Pao Lin Kuo


Affiliation: National Cheng Kung University
Country: Taiwan


  1. Yeh C, Wang Y, Wee S, Chen M, Chiang H, Kuo P, et al. Testis-Specific SEPT12 Expression Affects SUN Protein Localization and is Involved in Mammalian Spermiogenesis. Int J Mol Sci. 2019;20: pubmed publisher
    ..Based on these results, we suggest that SEPT12 is among the moderators of SPAG4/LAMIN complexes and is involved in the morphological formation of sperm during mammalian spermiogenesis. ..
  2. Huang C, Wang Y, Chen Y, Chen M, Chiang H, Kuo P, et al. CDC42 Negatively Regulates Testis-Specific SEPT12 Polymerization. Int J Mol Sci. 2018;19: pubmed publisher
    ..We concluded that CDC42 negatively regulates SEPT12 polymerization and is involved in terminal structure formation of sperm heads. ..
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    Kuo P, Guo H. Mechanism of recurrent spontaneous abortions in women with mosaicism of X-chromosome aneuploidies. Fertil Steril. 2004;82:1594-601 pubmed
    ..7% vs. 42.9%). The oocytes of women with X-chromosome mosaicism are in a suboptimal state of development and are prone to embryonic lethality. ..
  4. Tsai M, Cheng H, Su M, Chen M, Kuo P. Partial trisomy 8 mosaicism not detected by cultured amniotic-fluid cells. Taiwan J Obstet Gynecol. 2014;53:598-601 pubmed publisher
    ..Array-CGH using uncultured cells may be of help in providing more information on genetic dosage variations in such cases. ..
  5. Tsai Y, Tseng J, Wang C, Su M, Huang J, Kuo P. Medroxyprogesterone acetate drives M2 macrophage differentiation toward a phenotype of decidual macrophage. Mol Cell Endocrinol. 2017;452:74-83 pubmed publisher
    ..Taken together, MPA could drive monocyte differentiation toward an M2 phenotype that mimics decidual macrophages. This finding holds great potential to combat chronic endometrial inflammation. ..
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    Kuo P, Wang S, Lin Y, Lin Y, Teng Y, Hsu C. Expression profiles of the DAZ gene family in human testis with and without spermatogenic failure. Fertil Steril. 2004;81:1034-40 pubmed
    ..Although the sample size is limited, no compensatory increase of DAZL or BOULE transcription was found in men with DAZ deletion. ..
  7. Su M, Lin S, Chen Y, Kuo P. Gene-gene interactions and risk of recurrent miscarriages in carriers of endocrine gland-derived vascular endothelial growth factor and prokineticin receptor polymorphisms. Fertil Steril. 2014;102:1071-1077.e3 pubmed publisher
    ..The present study corroborates the clinical relevance of the EG-VEGF system in human early pregnancy, and provides evidence for the gene-gene interactions of EG-VEGF and PROKR variants. ..
  8. Su M, Huang J, Tsai H, Chen Y, Kuo P. A Common Variant of PROK1 (V67I) Acts as a Genetic Modifier in Early Human Pregnancy through Down-Regulation of Gene Expression. Int J Mol Sci. 2016;17: pubmed publisher
    ..This study may provide a general mechanism that the common variant of V67I, modifying the disease severity of PROK1-related pathophysiologies. ..
  9. Lai T, Wu Y, Wang Y, Chen M, Wang P, Chen T, et al. SEPT12-NDC1 Complexes Are Required for Mammalian Spermiogenesis. Int J Mol Sci. 2016;17: pubmed
    ..These results indicate that SEPT12-NDC1 complexes are involved in mammalian spermiogenesis. ..

More Information


  1. Kuo Y, Shen Y, Chen H, Lin Y, Wang Y, Chen Y, et al. SEPT12 orchestrates the formation of mammalian sperm annulus by organizing core octameric complexes with other SEPT proteins. J Cell Sci. 2015;128:923-34 pubmed publisher
    ..Taken together, our results demonstrate the molecular architecture of SEPT12 filaments at the sperm annulus, their mechanical support of sperm motility, and their correlation with male infertility. ..
  2. Chang W, Wu M, Pan H, Guo P, Lee C. Semen quality and insulin-like factor 3: Associations with urinary and seminal levels of phthalate metabolites in adult males. Chemosphere. 2017;173:594-602 pubmed publisher
  3. Song X, Hsu H, Su M, Chang T, Su P, Chen M, et al. Euchromatic variants of 8q21.2 in twins. Taiwan J Obstet Gynecol. 2017;56:227-229 pubmed publisher
    ..Many, but not all, EVs are clinically innocuous. This is the first case of 8q21.2 EV reported in the ethnic Han. More cases are needed to clarify whether 8q21.2 duplication as a bona fide EV. ..
  4. Huang J, Yu P, Li Y, Kuo P. NLRP7 contributes to in vitro decidualization of endometrial stromal cells. Reprod Biol Endocrinol. 2017;15:66 pubmed publisher
    ..IGFBP-1 expression decreased with the knockdown of NLRP7. Therefore, we suggest that NLRP7 contributes to in vitro decidualization of endometrial stromal cells. ..