Jen Kun Lin

Summary

Affiliation: National Taiwan University
Country: Taiwan

Publications

  1. ncbi request reprint Molecular targets of curcumin
    Jen Kun Lin
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Adv Exp Med Biol 595:227-43. 2007
  2. ncbi request reprint Inhibition of xanthine oxidase and suppression of intracellular reactive oxygen species in HL-60 cells by theaflavin-3,3'-digallate, (-)-epigallocatechin-3-gallate, and propyl gallate
    J K Lin
    Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Agric Food Chem 48:2736-43. 2000
  3. ncbi request reprint Suppression of protein kinase C and nuclear oncogene expression as possible action mechanisms of cancer chemoprevention by Curcumin
    Jen Kun Lin
    Institutes of Biochemistry, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei, Taiwan, 10018
    Arch Pharm Res 27:683-92. 2004
  4. ncbi request reprint Mechanisms of hypolipidemic and anti-obesity effects of tea and tea polyphenols
    Jen Kun Lin
    Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Nutr Food Res 50:211-7. 2006
  5. ncbi request reprint Cancer chemoprevention by tea polyphenols through modulating signal transduction pathways
    Jen Kun Lin
    Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei
    Arch Pharm Res 25:561-71. 2002
  6. ncbi request reprint Nitration and hydroxylation of aromatic amino acid and guanine by the air pollutant peroxyacetyl nitrate
    J K Lin
    Institute of Biochemistry, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei, Taiwan, ROC
    Chem Biol Interact 127:219-36. 2000
  7. ncbi request reprint Recent studies on the biofunctions and biotransformations of curcumin
    J K Lin
    Institutes of Biochemistry, College of Medicine, National Taiwan University, Taipei
    Biofactors 13:153-8. 2000
  8. ncbi request reprint Tangeretin induces cell-cycle G1 arrest through inhibiting cyclin-dependent kinases 2 and 4 activities as well as elevating Cdk inhibitors p21 and p27 in human colorectal carcinoma cells
    Min Hsiung Pan
    Institutes of Biochemistry, College of Medicine, National Taiwan University, Taipei, Taiwan
    Carcinogenesis 23:1677-84. 2002
  9. ncbi request reprint Induction of G1 phase arrest in MCF human breast cancer cells by pentagalloylglucose through the down-regulation of CDK4 and CDK2 activities and up-regulation of the CDK inhibitors p27(Kip) and p21(Cip)
    Wei Jen Chen
    Institute of Biochemistry, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei, Taiwan, ROC
    Biochem Pharmacol 65:1777-85. 2003
  10. ncbi request reprint Suppression of inducible nitric oxide synthase and cyclooxygenase-2 in downregulating nuclear factor-kappa B pathway by Garcinol
    Chiung Ho Liao
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei 10018, Taiwan
    Mol Carcinog 41:140-9. 2004

Collaborators

  • Yu Chih Liang
  • Ying Jan Wang
  • Chien Ho Chen
  • Wei Jen Chen
  • Chia Li Wu
  • Min Hsiung Pan
  • Wen Sen Lee
  • Shing Hwa Liu
  • Yung Sheng Lin
  • Shengmin Sang
  • Chien Huang Lin
  • Richard G Pestell
  • How Ran Guo
  • Ben Zhan Zhu
  • Chris Albanese
  • Hwai Jeng Lin
  • C T Ho
  • Chih Hung Hsu
  • Tzong Der Way
  • Meng Shih Weng
  • Hsiu Chen Huang
  • Shoei Yn Lin-Shiau
  • Yea Tzy Deng
  • Chiung Ho Liao
  • Yuan Soon Ho
  • Chun Te Chiang
  • Feng Lan Chiu
  • Sung Ho Chen
  • Ming Ching Kao
  • Kai Yang Syu
  • Jean Dean Liu
  • Shiu Chen Huang
  • Kuan Li Kuo
  • Shih Han Sun
  • Hung Hsiao Lee
  • Kuo Hui Lin
  • Shyr Yi Lin
  • Jiiang Huei Jeng
  • Po Tsun Kuo
  • Erica P Cai
  • Shu Huei Tsai
  • Jung Yie Kao
  • Jang Chang Lee
  • Kuan Hung Chen
  • Wei Jan Huang
  • Kuo Tai Hua
  • Yu Wen Chen
  • Yao Jen Tsai
  • Kuei Yao Hsu
  • Li Ching Chen
  • Chia Jen Tseng
  • Li Lun Ho
  • Ai Hsiang Lo
  • Ming Shyue Lee
  • Tsai Wen Chang
  • Cheng Huang
  • Sheng Yung Yu
  • Chin Chih Liu
  • Ming Young Chou
  • Chien Yu Huang
  • Chi Hung Huang
  • Tsung Pang Lin
  • Liang Chih Liu
  • Shih Chang Tsai
  • Chih Yen Tsai
  • Li Jiau Huang
  • Chih Shiang Chang
  • Sheng Chu Kuo
  • Yue Wen Chen
  • Chung Yang Huang
  • Shuang En Chuang
  • Shang Jie Tsai
  • Chih Hsiang Huang
  • How Tseng
  • Wei Ling Tso
  • Wein Shung Kuo
  • Chia Hwa Lee
  • Yueh Hsing Ou
  • Jan Show Chu
  • Mei Chi Chang
  • Yann Chwen Lai
  • Rong Jane Chen
  • Cheng Fei Yu
  • Ling Fang Hung
  • Shiann Pan
  • I Chun Liu
  • Linda Chen
  • Ming Shium Hsieh
  • Sheng Yow Ho
  • Hung Bin Liou

Detail Information

Publications79

  1. ncbi request reprint Molecular targets of curcumin
    Jen Kun Lin
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Adv Exp Med Biol 595:227-43. 2007
    ..It has been demonstrated that curcumin-induced apoptosis is mediated through the impairment of the ubiquitin-proteasome pathway...
