Tong Rong Jan

Summary

Affiliation: National Taiwan University
Country: Taiwan

Publications

  1. pmc A single exposure to iron oxide nanoparticles attenuates antigen-specific antibody production and T-cell reactivity in ovalbumin-sensitized BALB/c mice
    Chien Chang Shen
    Department and Graduate Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei
    Int J Nanomedicine 6:1229-35. 2011
  2. pmc Iron oxide nanoparticles suppressed T helper 1 cell-mediated immunity in a murine model of delayed-type hypersensitivity
    Chien Chang Shen
    Department and Graduate Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei
    Int J Nanomedicine 7:2729-37. 2012
  3. pmc A role of cellular glutathione in the differential effects of iron oxide nanoparticles on antigen-specific T cell cytokine expression
    Chien Chang Shen
    Department and Graduate Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan
    Int J Nanomedicine 6:2791-8. 2011
  4. pmc Oral supplementation with areca-derived polyphenols attenuates food allergic responses in ovalbumin-sensitized mice
    Chia Chi Wang
    School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan
    BMC Complement Altern Med 13:154. 2013
  5. ncbi request reprint Diosgenin, a steroidal sapogenin, enhances antigen-specific IgG2a and interferon-gamma expression in ovalbumin-sensitized BALB/c mice
    Tong Rong Jan
    Department of Veterinary Medicine, National Taiwan University, Taipei, Taiwan, ROC
    Planta Med 73:421-6. 2007
  6. ncbi request reprint Suppressive effects of cannabidiol on antigen-specific antibody production and functional activity of splenocytes in ovalbumin-sensitized BALB/c mice
    Tong Rong Jan
    Department of Veterinary Medicine, National Taiwan University, Taipei, Taiwan, ROC
    Int Immunopharmacol 7:773-80. 2007
  7. ncbi request reprint Cannabidiol-induced apoptosis in primary lymphocytes is associated with oxidative stress-dependent activation of caspase-8
    Hsin Ying Wu
    Department of Veterinary Medicine, National Taiwan University, No 1, Sec 4, Roosevelt Road, Taipei, Taiwan 106, ROC
    Toxicol Appl Pharmacol 226:260-70. 2008
  8. doi request reprint A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells
    Chi Ya Lee
    Department of Veterinary Medicine, National Taiwan University, Taipei, Taiwan
    Int Immunopharmacol 8:732-40. 2008
  9. doi request reprint Areca nut extracts enhance the development of CD11b(+) Gr-1(+) cells with the characteristics of myeloid-derived suppressor cells in antigen-stimulated mice
    Chia Chi Wang
    Animal Cancer Center, Department and Graduate Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei
    J Oral Pathol Med 40:769-77. 2011
  10. doi request reprint Diosgenin, a plant-derived sapogenin, enhances regulatory T-cell immunity in the intestine of mice with food allergy
    Chung Hsiung Huang
    Department and Graduate Institute of Veterinary Medicine, National Taiwan University, Taipei, Taiwan 106, Republic of China
    J Nat Prod 73:1033-7. 2010

