Yao Haur Kuo

Summary

Affiliation: National Research Institute of Chinese Medicine
Country: Taiwan

Publications

  1. ncbi Cytotoxic phenylpropanoids and a new triterpene, turformosinic acid, from Turpinia formosana Nakai
    Hui Chi Huang
    School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
    Molecules 17:1837-51. 2012
  2. ncbi Flavanone and diphenylpropane glycosides and glycosidic acyl esters from Viscum articulatum
    Yu Jen Kuo
    Division of Herbal Drugs and Natural Products, National Research Institute of Chinese Medicine, Taipei 112, Taiwan, Republic of China
    J Nat Prod 73:109-14. 2010
  3. ncbi Cytotoxic phenylpropanoid glycosides from the stems of Smilax china
    Yao Haur Kuo
    National Research Institute of Chinese Medicine, Taipei, 112 Taiwan, Republic of China
    J Nat Prod 68:1475-8. 2005
  4. ncbi Syntheses of C(18) dibenzocyclooctadiene lignan derivatives as anti-HBsAg and anti-HBeAg agents
    Yao Haur Kuo
    National Research Institute of Chinese Medicine, NO 155 1, Li Nong St, Sec 2, Shih Pai, Taipei 112, Taiwan
    Bioorg Med Chem 13:1555-61. 2005
  5. ncbi New anti-inflammatory and anti-proliferative constituents from fermented red mold rice Monascus purpureus NTU 568
    Ya Wen Hsu
    Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan
    Molecules 15:7815-24. 2010
  6. ncbi Taiwankadsurins A, B, and C, three new C19 homolignans from Kadsura philippinensis
    Ya Ching Shen
    Department of Marine Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    Org Lett 7:5297-300. 2005
  7. ncbi Antihepatitis activity (anti-HBsAg and anti-HBeAg) of C19 homolignans and six novel C18 dibenzocyclooctadiene lignans from Kadsura japonica
    Yao Haur Kuo
    National Research Institute of Chinese Medicine, Shih Pai, Taipei, Taiwan, R O C
    Planta Med 71:646-53. 2005
  8. ncbi Cytotoxic clerodane diterpenoids from Casearia membranacea
    Ya Ching Shen
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 68:1665-8. 2005
  9. ncbi Antioxidant and anti-inflammatory phenylpropanoid derivatives from Calamus quiquesetinervius
    Chao Lin Chang
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China
    J Nat Prod 73:1482-8. 2010
  10. ncbi C18 dibenzocyclooctadiene lignans from Kadsura philippinensis
    Ya Ching Shen
    Department of Marine Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 69:963-6. 2006

Collaborators

Detail Information

Publications79

  1. ncbi Cytotoxic phenylpropanoids and a new triterpene, turformosinic acid, from Turpinia formosana Nakai
    Hui Chi Huang
    School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
    Molecules 17:1837-51. 2012
    ..Compound 3 induced intrinsic apoptotic pathway in Hep2 cells with dose and time dependence (10 μg/mL for 8 h)...
  2. ncbi Flavanone and diphenylpropane glycosides and glycosidic acyl esters from Viscum articulatum
    Yu Jen Kuo
    Division of Herbal Drugs and Natural Products, National Research Institute of Chinese Medicine, Taipei 112, Taiwan, Republic of China
    J Nat Prod 73:109-14. 2010
    ..Biological evaluation showed that 1, 2, and 10 exhibited antioxidant activity using a DPPH method and that compounds 1, 3, and 11 were active in a lipopolysaccharide-induced nitric oxide assay...
  3. ncbi Cytotoxic phenylpropanoid glycosides from the stems of Smilax china
    Yao Haur Kuo
    National Research Institute of Chinese Medicine, Taipei, 112 Taiwan, Republic of China
    J Nat Prod 68:1475-8. 2005
    ..Structural elucidation of isolates 1-6 was based on spectroscopic data analysis. These new phenylpropanoids were evaluated against several human tumor cell lines...
  4. ncbi Syntheses of C(18) dibenzocyclooctadiene lignan derivatives as anti-HBsAg and anti-HBeAg agents
    Yao Haur Kuo
    National Research Institute of Chinese Medicine, NO 155 1, Li Nong St, Sec 2, Shih Pai, Taipei 112, Taiwan
    Bioorg Med Chem 13:1555-61. 2005
    ..Among these active C(18) dibenzocyclooctadiene lignan analogues, the lignan with a but-3-enoyl group (6) exhibited the most active inhibition...