  2. ncbi request reprint Inhibition of xanthine oxidase and suppression of intracellular reactive oxygen species in HL-60 cells by theaflavin-3,3'-digallate, (-)-epigallocatechin-3-gallate, and propyl gallate
    J K Lin
    Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Agric Food Chem 48:2736-43. 2000
    ..Therefore, the antioxidative activity of tea polyphenols and PG is due not only to their ability to scavenge superoxides but also to their ability to block XO and related oxidative signal transducers...
  3. ncbi request reprint Suppression of protein kinase C and nuclear oncogene expression as possible action mechanisms of cancer chemoprevention by Curcumin
    Jen Kun Lin
    Institutes of Biochemistry, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei, Taiwan, 10018
    Arch Pharm Res 27:683-92. 2004
    ..These results suggest that curcumin-glucuronide, dihydrocurcumin-glucuronide, tetrahydrocurcumin-glucuronide and tetrahydrocurcumin are the major metabolites of curcumin in mice, rats and humans...
  4. ncbi request reprint Mechanisms of hypolipidemic and anti-obesity effects of tea and tea polyphenols
    Jen Kun Lin
    Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Nutr Food Res 50:211-7. 2006
    ..The experimental data indicated that the molecular mechanisms of fatty acid synthase gene suppression by tea polyphenols (EGCG, theaflavins) may invite down-regulation of EGFR/PI3K/Akt/Sp-1 signal transduction pathways...
  5. ncbi request reprint Cancer chemoprevention by tea polyphenols through modulating signal transduction pathways
    Jen Kun Lin
    Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei
    Arch Pharm Res 25:561-71. 2002
    ..The mechanisms of this inhibition may be due to the blockade of the mitogenic and differentiating signals through modulating EGFR function, MAPK cascades, NFkappaB activation as well as c-myc, c-jun and c-fos expression...
  6. ncbi request reprint Nitration and hydroxylation of aromatic amino acid and guanine by the air pollutant peroxyacetyl nitrate
    J K Lin
    Institute of Biochemistry, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei, Taiwan, ROC
    Chem Biol Interact 127:219-36. 2000
    ..We also found that peroxynitrite and PAN are similar in their oxidizing activity. From these findings, we suggest that peroxynitrite may be considered as the reactive intermediate of PAN...
  7. ncbi request reprint Recent studies on the biofunctions and biotransformations of curcumin
    J K Lin
    Institutes of Biochemistry, College of Medicine, National Taiwan University, Taipei
    Biofactors 13:153-8. 2000
    ..These results suggest that curcumin-glucuronide, dihydro-curcumin-glucuronide, tetrahydrocurcumin-glucuronide and tetrahydrocurcumin are major metabolites of curcumin in mice...
  8. ncbi request reprint Tangeretin induces cell-cycle G1 arrest through inhibiting cyclin-dependent kinases 2 and 4 activities as well as elevating Cdk inhibitors p21 and p27 in human colorectal carcinoma cells
    Min Hsiung Pan
    Institutes of Biochemistry, College of Medicine, National Taiwan University, Taipei, Taiwan
    Carcinogenesis 23:1677-84. 2002
    ..These results suggest that tangeretin either exerts its growth-inhibitory effects through modulation of the activities of several key G1 regulatory proteins, such as Cdk2 and Cdk4, or mediates the increase of Cdk inhibitors p21 and p27...
  9. ncbi request reprint Induction of G1 phase arrest in MCF human breast cancer cells by pentagalloylglucose through the down-regulation of CDK4 and CDK2 activities and up-regulation of the CDK inhibitors p27(Kip) and p21(Cip)
    Wei Jen Chen
    Institute of Biochemistry, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei, Taiwan, ROC
    Biochem Pharmacol 65:1777-85. 2003
    ....
