Ching Chuan Kuo

Summary

Affiliation: National Health Research Institutes
Country: Taiwan

Publications

  1. doi request reprint Combination of arsenic trioxide and BCNU synergistically triggers redox-mediated autophagic cell death in human solid tumors
    Ching Chuan Kuo
    National Institute of Cancer Research, National Health Research Institutes, Tainan 704, Taiwan
    Free Radic Biol Med 51:2195-209. 2011
  2. ncbi request reprint 7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents
    Jang Yang Chang
    Institute of Cancer Research, National Health Research Institutes, Taipei, Taiwan, Republic of China
    J Med Chem 49:6656-9. 2006
  3. pmc A novel synthetic microtubule inhibitor, MPT0B214 exhibits antitumor activity in human tumor cells through mitochondria-dependent intrinsic pathway
    Nai Jung Chiang
    National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan, ROC
    PLoS ONE 8:e58953. 2013
  4. ncbi request reprint A novel bis-benzylidenecyclopentanone derivative, BPR0Y007, inducing a rapid caspase activation involving upregulation of Fas (CD95/APO-1) and wild-type p53 in human oral epidermoid carcinoma cells
    Shin Hun Juang
    Cancer Cooperative Ward in National Taiwan University Hospital, Division of Cancer Research, National Health Research Institutes, 7, Chung Shan Road, Taipei, Taiwan, ROC
    Biochem Pharmacol 68:293-303. 2004
  5. ncbi request reprint Salvinal, a novel microtubule inhibitor isolated from Salvia miltiorrhizae Bunge (Danshen), with antimitotic activity in multidrug-sensitive and -resistant human tumor cells
    Jang Yang Chang
    Division of Cancer Research, National Health Research Institutes, Taipei 100, Taiwan
    Mol Pharmacol 65:77-84. 2004
  6. doi request reprint Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents
    Gadarla Randheer Reddy
    Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, No 35, Keyan Road, Zhunan Town, Miaoli County 350, Taiwan, Republic of China
    J Med Chem 51:8163-7. 2008
  7. ncbi request reprint 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents
    Jang Yang Chang
    Institute of Cancer Research, National Health Research Institutes, Taipei 114, Taiwan
    J Med Chem 49:6412-5. 2006
  8. ncbi request reprint Structure-activity relationship studies of 3-aroylindoles as potent antimitotic agents
    Jing Ping Liou
    Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Miaoli County 350, Taiwan, Republic of China
    ChemMedChem 1:1106-18. 2006
  9. ncbi request reprint DNA repair enzyme, O6-methylguanine DNA methyltransferase, modulates cytotoxicity of camptothecin-derived topoisomerase I inhibitors
    Ching Chuan Kuo
    Division of Cancer Research, National Health Research Institutes, Taipei, Taiwan, Republic of China
    J Pharmacol Exp Ther 316:946-54. 2006
  10. ncbi request reprint Tamoxifen accelerates proteasomal degradation of O6-methylguanine DNA methyltransferase in human cancer cells
    Ching Chuan Kuo
    National Institute of Cancer Research, National Health Research Institutes, Taipei, Taiwan, Republic of China
    Int J Cancer 121:2293-300. 2007