  5. ncbi New anti-inflammatory and anti-proliferative constituents from fermented red mold rice Monascus purpureus NTU 568
    Ya Wen Hsu
    Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan
    Molecules 15:7815-24. 2010
    ..Furthermore, 1-4 also showed moderate antiproliferative effects against human laryngeal carcinoma (HEp-2) (IC(50) = 14.81~20.06 μg/mL) and human colon adenocarcinoma (WiDr) (IC(50) = 12.89~21.14 μg/mL)...
  6. ncbi Taiwankadsurins A, B, and C, three new C19 homolignans from Kadsura philippinensis
    Ya Ching Shen
    Department of Marine Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    Org Lett 7:5297-300. 2005
    ..Compound 2 exhibited mild cytotoxicity against human KB and Hela tumor cells...
  7. ncbi Antihepatitis activity (anti-HBsAg and anti-HBeAg) of C19 homolignans and six novel C18 dibenzocyclooctadiene lignans from Kadsura japonica
    Yao Haur Kuo
    National Research Institute of Chinese Medicine, Shih Pai, Taipei, Taiwan, R O C
    Planta Med 71:646-53. 2005
    ..9 and 11.9 microM for taiwanschirins A and B, respectively)...
  8. ncbi Cytotoxic clerodane diterpenoids from Casearia membranacea
    Ya Ching Shen
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 68:1665-8. 2005
    ..The cytotoxic activities of the isolated diterpenoids against human oral epidermoid (KB), medulla (Med), and colon (DLD-1) cancer cell lines were evaluated...
  9. ncbi Antioxidant and anti-inflammatory phenylpropanoid derivatives from Calamus quiquesetinervius
    Chao Lin Chang
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China
    J Nat Prod 73:1482-8. 2010
    ..6-8.4 μM). Of the tested isolates, compounds 4-6 and 9 showed potent inhibition (IC(50) 9.2-29.5 μM) of LPS-stimulated NO production when compared with a positive control substance, quercetin (IC(50) 34.5 μM)...
  10. ncbi C18 dibenzocyclooctadiene lignans from Kadsura philippinensis
    Ya Ching Shen
    Department of Marine Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 69:963-6. 2006
    ..The configurations of the biphenyl and cyclooctadiene moieties were deduced from circular dichroism (CD) and NOESY NMR spectra, respectively. Some of the compounds showed radical-scavenging activity in a DPPH-HPLC method...
  11. ncbi A novel NO-production-inhibiting triterpene and cytotoxicity of known alkaloids from Euonymus laxiflorus
    Yao Haur Kuo
    National Research Institute of Chinese Medicine, NO 155 1, Li Nong Street, Section 2, Shih Pai, Taipei, 112, Taiwan, Republic of China
    J Nat Prod 66:554-7. 2003
    ..Structural elucidations of these compounds were established by spectral analysis. Compound 1 displayed significant nitric oxide (NO) inhibitory effect...
  12. ncbi Triterpene acids from Euscaphis japonica and assessment of their cytotoxic and anti-NO activities
    Li Jie Zhang
    National Research Institute of Chinese Medicine, Taipei, Taiwan
    Planta Med 78:1584-90. 2012
    ..64 ± 0.87, 2.11 ± 1.54, 1.73 ± 0.64 µM, respectively). Some of the isolated triterpenoids showed marginal inhibitions on NO production induced by LPS...
  13. ncbi Asterolaurins A-F, xenicane diterpenoids from the Taiwanese soft coral Asterospicularia laurae
    Yu Chi Lin
    School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan, Republic of China
    J Nat Prod 72:1911-6. 2009
    ..Asterolaurin A (1) exhibited moderate cytotoxicity against HepG2 cells with an IC50 of 8.9 microM, while asterolaurin D (4) showed potent inhibition of elastase release and superoxide anion generation in vitro...
  14. ncbi Kadsuphilols A-H, oxygenated lignans from Kadsura philippinensis
    Ya Ching Shen
    School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan 100, Republic of China
    J Nat Prod 70:1139-45. 2007
    ..The in vitro radical-scavenging activities of these compounds using DPPH were tested and evaluated. Compound 3 exhibited more potent activity than vitamins C and E...
  15. ncbi Scabrolides A-D, four new norditerpenoids isolated from the soft coral Sinularia scabra
    Jyh Horng Sheu
    Department of Marine Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 65:1904-8. 2002
    ..The epimeric metabolites 6 and 7 have been shown to exhibit strong cytotoxic activity against KB and Hepa59T/VGH cancer cell lines...
  16. ncbi New bioactive clerodane diterpenoids from the roots of Casearia membranacea
    Ching Yu Chen
    Center of General Education, Tzu Hui Institute of Technology, Kaohsiung, Taiwan, Republic of China
    Chem Biodivers 5:162-7. 2008
    ..Caseamembrin T (2) exhibited the most potent activity against Daoy cells (ED(50)=10 ng/ml), superior to that of the standard drug mitomycin...
