Research Topics
Genomes and Genes
| Po Hsiu KuoSummaryAffiliation: National Cheng Kung University Country: Taiwan Publications
| Collaborators
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Detail Information
Publications
Associations of glutamate decarboxylase genes with initial sensitivity and age-at-onset of alcohol dependence in the Irish Affected Sib Pair Study of Alcohol DependencePo Hsiu Kuo
Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Taiwan
Drug Alcohol Depend 101:80-7. 2009..Halberstadt, L.J., Walsh, D., Kendler, K.S., 2005. The Irish Affected Sib Pair Study of Alcohol Dependence: study methodology and validation of diagnosis by interview and family history. Alcohol.-Clin. Exp. Res. 29 (3) 417-429]...- Using a factor mixture modeling approach in alcohol dependence in a general population samplePo Hsiu Kuo
Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Taiwan
Drug Alcohol Depend 98:105-14. 2008..Clinically, the expanded classification of AD may aid in identifying suitable treatments, interventions and additional sources of comorbidity based on these more homogenous subgroups of alcohol use problems... - Estimating the number and size of the main effects in genome-wide case-control association studiesPo Hsiu Kuo
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 East Leigh Street, Biotech 1, VIPBG, Suite 1 130, Richmond, Virginia 23219, USA
BMC Proc 1:S143. 2007..Further improvements and extensions of the proposed methods are conceivable, such as estimating the distribution of effect sizes and taking population stratification into account when obtain estimates of p0 and effect size... - Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) samplePo Hsiu Kuo
Institute of Clinical Medicine, College of Medicine, National Cheng Kung University Hospital 138, National Cheng Kung University, Sheng Li Road, Tainan 704, Taiwan
Alcohol Clin Exp Res 32:785-95. 2008..The present study examined evidence for the association of alcohol metabolism genes with AD in the Irish Affected Sib Pair Study of alcohol dependence... - The dystrobrevin binding protein 1 (DTNBP1) gene is associated with schizophrenia in the Irish Case Control Study of Schizophrenia (ICCSS) sampleBrien Riley
Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA
Schizophr Res 115:245-53. 2009..DTNBP1 is associated with schizophrenia in many studies, but the associated alleles and haplotypes vary between samples... 
Interaction between ALDH2*1*1 and DRD2/ANKK1 TaqI A1A1 genes may be associated with antisocial personality disorder not co-morbid with alcoholismRu Band Lu
Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Taiwan
Addict Biol 17:865-74. 2012..Our study made this distinction and showed that these two genes may be associated ASPD without co-morbid alcoholism...- MAOA interacts with the ALDH2 gene in anxiety-depression alcohol dependenceSheng Yu Lee
Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan
Alcohol Clin Exp Res 34:1212-8. 2010..The aim of this study was to determine whether the interaction between the MAOA and the ALDH2 genes is associated with ANX/DEP ALC... - AKT1 is associated with schizophrenia across multiple symptom dimensions in the Irish study of high density schizophrenia familiesDawn L Thiselton
Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23298 0424, USA
Biol Psychiatry 63:449-57. 2008..The AKT1 gene has also been implicated in schizophrenia by association studies and decreased protein expression in the brains of schizophrenic patients... 
A joint genomewide linkage analysis of symptoms of alcohol dependence and conduct disorderKenneth S Kendler
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
Alcohol Clin Exp Res 30:1972-7. 2006..Are the susceptibility genes underlying this peak specific for AD or do they increase risk for externalizing disorders more generally? Can we, in the IASPSAD, replicate prior evidence for linkage to conduct disorder (CD)?..- Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD)Laura M Hack
Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, USA
Alcohol Clin Exp Res 35:376-85. 2011..Many linkage and association studies have examined these relationships with inconsistent results, possibly because of low power, poor marker coverage, and/or an inappropriate correction for multiple testing... - Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol DependencePo Hsiu Kuo
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298, USA
Alcohol Clin Exp Res 30:1807-16. 2006..The goal of this study was to identify genomic regions containing susceptibility loci for alcohol-related traits... - Gene-temperament interactions might distinguish between bipolar I and bipolar II disorders: a cross-sectional survey of Han Chinese in TaiwanYi Ann Lu
Institute of Behavioral Medicine, National Cheng Kung University, Tainan, Taiwan
J Clin Psychiatry 73:339-45. 2012..In this study, we sought to clarify the relationship between bipolar I and bipolar II disorder... - The relationship between serotonin receptor 1B polymorphisms A-161T and alcohol dependenceSheng Yu Lee
Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Alcohol Clin Exp Res 33:1589-95. 2009.... - A genome-wide linkage analysis for the personality trait neuroticism in the Irish affected sib-pair study of alcohol dependencePo Hsiu Kuo
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
Am J Med Genet B Neuropsychiatr Genet 144:463-8. 2007..These results, together with prior studies, indicate several potential regions for quantitative trait loci for neuroticism that warrant further study... - No association of dysbindin with symptom factors of schizophrenia in an Irish case-control sampleSarah E Bergen
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23219, USA
Am J Med Genet B Neuropsychiatr Genet 153:700-5. 2010..Several possibilities, such as differing risk haplotypes, may explain this finding... - Interaction of the DRD3 and BDNF gene variants in subtyped bipolar disorderSheng Yu Lee
Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan
Prog Neuropsychopharmacol Biol Psychiatry 39:382-7. 2012..Because BDNF regulates DRD3 expression (1), we also examined possible interactions between these genes... - Prioritization and association analysis of murine-derived candidate genes in anxiety-spectrum disordersJohn M Hettema
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
Biol Psychiatry 70:888-96. 2011.... - A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom countsGursharan Kalsi
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298, USA
Hum Mol Genet 19:2497-506. 2010..Haplotype-specific expression measurements in post-mortem tissue samples suggested a functional role for DKK2. This evidence notwithstanding, replication is needed before confidence can be placed in these findings... - The profile and familiality of personality traits in mood disorder familiesPei Jung Wu
Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
J Affect Disord 138:367-74. 2012..The current study aimed to investigate the profile of personality traits in patients with bipolar disorders and major depressive disorder (MDD). Familial aggregation of personality traits in mood disorder families was also evaluated... - The temporal relationship of the onsets of alcohol dependence and major depression: using a genetically informative study designPo Hsiu Kuo
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
Psychol Med 36:1153-62. 2006..In this longitudinal study, we used a genetically informative population-based twin sample to examine the age-at-onset distributions and the temporal relationship of AD and MD... - Empirically derived subgroups of bipolar I patients with different comorbidity patterns of anxiety and substance use disorders in Han Chinese populationHan Chieh Tsai
Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Taiwan
J Affect Disord 136:81-9. 2012..The present study sought to identify subgroups of BPI patients using comorbidity patterns with ANX and SUD... - MAOA-uVNTR polymorphism may modify the protective effect of ALDH2 gene against alcohol dependence in antisocial personality disorderSheng Yu Lee
The Institute of Behavioral Medicine, Graduate Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, No 138 Sheng Li Road, Tainan, Taiwan, Republic of China
Alcohol Clin Exp Res 33:985-90. 2009..The objective of this study is to determine whether the interaction between the MAOA and the ALDH2 genes is associated with subjects with antisocial personality disorder (ASPD) having alcoholism... - Genomewide association analysis followed by a replication study implicates a novel candidate gene for neuroticismEdwin J C G van den Oord
Center for Biomarker Research and Personalized Medicine, Medical College of Virginia, Virginia Commonwealth University, PO Box 980533, Richmond, VA 23298 0533, USA
Arch Gen Psychiatry 65:1062-71. 2008..It has long been linked to internalizing psychiatric conditions, such as anxiety and depression, and it accounts for much of the substantial comorbidity seen between these disorders... - Candidate genes for schizophrenia: a survey of association studies and gene rankingJingchun Sun
Department of Psychiatry and Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
Am J Med Genet B Neuropsychiatr Genet 147:1173-81. 2008..The evaluation of this candidate gene set against sets selected by other methods suggested its utility in follow-up association studies and in further bioinformatics analysis. We also examined the functional biases of the selected genes... - Efficient calculation of empirical P-values for genome-wide linkage analysis through weighted permutationSarah E Medland
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
Behav Genet 39:91-100. 2009..We demonstrate the validity of this approach through simulation... - High oxidative stress is correlated with frailty in elderly chineseI Chien Wu
Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan
J Am Geriatr Soc 57:1666-71. 2009..To evaluate the relationship between oxidative stress and frailty in elderly people... - ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposureJingchun Chen
Department of Psychiatry and Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, United States of America
PLoS ONE 6:e28790. 2011..The independent associations of this locus with schizophrenia and with numCIG in non-schizophrenic subjects suggest that this locus may be a common liability to both conditions... - Cohort trends in prevalence and spousal concordance for smokingPo Hsiu Kuo
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23219, USA
Drug Alcohol Depend 88:122-9. 2007..19-0.49). Despite using a simplified smoking assessment, findings in this study demonstrated changes of lifetime smoking patterns across birth cohorts and the presence of assortative mating for smoking behavior... - Genomewide linkage survey of nicotine dependence phenotypesPatrick F Sullivan
Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
Drug Alcohol Depend 93:210-6. 2008..We sought to identify genomic regions that might contain etiologically-relevant loci using genomewide univariate and bivariate linkage analyses... - Multiple testing in the genomics era: findings from Genetic Analysis Workshop 15, Group 15Lisa J Martin
Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Genet Epidemiol 31:S124-31. 2007..We show that while each approach may have certain advantages, adequate error control is largely dependent upon the question under consideration and often requires the use of multiple analytic strategies... - A twin study of competence and behavioral/emotional problems among adolescents in taiwanPo-Hsiu Kuo
Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
Behav Genet 34:63-74. 2004..Gender differences in heritability exist for various CBCL-based competence and behavioral/emotional problems...