Collaborators

Detail Information

Publications31

  1. pmc A single exposure to iron oxide nanoparticles attenuates antigen-specific antibody production and T-cell reactivity in ovalbumin-sensitized BALB/c mice
    Chien Chang Shen
    Department and Graduate Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei
    Int J Nanomedicine 6:1229-35. 2011
    ..The present study investigated the effect of iron oxide nanoparticles on antigen-specific immune responses in mice sensitized with the T cell-dependent antigen ovalbumin (OVA)...
  2. pmc Iron oxide nanoparticles suppressed T helper 1 cell-mediated immunity in a murine model of delayed-type hypersensitivity
    Chien Chang Shen
    Department and Graduate Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei
    Int J Nanomedicine 7:2729-37. 2012
    ..The present study aimed to investigate the effect of iron oxide nanoparticles on delayed-type hypersensitivity (DTH), whose pathophysiology requires the participation of T helper 1 cells and macrophages...
  3. pmc A role of cellular glutathione in the differential effects of iron oxide nanoparticles on antigen-specific T cell cytokine expression
    Chien Chang Shen
    Department and Graduate Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan
    Int J Nanomedicine 6:2791-8. 2011
    ..The present study investigates the direct effect of iron oxide nanoparticles on antigen-specific cytokine expression by T cells, and potential underlying mechanisms...
  4. pmc Oral supplementation with areca-derived polyphenols attenuates food allergic responses in ovalbumin-sensitized mice
    Chia Chi Wang
    School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan
    BMC Complement Altern Med 13:154. 2013
    ..The objective of this study is to investigate the effect of polyphenol-enriched areca nut extracts (PANE) against food allergy, a T cell-mediated immune disorder...
  5. ncbi request reprint Diosgenin, a steroidal sapogenin, enhances antigen-specific IgG2a and interferon-gamma expression in ovalbumin-sensitized BALB/c mice
    Tong Rong Jan
    Department of Veterinary Medicine, National Taiwan University, Taipei, Taiwan, ROC
    Planta Med 73:421-6. 2007
    ....
  6. ncbi request reprint Suppressive effects of cannabidiol on antigen-specific antibody production and functional activity of splenocytes in ovalbumin-sensitized BALB/c mice
    Tong Rong Jan
    Department of Veterinary Medicine, National Taiwan University, Taipei, Taiwan, ROC
    Int Immunopharmacol 7:773-80. 2007
    ....
  7. ncbi request reprint Cannabidiol-induced apoptosis in primary lymphocytes is associated with oxidative stress-dependent activation of caspase-8
    Hsin Ying Wu
    Department of Veterinary Medicine, National Taiwan University, No 1, Sec 4, Roosevelt Road, Taipei, Taiwan 106, ROC
    Toxicol Appl Pharmacol 226:260-70. 2008
    ..Collectively, the present study demonstrated that the apoptotic effect of CBD in primary lymphocytes is closely associated with oxidative stress-dependent activation of caspase-8...
  8. doi request reprint A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells
    Chi Ya Lee
    Department of Veterinary Medicine, National Taiwan University, Taipei, Taiwan
    Int Immunopharmacol 8:732-40. 2008
    ..The results demonstrated that both thymocytes and EL-4 thymoma cells were susceptible to CBD-induced apoptosis and that ROS played a critical role in the apoptosis induction...
  9. doi request reprint Areca nut extracts enhance the development of CD11b(+) Gr-1(+) cells with the characteristics of myeloid-derived suppressor cells in antigen-stimulated mice
    Chia Chi Wang
    Animal Cancer Center, Department and Graduate Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei
    J Oral Pathol Med 40:769-77. 2011
    ..As areca nut extracts (ANE) have been reported to induce a proinflammatory effect in antigen-stimulated mice, we hypothesized that ANE might enhance the development of MDSC...
  10. doi request reprint Diosgenin, a plant-derived sapogenin, enhances regulatory T-cell immunity in the intestine of mice with food allergy
    Chung Hsiung Huang
    Department and Graduate Institute of Veterinary Medicine, National Taiwan University, Taipei, Taiwan 106, Republic of China
    J Nat Prod 73:1033-7. 2010
    ..These results suggest that the suppressive effect of 1 on allergen-induced intestinal Th2 responses is closely associated with an up-regulation of the regulatory T-cell immunity in the inflammatory site...