  17. ncbi Four new nonaoxygenated C18 dibenzocylcooctadiene lignans from Kadsura philippinensis
    Ya Ching Shen
    School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan
    Chem Pharm Bull (Tokyo) 55:280-3. 2007
    ..The stereochemistries of the biphenyl and octadiene moieties were deduced from circular dichorism (CD) and the NOESY spectra, respectively. The in vitro antiplatelet aggregation activity of metabolites 1-4 also have been evaluated...
  18. ncbi Induction of apoptosis in human breast adenocarcinoma cells MCF-7 by monapurpyridine A, a new azaphilone derivative from Monascus purpureus NTU 568
    Li Chuan Hsu
    Department of Biochemical Science and Technology, National Taiwan University, Taipei 10617, Taiwan
    Molecules 17:664-73. 2012
    ..All evidence supported that MPA was suitable for developing into a chemotherapeutic or chemopreventive agent against breast cancer...
  19. ncbi Tasumatrols U-Z, taxane diterpene esters from Taxus sumatrana
    Ya Ching Shen
    School of Pharmacy, College of Medicine, National Taiwan University, Jen Ai Rd Sec 1, Taipei 100, Taiwan
    J Nat Prod 71:576-80. 2008
    ..The structures were established on the basis of detailed spectroscopic analyses, particularly HRESIMS and 2D NMR techniques. Compound 5 showed cytotoxicity against a human hepatoma (Hep2) cell line...
  20. ncbi Frajunolides E-K, briarane diterpenes from Junceella fragilis
    Chia Ching Liaw
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 71:1551-6. 2008
    ..The structures of 1-7 were determined by analysis of HRESIMS and 2D NMR spectroscopic data. Cytotoxicity and in vitro anti-inflammatory activities of compounds 1-7 were also evaluated...
  21. ncbi Chemical transformation and biological activities of ambrein, a major product of ambergris from Physeter macrocephalus (sperm whale)
    Ya Ching Shen
    School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan 100, Republic of China
    J Nat Prod 70:147-53. 2007
    ..The anti-inflammatory activities of 1-11, in terms of the inhibition of human neutrophil function, were also evaluated...
  22. ncbi New isoflavonoid glycosides and related constituents from astragali radix ( Astragalus membranaceus ) and their inhibitory activity on nitric oxide production
    Li Jie Zhang
    National Research Institute of Chinese Medicine, Taipei 112, Taiwan, Republic of China
    J Agric Food Chem 59:1131-7. 2011
    ..Furthermore, characteristic peaks for the 11 major compounds in the chromatogram were unambiguously confirmed...
  23. ncbi Labdane diterpenoid glycosides from Alpinia densespicata and their nitric oxide inhibitory activities in macrophages
    Yu Jen Kuo
    National Research Institute of Chinese Medicine, Taipei, Taiwan, Republic of China
    J Nat Prod 72:1097-101. 2009
    ..Structural elucidation of compounds 1-6 was based on spectroscopic data. Compounds 1-9 all exhibited moderate NO inhibitory activities, whereas they were noncytotoxic at 20 microM against several human tumor cell lines...
  24. ncbi Cytotoxic polyisoprenyl benzophenonoids from Garcinia subelliptica
    Li Jie Zhang
    National Research Institute of Chinese Medicine, Taipei 112, Taiwan, Republic of China
    J Nat Prod 73:557-62. 2010
    ..Biological evaluation showed that all compounds 1-9 exhibited cytotoxic activity against a small panel of human tumor cell lines (A549, DU145, KB, vincristine-resistant KB)...
  25. ncbi Arisanschinins A-E, lignans from Schisandra arisanensis hay
    Chin Cheng Liu
    College of Medicine, National Taiwan University, Taipei, Taiwan
    Planta Med 76:1605-10. 2010
    ..Compound 1 showed significant inhibition of α-glucosidase IN VITRO. The radical-scavenging activities of these compounds were evaluated using DPPH...
  26. ncbi Protective effect of deferricoprogen isolated from Monascus purpureus NTU 568 on citrinin-induced apoptosis in HEK-293 cells
    Li Chuan Hsu
    Department of Biochemical Science and Technology, College of Life Science, National Taiwan University, Taipei 106, Taiwan, Republic of China
    J Agric Food Chem 60:7880-5. 2012
    ..DFC was found to be protective against the cytotoxicity and cell death induced by citrinin on human embryonic kidney (HEK-293) cells. DFC also demonstrated anti-apoptotic property in preventing citrinin-induced apoptosis...
