Sung Hsin Kuo

Summary

Affiliation: National Taiwan University
Country: Taiwan

Publications

  1. pmc Clinicopathologic features and responses to radiotherapy of myeloid sarcoma
    Wan Yu Chen
    Division of Radiation Oncology, Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Radiat Oncol 8:245. 2013
  2. doi request reprint Lack of compensatory pAKT activation and eIF4E phosphorylation of lymphoma cells towards mTOR inhibitor, RAD001
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital, Taiwan
    Eur J Cancer 47:1244-57. 2011
  3. ncbi request reprint Nuclear expression of BCL10 or nuclear factor kappa B helps predict Helicobacter pylori-independent status of low-grade gastric mucosa-associated lymphoid tissue lymphomas with or without t(11;18)(q21;q21)
    Kun Huei Yeh
    Department of Oncology, National Taiwan University Hospital, No 7, Chung Shan S Rd, Taipei, Taiwan
    Blood 106:1037-41. 2005
  4. doi request reprint Combinations of mTORC1 inhibitor RAD001 with gemcitabine and paclitaxel for treating non-Hodgkin lymphoma
    Chun Te Chiang
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Cancer Lett 298:195-203. 2010
  5. ncbi request reprint Expression of CD86 and increased infiltration of NK cells are associated with Helicobacter pylori-dependent state of early stage high-grade gastric MALT lymphoma
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital, No 7, Chung Shan South Road, Taipei, Taiwan, China
    World J Gastroenterol 11:4357-62. 2005
  6. ncbi request reprint Phase II study of weekly paclitaxel and 24-hour infusion of high-dose 5-fluorouracil and leucovorin in the treatment of recurrent or metastatic gastric cancer
    Kun Huei Yeh
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Oncology 69:88-95. 2005
  7. ncbi request reprint Effects of glucocorticoids on the growth and chemosensitivity of carcinoma cells are heterogeneous and require high concentration of functional glucocorticoid receptors
    Yen Shen Lu
    Department of Oncology, National Taiwan University Hospital, Taipei 10016, Taiwan, China
    World J Gastroenterol 11:6373-80. 2005
  8. doi request reprint Helicobacter pylori eradication therapy is effective in the treatment of early-stage H pylori-positive gastric diffuse large B-cell lymphomas
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Blood 119:4838-44; quiz 5057. 2012
  9. ncbi request reprint Phase II study of combination doxorubicin, interferon-alpha, and high-dose tamoxifen treatment for advanced hepatocellular carcinoma
    Yen Shen Lu
    Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Hepatogastroenterology 51:815-9. 2004
  10. ncbi request reprint Nuclear expression of BCL10 or nuclear factor kappa B predicts Helicobacter pylori-independent status of early-stage, high-grade gastric mucosa-associated lymphoid tissue lymphomas
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medidine, Taipei, Taiwan
    J Clin Oncol 22:3491-7. 2004

Collaborators

Detail Information

Publications44

  1. pmc Clinicopathologic features and responses to radiotherapy of myeloid sarcoma
    Wan Yu Chen
    Division of Radiation Oncology, Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Radiat Oncol 8:245. 2013
    ..To evaluate clinicopathological features, radiotherapeutic parameters, and their associations with responses to radiotherapy (RT) in patients with myeloid sarcoma (MS)...
  2. doi request reprint Lack of compensatory pAKT activation and eIF4E phosphorylation of lymphoma cells towards mTOR inhibitor, RAD001
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital, Taiwan
    Eur J Cancer 47:1244-57. 2011
    ..These findings indicate that the basis for enhanced activity of mTOR inhibitors in NHL may be the lack of compensatory activation of AKT and eIF4E phosphorylation in lymphoma cells...
  3. ncbi request reprint Nuclear expression of BCL10 or nuclear factor kappa B helps predict Helicobacter pylori-independent status of low-grade gastric mucosa-associated lymphoid tissue lymphomas with or without t(11;18)(q21;q21)
    Kun Huei Yeh
    Department of Oncology, National Taiwan University Hospital, No 7, Chung Shan S Rd, Taipei, Taiwan
    Blood 106:1037-41. 2005
    ..In summary, nuclear expression of BCL10 or NF-kappaB is predictive of H pylori-independent status of low-grade gastric MALT lymphoma with or without t(11;18)(q21; q21)...
