Research Topics
Genomes and Genes | Jen Kun LinSummaryAffiliation: National Taiwan University Country: Taiwan Publications
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Publications
Molecular targets of curcuminJen Kun Lin
Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
Adv Exp Med Biol 595:227-43. 2007..It has been demonstrated that curcumin-induced apoptosis is mediated through the impairment of the ubiquitin-proteasome pathway...- Inhibition of xanthine oxidase and suppression of intracellular reactive oxygen species in HL-60 cells by theaflavin-3,3'-digallate, (-)-epigallocatechin-3-gallate, and propyl gallateJ K Lin
Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei, Taiwan
J Agric Food Chem 48:2736-43. 2000..Therefore, the antioxidative activity of tea polyphenols and PG is due not only to their ability to scavenge superoxides but also to their ability to block XO and related oxidative signal transducers... - Suppression of protein kinase C and nuclear oncogene expression as possible action mechanisms of cancer chemoprevention by CurcuminJen Kun Lin
Institutes of Biochemistry, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei, Taiwan, 10018
Arch Pharm Res 27:683-92. 2004..These results suggest that curcumin-glucuronide, dihydrocurcumin-glucuronide, tetrahydrocurcumin-glucuronide and tetrahydrocurcumin are the major metabolites of curcumin in mice, rats and humans... - Cancer chemoprevention by tea polyphenols through modulating signal transduction pathwaysJen Kun Lin
Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei
Arch Pharm Res 25:561-71. 2002..The mechanisms of this inhibition may be due to the blockade of the mitogenic and differentiating signals through modulating EGFR function, MAPK cascades, NFkappaB activation as well as c-myc, c-jun and c-fos expression... - Mechanisms of hypolipidemic and anti-obesity effects of tea and tea polyphenolsJen Kun Lin
Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
Mol Nutr Food Res 50:211-7. 2006..The experimental data indicated that the molecular mechanisms of fatty acid synthase gene suppression by tea polyphenols (EGCG, theaflavins) may invite down-regulation of EGFR/PI3K/Akt/Sp-1 signal transduction pathways... - Recent studies on the biofunctions and biotransformations of curcuminJ K Lin
Institutes of Biochemistry, College of Medicine, National Taiwan University, Taipei
Biofactors 13:153-8. 2000..These results suggest that curcumin-glucuronide, dihydro-curcumin-glucuronide, tetrahydrocurcumin-glucuronide and tetrahydrocurcumin are major metabolites of curcumin in mice... - Nitration and hydroxylation of aromatic amino acid and guanine by the air pollutant peroxyacetyl nitrateJ K Lin
Institute of Biochemistry, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei, Taiwan, ROC
Chem Biol Interact 127:219-36. 2000..We also found that peroxynitrite and PAN are similar in their oxidizing activity. From these findings, we suggest that peroxynitrite may be considered as the reactive intermediate of PAN... - Apoptosis of human melanoma cells induced by the novel compounds propolin A and propolin B from Taiwenese propolisChia Nan Chen
Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Section 1, Jen Ai Road, Taipei 100, Taiwan, ROC
Cancer Lett 245:218-31. 2007..All these results indicated that propolin A and propolin B may trigger apoptosis of A2058 cells through mitochondria-dependent pathways and also shown that propolin A and propolin B were strong antioxidants... - Theanaphthoquinone inhibits fatty acid synthase expression in EGF-stimulated human breast cancer cells via the regulation of EGFR/ErbB-2 signalingMeng Shih Weng
Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei 10018, Taiwan
Toxicol Appl Pharmacol 218:107-18. 2007..In summary, our findings suggest that TNQ modulates FAS expression by the regulation of EGFR/ErbB-2 pathways and induces cell death in breast cancer cells... - Sensitizing HER2-overexpressing cancer cells to luteolin-induced apoptosis through suppressing p21(WAF1/CIP1) expression with rapamycinChun Te Chiang
Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei 10018, Taiwan
Mol Cancer Ther 6:2127-38. 2007.... - Diosgenin, a naturally occurring steroid, suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt, mTOR and JNK phosphorylationChun Te Chiang
Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei 100, Taiwan
FEBS Lett 581:5735-42. 2007..These results suggested that diosgenin has the potential to advance as chemopreventive or chemotherapeutic agent for cancers that overexpress HER2... - Apoptosis of cultured astrocytes induced by the copper and neocuproine complex through oxidative stress and JNK activationSung Ho Chen
Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan
Toxicol Sci 102:138-49. 2008..Their clinical implications in the etiology of neurodegenerative diseases deserve further investigation... - Theaflavins attenuate hepatic lipid accumulation through activating AMPK in human HepG2 cellsChih Li Lin
Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
J Lipid Res 48:2334-43. 2007..Our results show that theaflavins are bioavailable both in vitro and in vivo and may be active in the prevention of fatty liver and obesity... - Arsenite stimulates cyclooxygenase-2 expression through activating IkappaB kinase and nuclear factor kappaB in primary and ECV304 endothelial cellsShu Huei Tsai
Department of Orthopaedics and Traumatology, School of Medicine, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan
J Cell Biochem 84:750-8. 2002..Arsenite could induce IKK activity, which leads to the phosphorylation and degradation of IkappaB in ECV304 cells. Therefore, it appears that IKK signaling pathway is involved in arsenite-mediated Cox-2 expression... 