  10. ncbi request reprint Suppression of inducible nitric oxide synthase and cyclooxygenase-2 in downregulating nuclear factor-kappa B pathway by Garcinol
    Chiung Ho Liao
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei 10018, Taiwan
    Mol Carcinog 41:140-9. 2004
    ..The NF-kappa B signaling pathway leads to inflammatory reaction and our results suggest that garcinol suppresses the expression of iNOS in this pathway...
  11. ncbi request reprint Microtubule damaging agents induce apoptosis in HL 60 cells and G2/M cell cycle arrest in HT 29 cells
    Chia Jen Tseng
    Graduate Institute of Biomedical Technology, Taipei Medical University, No 250, Wu Hsing Street, Taipei 110, Taiwan, ROC
    Toxicology 175:123-42. 2002
    ..The results from the present study highlight the molecular mechanisms underlying of the PDP-induced anti-cancer activity...
  12. ncbi request reprint In vitro and in vivo studies of the anticancer action of terbinafine in human cancer cell lines: G0/G1 p53-associated cell cycle arrest
    Wen Sen Lee
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    Int J Cancer 106:125-37. 2003
    ..These findings demonstrate for the first time that TB can inhibit the proliferation of tumor cells in vitro and in vivo...
  13. ncbi request reprint Propolin C from propolis induces apoptosis through activating caspases, Bid and cytochrome c release in human melanoma cells
    Chia Nan Chen
    Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Section 1, Jen Ai Road, 100, ROC, Taipei, Taiwan
    Biochem Pharmacol 67:53-66. 2004
    ..0microM. In conclusion, the isolation and characterization of propolin C from bee propolis are described for the first time, and this compound is a powerful inducer of apoptosis in human melanoma cells...
  14. ncbi request reprint Effects of garcinol on free radical generation and NO production in embryonic rat cortical neurons and astrocytes
    Chiung Ho Liao
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Biochem Biophys Res Commun 329:1306-14. 2005
    ..Garcinol may exert a similar anti-inflammatory effect and may be neuroprotective against brain injury...
  15. ncbi request reprint Factors affecting the levels of tea polyphenols and caffeine in tea leaves
    Yung Sheng Lin
    Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Agric Food Chem 51:1864-73. 2003
    ..All tea extracts extracted by 75% ethanol have stronger biological functions than those extracted by boiling water...
  16. ncbi request reprint Apoptosis of human melanoma cells induced by the novel compounds propolin A and propolin B from Taiwenese propolis
    Chia Nan Chen
    Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Section 1, Jen Ai Road, Taipei 100, Taiwan, ROC
    Cancer Lett 245:218-31. 2007
    ..All these results indicated that propolin A and propolin B may trigger apoptosis of A2058 cells through mitochondria-dependent pathways and also shown that propolin A and propolin B were strong antioxidants...
  17. ncbi request reprint Degradation of HER2/neu by apigenin induces apoptosis through cytochrome c release and caspase-3 activation in HER2/neu-overexpressing breast cancer cells
    Tzong Der Way
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei 10018, Taiwan
    FEBS Lett 579:145-52. 2005
    ..These results provided new insights into the structure-activity relationship of flavonoids...
  18. ncbi request reprint Theanaphthoquinone inhibits fatty acid synthase expression in EGF-stimulated human breast cancer cells via the regulation of EGFR/ErbB-2 signaling
    Meng Shih Weng
    Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei 10018, Taiwan
    Toxicol Appl Pharmacol 218:107-18. 2007
    ..In summary, our findings suggest that TNQ modulates FAS expression by the regulation of EGFR/ErbB-2 pathways and induces cell death in breast cancer cells...
  19. ncbi request reprint Apigenin induces apoptosis through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the phosphatidylinositol 3-kinase/Akt-dependent pathway
    Tzong Der Way
    Institute of Biochemistry and Molecular Biology, College of Medicine National Taiwan University No 1, Section 1, Jen Ai Rd, Taipei 10018, Taiwan
    J Biol Chem 279:4479-89. 2004
    ..Apigenin-induced degradation of mature HER2/neu involves polyubiquitination of HER2/neu and subsequent hydrolysis by the proteasome...
  20. ncbi request reprint Cytotoxic prenylflavanones from Taiwanese propolis
    Chia Nan Chen
    Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei, Taiwan 100, Republic of China
    J Nat Prod 66:503-6. 2003
    ..Furthermore, both propolin A (2) and B (3) are potential antioxidant agents and show strong scavenging effects against most types of free radicals...
  21. ncbi request reprint Lipid peroxidation and cell death mechanisms in pulmonary epithelial cells induced by peroxynitrite and nitric oxide
    Yuan Soon Ho
    School of Medical Technology, Taipei Medical University, Taipei, Taiwan
    Arch Toxicol 76:484-93. 2002
    ..The relationship between caspase activation and the cleavage of other death substrates during postmitotic apoptosis in A549 cells needs further investigation...