  4. doi request reprint Combinations of mTORC1 inhibitor RAD001 with gemcitabine and paclitaxel for treating non-Hodgkin lymphoma
    Chun Te Chiang
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Cancer Lett 298:195-203. 2010
    ..In conclusion, synergistic cytotoxicity was observed with RAD001 plus gemcitabine and paclitaxel in NHL cells. Combination therapy with these three drugs should be examined in patients with refractory or relapsed NHL...
  5. ncbi request reprint Expression of CD86 and increased infiltration of NK cells are associated with Helicobacter pylori-dependent state of early stage high-grade gastric MALT lymphoma
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital, No 7, Chung Shan South Road, Taipei, Taiwan, China
    World J Gastroenterol 11:4357-62. 2005
    ..To examine whether the expression of co-stimulatory marker CD86 (B7.2) and the infiltration of CD56 (+) natural killer (NK) cells can be useful markers to predict H pylori-dependent status of high-grade gastric MALT lymphoma...
  6. ncbi request reprint Phase II study of weekly paclitaxel and 24-hour infusion of high-dose 5-fluorouracil and leucovorin in the treatment of recurrent or metastatic gastric cancer
    Kun Huei Yeh
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Oncology 69:88-95. 2005
    ..This paclitaxel-HDFL regimen is effective and well tolerated in the treatment of advanced gastric cancer...
  7. ncbi request reprint Effects of glucocorticoids on the growth and chemosensitivity of carcinoma cells are heterogeneous and require high concentration of functional glucocorticoid receptors
    Yen Shen Lu
    Department of Oncology, National Taiwan University Hospital, Taipei 10016, Taiwan, China
    World J Gastroenterol 11:6373-80. 2005
    ..To determine how glucocorticoids (GCs) may affect the growth and chemosensitivity of common carcinoma cells...
  8. doi request reprint Helicobacter pylori eradication therapy is effective in the treatment of early-stage H pylori-positive gastric diffuse large B-cell lymphomas
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Blood 119:4838-44; quiz 5057. 2012
    ..Similar to DLBCL(MALT), a substantial portion of early-stage HP-positive gastric pure (de novo) DLBCLs remains HP-dependent and responds to antibiotic treatment. Prospective studies to validate the findings are warranted...
  9. ncbi request reprint Phase II study of combination doxorubicin, interferon-alpha, and high-dose tamoxifen treatment for advanced hepatocellular carcinoma
    Yen Shen Lu
    Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Hepatogastroenterology 51:815-9. 2004
    ..In this study, we sought to clarify if the addition of Interferon-alpha2b to HTD regimen could further improve the control of advanced hepatocellular carcinoma...
  10. ncbi request reprint Nuclear expression of BCL10 or nuclear factor kappa B predicts Helicobacter pylori-independent status of early-stage, high-grade gastric mucosa-associated lymphoid tissue lymphomas
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medidine, Taipei, Taiwan
    J Clin Oncol 22:3491-7. 2004
    ..This study examined whether nuclear expression of BCL10 or nuclear factor kappa B (NF-kappaB) is useful in predicting H. pylori-independent status in patients with stage IE high-grade gastric MALT lymphomas...
  11. doi request reprint Translocation of Helicobacter pylori CagA into Human B lymphocytes, the origin of mucosa-associated lymphoid tissue lymphoma
    Wei Cheng Lin
    Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Cancer Res 70:5740-8. 2010
    ..pylori and is associated with the development of MALT lymphomas...
  12. ncbi request reprint Survival of stage IIIB/IV non-small cell lung cancer patients who received chemotherapy but did not participate in clinical trials
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, No 7, Chung Shan South Rd, Taipei, Taiwan
    Lung Cancer 48:275-80. 2005
    ..36; progression-free survival: P=0.57). Our data suggest that the survival of patients who received chemotherapy but did not participate in clinical trials was similar to patients participated in clinical trials...
  13. doi request reprint The CYP19 TTTA repeat polymorphism is related to the prognosis of premenopausal stage I-II and operable stage III breast cancers
    Chiun Sheng Huang
    Department of Surgery, National Taiwan University Hospital, No 7, Chung Shan South Road, Taipei, Taiwan
    Oncologist 13:751-60. 2008
    ....