  11. doi request reprint Methamphetamine and diazepam suppress antigen-specific cytokine expression and antibody production in ovalbumin-sensitized BALB/c mice
    Shiaw Pyng Wey
    Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan, ROC
    Toxicol Lett 181:157-62. 2008
    ..These results indicated that the central depressant diazepam did not affect methamphetamine-mediated immunosuppression. Rather, both drugs markedly suppressed antigen-specific antibody production and T-cell reactivity...
  12. doi request reprint Areca-nut extract modulates antigen-specific immunity and augments inflammation in ovalbumin-sensitized mice
    Chia Chi Wang
    Department and Graduate Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan
    Immunopharmacol Immunotoxicol 33:315-22. 2011
    ..Taken together, these results demonstrated that ANE modulated antigen-specific immune responses and promoted inflammatory reactions in vivo, which may contribute to immune deregulation associated with areca-related diseases...
  13. doi request reprint Silibinin attenuates antigen-specific IgE production through the modulation of Th1/Th2 balance in ovalbumin-sensitized BALB/c mice
    Fu Hua Kuo
    Department and Graduate Institute of Veterinary Medicine, National Taiwan University, No 1, Sec 4, Roosevelt Road, Taipei 10617, Taiwan, ROC
    Phytomedicine 16:271-6. 2009
    ..Together, these results suggest that silibinin treatment polarizes the Th1/Th2 immune balance toward the Th1-dominant direction, which may be beneficial against IgE-mediated allergy...
  14. doi request reprint Highly oligomeric procyanidins from areca nut induce lymphocyte apoptosis via the depletion of intracellular thiols
    Chia Chi Wang
    Department and Graduate Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan
    Toxicol In Vitro 23:1234-41. 2009
    ....
  15. doi request reprint Cannabidiol hydroxyquinone-induced apoptosis of splenocytes is mediated predominantly by thiol depletion
    Hsin Ying Wu
    Department and Graduate Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, No 1 Sec 4 Roosevelt Road, Taipei, Taiwan, ROC
    Toxicol Lett 195:68-74. 2010
    ....
  16. doi request reprint Cannabidiol attenuates delayed-type hypersensitivity reactions via suppressing T-cell and macrophage reactivity
    Der Zen Liu
    Graduate Institute of Biomedical Materials and Engineering, Taipei Medical University, Taipei, Taiwan, China
    Acta Pharmacol Sin 31:1611-7. 2010
    ..to investigate the effects cannabidiol (CBD) on delayed-type hypersensitivity (DTH) reactions and antigen-induced T-cell cytokine expression...
  17. ncbi request reprint Cannabidiol induced a contrasting pro-apoptotic effect between freshly isolated and precultured human monocytes
    Hsin Ying Wu
    Department and Graduate Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan
    Toxicol Appl Pharmacol 246:141-7. 2010
    ....
  18. pmc Iron oxide nanoparticles suppress the production of IL-1beta via the secretory lysosomal pathway in murine microglial cells
    Hsin Ying Wu
    Department and Graduate Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, NO, 1, Sec, 4, Roosevelt Road, Taipei 10617, Taiwan
    Part Fibre Toxicol 10:46. 2013
    ..The present study investigated the direct effect of IONPs on the production of pro-inflammatory cytokines by murine microglia stimulated with lipopolysaccharide (LPS)...
  19. doi request reprint Gene-expression profiling to identify genes related to spontaneous tumor regression in a canine cancer model
    Hsin Chien Chiang
    Animal Cancer Center, School of Veterinary Medicine, Taipei 106, Taiwan, ROC
    Vet Immunol Immunopathol 151:207-16. 2013
    ....
  20. doi request reprint Cannabidiol-induced apoptosis in murine microglial cells through lipid raft
    Hsin Ying Wu
    Department and Graduate Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan
    Glia 60:1182-90. 2012
    ..Taken together, these results suggest that CBD induces a marked proapoptotic effect in primary microglia through lipid raft coalescence and elevated expression of GM1 ganglioside and caveolin-1...
  21. ncbi request reprint Diosgenin attenuates allergen-induced intestinal inflammation and IgE production in a murine model of food allergy
    Chung Hsiung Huang
    Department and Graduate Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
    Planta Med 75:1300-5. 2009
    ..These results demonstrated the IN VIVO anti-allergic activity of diosgenin, which is associated with the suppression of IgE production and mast cell infiltration and degranulation...