  22. ncbi request reprint Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-kappaB in mouse macrophages
    Ai Hsiang Lo
    Institute of Biochemistry, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei, Taiwan
    Carcinogenesis 23:983-91. 2002
    ..These results suggest that carnosol suppresses the NO production and iNOS gene expression by inhibiting NF-kappaB activation, and provide possible mechanisms for its anti-inflammatory and chemopreventive action...
  23. ncbi request reprint Capillary electrophoretic determination of theanine, caffeine, and catechins in fresh tea leaves and oolong tea and their effects on rat neurosphere adhesion and migration
    Chia Nan Chen
    Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Section 1, Jen Ai Road, Taipei, Taiwan 100
    J Agric Food Chem 51:7495-503. 2003
    ..These results indicated that EGCg might affect neural stem cell survival or differentiation...
  24. ncbi request reprint Mechanisms of cancer chemoprevention by hop bitter acids (beer aroma) through induction of apoptosis mediated by Fas and caspase cascades
    Wei Jen Chen
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Agric Food Chem 52:55-64. 2004
    ..The induction of apoptosis by hop bitter acids may offer a pivotal mechanism for their chemopreventive action...
  25. ncbi request reprint Induction of G1 arrest and apoptosis in human jurkat T cells by pentagalloylglucose through inhibiting proteasome activity and elevating p27Kip1, p21Cip1/WAF1, and Bax proteins
    Wei Jen Chen
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Biol Chem 279:13496-505. 2004
    ..Our findings suggest a mechanism for the effect of pentagalloylglucose on the cell cycle in human leukemic cells: that pentagalloylglucose down-regulates proteasome-mediated pathways because it is a proteasome inhibitor...
  26. ncbi request reprint Antitumor effects of miconazole on human colon carcinoma xenografts in nude mice through induction of apoptosis and G0/G1 cell cycle arrest
    Chih Hsiung Wu
    School of Medicine, Taipei Medical University, Taipei, Taiwan
    Toxicol Appl Pharmacol 180:22-35. 2002
    ..Our study provides the novel mechanisms of antitumor effects of MIC and such results may have significant applications for cancer chemotherapy...
  27. ncbi request reprint Penta-O-galloyl-beta-D-glucose inhibits the invasion of mouse melanoma by suppressing metalloproteinase-9 through down-regulation of activator protein-1
    Li Lun Ho
    Institute of Biochemistry, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei, Taiwan
    Eur J Pharmacol 453:149-58. 2002
    ..The result may provide a potential mechanism for 5GG in cancer chemopreventive action...
  28. ncbi request reprint Pu-erh tea supplementation suppresses fatty acid synthase expression in the rat liver through downregulating Akt and JNK signalings as demonstrated in human hepatoma HepG2 cells
    Chun Te Chiang
    Institute of Biochemistry and Molecular Biology, College of Medicine National Taiwan University, Taipei
    Oncol Res 16:119-28. 2005
    ..The active principles and molecular mechanisms that exerted these biological effects in pu-erh tea deserve future exploration...
  29. ncbi request reprint Carnosol inhibits the invasion of B16/F10 mouse melanoma cells by suppressing metalloproteinase-9 through down-regulating nuclear factor-kappa B and c-Jun
    Shiu Chen Huang
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No 1, Section 1, Jen ai Road Taipei 10018, Taiwan
    Biochem Pharmacol 69:221-32. 2005
    ..Taken together, these results indicate that carnosol targets MMP-mediated cellular events in cancer cells and provides a new mechanism for its anticancer activity...
  30. ncbi request reprint Chrysin induces G1 phase cell cycle arrest in C6 glioma cells through inducing p21Waf1/Cip1 expression: involvement of p38 mitogen-activated protein kinase
    Meng Shih Weng
    Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei 10018, Taiwan
    Biochem Pharmacol 69:1815-27. 2005
    ..These results suggest that chrysin exerts its growth-inhibitory effects either through activating p38-MAPK leading to the accumulation of p21(Waf1/Cip1) protein or mediating the inhibition of proteasome activity...
  31. ncbi request reprint Comparative studies on the hypolipidemic and growth suppressive effects of oolong, black, pu-erh, and green tea leaves in rats
    Kuan Li Kuo
    Wun Shan Branch, Tea Research and Extension Station, Taipei, Taiwan
    J Agric Food Chem 53:480-9. 2005
    ....
  32. ncbi request reprint Diosgenin, a naturally occurring steroid, suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt, mTOR and JNK phosphorylation
    Chun Te Chiang
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei 100, Taiwan
    FEBS Lett 581:5735-42. 2007
    ..These results suggested that diosgenin has the potential to advance as chemopreventive or chemotherapeutic agent for cancers that overexpress HER2...