  27. ncbi Chromanones and dihydrocoumarins from Calophyllum blancoi
    Ya Ching Shen
    Institute of Marine Resources, National Sun Yat Sen University, Taiwan, Republic of China
    Chem Pharm Bull (Tokyo) 52:402-5. 2004
    ..Compounds 3, 4, 5, 7, and 8 showed mild activity against KB (human oral epidermoid carcinoma) and Hela (human cervical epitheloid carcinoma) tumor cell lines...
  28. ncbi A novel cytotoxic C-methylated biflavone, taiwanhomoflavone-B from the twigs of Cephalotaxus wilsoniana
    Yao Haur Kuo
    National Research Institute of Chinese Medicine, Taipei, Taiwan, R O C
    Chem Pharm Bull (Tokyo) 50:1607-8. 2002
    ..The structure of 1 was elucidated on the basis of spectroscopic analysis. Taiwanhomoflavone-B is cytotoxic with ED(50) values of 3.8 and 3.5 microg/ml, against KB oral epidermoid carcinoma and Hepa-3B hepatoma cells, respectively...
  29. ncbi New taxane diterpenoids from the roots of Taiwanese Taxus mairei
    Ya Ching Shen
    Institute of Marine Resources, National Sun Yat Sen University, Kaohsiung, Taiwan, Republic of China
    Chem Pharm Bull (Tokyo) 50:781-7. 2002
    ....
  30. ncbi Triterpenoidal saponins from Hydrocotyle sibthorpioides
    Hui Chi Huang
    National Research Institute of Chinese Medicine, Shih Pai, Taipei, Taiwan, ROC
    Phytochemistry 69:1597-603. 2008
    ..Biological evaluation established that saponins possessing four sugar units (three d-glucoses and one l-arabinose) (4-7) exhibited moderate cytotoxicity against KB, Daoy and WiDr human tumor cell lines...
  31. ncbi Cembrane diterpenoids from the taiwanese soft coral Sarcophyton stolidotum
    Yuan Bin Cheng
    Institute of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 71:1141-5. 2008
    ..Sarcostolide E (5) exhibited weak to moderate cytotoxic activity against human WiDr and Daoy tumor cell lines. A biogenetic pathway and relationship for compounds 1-7 was also proposed...
  32. ncbi Anti-inflammatory cembranoids from the soft corals Sinularia querciformis and Sinularia granosa
    Yi Lu
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 71:1754-9. 2008
    ..However, compounds 3, 7, and 8 significantly inhibited the accumulation of the pro-inflammatory iNOS and COX-2 proteins in LPS-stimulated RAW264.7 macrophage cells...
  33. ncbi Antioxidant and anti-nitric oxide components from Quercus glauca
    Chien Chang Shen
    National Research Institute of Chinese Medicine, Taipei 112, Taiwan, ROC
    Chem Pharm Bull (Tokyo) 60:924-9. 2012
    ..Moreover, compounds 9 and 14 strongly inhibited nitric oxide (NO) production with IC<inf>50</inf> values of 8.25 and 14.04 µM, respectively, and compounds 1, 4-6, 14, and 15 showed moderate antioxidant activities...
  34. ncbi Frajunolides L-O, four new 8-Hydroxybriarane diterpenoids from the Gorgonian Junceella fragilis
    Chia Ching Liaw
    School of Pharmacy, College of Medicine, National Taiwan University, Taipei
    Mar Drugs 9:1477-86. 2011
    ..Compounds 1 and 4 showed weak anti-inflammatory activity as tested by superoxide anion generation and elastase release by human neutrophil in response to fMLP/CB. Compound 3 showed selective inhibition on elastase release in vitro...
  35. ncbi New bioactive orange pigments with yellow fluorescence from Monascus-fermented dioscorea
    Ya Wen Hsu
    Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan, ROC
    J Agric Food Chem 59:4512-8. 2011
    ..7 cells. Compounds 1-4 also exhibited antiproliferative activities against human laryngeal carcinoma (HEp-2) and human colon adenocarinoma (WiDr)...
  36. ncbi Antioxidant phenylpropanoid glycosides from Smilax bracteata
    Lijie Zhang
    National Research Institute of Chinese Medicine, Taipei 112, Taiwan, ROC
    Phytochemistry 69:1398-404. 2008
    ..Their structures were elucidated on the basis of spectroscopic analyses. Moreover, 1-6 exhibited moderate scavenging activities against DPPH radicals...