Suppression of free fatty acid-induced insulin resistance by phytopolyphenols in C2C12 mouse skeletal muscle cellsYea Tzy Deng
Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
J Agric Food Chem 60:1059-66. 2012..These findings may suggest that curcumin shows the best capacity to improve FFA-induced insulin resistance than the other two, and ECG was more effective than EGCG in attenuating insulin resistance...- Epigallocatechin gallate (EGCG) attenuates high glucose-induced insulin signaling blockade in human hepG2 hepatoma cellsChih Li Lin
Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
Mol Nutr Food Res 52:930-9. 2008.... - Tangeretin suppresses IL-1beta-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cellsKuan Hung Chen
Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei 10018, Taiwan
Biochem Pharmacol 73:215-27. 2007.... - Chemical composition of Solanum nigrum linn extract and induction of autophagy by leaf water extract and its major flavonoids in AU565 breast cancer cellsHsiu Chen Huang
Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
J Agric Food Chem 58:8699-708. 2010.... - EGCG inhibits the invasion of highly invasive CL1-5 lung cancer cells through suppressing MMP-2 expression via JNK signaling and induces G2/M arrestYea Tzy Deng
Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
J Agric Food Chem 59:13318-27. 2011..In addition, EGCG may suppress cell proliferation in CL1-5 cells through inducing G2/M arrest... - EGCG stabilizes p27kip1 in E2-stimulated MCF-7 cells through down-regulation of the Skp2 proteinHsiu Chen Huang
Institute of Biochemistry and Molecular Biology, National Taiwan University Medicine College, Taipei 100, Taiwan
Endocrinology 149:5972-83. 2008..The therapeutic strategies designed to reduce Skp2 may therefore play an important clinical role in treatment of breast cancer cells... - Rotenone induces apoptosis in MCF-7 human breast cancer cell-mediated ROS through JNK and p38 signalingYea Tzy Deng
Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
Mol Carcinog 49:141-51. 2010..Taken together, these results indicate rotenone may induce apoptosis through ROS and JNK/p38 MAPKs activation in MCF-7 cells... - Involvement of activating transcription factors JNK, NF-kappaB, and AP-1 in apoptosis induced by pyrrolidine dithiocarbamate/Cu complexSung Ho Chen
Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan
Eur J Pharmacol 594:9-17. 2008..Based on these findings; we conclude that PDTC/Cu complex-induced apoptosis is mediated by activation of JNK, NF-kappaB, AP-1 and caspase 3. Due to its high potency, PDTC may be useful as a therapeutic anti-cancer drug... - Determination of theanine, GABA, and other amino acids in green, oolong, black, and Pu-erh teas with dabsylation and high-performance liquid chromatographyKai Yang Syu
Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
J Agric Food Chem 56:7637-43. 2008..Furthermore, the raw (natural fermented) Pu-erh tea contained more theanine than ripe (wet fermented) Pu-erh tea, and the GABA contents in normal teas were generally lower than that in GABA tea... - Downregulation of androgen receptor expression by luteolin causes inhibition of cell proliferation and induction of apoptosis in human prostate cancer cells and xenograftsFeng Lan Chiu
Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
Prostate 68:61-71. 2008..Our aim was to investigate how luteolin, a natural flavonoid, affects cell growth and AR expression in prostate cancer cells and xenografts... - Cycle arrest and apoptosis in MDA-MB-231/Her2 cells induced by curcuminShih Han Sun
Institutes of Biochemistry and Molecular Biology, College of Medicine National Taiwan University, Taipei, Taiwan
Eur J Pharmacol 690:22-30. 2012..The findings indicate that curcumin is of potential value for the chemoprevention of breast cancer, especially in breast cancer with Skp2/Her2 overexpression... - Novel regimen through combination of memantine and tea polyphenol for neuroprotection against brain excitotoxicityChang mu Chen
Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
