Yung Chih Kuo


Affiliation: National Chung Cheng University
Country: Taiwan


  1. Kuo Y, Huang M. Material-driven differentiation of induced pluripotent stem cells in neuron growth factor-grafted poly(?-caprolactone)-poly(?-hydroxybutyrate) scaffolds. Biomaterials. 2012;33:5672-82 pubmed publisher
    ..The material-driven differentiation in NGF-grafted PCL-PHB constructs can be promising in guiding iPS cells to produce neurons for nerve tissue engineering. ..
  2. Kuo Y, Chang Y, Rajesh R. Targeted delivery of etoposide, carmustine and doxorubicin to human glioblastoma cells using methoxy poly(ethylene glycol)‑poly(ε‑caprolactone) nanoparticles conjugated with wheat germ agglutinin and folic acid. Mater Sci Eng C Mater Biol Appl. 2019;96:114-128 pubmed publisher
    ..WFNPs carrying ETO, BCNU and DOX acted as dual-targeting nanocarriers, and their use can be a promising approach to inhibiting GBM growth in the brain. ..
  3. Kuo Y, Chen C, Rajesh R. Optimized liposomes with transactivator of transcription peptide and anti-apoptotic drugs to target hippocampal neurons and prevent tau-hyperphosphorylated neurodegeneration. Acta Biomater. 2019;87:207-222 pubmed publisher
  4. Kuo Y, Wang C. Surface modification with peptide for enhancing chondrocyte adhesion and cartilage regeneration in porous scaffolds. Colloids Surf B Biointerfaces. 2011;84:63-70 pubmed publisher
    ..The peptide-grafted PEO/chitosan scaffolds can be applied to the treatment for injured cartilage in preclinical trials. ..
  5. Kuo Y, Tsai H. Rosmarinic acid- and curcumin-loaded polyacrylamide-cardiolipin-poly(lactide-co-glycolide) nanoparticles with conjugated 83-14 monoclonal antibody to protect β-amyloid-insulted neurons. Mater Sci Eng C Mater Biol Appl. 2018;91:445-457 pubmed publisher
    ..These results evidenced that the current 83-14 MAb-RA-CUR-PAAM-CL-PLGA NPs can be a promising pharmacotherapy to permeate the BBB and reduce the fibrillar Aβ-induced neurotoxicity. ..
  6. Kuo Y, Chen C. Inverted colloidal crystal scaffolds with induced pluripotent stem cells for nerve tissue engineering. Colloids Surf B Biointerfaces. 2013;102:789-94 pubmed publisher
    ..The induction with CSRARKQAASIKVAVSADR in ICC topography can improve the differentiation of iPS cells toward neurons for nerve tissue engineering. ..
  7. Kuo Y, Chung C. TATVHL peptide-grafted alginate/poly(?-glutamic acid) scaffolds with inverted colloidal crystal topology for neuronal differentiation of iPS cells. Biomaterials. 2012;33:8955-66 pubmed publisher
    ..TATVHL peptide-grafted alginate/?-PGA ICC scaffolds can be promising for establishing nerve tissue from iPS cells. ..
  8. Kuo Y, Tsai Y. Inverted colloidal crystal scaffolds for uniform cartilage regeneration. Biomacromolecules. 2010;11:731-9 pubmed publisher
    ..The ICC constructs with well-controlled pore regularity and unique topography can generate uniform tissue-engineered cartilage. ..
  9. Kuo Y, Wang C. Neuronal differentiation of induced pluripotent stem cells in hybrid polyester scaffolds with heparinized surface. Colloids Surf B Biointerfaces. 2012;100:9-15 pubmed publisher
    ..The heparinized PCL-PHB scaffolds can be efficient biomaterials in guiding the differentiation of iPS cells for nerve tissue engineering. ..

More Information


  1. Kuo Y, Wang C. Cartilage regeneration by culturing chondrocytes in scaffolds grafted with TATVHL peptide. Colloids Surf B Biointerfaces. 2012;93:235-40 pubmed publisher
    ..TATVHL peptide can be a promising bioactive molecule to improve chondrogenesis in porous biomaterials. ..