  33. ncbi request reprint Sensitizing HER2-overexpressing cancer cells to luteolin-induced apoptosis through suppressing p21(WAF1/CIP1) expression with rapamycin
    Chun Te Chiang
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei 10018, Taiwan
    Mol Cancer Ther 6:2127-38. 2007
    ....
  34. ncbi request reprint Bcl-2 overexpression inhibits tetrachlorohydroquinone-induced apoptosis in NIH3T3 cells: a possible mechanism for tumor promotion
    Yu Ping Lin
    Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Mol Carcinog 40:24-33. 2004
    ..Thus, our results suggest TCHQ-induced tumor promotion may be through a mechanism of upregulation of Bcl-2 protein and subsequent apoptosis inhibition...
  35. ncbi request reprint Black tea polyphenol theaflavins inhibit aromatase activity and attenuate tamoxifen resistance in HER2/neu-transfected human breast cancer cells through tyrosine kinase suppression
    Tzong Der Way
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei 10018
    Eur J Cancer 40:2165-74. 2004
    ..These findings suggest the use of black tea polyphenols may be beneficial in the chemoprevention of hormone-dependent breast tumours and represent a possible remedy to overcome hormonal resistance of hormone-independent breast tumours...
  36. ncbi request reprint Theaflavin-3,3'-digallate and penta-O-galloyl-beta-D-glucose inhibit rat liver microsomal 5alpha-reductase activity and the expression of androgen receptor in LNCaP prostate cancer cells
    Hung Hsiao Lee
    Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei, Taiwan
    Carcinogenesis 25:1109-18. 2004
    ..In conclusion, our result suggests that TF3 and 5GG might be useful chemoprevention agents for prostate cancer through suppressing the function of androgen and its receptor...
  37. ncbi request reprint Molecular mechanisms of G0/G1 cell-cycle arrest and apoptosis induced by terfenadine in human cancer cells
    Jean Dean Liu
    Department of Internal Medicine, School of Medicine, Taipei Medical University and Hospital, Taipei, Taiwan
    Mol Carcinog 37:39-50. 2003
    ..Our study showed the molecular mechanisms for TF-induced cell growth inhibition and the occurrence of apoptosis in human cancer cells...
  38. ncbi request reprint Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory skin edema and ornithine decarboxylase activity by theaflavin-3,3'-digallate in mouse
    Yu Chih Liang
    Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei, Taiwan
    Nutr Cancer 42:217-23. 2002
    ..These results suggested that TF-3 was a potential inhibitor of ODC activity and TPA-induced edema and might be effective in cancer chemoprevention...
  39. ncbi request reprint Resveratrol-induced G2 arrest through the inhibition of CDK7 and p34CDC2 kinases in colon carcinoma HT29 cells
    Yu Chih Liang
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No 1, Section 1 Jen Ai Road, Taipei, Taiwan
    Biochem Pharmacol 65:1053-60. 2003
    ....
  40. ncbi request reprint Apoptosis of cultured astrocytes induced by the copper and neocuproine complex through oxidative stress and JNK activation
    Sung Ho Chen
    Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Toxicol Sci 102:138-49. 2008
    ..Their clinical implications in the etiology of neurodegenerative diseases deserve further investigation...
  41. ncbi request reprint Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells
    Chiung Ho Liao
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Cell Biochem 96:155-69. 2005
    ..Garcinol also significantly inhibited the expression of MMP-7 in IL-1beta-induced HT-29 cells. These results suggest that garcinol reduces cell invasion and survival through the inhibition of FAK's downstream signaling...
  42. ncbi request reprint Tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NFkappaB activation and cyclin D1 up-regulation
    Yuan Soon Ho
    Graduate Institute of Biomedical Technology, Taipei Medical University, Taipei, Taiwan
    Toxicol Appl Pharmacol 205:133-48. 2005
    ..In summary, our findings demonstrate for the first time that NNK could stimulate normal human bronchial cell proliferation through activation of the NFkappaB, which in turn up-regulated the cyclin D1 expression...
  43. ncbi request reprint Involvement of c-jun N-terminal kinase activation in 15-deoxy-delta12,14-prostaglandin J2-and prostaglandin A1-induced apoptosis in AGS gastric epithelial cells
    Jean Dean Liu
    Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan
    Mol Carcinog 37:16-24. 2003
    ..These results suggested that CyPGs, such as 15d-PGJ(2) and PGA(1), activated JNK signaling pathway, and that JNK activation may be involved in 15d-PGJ(2)- and PGA(1)-induced apoptosis...
  44. ncbi request reprint Bowman-Birk inhibitor abates proteasome function and suppresses the proliferation of MCF7 breast cancer cells through accumulation of MAP kinase phosphatase-1
    Yu Wen Chen
    Institute of Biochemistry and Molecular Biology and Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Carcinogenesis 26:1296-306. 2005
    ..Our results support the notion that proteasome inhibition by BBI is a novel mechanism that contributes to prevention of cancer and further provides evidence that soybean products have the potential to advance as chemopreventive agents...