J Neurosci Res 86:2696-704. 2008..These findings provide useful information about the potential application of memantine and tea polyphenols in preventing clinical excitotoxic injury such as brain trauma, brain ischemia, epilepsy, and Alzheimer's disease... - Garcinol promotes neurogenesis in rat cortical progenitor cells through the duration of extracellular signal-regulated kinase signalingMeng Shih Weng
Department of Nutritional Science, Fu Jen Catholic University, Taipei, Taiwan
J Agric Food Chem 59:1031-40. 2011..Noteworthy, garcinol could promote neurite outgrowth in EGF-responsive neural precursor cells and modulate the ERK pathway in the enhancement of neuronal survival... - Factors affecting the levels of tea polyphenols and caffeine in tea leavesYung-Sheng Lin
Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei, Taiwan
J Agric Food Chem 51:1864-73. 2003..All tea extracts extracted by 75% ethanol have stronger biological functions than those extracted by boiling water... - Ursolic acid inhibits IL-1beta or TNF-alpha-induced C6 glioma invasion through suppressing the association ZIP/p62 with PKC-zeta and downregulating the MMP-9 expressionHsiu Chen Huang
Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
Mol Carcinog 48:517-31. 2009..These results all showcase the potential UA has in the chemoprevention and treatment of cancer metastasis and invasion... - Epigallocatechin gallate (EGCG) suppresses beta-amyloid-induced neurotoxicity through inhibiting c-Abl/FE65 nuclear translocation and GSK3 beta activationChih Li Lin
Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
Neurobiol Aging 30:81-92. 2009..Our results indicated that the neuroprotective action of EGCG may take place through some mechanisms other than the promotion of APP nonamyloidogenic proteolysis, as was reported previously... - Epigallocatechin gallate (EGCG) and rutin suppress the glucotoxicity through activating IRS2 and AMPK signaling in rat pancreatic beta cellsErica P Cai
Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan 100
J Agric Food Chem 57:9817-27. 2009.... - Propolin H from Taiwanese propolis induces G1 arrest in human lung carcinoma cellsMeng Shih Weng
Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei 10018, Taiwan
J Agric Food Chem 55:5289-98. 2007..Propolin H exerts its significantly growth inhibitory effects and may have therapeutic applications... - Tomatidine inhibits iNOS and COX-2 through suppression of NF-kappaB and JNK pathways in LPS-stimulated mouse macrophagesFeng Lan Chiu
Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No 1 Section 1, Jen Ai Road, Taipei 10018, Taiwan
FEBS Lett 582:2407-12. 2008..Here, we demonstrate that tomatidine acts as an anti-inflammatory agent by blocking NF-kappaB and JNK signaling, and may possibly be developed as a useful agent for the chemoprevention of cancer or inflammatory diseases... - Determination of tea polyphenols and caffeine in tea flowers (Camellia sinensis) and their hydroxyl radical scavenging and nitric oxide suppressing effectsYung-Sheng Lin
Institute of Biochemistry, College of Medicine, National Taiwan University, No. 1, Section 1, Jen-Ai Road, Taipei, Taiwan
J Agric Food Chem 51:975-80. 2003..The present study demonstrates that both tea flowers and tea leaves contain appreciable amounts of catechins and caffeine. It is likely that tea flowers might be useful for making alternative tea beverages... - Comparative studies on the hypolipidemic and growth suppressive effects of oolong, black, pu-erh, and green tea leaves in ratsKuan-Li Kuo
Wun-Shan Branch, Tea Research and Extension Station, Taipei, Taiwan
J Agric Food Chem 53:480-9. 2005.... - Capillary electrophoretic determination of theanine, caffeine, and catechins in fresh tea leaves and oolong tea and their effects on rat neurosphere adhesion and migrationChia-Nan Chen
Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Section 1, Jen-Ai Road, Taipei, Taiwan 100