Collaborators

  • Hsing Pang Hsieh
  • Li Tzong Chen
  • Jang-Yang Chang
  • Ko Jiunn Liu
  • Chun Hei Antonio Cheung
  • Yueh Hsiung Kuo
  • Kuo Li Chen
  • Chien Chang Huang
  • Hsien Tsung Yao
  • Chun Cheng Lin
  • Miao Fen Chen
  • Shiow Ju Lee
  • Kai Ming Chou
  • Jing Ping Liou
  • Huang Hui Chen
  • Chi Yen Chang
  • Shin Hun Juang
  • Wen Yu Pan
  • Yu Shan Wu
  • Su Ying Wu
  • Yen Shih Tung
  • Mohane Selvaraj Coumar
  • Teng Kuang Yeh
  • Uan Kang Tan
  • Nai Jung Chiang
  • Chih Cheng Chen
  • Yun Ching Cheng
  • Yi Kun Chiang
  • Chun Wei Chang
  • Gadarla Randheer Reddy
  • Li Chen Ma
  • Chia Bao Chu
  • Wen Yang Lai
  • Joseph T Tseng
  • Kuang Hsing Shih
  • Kuan Der Lee
  • Yun Hsia Cheng
  • Yen Wen Huang
  • Hui Ju Tsai
  • Yu Tsen Chen
  • Ching Kuo Lee
  • Paritosh Shukla
  • Jian Sung Wu
  • Ting fang Chen
  • Wenchang Chiang
  • Chun Chen Liao
  • Ya Lin Chien
  • Yen Ting Cheng
  • Hui Yi Shiao
  • Hsu Yi Sun
  • Ying Jun Chen
  • Chang Ying Chu
  • Fu Ming Kuo
  • Ching Ping Chen
  • Chiung Tong Chen
  • Chia Ling Hsiao
  • Mei Jung Lai
  • Jin Fen Liu
  • Jiann Yih Yeh
  • Meng Ju Lin
  • Cheng Li Hsu
  • Shyh Fong Chen
  • Chia Chi Lung
  • Pi Chen Hsu
  • Kuo Chu Fu
  • Leeyuan Huang
  • Thomas C K Chan
  • Pao Chiung Hong
  • Ching Jer Chang
  • Yu Chen Li
  • Kuo Shun Hsu
  • Yu Chin Wang
  • Her Shyong Shiah
  • Curtis L Ashendel
  • Tom S Chen
  • Ke Ta Lin
  • Ping Hsun Lu
  • Fu Ming Guo
  • Neeraj Mahindroo
  • Yi Wei Chang
  • Yi Mei Hung