  22. ncbi request reprint Involvement of the mitochondrion-dependent pathway and oxidative stress in the apoptosis of murine splenocytes induced by areca nut extract
    Chia Chi Wang
    Department and Graduate Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan, ROC
    Toxicol In Vitro 23:840-7. 2009
    ..Collectively, these results demonstrated the pro-apoptotic effect of ANE in primary lymphocytes, which was mediated, at least in part, by the activation of the mitochondrion-dependent pathway and oxidative stress...
  23. doi request reprint CD5-low expression lymphocytes in canine peripheral blood show characteristics of natural killer cells
    Yi Chun Huang
    Animal Cancer Research Center, Department of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, 1 Roosevelt Road, Section 4, Taipei 106, Taiwan
    J Leukoc Biol 84:1501-10. 2008
    ..Taken together, the CD5lo subset in canine PBL is closely related to canine NK cells, and CD5lo can be used as a phenotypic marker for an IL-2-dependent canine NK cell enrichment...
  24. doi request reprint Impairment of thymocyte function via induction of apoptosis by areca nut extract
    Chin Cheng Lee
    Department of Pathology and Laboratory Medicine, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    J Immunotoxicol 11:190-6. 2014
    ..Collectively, the data suggested that the thymus is a sensitive target to ANE. Early exposure to ANE may interfere with the development and functionality of thymic T-cells...
  25. ncbi request reprint Immunopathological effects of porcine circovirus type 2 (PCV2) on swine alveolar macrophages by in vitro inoculation
    Hui Wen Chang
    Department of Veterinary Medicine, College of Bio Resources and Agriculture, Graduate Institute of Veterinary Medicine, National Taiwan University, No 1, Sec 4, Roosevelt Rd, Taipei 106, Taiwan, ROC
    Vet Immunol Immunopathol 110:207-19. 2006
    ....
  26. doi request reprint Synergistic antiviral effect of Galanthus nivalis agglutinin and nelfinavir against feline coronavirus
    Li En Hsieh
    Graduate Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei 10617, Taiwan
    Antiviral Res 88:25-30. 2010
    ..These results suggest that the combined use of GNA and nelfinavir has therapeutic potential in the prophylaxis and treatment of cats with early-diagnosed FIP...
  27. doi request reprint GMP-compliant automated synthesis of [(18)F]AV-45 (Florbetapir F 18) for imaging beta-amyloid plaques in human brain
    Cheng Hsiang Yao
    Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taiwan, ROC
    Appl Radiat Isot 68:2293-7. 2010
    ..The specific activity of [(18)F]AV-45 reached as high as 470+/-135 TBq/mmol (n=19). The present studies show that [(18)F]AV-45 can be manufactured under GMP-compliant conditions and could be widely available for routine clinical use...
  28. doi request reprint Adjuvant effect of liposome in chicken result from induction of nitric oxide
    Yuh Feng Lin
    Taipei Medical University Shuang Ho Hospital, Taiwan
    Biomed Mater 6:015011. 2011
    ..This finding may be useful for developing potent mucosal vaccine delivery systems in the future...
  29. ncbi request reprint Attenuation of the ovalbumin-induced allergic airway response by cannabinoid treatment in A/J mice
    Tong Rong Jan
    Department of Pharmacology and Toxicology, National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI 48824, USA
    Toxicol Appl Pharmacol 188:24-35. 2003
    ....
  30. ncbi request reprint Immune responses in the lung and local lymph node of A/J mice to intranasal sensitization and challenge with adjuvant-free ovalbumin
    Aimen K Farraj
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Pathol 31:432-47. 2003
    ..The results of this study indicate that A/J mice intranasally instilled with ovalbumin without adjuvant have the hallmark histopathologic and immunologic features of IgE-mediated allergic airway disease of humans...
  31. ncbi request reprint Cannabinol enhancement of interleukin-2 (IL-2) expression by T cells is associated with an increase in IL-2 distal nuclear factor of activated T cell activity
    Tong Rong Jan
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Mol Pharmacol 61:446-54. 2002
    ..Collectively, these results suggest that increased IL-2 secretion by CBN is mediated through the enhancement of IL-2 gene transcription by activation of NF-AT in a CB1/CB2-independent manner...