  45. ncbi request reprint Arsenite stimulates cyclooxygenase-2 expression through activating IkappaB kinase and nuclear factor kappaB in primary and ECV304 endothelial cells
    Shu Huei Tsai
    Department of Orthopaedics and Traumatology, School of Medicine, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan
    J Cell Biochem 84:750-8. 2002
    ..Arsenite could induce IKK activity, which leads to the phosphorylation and degradation of IkappaB in ECV304 cells. Therefore, it appears that IKK signaling pathway is involved in arsenite-mediated Cox-2 expression...
  46. ncbi request reprint Determination of tea polyphenols and caffeine in tea flowers (Camellia sinensis) and their hydroxyl radical scavenging and nitric oxide suppressing effects
    Yung Sheng Lin
    Institute of Biochemistry, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei, Taiwan
    J Agric Food Chem 51:975-80. 2003
    ..The present study demonstrates that both tea flowers and tea leaves contain appreciable amounts of catechins and caffeine. It is likely that tea flowers might be useful for making alternative tea beverages...
  47. doi request reprint Suppression of free fatty acid-induced insulin resistance by phytopolyphenols in C2C12 mouse skeletal muscle cells
    Yea Tzy Deng
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Agric Food Chem 60:1059-66. 2012
    ..These findings may suggest that curcumin shows the best capacity to improve FFA-induced insulin resistance than the other two, and ECG was more effective than EGCG in attenuating insulin resistance...
  48. doi request reprint Chemical composition of Solanum nigrum linn extract and induction of autophagy by leaf water extract and its major flavonoids in AU565 breast cancer cells
    Hsiu Chen Huang
    Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Agric Food Chem 58:8699-708. 2010
    ....
  49. doi request reprint Epigallocatechin gallate (EGCG) attenuates high glucose-induced insulin signaling blockade in human hepG2 hepatoma cells
    Chih Li Lin
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Nutr Food Res 52:930-9. 2008
    ....
  50. ncbi request reprint Pentagalloylglucose inhibits estrogen receptor alpha by lysosome-dependent depletion and modulates ErbB/PI3K/Akt pathway in human breast cancer MCF-7 cells
    Kuo Tai Hua
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Carcinog 45:551-60. 2006
    ....
  51. doi request reprint EGCG inhibits the invasion of highly invasive CL1-5 lung cancer cells through suppressing MMP-2 expression via JNK signaling and induces G2/M arrest
    Yea Tzy Deng
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Agric Food Chem 59:13318-27. 2011
    ..In addition, EGCG may suppress cell proliferation in CL1-5 cells through inducing G2/M arrest...
  52. doi request reprint EGCG stabilizes p27kip1 in E2-stimulated MCF-7 cells through down-regulation of the Skp2 protein
    Hsiu Chen Huang
    Institute of Biochemistry and Molecular Biology, National Taiwan University Medicine College, Taipei 100, Taiwan
    Endocrinology 149:5972-83. 2008
    ..The therapeutic strategies designed to reduce Skp2 may therefore play an important clinical role in treatment of breast cancer cells...
  53. ncbi request reprint Molecular modeling of flavonoids that inhibits xanthine oxidase
    Chun Mao Lin
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei, Taiwan, ROC
    Biochem Biophys Res Commun 294:167-72. 2002
    ..Isovitexin showed the weakest inhibitory effect among the compounds tested. The bulky group of sugar in isovitexin may hamper its interaction with xanthine oxidase...
  54. ncbi request reprint Tangeretin suppresses IL-1beta-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells
    Kuan Hung Chen
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei 10018, Taiwan
    Biochem Pharmacol 73:215-27. 2007
    ....
  55. ncbi request reprint Theaflavins attenuate hepatic lipid accumulation through activating AMPK in human HepG2 cells
    Chih Li Lin
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Lipid Res 48:2334-43. 2007
    ..Our results show that theaflavins are bioavailable both in vitro and in vivo and may be active in the prevention of fatty liver and obesity...
  56. doi request reprint Determination of theanine, GABA, and other amino acids in green, oolong, black, and Pu-erh teas with dabsylation and high-performance liquid chromatography
    Kai Yang Syu
    Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Agric Food Chem 56:7637-43. 2008
    ..Furthermore, the raw (natural fermented) Pu-erh tea contained more theanine than ripe (wet fermented) Pu-erh tea, and the GABA contents in normal teas were generally lower than that in GABA tea...
  57. doi request reprint Involvement of activating transcription factors JNK, NF-kappaB, and AP-1 in apoptosis induced by pyrrolidine dithiocarbamate/Cu complex
    Sung Ho Chen
    Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Eur J Pharmacol 594:9-17. 2008
    ..Based on these findings; we conclude that PDTC/Cu complex-induced apoptosis is mediated by activation of JNK, NF-kappaB, AP-1 and caspase 3. Due to its high potency, PDTC may be useful as a therapeutic anti-cancer drug...