J Agric Food Chem 51:7495-503. 2003..These results indicated that EGCg might affect neural stem cell survival or differentiation... - Pu-erh tea supplementation suppresses fatty acid synthase expression in the rat liver through downregulating Akt and JNK signalings as demonstrated in human hepatoma HepG2 cellsChun-Te Chiang
Institute of Biochemistry and Molecular Biology, College of Medicine National Taiwan University, Taipei
Oncol Res 16:119-28. 2005..The active principles and molecular mechanisms that exerted these biological effects in pu-erh tea deserve future exploration... - Black tea polyphenol theaflavins inhibit aromatase activity and attenuate tamoxifen resistance in HER2/neu-transfected human breast cancer cells through tyrosine kinase suppressionTzong-Der Way
Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No. 1, Section. 1, Jen-Ai Road, Taipei 10018
Eur J Cancer 40:2165-74. 2004..These findings suggest the use of black tea polyphenols may be beneficial in the chemoprevention of hormone-dependent breast tumours and represent a possible remedy to overcome hormonal resistance of hormone-independent breast tumours... - Mechanisms of cancer chemoprevention by hop bitter acids (beer aroma) through induction of apoptosis mediated by Fas and caspase cascadesWei-Jen Chen
Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
J Agric Food Chem 52:55-64. 2004..The induction of apoptosis by hop bitter acids may offer a pivotal mechanism for their chemopreventive action... - Arecoline N-oxide: its mutagenicity and possible role as ultimate carcinogen in areca oral carcinogenesisKuo Hui Lin
Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
J Agric Food Chem 59:3420-8. 2011..The mutagenicity of arecoline N-oxide was strongly inhibited by the N-oxide reducing agent titanium trichloride. The possible role of arecoline N-oxide in the induction of oral carcinogenesis by areca nut chewing is discussed... - Penta-O-galloyl-beta-D-glucose suppresses prostate cancer bone metastasis by transcriptionally repressing EGF-induced MMP-9 expressionPo Tsun Kuo
Institute of Biochemistry, College of Life Science, National Chung Hsing University, Taichung, Taiwan
J Agric Food Chem 57:3331-9. 2009..These in vitro and in vivo results suggest that 5GG may be a therapeutic candidate for the treatment of advanced prostate cancer... - HPLC analysis of naturally occurring methylated catechins, 3' '- and 4' '-methyl-epigallocatechin gallate, in various fresh tea leaves and commercial teas and their potent inhibitory effects on inducible nitric oxide synthase in macrophagesFeng-Lan Chiu
Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Number 1, Section 1, Taipei, Taiwan
J Agric Food Chem 53:7035-42. 2005..We also found that 3' '-Me-EGCG has a higher inhibitory effect on the nitric oxide generation and inducible nitric oxide synthase (iNOS) expression as compared with EGCG, while 4' '-Me-EGCG and 4',4' '-di-Me-EGCG were less effective... - Apigenin induces apoptosis through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the phosphatidylinositol 3-kinase/Akt-dependent pathwayTzong-Der Way
Institute of Biochemistry and Molecular Biology, College of Medicine National Taiwan University No. 1, Section 1, Jen-Ai Rd, Taipei 10018, Taiwan
J Biol Chem 279:4479-89. 2004..Apigenin-induced degradation of mature HER2/neu involves polyubiquitination of HER2/neu and subsequent hydrolysis by the proteasome... - Degradation of HER2/neu by apigenin induces apoptosis through cytochrome c release and caspase-3 activation in HER2/neu-overexpressing breast cancer cellsTzong-Der Way
Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No. 1, Section 1, Jen-Ai Road, Taipei 10018, Taiwan
FEBS Lett 579:145-52. 2005..These results provided new insights into the structure-activity relationship of flavonoids... - Chrysin induces G1 phase cell cycle arrest in C6 glioma cells through inducing p21Waf1/Cip1 expression: involvement of p38 mitogen-activated protein kinaseMeng-Shih Weng
Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No. 1, Section 1, Jen-Ai Road, Taipei 10018, Taiwan