  37. ncbi Effects of Monascus-fermented rice extract on malignant cell-associated neovascularization and intravasation determined using the chicken embryo chorioallantoic membrane model
    Bing Ying Ho
    Institute of Microbiology and Biochemistry, College of Life Science, National Taiwan University, Taipei, Taiwan
    Integr Cancer Ther 9:204-12. 2010
    ..In summary, Monascus-fermented products exert a potent effect on tumor growth and activation, suggesting that they may serve as supplementary agents in adjuvant cancer therapy...
  38. ncbi Two novel sesquiterpene lactones, cytotoxic vernolide-A and -B, from Vernonia cinerea
    Yao Haur Kuo
    National Research Institute of Chinese Medicine, Shih Pai, Taipei, Taiwan, R O C
    Chem Pharm Bull (Tokyo) 51:425-6. 2003
    ..02, 0.05, 0.53, 0.04 microg/ml for KB, DLD-1, NCI-661, and Hela, respectively); vernolide-B had marginal cytoxicity (ED(50)=3.78, 5.88, 6.42 microg/ml for KB, NCI-661, and Hela, respectively)...
  39. ncbi Oxygenated lignans from the fruits of Schisandra arisanensis
    Yuan Bin Cheng
    School of Pharmacy, College of Medicine, National Taiwan University, Jen Ai Road Sec 1, Taipei 100, Taiwan, Republic of China
    J Nat Prod 72:1663-8. 2009
    ..The structure of compound 1 was confirmed by X-ray crystallographic analysis. Immunomodulatory activity of the isolated lignans was tested and evaluated...
  40. ncbi Cytotoxic constituents from Podocarpus fasciculus
    Yu Jen Kuo
    National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC
    Chem Pharm Bull (Tokyo) 56:585-8. 2008
    ..Preliminary structure-activity relationship studies of the isolated diterpenoids and biflavonoids are discussed...
  41. ncbi Laxifolone A suppresses LPS/IFN-gamma-induced NO synthesis by attenuating NF-kappaB translocation: role of NF-kappaB p105 level
    Han Chieh Ko
    Division of Basic Chinese Medical Research, National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC
    Planta Med 71:514-9. 2005
    ..In summary, these results suggest that inhibition of NF-kappaB p105 degradation in cytoplasm may participate in the abrogation of LPS/IFN-gamma-induced NF-kappaB translocation and subsequent NO synthesis by laxifolone A...
  42. ncbi Anti-tumor and anti-inflammatory properties of ankaflavin and monaphilone A from monascus purpureus NTU 568
    Li Chuan Hsu
    Department of Biochemical Science and Technology, College of Life Science, National Taiwan University, Taipei 106, Taiwan, Republic of China
    J Agric Food Chem 59:1124-30. 2011
    ..7 cells. All evidence support that azaphilonidal derivatives from M. purpureus NTU 568, such as AK and MA, are suitable for the development of chemotherapy or chemopreventive agents...
  43. ncbi New dammarane-type saponins from the galls of Sapindus mukorossi
    Yao Haur Kuo
    National Research Institute of Chinese Medicine, Taipei 112, Taiwan, Republic of China
    J Agric Food Chem 53:4722-7. 2005
    ....
  44. ncbi A novel compound with antioxidant activity produced by Serratia ureilytica TKU013
    Yao Haur Kuo
    National Research Institute of Chinese Medicine, Taipei 112, Taiwan
    J Agric Food Chem 60:9043-7. 2012
    ..Furthermore, the major secondary metabolites of EtOAc extract of the cultured supernatant were examined by the fingerprinting data of the HPLC system...
  45. ncbi Monaphilones A-C, three new antiproliferative azaphilone derivatives from Monascus purpureus NTU 568
    Ya Wen Hsu
    Institute of Microbiology and Biochemistry, National Taiwan University, Taipei, Taiwan, Republic of China
    J Agric Food Chem 58:8211-6. 2010
    ....
  46. ncbi Cespihypotins Q-V, verticillene diterpenoids from Cespitularia hypotentaculata
    Ya Ching Shen
    School of Pharmacy, College of Medicine, National Taiwan University, Jen Ai Road, Sec 1, Taipei 100, Taiwan, Republic of China
    J Nat Prod 71:1993-7. 2008
    ..The relative configuration was deduced by interpretation of NOESY spectra. Cespihypotin T exhibited significant cytotoxic activity against human Daoy and WiDr tumor cell lines...
  47. ncbi Synchronous high-performance liquid chromatography with a photodiode array detector and mass spectrometry for the determination of citrinin, monascin, ankaflavin, and the lactone and acid forms of monacolin K in red mold rice
    Cheng Lun Wu
    Sunway Biotechnology Co, R and D Division, Taipei, Taiwan, Republic of China
    J AOAC Int 94:179-90. 2011
    ..05% trifluoroacetic acid in acetonitrile-water (62.5 + 37.5, v/v)...