  14. doi request reprint Establishment of a novel MALT lymphoma cell line, ma-1, from a patient with t(14;18)(q32;q21)-positive Helicobacter pylori-independent gastric MALT lymphoma
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei
    Genes Chromosomes Cancer 50:908-21. 2011
    ....
  15. pmc Fractionated evaluation of immunohistochemical hormone receptor expression enhances prognostic prediction in breast cancer patients treated with tamoxifen as adjuvant therapy
    Ching Hung Lin
    Department of Oncology, National Taiwan University Hospital, Taiwan, Taipei 10016
    J Zhejiang Univ Sci B 11:1-9. 2010
    ..To compare the prognostic prediction between dichotomized and fractionated evaluations of hormone receptor expressions...
  16. doi request reprint Nuclear expression of glioma-associated oncogene homolog 1 and nuclear factor-κB is associated with a poor prognosis of pancreatic cancer
    Shih Hung Yang
    Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Oncology 85:86-94. 2013
    ..We investigated the association of the hedgehog pathway with nuclear factor (NF)-κB and clinical outcomes in pancreatic cancer patients...
  17. doi request reprint E2A-positive gastric MALT lymphoma has weaker plasmacytoid infiltrates and stronger expression of the memory B-cell-associated miR-223: possible correlation with stage and treatment response
    Ting Yun Liu
    Department of Pathology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan, ROC
    Mod Pathol 23:1507-17. 2010
    ..A prospective study would be necessary to verify the association between E2A expression and a poor response to Helicobacter eradication therapy...
  18. ncbi request reprint Long-term results of anti-Helicobacter pylori therapy in early-stage gastric high-grade transformed MALT lymphoma
    Li Tzong Chen
    Division of Cancer Research, National Health Research Institutes, Taipei, Taiwan
    J Natl Cancer Inst 97:1345-53. 2005
    ..Several independent clinical studies have reported that Helicobacter pylori eradication therapy could achieve complete remission in some patients with H. pylori-positive early-stage gastric mucosa-associated lymphoid tissue (MALT) lymphoma...
  19. doi request reprint Inferior survival of advanced pancreatic cancer patients who received gemcitabine-based chemotherapy but did not participate in clinical trials
    Shih Hung Yang
    Department of Oncology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan, ROC
    Oncology 81:143-50. 2011
    ..Advanced pancreatic cancer, even when treated, is highly lethal. The best choice of gemcitabine-based therapy and the prognostic factors affecting the success of treatment remain uncertain...
  20. ncbi request reprint Differential clinical characteristics, treatment response and prognosis of locally advanced adenocarcinoma/adenosquamous carcinoma and squamous cell carcinoma of cervix treated with definitive radiotherapy
    Jenny Ling Yu Chen
    Department of Oncology, National Taiwan University Hospital Yun Lin Branch, Yun Lin, Taiwan
    Acta Obstet Gynecol Scand 93:661-8. 2014
    ..To compare tumor characteristics and clinical outcome of patients with cervical locally advanced adenocarcinoma (AC)/adenosquamous carcinoma (ASC) and squamous cell carcinoma (SCC)...
  21. doi request reprint Long-term follow-up of gastrectomized patients with mucosa-associated lymphoid tissue lymphoma: need for a revisit of surgical treatment
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
    Ann Surg 247:265-9. 2008
    ....
  22. ncbi request reprint p53 overexpression and mutation in metaplastic carcinoma of the breast: genetic evidence for a monoclonal origin of both the carcinomatous and the heterogeneous sarcomatous components
    Huang Chun Lien
    Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    J Pathol 204:131-9. 2004
    ..The findings therefore support a monoclonal histogenesis of the various components, but are neutral regarding the role of p53 alteration in the development of metaplastic change in MCBs...
  23. doi request reprint t(11;18)(q21;q21) translocation as predictive marker for non-responsiveness to salvage thalidomide therapy in patients with marginal zone B-cell lymphoma with gastric involvement
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Cancer Chemother Pharmacol 68:1387-95. 2011
    ..Thalidomide is an anti-angiogenic agent with anti-TNF-α and anti-NF-κB activity. This retrospective study evaluated the efficacy of thalidomide in standard therapy-failure gastric MALT lymphoma...