Detail Information

Publications21

  1. doi request reprint Combination of arsenic trioxide and BCNU synergistically triggers redox-mediated autophagic cell death in human solid tumors
    Ching Chuan Kuo
    National Institute of Cancer Research, National Health Research Institutes, Tainan 704, Taiwan
    Free Radic Biol Med 51:2195-209. 2011
    ..These findings will be useful in designing future clinical trials of combination chemotherapy with As(2)O(3) and BCNU, with the potential for broad use against a variety of solid tumors...
  2. ncbi request reprint 7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents
    Jang Yang Chang
    Institute of Cancer Research, National Health Research Institutes, Taipei, Taiwan, Republic of China
    J Med Chem 49:6656-9. 2006
    ..2 microM, respectively. Compound 15 inhibited the human cancer cell growth of KB, MKN45, H460, HT29, and TSGH, as well as one human-resistant cancer line of KB-vin 10, with an IC50 of 9.6, 8.8, 9.4, 8.6, 10.8, and 8.9 nM, respectively...
  3. pmc A novel synthetic microtubule inhibitor, MPT0B214 exhibits antitumor activity in human tumor cells through mitochondria-dependent intrinsic pathway
    Nai Jung Chiang
    National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan, ROC
    PLoS ONE 8:e58953. 2013
    ..Notably, several KB-derived multidrug-resistant cancer cell lines were also sensitive to MPT0B214 treatment. These findings showed that MPT0B214 is a potential compound in the treatment of various malignancies...
  4. ncbi request reprint A novel bis-benzylidenecyclopentanone derivative, BPR0Y007, inducing a rapid caspase activation involving upregulation of Fas (CD95/APO-1) and wild-type p53 in human oral epidermoid carcinoma cells
    Shin Hun Juang
    Cancer Cooperative Ward in National Taiwan University Hospital, Division of Cancer Research, National Health Research Institutes, 7, Chung Shan Road, Taipei, Taiwan, ROC
    Biochem Pharmacol 68:293-303. 2004
    ..Overall, our results demonstrated that the BPR0Y007 could induce an early cytotoxic apoptosis through a caspase-8-dependent but mitochondrial-caspase-9 independent pathway, and involving upregulation of p53...
  5. ncbi request reprint Salvinal, a novel microtubule inhibitor isolated from Salvia miltiorrhizae Bunge (Danshen), with antimitotic activity in multidrug-sensitive and -resistant human tumor cells
    Jang Yang Chang
    Division of Cancer Research, National Health Research Institutes, Taipei 100, Taiwan
    Mol Pharmacol 65:77-84. 2004
    ..Notably, Salvinal is a poor substrate for transport by P-glycoprotein and MRP. Salvinal may be useful in the treatment of human cancers, particularly in patients with drug resistance...
  6. doi request reprint Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents
    Gadarla Randheer Reddy
    Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, No 35, Keyan Road, Zhunan Town, Miaoli County 350, Taiwan, Republic of China
    J Med Chem 51:8163-7. 2008
    ..1-26.3 nM against a panel of human cancer cell lines including multiple-drug resistant cell line. Compound 9 demonstrated better antiproliferative activity and has a comparable tubulin binding efficacy as that of colchicine...
  7. ncbi request reprint 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents
    Jang Yang Chang
    Institute of Cancer Research, National Health Research Institutes, Taipei 114, Taiwan
    J Med Chem 49:6412-5. 2006
    ..Structure activity relationship information suggests that the NH(2) substituent at the 2-position of either ring A or ring B in combretastatin molecular skeleton may play an important role in the bioactivity of this series of compounds...
  8. ncbi request reprint Structure-activity relationship studies of 3-aroylindoles as potent antimitotic agents
    Jing Ping Liou
    Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Miaoli County 350, Taiwan, Republic of China
    ChemMedChem 1:1106-18. 2006
    ..The N,N-dimethylamino derivative 13 not only displayed potent cytotoxicity and antitubulin activity, but also showed a markedly improved physicochemical profile relative to the parent compound...
  9. ncbi request reprint DNA repair enzyme, O6-methylguanine DNA methyltransferase, modulates cytotoxicity of camptothecin-derived topoisomerase I inhibitors
    Ching Chuan Kuo
    Division of Cancer Research, National Health Research Institutes, Taipei, Taiwan, Republic of China
    J Pharmacol Exp Ther 316:946-54. 2006
    ..Our data indicate that MGMT can modulate cytotoxicity of CPT-derived topoisomerase I inhibitors...
  10. ncbi request reprint Tamoxifen accelerates proteasomal degradation of O6-methylguanine DNA methyltransferase in human cancer cells
    Ching Chuan Kuo
    National Institute of Cancer Research, National Health Research Institutes, Taipei, Taiwan, Republic of China
    Int J Cancer 121:2293-300. 2007
    ..These findings provide a strong rationale for combined chemo/hormonal therapy with tamoxifen and BCNU in the treatment of human cancers...
  11. pmc Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers
    Chun Hei Antonio Cheung
    National Institute of Cancer Research, National Health Research Institutes, Tainan 704, Taiwan ROC
    Mol Cancer 8:43. 2009