  2. Kuo Y, Tsai Y. Heparin-conjugated scaffolds with pore structure of inverted colloidal crystals for cartilage regeneration. Colloids Surf B Biointerfaces. 2011;82:616-23 pubmed publisher
    ..Therefore, the ordered pores in the heparinized ICC constructs could favor the chondrocyte culture to regenerate a uniform distribution of cartilage. ..
  3. Kuo Y, Hsu Y. Tissue-engineered polyethylene oxide/chitosan scaffolds as potential substitutes for articular cartilage. J Biomed Mater Res A. 2009;91:277-87 pubmed publisher
    ..The present PEO/chitosan scaffolds showed enhancements in biomedical characteristics for the formation of tissue-engineered cartilage toward clinical prosthesis. ..
  4. Kuo Y, Lee C. Methylmethacrylate-sulfopropylmethacrylate nanoparticles with surface RMP-7 for targeting delivery of antiretroviral drugs across the blood-brain barrier. Colloids Surf B Biointerfaces. 2012;90:75-82 pubmed publisher
    ..Endocytosis of RMP-7/MMA-SPM NPs and tight junction mediation can improve the permeability of D4T, DLV, and SQV across the BBB. ..
  5. Kuo Y, Chen Y. Targeting delivery of etoposide to inhibit the growth of human glioblastoma multiforme using lactoferrin- and folic acid-grafted poly(lactide-co-glycolide) nanoparticles. Int J Pharm. 2015;479:138-49 pubmed publisher
    ..Lf/FA/PLGA NPs with loaded etoposide can be a promising anticancer pharmacotherapy to enhance the delivery of etoposide to malignant brain tumors for preclinical trials. ..
  6. Kuo Y, Wang C. Guided differentiation of induced pluripotent stem cells into neuronal lineage in alginate-chitosan-gelatin hydrogels with surface neuron growth factor. Colloids Surf B Biointerfaces. 2013;104:194-9 pubmed publisher
    ..Alginate-chitosan-gelatin scaffolds with surface NGF can guide the differentiation of iPS cells for regenerating neurons. ..
  7. Kuo Y, Chen H. Entrapment and release of saquinavir using novel cationic solid lipid nanoparticles. Int J Pharm. 2009;365:206-13 pubmed publisher
    ..Hence, the current CSLNs could carry SQV for the improved medication of individuals infected by human immunodeficiency viruses. ..
  8. Kuo Y, Lin C. Accelerated nerve regeneration using induced pluripotent stem cells in chitin-chitosan-gelatin scaffolds with inverted colloidal crystal geometry. Colloids Surf B Biointerfaces. 2013;103:595-600 pubmed publisher
    ..ICC topography in chitin-chitosan-gelatin scaffolds can accelerate neuronal differentiation of iPS cells. ..
  9. Kuo Y, Chung C. Chondrogenesis in scaffolds with surface modification of elastin and poly-L-lysine. Colloids Surf B Biointerfaces. 2012;93:85-91 pubmed publisher
    ..Elastin- and poly-L-lysine-grafted polyethylene oxide/chitin/chitosan scaffolds are effective in producing cartilaginous components. ..
  10. Kuo Y, Cheng S. Brain targeted delivery of carmustine using solid lipid nanoparticles modified with tamoxifen and lactoferrin for antitumor proliferation. Int J Pharm. 2016;499:10-19 pubmed publisher
    ..TX-Lf-BCNU-SLNs can be effective in infiltrating the BBB and delivering BCNU to GBM for future chemotherapy application. ..
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    Kuo Y, Kuo C. Electromagnetic interference in the permeability of saquinavir across the blood-brain barrier using nanoparticulate carriers. Int J Pharm. 2008;351:271-81 pubmed
    ..This combination would be beneficial to the clinical application to the therapy of AIDS and other brain-related diseases. ..
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    Kuo Y, Chen H. Effect of nanoparticulate polybutylcyanoacrylate and methylmethacrylate-sulfopropylmethacrylate on the permeability of zidovudine and lamivudine across the in vitro blood-brain barrier. Int J Pharm. 2006;327:160-9 pubmed
    ..In the presence of 0.5% ethanol, 4-12% enhancement in the BBB permeability of the two drugs was obtained in the current carrier-mediated system. ..