Biochem Pharmacol 69:1815-27. 2005..These results suggest that chrysin exerts its growth-inhibitory effects either through activating p38-MAPK leading to the accumulation of p21(Waf1/Cip1) protein or mediating the inhibition of proteasome activity... - Propolin C from propolis induces apoptosis through activating caspases, Bid and cytochrome c release in human melanoma cellsChia-Nan Chen
Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Section 1, Jen-Ai Road, 100, ROC, Taipei, Taiwan
Biochem Pharmacol 67:53-66. 2004..0microM. In conclusion, the isolation and characterization of propolin C from bee propolis are described for the first time, and this compound is a powerful inducer of apoptosis in human melanoma cells... - Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-kappaB in mouse macrophagesAi-Hsiang Lo
Institute of Biochemistry, College of Medicine, National Taiwan University, No. 1, Section 1, Jen-Ai Road, Taipei, Taiwan
Carcinogenesis 23:983-91. 2002..These results suggest that carnosol suppresses the NO production and iNOS gene expression by inhibiting NF-kappaB activation, and provide possible mechanisms for its anti-inflammatory and chemopreventive action... - Lipid peroxidation and cell death mechanisms in pulmonary epithelial cells induced by peroxynitrite and nitric oxideYuan-Soon Ho
School of Medical Technology, Taipei Medical University, Taipei, Taiwan
Arch Toxicol 76:484-93. 2002..The relationship between caspase activation and the cleavage of other death substrates during postmitotic apoptosis in A549 cells needs further investigation... - Tangeretin induces cell-cycle G1 arrest through inhibiting cyclin-dependent kinases 2 and 4 activities as well as elevating Cdk inhibitors p21 and p27 in human colorectal carcinoma cellsMin-Hsiung Pan
Institutes of Biochemistry, College of Medicine, National Taiwan University, Taipei, Taiwan
Carcinogenesis 23:1677-84. 2002..These results suggest that tangeretin either exerts its growth-inhibitory effects through modulation of the activities of several key G1 regulatory proteins, such as Cdk2 and Cdk4, or mediates the increase of Cdk inhibitors p21 and p27... - Penta-O-galloyl-beta-D-glucose inhibits the invasion of mouse melanoma by suppressing metalloproteinase-9 through down-regulation of activator protein-1Li-Lun Ho
Institute of Biochemistry, College of Medicine, National Taiwan University, No. 1, Section 1, Jen-Ai Road, Taipei, Taiwan
Eur J Pharmacol 453:149-58. 2002..The result may provide a potential mechanism for 5GG in cancer chemopreventive action... - Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory skin edema and ornithine decarboxylase activity by theaflavin-3,3'-digallate in mouseYu-Chih Liang
Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei, Taiwan
Nutr Cancer 42:217-23. 2002..These results suggested that TF-3 was a potential inhibitor of ODC activity and TPA-induced edema and might be effective in cancer chemoprevention... - Molecular modeling of flavonoids that inhibits xanthine oxidaseChun-Mao Lin
Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No. 1, Section 1, Jen-Ai Road, Taipei, Taiwan, ROC
Biochem Biophys Res Commun 294:167-72. 2002..Isovitexin showed the weakest inhibitory effect among the compounds tested. The bulky group of sugar in isovitexin may hamper its interaction with xanthine oxidase... - Cytotoxic prenylflavanones from Taiwanese propolisChia-Nan Chen
Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No. 1, Section 1, Jen-Ai Road, Taipei, Taiwan 100, Republic of China
J Nat Prod 66:503-6. 2003..Furthermore, both propolin A (2) and B (3) are potential antioxidant agents and show strong scavenging effects against most types of free radicals... - Effects of garcinol on free radical generation and NO production in embryonic rat cortical neurons and astrocytesChiung-Ho Liao
Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
Biochem Biophys Res Commun 329:1306-14. 2005..Garcinol may exert a similar anti-inflammatory effect and may be neuroprotective against brain injury... - Antitumor effects of miconazole on human colon carcinoma xenografts in nude mice through induction of apoptosis and G0/G1 cell cycle arrestChih-Hsiung Wu