    ..The purpose of this study is to evaluate the effect of survivin on the resistance and susceptibility of human cancer cells to microtubule de-stabilizer-induced cell death...
  12. doi request reprint Targeting cathepsin S induces tumor cell autophagy via the EGFR-ERK signaling pathway
    Kuo Li Chen
    National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan, ROC
    Cancer Lett 317:89-98. 2012
    ..In conclusion, the current study reveals that cathepsin S plays an important role in the regulation of cell autophagy through interference with the EGFR-ERK/MAPK-signaling pathway...
  13. ncbi request reprint D-501036, a novel selenophene-based triheterocycle derivative, exhibits potent in vitro and in vivo antitumoral activity which involves DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation
    Shin Hun Juang
    Institute of Cancer Research, National Health Research Institutes, 7th Floor, No 161, Section 6, Min Chuan East Road, Taipei 114, Taiwan, Republic of China
    Mol Cancer Ther 6:193-202. 2007
    ..Notably, D-501036 shows potent activity against the growth of xenograft tumors of human renal carcinoma A-498 cells. Thus, D-501036 is a promising anticancer compound that has strong potential for the management of human cancers...
  14. doi request reprint Transcriptional repression of O6-methylguanine DNA methyltransferase gene rendering cells hypersensitive to N,N'-bis(2-chloroethyl)-N-nitrosurea in camptothecin-resistant cells
    Li Chen Ma
    National Institute of Cancer Research, National Health Research Institutes, 2F, 367, Sheng Li Road, Tainan 704, Taiwan, Republic of China
    Mol Pharmacol 74:517-26. 2008
    ..In addition, this study supports a new indication for treating patients who are receiving refractory CPT derivatives with BCNU...
  15. doi request reprint Antimutagenic constituents of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) with potential cancer chemopreventive activity
    Huang Hui Chen
    National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan
    J Agric Food Chem 59:6444-52. 2011
    ..In summary, we first identified six antimutagenic constituents from adlay hull. Among them, trans-coniferylaldehyde would be a highly promising agent for cancer chemoprevention and merits further investigation...
  16. doi request reprint Scaffold-hopping strategy: synthesis and biological evaluation of 5,6-fused bicyclic heteroaromatics to identify orally bioavailable anticancer agents
    Yen Shih Tung
    Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Miaoli County, Taiwan, ROC
    J Med Chem 54:3076-80. 2011
    ..Among these, 7-azaindole core 12 showed potent in vitro anticancer activity and improved oral bioavailability (F = 35%) compared with 1 (F < 10%)...
  17. doi request reprint Synthesis and evaluation of 3-aroylindoles as anticancer agents: metabolite approach
    Yu Shan Wu
    Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 350, Taiwan, Republic of China
    J Med Chem 52:4941-5. 2009
    ..Insights gained from the major inactive metabolite of 2 led to the development of 29, with better pharmacokinetics and improved potency in the tumor xenograft model than 2...
  18. doi request reprint Gene expression profiling for analysis acquired oxaliplatin resistant factors in human gastric carcinoma TSGH-S3 cells: the role of IL-6 signaling and Nrf2/AKR1C axis identification
    Chih Cheng Chen
    Department of Hematology and Oncology, Chang Gung Memorial Hospital at Chiayi, Chiayi, Taiwan, ROC Chang Gung University, College of Medicine, Chang Gung Institute of Technology, Chiayi, Taiwan, ROC Graduate Institute of Clinical Medical Sciences, Chang Gung University, Tao Yuan, Taiwan, ROC
    Biochem Pharmacol 86:872-87. 2013
    ..Manipulation of Nrf2/AKR1Cs activity may be useful for management of oxaliplatin-refractory gastric cancers. ..
  19. doi request reprint MPT0B098, a novel microtubule inhibitor that destabilizes the hypoxia-inducible factor-1α mRNA through decreasing nuclear-cytoplasmic translocation of RNA-binding protein HuR
    Yun Ching Cheng
    National Institute of Cancer Research, National Health Research Institutes, Taiwan, PR China
    Mol Cancer Ther 12:1202-12. 2013
    ..Taken together, our results provide a novel mechanism of inhibiting HIF-1α of a microtubule inhibitor MPT0B098. MPT0B098 is a promising anticancer drug candidate with potential for the treatment of human malignancies...
  20. doi request reprint 4-Ketopinoresinol, a novel naturally occurring ARE activator, induces the Nrf2/HO-1 axis and protects against oxidative stress-induced cell injury via activation of PI3K/AKT signaling
    Huang Hui Chen
    National Institute of Cancer Research, National Health Research Institutes, Tainan 704, Taiwan
    Free Radic Biol Med 52:1054-66. 2012
    ....
  21. ncbi request reprint BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo
    Ching Chuan Kuo
    Division of Cancer Research, National Health Research Institutes, Taipei, Taiwan, ROC
    Cancer Res 64:4621-8. 2004
    ..v. doses of 50 mg/kg in nude mice. These findings indicate BPR0L075 is a promising anticancer compound with antimitotic activity that has potential for management of various malignancies, particularly for patients with drug resistance...