lin W. Inhibition of AMPK through Lyn-Syk-Akt enhances FcÎµRI signal pathways for allergic response. J Mol Med (Berl). 2016;94:183-94 pubmed publisher
..AMPK is inhibited by FcÎµRI via Lyn-Syk-Akt signaling in RBL-2H3 cells. AMPK inhibition supports FcÎµRI-mediated Lyn signaling and allergic response. Metformin has inhibitory effect on passive cutaneous anaphylaxis. ..