Ben Yang Liao

Summary

Affiliation: National Health Research Institutes
Country: Taiwan

Publications

  1. pmc Flagellated algae protein evolution suggests the prevalence of lineage-specific rules governing evolutionary rates of eukaryotic proteins
    Ting Yan Chang
    Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan, Republic of China
    Genome Biol Evol 5:913-22. 2013
  2. pmc Impact of extracellularity on the evolutionary rate of Mammalian proteins
    Ben Yang Liao
    Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Miaoli County 350, Taiwan, ROC
    Genome Biol Evol 2010:39-43. 2010
  3. pmc MamPhEA: a web tool for mammalian phenotype enrichment analysis
    Meng Pin Weng
    Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli County 350, Taiwan, ROC
    Bioinformatics 26:2212-3. 2010
  4. pmc Natural selection drives rapid evolution of mouse embryonic heart enhancers
    Ben Yang Liao
    Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan Town, Miaoli County 350, Taiwan, ROC
    BMC Syst Biol 6:S1. 2012
  5. pmc Mammalian genes preferentially co-retained in radiation hybrid panels tend to avoid coexpression
    Ben Yang Liao
    Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli County, Taiwan, Republic of China
    PLoS ONE 7:e32284. 2012
  6. pmc Contrasting genetic paths to morphological and physiological evolution
    Ben Yang Liao
    Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Miaoli County 350, Taiwan, Republic of China
    Proc Natl Acad Sci U S A 107:7353-8. 2010
  7. doi request reprint DroPhEA: Drosophila phenotype enrichment analysis for insect functional genomics
    Meng Pin Weng
    Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli County 350, Taiwan, R O C
    Bioinformatics 27:3218-9. 2011
  8. pmc Transcriptomes of mouse olfactory epithelium reveal sexual differences in odorant detection
    Meng Shin Shiao
    Genomics Research Center, Academia Sinica, Taipei, Taiwan, ROC
    Genome Biol Evol 4:703-12. 2012
  9. ncbi request reprint Assessing determinants of exonic evolutionary rates in mammals
    Feng Chi Chen
    Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli County, Taiwan, Republic of China
    Mol Biol Evol 29:3121-9. 2012
  10. doi request reprint DNA methylation rebalances gene dosage after mammalian gene duplications
    Andrew Ying Fei Chang
    Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Taiwan, Republic of China
    Mol Biol Evol 29:133-44. 2012

Collaborators

Detail Information

Publications13

  1. pmc Flagellated algae protein evolution suggests the prevalence of lineage-specific rules governing evolutionary rates of eukaryotic proteins
    Ting Yan Chang
    Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan, Republic of China
    Genome Biol Evol 5:913-22. 2013
    ..These results suggest no simple and universal rules governing protein evolutionary rates across different eukaryotic lineages. Instead, gene properties influence the rate of protein evolution in a lineage-specific manner...
  2. pmc Impact of extracellularity on the evolutionary rate of Mammalian proteins
    Ben Yang Liao
    Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Miaoli County 350, Taiwan, ROC
    Genome Biol Evol 2010:39-43. 2010
    ..Similar results were also found from principal component regression analysis. Our findings suggest that different rules govern the pace of protein sequence evolution in mammals and yeasts...
  3. pmc MamPhEA: a web tool for mammalian phenotype enrichment analysis
    Meng Pin Weng
    Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli County 350, Taiwan, ROC
    Bioinformatics 26:2212-3. 2010
    ....
  4. pmc Natural selection drives rapid evolution of mouse embryonic heart enhancers
    Ben Yang Liao
    Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan Town, Miaoli County 350, Taiwan, ROC
    BMC Syst Biol 6:S1. 2012
    ..However, it is unknown whether this phenomenon is due to elevated mutation rates, or is a consequence of natural selection...
  5. pmc Mammalian genes preferentially co-retained in radiation hybrid panels tend to avoid coexpression
    Ben Yang Liao
    Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli County, Taiwan, Republic of China
    PLoS ONE 7:e32284. 2012
    ..Therefore, coexpression information must be applied cautiously to the exploration of the functional relatedness of genes in a genome...
  6. pmc Contrasting genetic paths to morphological and physiological evolution
    Ben Yang Liao
    Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Miaoli County 350, Taiwan, Republic of China
    Proc Natl Acad Sci U S A 107:7353-8. 2010
    ..Thus, morphological and physiological changes have a differential molecular basis; separating them helps discern the genetic mechanisms of phenotypic evolution...
  7. doi request reprint DroPhEA: Drosophila phenotype enrichment analysis for insect functional genomics
    Meng Pin Weng
    Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli County 350, Taiwan, R O C
    Bioinformatics 27:3218-9. 2011
    ..DroPhEA allows users to specify mutation or ortholog types, displays enriched term results in a hierarchical structure and supports analyses on gene sets of all insect species with a fully sequenced genome...
  8. pmc Transcriptomes of mouse olfactory epithelium reveal sexual differences in odorant detection
    Meng Shin Shiao
    Genomics Research Center, Academia Sinica, Taipei, Taiwan, ROC
    Genome Biol Evol 4:703-12. 2012
    ..This study suggests the sexual differences in detecting environmental odorants in MOS and demonstrates that mRNA-seq provides a powerful tool for detecting genes with low expression levels and with high sequence similarities...
  9. ncbi request reprint Assessing determinants of exonic evolutionary rates in mammals
    Feng Chi Chen
    Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli County, Taiwan, Republic of China
    Mol Biol Evol 29:3121-9. 2012
    ....
  10. doi request reprint DNA methylation rebalances gene dosage after mammalian gene duplications
    Andrew Ying Fei Chang
    Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Taiwan, Republic of China
    Mol Biol Evol 29:133-44. 2012
    ..Our results suggest that during mammalian evolution, DNA methylation plays a dominant role in dosage rebalance after gene duplication by inhibiting transcription initiation of duplicate genes...
  11. pmc Functional characterization of motif sequences under purifying selection
    De Hua Chen
    Institute of Statistical Science, Academia Sinica, Taipei, Taiwan, ROC
    Nucleic Acids Res 41:2105-20. 2013
    ..The validation results reveal the dependencies between natural selection and functions of cis-regulatory elements and shed light on the evolution of gene regulatory networks...
  12. pmc Exploring the selective constraint on the sizes of insertions and deletions in 5' untranslated regions in mammals
    Chun Hsi Chen
    Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli County, 350 Taiwan
    BMC Evol Biol 11:192. 2011
    ..The presence of non-3n indels in uORFs can potentially disrupt the functions of these regulatory elements. We thus hypothesize that natural selection disfavors non-3n indels in 5'UTRs when these regulatory elements are present...
  13. pmc Scanning for the signatures of positive selection for human-specific insertions and deletions
    Chun Hsi Chen
    Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli County, Taiwan
    Genome Biol Evol 2009:415-9. 2009
    ..Our results suggest that HS indels may have been associated with human adaptive changes at both the species level and the subpopulation level...