  24. doi request reprint Radiotherapy in lung adenocarcinoma with brain metastases: effects of activating epidermal growth factor receptor mutations on clinical response
    Chien Hung Gow
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Clin Cancer Res 14:162-8. 2008
    ..To elucidate the role of EGFR mutations in radiation treatment, we evaluated the clinical response to WBRT and survival of lung adenocarcinoma patients with brain metastases...
  25. doi request reprint Early low-grade gastric MALToma rarely transforms into diffuse large cell lymphoma or progresses beyond the stomach and regional lymph nodes
    Ting Yun Liu
    Department of Pathology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
    J Formos Med Assoc 109:463-71. 2010
    ..We aim to determine the frequency of transformation...
  26. ncbi request reprint Glucocorticoid receptor expression in advanced non-small cell lung cancer: clinicopathological correlation and in vitro effect of glucocorticoid on cell growth and chemosensitivity
    Yen Shen Lu
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Lung Cancer 53:303-10. 2006
    ..The effect of GC treatment on the chemosensitivity in NSCLC patients remains to be established...
  27. pmc CYP19 genetic polymorphism haplotype AASA is associated with a poor prognosis in premenopausal women with lymph node-negative, hormone receptor-positive breast cancer
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan
    Biomed Res Int 2013:562197. 2013
    ..01). Our results indicate that, in patients with LN-negative, HR-positive breast cancers, genetic polymorphism haplotype AASA is associated with poor survival of premenopausal women but does not affect survival of postmenopausal women. ..
  28. ncbi request reprint Comparison of the expression and prognostic significance of differentiation markers between diffuse large B-cell lymphoma of central nervous system origin and peripheral nodal origin
    Ching Hung Lin
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Clin Cancer Res 12:1152-6. 2006
    ..The purpose of this study was to compare the expression frequencies and prognostic significance of a panel of cell differentiation markers between these two disease entities...
  29. ncbi request reprint Caveolin-1 expression is significantly associated with drug resistance and poor prognosis in advanced non-small cell lung cancer patients treated with gemcitabine-based chemotherapy
    Chao Chi Ho
    Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan, Republic of China
    Lung Cancer 59:105-10. 2008
    ..003) and OS (P=0.008), respectively. Caveolin-1 expression significantly correlated with drug resistance and a poor prognosis in advanced NSCLC patients treated with gemcitabine-based chemotherapy...
  30. doi request reprint Phase II study of docetaxel, capecitabine, and cisplatin as neoadjuvant chemotherapy for locally advanced breast cancer
    Yen Shen Lu
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan, ROC
    Cancer Chemother Pharmacol 67:1257-63. 2011
    ..The purpose of this study was to assess the efficacy of a combination of docetaxel, capecitabine, and cisplatin (TXP) in patients diagnosed with locally advanced breast cancer (LABC)...
  31. doi request reprint Dose variation and regimen modification of adjuvant chemotherapy in daily practice affect survival of stage I-II and operable stage III Taiwanese breast cancer patients
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Breast 17:646-53. 2008
    ..032) and OS (HR=0.54; P=0.025) than those treated with non-standard adjuvant chemotherapy. Breast cancer patients receiving standard adjuvant chemotherapy have a better DFS and OS than those receiving non-standard adjuvant chemotherapy...
  32. doi request reprint Outcome analysis of cervical adenosquamous carcinoma compared with adenocarcinoma
    Jenny Ling Yu Chen
    Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Acta Obstet Gynecol Scand 91:1158-66. 2012
    ..To compare survival between patients with cervical adenocarcinoma (AC) and adenosquamous carcinoma (ASC)...
  33. doi request reprint Overexpression of B cell-activating factor of TNF family (BAFF) is associated with Helicobacter pylori-independent growth of gastric diffuse large B-cell lymphoma with histologic evidence of MALT lymphoma
    Sung Hsin Kuo
    Departments of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei
    Blood 112:2927-34. 2008
    ..Our results indicate that autocrine BAFF signal transduction pathways may contribute to HP-independent growth of gastric DLBCL (MALT)...