  48. ncbi Maleimide and maleic anhydride derivatives from the mycelia of Antrodia cinnamomea and their nitric oxide inhibitory activities in macrophages
    Ming Der Wu
    Food Industry Research and Development Institute, No 331, Shih Pin Road, Hsinchu 300, Taiwan, Republic of China
    J Nat Prod 71:1258-61. 2008
    ..Structural elucidation of compounds 1-4 was carried out by spectroscopic data. Compound 1 displayed significant inhibitory effect on nitric oxide (NO) production...
  49. ncbi Antiproliferative and hypoglycemic cucurbitane-type glycosides from the fruits of Momordica charantia
    Ping Chun Hsiao
    Divison of Herbal Drugs and Natural Products, National Research Institute of Chinese Medicine, Taipei 112, Taiwan
    J Agric Food Chem 61:2979-86. 2013
    ..In addition, compound 14 showed potent hypoglycemic activities by glucose uptake assay...
  50. ncbi Ajugalide-B (ATMA) is an anoikis-inducing agent from Ajuga taiwanensis with antiproliferative activity against tumor cells in vitro
    Chun Tang Chiou
    Division of Herbal Medicine and Natural Product, National Research Institute of Chinese Medicine, Taipei 112, Taiwan, Republic of China
    Phytochemistry 80:64-9. 2012
    ..Furthermore, ATMA also blocks anchorage-independent growth and cell migration and, therefore, ATMA may serve as a lead compound for the developing of anti-cancer therapeuties with anoikis-inducing properties...
  51. ncbi New cytotoxic prostanoids from Taiwanese soft coral Clavularia viridis
    Ya Ching Shen
    School of Pharmacy, College of Medicine, National Taiwan University, No 1 Jen Ai Road Sect 1, Taipei, Taiwan, Republic of China
    Chem Biodivers 7:2702-8. 2010
    ..Pharmacological studies revealed that compounds 1-4 exhibited potent cytotoxicity against human cancer cells...
  52. ncbi Bioactive xenicane diterpenoids from the Taiwanese soft coral Asterospicularia laurae
    Yun Sheng Lin
    School of Pharmacy, College of Medicine, National Taiwan University, Jen Ai Rd Sec 1, Taipei 100, Taiwan, Republic of China
    Chem Biodivers 8:1310-7. 2011
    ..Their chemical structures were determined through extensive spectroscopic analyses ((1) H- and (13) C-NMR, (1) H,(1) H-COSY, HMBC, and NOESY). Compound 2 exhibited cytotoxic activity against HEp-2, Daoy, MCF-7, and WiDr tumor cells...
  53. ncbi The anti-HBsAg (human type B hepatitis, surface antigen) and anti-HBeAg (human type B hepatitis, e antigen) C18 dibenzocyclooctadiene lignans from Kadsura matsudai and Schizandra arisanensis
    Ming Der Wu
    Department of Chemistry, National Sun Yat Sen University, Kaohsiung, Taiwan
    Chem Pharm Bull (Tokyo) 51:1233-6. 2003
    ..Preliminary structure-activity relationship studies for these isolated lignans are also discussed...
  54. ncbi Isolation and identification of a novel antioxidant with antitumour activity from Serratia ureilytica using squid pen as fermentation substrate
    Yao Haur Kuo
    Division of Herbal Medicines and Natural Products, National Research Institute of Chinese Medicine, Taipei, 112, Taiwan
    Mar Biotechnol (NY) 13:451-61. 2011
    ..The structure of Serranticin is analogous to that of siderophores (hexacoordinated catecholamine), which are iron chelators. As such, Serranticin has the potential for use as a deferration agent in various iron overload diseases...
  55. ncbi Synthesis of 1-substituted carbazolyl-1,2,3,4-tetrahydro- and carbazolyl-3,4-dihydro-β-carboline analogs as potential antitumor agents
    Ya Ching Shen
    School of Pharmacy, National Taiwan University, Taipei 100, Taiwan
    Mar Drugs 9:256-77. 2011
    ..The structure and activity relationship (SAR) study revealed correlation between carbon numbers of the side chain and biological activities. The molecular complex with DNA for compound 2 was proposed...
  56. ncbi New taxane diterpenoids from the leaves and twigs of Taxus sumatrana
    Ya Ching Shen
    Institute of Marine Resources, National Sun Yat Sen University, 70 Lien Hai Road, Kaohsiung, Taiwan 80424, Republic of China
    J Nat Prod 65:1848-52. 2002
    ..Taxuspine F and compound 5 possessed moderate activity against Hepa cells only, while 3, 6, 7, and 10-deacetylbaccatin III showed only marginal activity against Hepa cells...