School of Medicine, Taipei Medical University, Taipei, Taiwan
Toxicol Appl Pharmacol 180:22-35. 2002..Our study provides the novel mechanisms of antitumor effects of MIC and such results may have significant applications for cancer chemotherapy... - Pentagalloylglucose inhibits estrogen receptor alpha by lysosome-dependent depletion and modulates ErbB/PI3K/Akt pathway in human breast cancer MCF-7 cellsKuo-Tai Hua
Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
Mol Carcinog 45:551-60. 2006.... - Carnosol inhibits the invasion of B16/F10 mouse melanoma cells by suppressing metalloproteinase-9 through down-regulating nuclear factor-kappa B and c-JunShiu-Chen Huang
Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No. 1, Section 1, Jen-ai Road Taipei 10018, Taiwan
Biochem Pharmacol 69:221-32. 2005..Taken together, these results indicate that carnosol targets MMP-mediated cellular events in cancer cells and provides a new mechanism for its anticancer activity... - Microtubule damaging agents induce apoptosis in HL 60 cells and G2/M cell cycle arrest in HT 29 cellsChia-Jen Tseng
Graduate Institute of Biomedical Technology, Taipei Medical University, No. 250, Wu-Hsing Street, Taipei 110, Taiwan, ROC
Toxicology 175:123-42. 2002..The results from the present study highlight the molecular mechanisms underlying of the PDP-induced anti-cancer activity... - Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signalingMin Hsiung Pan
Department of Seafood Science, National Kaohsiung Marine University, No 142, Hai Chuan Road, Nan Tzu, Kaohsiung 811, Taiwan
J Agric Food Chem 55:5030-7. 2007..Taken together, these findings extend our previous study to indicate that EGCG may be useful in the chemoprevention of breast carcinoma in which FAS overexpression results from HER2 or/and HER3 signaling... - Pre-clinical and early-phase clinical studies of curcumin as chemopreventive agent for endemic cancers in TaiwanChih-Hung Hsu
Department of Oncology, National Taiwan University Hospital, Taipei
Gan To Kagaku Ryoho 29:194-200. 2002 - Prevention of cellular ROS damage by isovitexin and related flavonoidsChun-Mao Lin
Planta Med 68:365-7. 2002..In addition, excess hydrogen peroxide induced by cadmium in A2780 ovarian cells was significantly suppressed by isovitexin. These results suggest that isovitexin in rice may protect cells from oxidative stress... - Induction of apoptosis by hydroxydibenzoylmethane through coordinative modulation of cyclin D3, Bcl-X(L), and Bax, release of cytochrome c, and sequential activation of caspases in human colorectal carcinoma cellsMin Hsiung Pan
Department of Marine Food Science, National Kaohsiung Institution of Marine Technology, Kaohsiung, Taiwan
J Agric Food Chem 51:3977-84. 2003..The induction of apoptosis by HDB may provide a pivotal mechanism for its cancer chemopreventive action... - Propolin G, a prenylflavanone, isolated from Taiwanese propolis, induces caspase-dependent apoptosis in brain cancer cellsWei Jan Huang
Chang Gung Institute of Technology, Chiayi, Taiwan
J Agric Food Chem 55:7366-76. 2007.... - Induction of apoptosis by 1-(2-hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione through reactive oxygen species production, GADD153 expression, and caspases activation in human epidermoid carcinoma cellsMin Hsiung Pan
Department of Seafood Science, National Kaohsiung Marine University, Kaohsiung 811, Taiwan
J Agric Food Chem 53:9039-49. 2005..These findings suggest that HMDB creates an oxidative cellular environment that induces DNA damage and GADD153 gene activation, which in turn helps trigger apoptosis in A431 cells... - Geraniin-mediated apoptosis by cleavage of focal adhesion kinase through up-regulation of Fas ligand expression in human melanoma cellsJang Chang Lee
Graduate Institute of Pharmaceutical Chemistry, College of Pharmacy, China Medical University, Taichung, Taiwan
Mol Nutr Food Res 52:655-63. 2008..The geraniin-induced apoptosis may provide a pivotal mechanism for its cancer-chemopreventive action...