  34. ncbi request reprint Gemcitabine plus conventional-dose epirubicin versus gemcitabine plus cisplatin as first-line chemotherapy for stage IIIB/IV non-small cell lung carcinoma--a randomized phase II trial
    Chiun Hsu
    Department of Oncology, National Taiwan University Hospital, 7, Chung Shan South Road, Taipei, 100, Taiwan
    Lung Cancer 62:334-43. 2008
    ....
  35. doi request reprint Comprehensive locoregional treatment and systemic therapy for postmastectomy isolated locoregional recurrence
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Int J Radiat Oncol Biol Phys 72:1456-64. 2008
    ..To assess the impact of comprehensive locoregional therapy and systemic therapy on disease control and survival for postmastectomy patients with isolated locoregional recurrence (ILRR)...
  36. pmc Prone breast forward intensity-modulated radiotherapy for Asian women with early left breast cancer: factors for cardiac sparing and clinical outcomes
    Jenny Ling Yu Chen
    Division of Radiation Oncology, Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    J Radiat Res 54:899-908. 2013
    ..At a median follow-up time of 26.8 months, no locoregional or distant recurrence or death was noted...
  37. doi request reprint Volumetric modulated arc therapy for nasopharyngeal carcinoma: a dosimetric comparison with TomoTherapy and step-and-shoot IMRT
    Szu Huai Lu
    Division of Radiation Oncology, Departments of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Radiother Oncol 104:324-30. 2012
    ....
  38. doi request reprint Expression of BCL10 in cervical cancer has a role in the regulation of cell growth through the activation of NF-κB-dependent cyclin D1 signaling
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Gynecol Oncol 126:245-51. 2012
    ..Since NF-κB activation has been shown to occur in the pathogenesis of cervical cancer, we sought to investigate whether BCL10 possesses clinical significance in relation to cervical cancer...
  39. pmc Increased risk of parvovirus B19 infection in young adult cancer patients receiving multiple courses of chemotherapy
    Sung Hsin Kuo
    Cancer Research Center, Taipei, Taiwan
    J Clin Microbiol 40:3909-12. 2002
    ..Prospective studies to define the time course and clinical consequence of B19 infection in this group of patients are needed...
  40. pmc IL-22 negatively regulates Helicobacter pylori-induced CCL20 expression in gastric epithelial cells
    Jia Perng Chen
    Institute of Microbiology and Immunology, National Yang Ming University, Taipei, Taiwan
    PLoS ONE 9:e97350. 2014
    ..Together, our findings suggest that IL-22 plays a role in the control of overproduction of the inflammatory chemokine and thus may protect the gastric mucosa from inflammation-mediated damage. ..
  41. doi request reprint Postoperative intensity-modulated radiotherapy for squamous cell carcinoma of the external auditory canal and middle ear: treatment outcomes, marginal misses, and perspective on target delineation
    Wan Yu Chen
    Division of Radiation Oncology, Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Int J Radiat Oncol Biol Phys 82:1485-93. 2012
    ..Failure patterns related to spatial dose distribution were also analyzed to provide insight into target delineation...
  42. doi request reprint The Aurora kinase inhibitor VE-465 has anticancer effects in pre-clinical studies of human hepatocellular carcinoma
    Zhong Zhe Lin
    National Center of Excellence for Clinical Trial and Research, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan
    J Hepatol 50:518-27. 2009
    ..Recently, aberrant expression of Aurora kinases has been reported in various human cancers including HCC. We sought to investigate the potential of a potent and selective Aurora kinase inhibitor, VE-465, for targeted therapy of HCC...
  43. doi request reprint Clinicopathologic features and treatment outcome of non-Hodgkin lymphoma of the breast--a review of 42 primary and secondary cases in Taiwanese patients
    Yu Chin Lin
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Leuk Lymphoma 50:918-24. 2009
    ..Further investigation of underlying mechanisms of young age- and stage IIE disease-related poor prognosis in patients with PBL is needed...
  44. doi request reprint Molecular subtypes of breast cancer emerging in young women in Taiwan: evidence for more than just westernization as a reason for the disease in Asia
    Ching Hung Lin
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Cancer Epidemiol Biomarkers Prev 18:1807-14. 2009
    ..As a first step to investigate the possible etiology, we examined the molecular subtypes of female breast cancer in Taiwan...