  57. ncbi Simplexins A-I, eunicellin-based diterpenoids from the soft coral Klyxum simplex
    Shwu Li Wu
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 72:994-1000. 2009
    ..Compound 5 was shown to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 proteins in LPS-stimulated RAW264.7 macrophage cells...
  58. ncbi New beta-caryophyllene-derived terpenoids from the soft coral Sinularia nanolobata
    Atallah F Ahmed
    Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 67:592-7. 2004
    ..The cytotoxicity of 1-6 against the growth of a limited panel of cancer cell lines is also described...
  59. ncbi Two new subergane-based sesquiterpenes from a Taiwanese Gorgonian coral Subergorgia suberosa
    Guey-Horng Wang
    Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 65:1033-6. 2002
    ..Subergorgiol (1) may be the biosynthetic precursor of 2-6. Compound 3 was found to exhibit moderate cytotoxicity against the growth of HeLa cancer cells...
  60. ncbi Cespitulactones A and B, new diterpenoids from Cespitularia taeniata
    Ya Ching Shen
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, ROC
    Bioorg Med Chem Lett 16:2369-72. 2006
    ..Their structures were elucidated on the basis of extensive spectroscopic analysis and chemical derivatization. The isolated compounds were also evaluated for cytotoxicity toward human cancer cell lines...
  61. ncbi Xenicane-type diterpenes with cytotoxicity from Xenia florida
    Yuan-Bin Cheng
    Institute of Marine Resources, National Sun Yat-Sen University, 70 Lien-Hai Road, Kaohsiung, Taiwan 80424, Republic of China
    J Nat Prod 69:675-8. 2006
    ..The absolute configuration of 1 was determined by NOESY, CD, and Mosher's methods. Florxenilides A (1) and B (2) exhibited cytotoxicity against human colon cancer (WiDr) cells at 4.5 and 3.7 muM, respectively...
  62. ncbi Oxygenated terpenoids from a formosan soft coral Sinularia gibberosa
    Atallah F Ahmed
    Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 68:1208-12. 2005
    ..Metabolites 2 and 4 were found to exhibit moderate cytotoxicity toward a human liver carcinoma cell line...
  63. ncbi New cytotoxic 6-oxygenated 8,9-dihydrofurocoumarins, hedyotiscone A - C, from Hedyotis biflora
    Yung Husan Chen
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan, R O C
    Planta Med 72:75-8. 2006
    ..4, 17.4, 4.9, 8.0, and 9.2 microg/mL, respectively. Ursolic acid showed significant cytotoxicity against MDA-MB-231 cells (human breast carcinoma cells) with an IC50 value of 1.49 microg/mL...
  64. ncbi Schizandra arisanensis extract attenuates cytokine-mediated cytotoxicity in insulin-secreting cells
    Yi Shin Hsu
    Division of Herbal Drugs and Natural Products, National Research Institute of Chinese Medicine, Taipei 112, Taiwan, China
    World J Gastroenterol 18:6809-18. 2012
    ..To explore the bioactivity of an ethanolic extract of Schizandra arisanensis (SA-Et) and isolated constituents against interleukin-1β and interferon-γ-mediated β cell death and abolition of insulin secretion...
  65. ncbi Manaarenolides A-I, diterpenoids from the soft coral Sinularia manaarensis
    Jui-Hsin Su
    Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 69:1134-9. 2006
    ..The biosynthetic relationship between these new metabolites and 10 and 11 is also discussed...
  66. ncbi Scabrolides E-G, three new norditerpenoids from the soft coral Sinularia scabra
    Atallah F Ahmed
    Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 67:2079-82. 2004
    ..Metabolite 1 was found to exhibit significant cytotoxicity against the growth of Hepa59T/VGH and KB cell lines...
  67. ncbi Anti-platelet aggregation triterpene saponins from the galls of Sapindus mukorossi
    Hui Chi Huang
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan
    Chem Pharm Bull (Tokyo) 55:1412-5. 2007
    ..Their structures were elucidated on the basis of spectroscopic analysis and chemical hydrolysis. Biological evaluation showed that both sapinmusaponins Q and R demonstrated more potent anti-platelet aggregation activity than aspirin...
  68. ncbi The metabolic benefits of Polygonum hypoleucum Ohwi in HepG2 cells and Wistar rats under lipogenic stress
    Pei Min Chao
    Institute of Nutrition, China Medical University, Taichung, Taiwan
    J Agric Food Chem 58:5174-80. 2010
    ..These results confirm that P. hypoleucum Ohwi, acting partly through ACC inhibition, has favorable effects in alleviating metabolic disturbances occurring under lipogenic conditions...