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    Kuo Y, Lin C. Effect of genipin-crosslinked chitin-chitosan scaffolds with hydroxyapatite modifications on the cultivation of bovine knee chondrocytes. Biotechnol Bioeng. 2006;95:132-44 pubmed
  14. Kuo Y, Liang C. Inhibition of human brain malignant glioblastoma cells using carmustine-loaded catanionic solid lipid nanoparticles with surface anti-epithelial growth factor receptor. Biomaterials. 2011;32:3340-50 pubmed publisher
    ..Anti-EGFR/BCNU-CASLNs demonstrated the properties including an effective delivery to U87MG cells and antiproliferative efficacy against the growth of malignant brain tumors. ..
  15. Kuo Y, Lee C. Dual targeting of solid lipid nanoparticles grafted with 83-14 MAb and anti-EGF receptor for malignant brain tumor therapy. Life Sci. 2016;146:222-31 pubmed publisher
    ..The conjugation of 8314MAb and AEGFR on ETP-loaded SLNs can be a promising strategy to deliver antitumor ETP to the brain and restrain the propagation of GBM. ..
  16. Kuo Y, Hsueh C. Neuronal production from induced pluripotent stem cells in self-assembled collagen-hyaluronic acid-alginate microgel scaffolds with grafted GRGDSP/Ln5-P4. Mater Sci Eng C Mater Biol Appl. 2017;76:760-774 pubmed publisher
    ..Self-assembled microgel comprising COLMA, HAMA, ALGMA, and GRGDSP/Ln5-P4 may be promising in producing mature neural lineage from iPSCs, to provide better treatment for damaged nervous tissue. ..
  17. Kuo Y, Liu Y, Rajesh R. Pancreatic differentiation of induced pluripotent stem cells in activin A-grafted gelatin-poly(lactide-co-glycolide) nanoparticle scaffolds with induction of LY294002 and retinoic acid. Mater Sci Eng C Mater Biol Appl. 2017;77:384-393 pubmed publisher
    ..The use of activin A-grafted gelatin-PLGA NP scaffolds induced by LY294002 and RA can be a promising approach to developing pancreatic islet cells from iPSCs. ..
  18. Kuo Y, Rajesh R. Nerve growth factor-loaded heparinized cationic solid lipid nanoparticles for regulating membrane charge of induced pluripotent stem cells during differentiation. Mater Sci Eng C Mater Biol Appl. 2017;77:680-689 pubmed publisher
    ..NGF-loaded HCSLNs with EQ 1 had higher viability of iPSCs than NGF-loaded HCSLNs with SA. NGF-loaded HCSLNs with EQ 1 may be promising formulation to regulate the membrane charge of iPSCs during neuronal differentiation. ..
  19. Kuo Y, Rajesh R. Targeted delivery of rosmarinic acid across the blood-brain barrier for neuronal rescue using polyacrylamide-chitosan-poly(lactide-co-glycolide) nanoparticles with surface cross-reacting material 197 and apolipoprotein E. Int J Pharm. 2017;528:228-241 pubmed publisher
    ..Thus, CRM197-ApoE-RA-PAAM-CH-PLGA NPs can be a promising formulation to deliver RA to A?-insulted neurons in the pharmacotherapy of Alzheimer's disease. ..
  20. Kuo Y, Ku H, Rajesh R. Chitosan/γ-poly(glutamic acid) scaffolds with surface-modified albumin, elastin and poly-l-lysine for cartilage tissue engineering. Mater Sci Eng C Mater Biol Appl. 2017;78:265-277 pubmed publisher
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    Kuo Y. Loading efficiency of stavudine on polybutylcyanoacrylate and methylmethacrylate-sulfopropylmethacrylate copolymer nanoparticles. Int J Pharm. 2005;290:161-72 pubmed
    ..These outcomes imply that for oral administration, D4T-loaded MMA-SPM NPs may be more advantageous than D4T-loaded PBCA NPs, and D4T-loaded PBCA NPs may be more favorable than D4T-loaded MMA-SPM NPs for intravenous injection...
  22. Kuo Y, Chung C. Solid lipid nanoparticles comprising internal Compritol 888 ATO, tripalmitin and cacao butter for encapsulating and releasing stavudine, delavirdine and saquinavir. Colloids Surf B Biointerfaces. 2011;88:682-90 pubmed publisher
    ..The order of drug in the cumulative release percentage was D4T>DLV>SQV. SLNs containing Compritol 888 ATO, tripalmitin, and cacao butter are efficient in carrying antiretroviral agents for medicinal application...