  58. doi request reprint Rotenone induces apoptosis in MCF-7 human breast cancer cell-mediated ROS through JNK and p38 signaling
    Yea Tzy Deng
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Carcinog 49:141-51. 2010
    ..Taken together, these results indicate rotenone may induce apoptosis through ROS and JNK/p38 MAPKs activation in MCF-7 cells...
  59. ncbi request reprint Downregulation of androgen receptor expression by luteolin causes inhibition of cell proliferation and induction of apoptosis in human prostate cancer cells and xenografts
    Feng Lan Chiu
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Prostate 68:61-71. 2008
    ..Our aim was to investigate how luteolin, a natural flavonoid, affects cell growth and AR expression in prostate cancer cells and xenografts...
  60. ncbi request reprint Role of HER2/HER3 co-receptor in breast carcinogenesis
    Tzong Der Way
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Future Oncol 1:841-9. 2005
    ..This indicates that inhibition of HER2/HER3 heterodimer function may be an especially effective and unique strategy for blocking the HER2-mediated carcinogenesis of breast cancer cells...
  61. ncbi request reprint Mutagenicity study of butachlor and its metabolites using Salmonella typhimurium
    Kuei Yao Hsu
    Department of Anesthesiology, Buddhist Tzu Chi General Hospital, Shin Dien, Taipei, Taiwan
    J Microbiol Immunol Infect 38:409-16. 2005
    ..Although the molecular mechanism of butachlor-induced cellular toxicity is still not clear, it is likely that the cellular transformation ability of butachlor is partly associated with its mutagenicity...
  62. ncbi request reprint HPLC analysis of naturally occurring methylated catechins, 3' '- and 4' '-methyl-epigallocatechin gallate, in various fresh tea leaves and commercial teas and their potent inhibitory effects on inducible nitric oxide synthase in macrophages
    Feng Lan Chiu
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Number 1, Section 1, Taipei, Taiwan
    J Agric Food Chem 53:7035-42. 2005
    ..We also found that 3' '-Me-EGCG has a higher inhibitory effect on the nitric oxide generation and inducible nitric oxide synthase (iNOS) expression as compared with EGCG, while 4' '-Me-EGCG and 4',4' '-di-Me-EGCG were less effective...
  63. doi request reprint Cycle arrest and apoptosis in MDA-MB-231/Her2 cells induced by curcumin
    Shih Han Sun
    Institutes of Biochemistry and Molecular Biology, College of Medicine National Taiwan University, Taipei, Taiwan
    Eur J Pharmacol 690:22-30. 2012
    ..The findings indicate that curcumin is of potential value for the chemoprevention of breast cancer, especially in breast cancer with Skp2/Her2 overexpression...
  64. doi request reprint Garcinol promotes neurogenesis in rat cortical progenitor cells through the duration of extracellular signal-regulated kinase signaling
    Meng Shih Weng
    Department of Nutritional Science, Fu Jen Catholic University, Taipei, Taiwan
    J Agric Food Chem 59:1031-40. 2011
    ..Noteworthy, garcinol could promote neurite outgrowth in EGF-responsive neural precursor cells and modulate the ERK pathway in the enhancement of neuronal survival...
  65. doi request reprint Novel regimen through combination of memantine and tea polyphenol for neuroprotection against brain excitotoxicity
    Chang mu Chen
    Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    J Neurosci Res 86:2696-704. 2008
    ..These findings provide useful information about the potential application of memantine and tea polyphenols in preventing clinical excitotoxic injury such as brain trauma, brain ischemia, epilepsy, and Alzheimer's disease...
  66. doi request reprint Epigallocatechin gallate (EGCG) and rutin suppress the glucotoxicity through activating IRS2 and AMPK signaling in rat pancreatic beta cells
    Erica P Cai
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan 100
    J Agric Food Chem 57:9817-27. 2009
    ....
  67. ncbi request reprint Propolin H from Taiwanese propolis induces G1 arrest in human lung carcinoma cells
    Meng Shih Weng
    Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei 10018, Taiwan
    J Agric Food Chem 55:5289-98. 2007
    ..Propolin H exerts its significantly growth inhibitory effects and may have therapeutic applications...
  68. doi request reprint Ursolic acid inhibits IL-1beta or TNF-alpha-induced C6 glioma invasion through suppressing the association ZIP/p62 with PKC-zeta and downregulating the MMP-9 expression
    Hsiu Chen Huang
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Carcinog 48:517-31. 2009
    ..These results all showcase the potential UA has in the chemoprevention and treatment of cancer metastasis and invasion...