  69. ncbi Astragalus membranaceus flavonoids (AMF) ameliorate chronic fatigue syndrome induced by food intake restriction plus forced swimming
    Yao Haur Kuo
    National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC
    J Ethnopharmacol 122:28-34. 2009
    ..Alteration of immune function may be associated with chronic fatigue syndrome (CFS) and this study reveals the immunoregulatory effect of Astragalus membranaceus flavonoids (AMF)...
  70. ncbi Administration of a decoction of sucrose- and polysaccharide-rich radix astragali (huang qi) ameliorated insulin resistance and Fatty liver but affected Beta-cell function in type 2 diabetic rats
    Yi Chen Juan
    Institute of Pharmacology, Yang Ming University, Taipei 112, Taiwan
    Evid Based Complement Alternat Med 2011:349807. 2011
    ..In conclusion, a proper administration dosage and a reduction in the sucrose content are keys to maximizing the merits of this herb...
  71. ncbi Evaluation of caffeic acid amide analogues as anti-platelet aggregation and anti-oxidative agents
    Chia-Cheng Hung
    National Research Institute of Chinese Medicine, Shin-Pai, Taipei 112, Taiwan
    Bioorg Med Chem 13:1791-7. 2005
    ..This study also exhibited that caffeic anilides displayed more potent anti-oxidative activity in the radical scavenging activity assay than trolox and vitamin E...
  72. ncbi Sapinmusaponins F-J, bioactive tirucallane-type saponins from the galls of Sapindus mukorossi
    Hui-Chi Huang
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China
    J Nat Prod 69:763-7. 2006
    ..Compounds 1-5 also showed moderate activity in a 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced Epstein-Barr virus early antigen (EBV-EA) activation assay...
  73. ncbi Neolemnane-type sesquiterpenoids from a formosan soft coral Paralemnalia thyrsoides
    Ho Cheng Huang
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung, Taiwan
    Chem Pharm Bull (Tokyo) 55:876-80. 2007
    ..Cytotoxicity of these metabolites toward a limited panel of cancer cell lines also is reported...
  74. ncbi Triterpenoid saponins from the fruits and galls of Sapindus mukorossi
    Hui Chi Huang
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
    Phytochemistry 69:1609-16. 2008
    ..Their structures were elucidated by 1D and 2D NMR spectroscopic techniques and acid hydrolysis. Biological evaluation indicated that saponins 1-4 and 7-13 showed moderate cytotoxicity against several human tumor cell lines...
  75. ncbi Synthesis and antitumor activity of cis-dichloroplatinum(II) complexes of 1-(2-aminophenyl)-1,2,3,4-tetrahydroisoquinolines
    Chen-Yuan Kuo
    Department of Biological Engineering, Yung-Ta Institute of Technology and Commerce, Pingtung, Taiwan, ROC
    Eur J Med Chem 41:940-9. 2006
    ..The "trans influence" dominates the control of the stability of [1-(2-aminophenyl)-1,2,3,4-THIQ]dichloroplatinums(II)...
  76. ncbi New nitrogen-containing sesquiterpenoids from the Taiwanese soft coral Cespitularia taeniata May
    Yuan Bin Cheng
    School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC
    Chem Biodivers 6:1266-72. 2009
    ..The in vitro cytotoxic activities of the isolated metabolites were tested against KB, Daoy, and WiDr cell lines. A biogenetic pathway for these novel compounds was proposed...
  77. ncbi DNA topoisomerase I inhibitor, ergosterol peroxide from Penicillium oxalicum
    Li-Ming Yang Kuo
    National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC
    Planta Med 71:77-9. 2005
    ..56 microg/mL]...
  78. ncbi Molluscicidal saponins from Sapindus mukorossi, inhibitory agents of golden apple snails, Pomacea canaliculata
    Hui Chi Huang
    Graduate Institute of Natural Products, Kaohsiung Medical University, 100, Shi Chuan first Rd, Kaohsiung, Taiwan
    J Agric Food Chem 51:4916-9. 2003
    ..The bioassay data revealed that 1-7 were molluscicidal, causing 70-100% mortality at 10 ppm against the golden apple snail...
  79. ncbi 1alpha,3beta,5beta-trihydroxy-24-methylenecholestan-6-one: a novel steroid from a soft coral Sinularia gibberosa
    Atallah F Ahmed
    Department of Marine Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, ROC
    Steroids 68:377-81. 2003
    ..Gibberoketosterol is the first example of 1alpha,3beta,5beta-trihydroxy-6-oxosteroids isolated from natural sources and was found to exhibit a moderate cytotoxicity against the growth of Hepa59T/VGH cancer cells...