  69. ncbi request reprint Epigallocatechin gallate (EGCG) suppresses beta-amyloid-induced neurotoxicity through inhibiting c-Abl/FE65 nuclear translocation and GSK3 beta activation
    Chih Li Lin
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Neurobiol Aging 30:81-92. 2009
    ..Our results indicated that the neuroprotective action of EGCG may take place through some mechanisms other than the promotion of APP nonamyloidogenic proteolysis, as was reported previously...
  70. doi request reprint Tomatidine inhibits iNOS and COX-2 through suppression of NF-kappaB and JNK pathways in LPS-stimulated mouse macrophages
    Feng Lan Chiu
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No 1 Section 1, Jen Ai Road, Taipei 10018, Taiwan
    FEBS Lett 582:2407-12. 2008
    ..Here, we demonstrate that tomatidine acts as an anti-inflammatory agent by blocking NF-kappaB and JNK signaling, and may possibly be developed as a useful agent for the chemoprevention of cancer or inflammatory diseases...
  71. doi request reprint Penta-O-galloyl-beta-D-glucose suppresses prostate cancer bone metastasis by transcriptionally repressing EGF-induced MMP-9 expression
    Po Tsun Kuo
    Institute of Biochemistry, College of Life Science, National Chung Hsing University, Taichung, Taiwan
    J Agric Food Chem 57:3331-9. 2009
    ..These in vitro and in vivo results suggest that 5GG may be a therapeutic candidate for the treatment of advanced prostate cancer...
  72. doi request reprint Arecoline N-oxide: its mutagenicity and possible role as ultimate carcinogen in areca oral carcinogenesis
    Kuo Hui Lin
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Agric Food Chem 59:3420-8. 2011
    ..The mutagenicity of arecoline N-oxide was strongly inhibited by the N-oxide reducing agent titanium trichloride. The possible role of arecoline N-oxide in the induction of oral carcinogenesis by areca nut chewing is discussed...
  73. ncbi request reprint Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling
    Min Hsiung Pan
    Department of Seafood Science, National Kaohsiung Marine University, No 142, Hai Chuan Road, Nan Tzu, Kaohsiung 811, Taiwan
    J Agric Food Chem 55:5030-7. 2007
    ..Taken together, these findings extend our previous study to indicate that EGCG may be useful in the chemoprevention of breast carcinoma in which FAS overexpression results from HER2 or/and HER3 signaling...
  74. ncbi request reprint Induction of apoptosis by hydroxydibenzoylmethane through coordinative modulation of cyclin D3, Bcl-X(L), and Bax, release of cytochrome c, and sequential activation of caspases in human colorectal carcinoma cells
    Min Hsiung Pan
    Department of Marine Food Science, National Kaohsiung Institution of Marine Technology, Kaohsiung, Taiwan
    J Agric Food Chem 51:3977-84. 2003
    ..The induction of apoptosis by HDB may provide a pivotal mechanism for its cancer chemopreventive action...
  75. ncbi request reprint Prevention of cellular ROS damage by isovitexin and related flavonoids
    Chun Mao Lin
    Planta Med 68:365-7. 2002
    ..In addition, excess hydrogen peroxide induced by cadmium in A2780 ovarian cells was significantly suppressed by isovitexin. These results suggest that isovitexin in rice may protect cells from oxidative stress...
  76. ncbi request reprint Induction of apoptosis by 1-(2-hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione through reactive oxygen species production, GADD153 expression, and caspases activation in human epidermoid carcinoma cells
    Min Hsiung Pan
    Department of Seafood Science, National Kaohsiung Marine University, Kaohsiung 811, Taiwan
    J Agric Food Chem 53:9039-49. 2005
    ..These findings suggest that HMDB creates an oxidative cellular environment that induces DNA damage and GADD153 gene activation, which in turn helps trigger apoptosis in A431 cells...
  77. ncbi request reprint Propolin G, a prenylflavanone, isolated from Taiwanese propolis, induces caspase-dependent apoptosis in brain cancer cells
    Wei Jan Huang
    Chang Gung Institute of Technology, Chiayi, Taiwan
    J Agric Food Chem 55:7366-76. 2007
    ....
  78. ncbi request reprint Pre-clinical and early-phase clinical studies of curcumin as chemopreventive agent for endemic cancers in Taiwan
    Chih Hung Hsu
    Department of Oncology, National Taiwan University Hospital, Taipei
    Gan To Kagaku Ryoho 29:194-200. 2002
  79. doi request reprint Geraniin-mediated apoptosis by cleavage of focal adhesion kinase through up-regulation of Fas ligand expression in human melanoma cells
    Jang Chang Lee
    Graduate Institute of Pharmaceutical Chemistry, College of Pharmacy, China Medical University, Taichung, Taiwan
    Mol Nutr Food Res 52:655-63. 2008
    ..The geraniin-induced apoptosis may provide a pivotal mechanism for its cancer-chemopreventive action...