Research Topics
Genomes and Genes
Species | Hai Gwo HwuSummaryAffiliation: National Taiwan University Country: Taiwan Publications
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Detail Information
Publications
A protein interaction based model for schizophrenia studyPei Chun Hsu
Institute of Biomedical Informatics, National Yang Ming University, Taiwan
BMC Bioinformatics 9:S23. 2008..Individuals with multiple candidate genes may have increased risk. However it is not clear what kind of gene combinations may produce the disease phenotype. Their collective effect remains to be studied...
Association of 5HT2A receptor gene polymorphism and alcohol abuse with behavior problemsH G Hwu
Department of Psychiatry, College of Medicine, National Taiwan University, Taipei, Taiwan
Am J Med Genet 96:797-800. 2000..Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:797-800, 2000...- Taiwan schizophrenia linkage study: the field studyHai Gwo Hwu
Department of Psychiatry, National Taiwan University Hospital and Medical College, and Department of Psychology, College of Science, National Taiwan University, Taipei, Taiwan
Am J Med Genet B Neuropsychiatr Genet 134:30-6. 2005..1 years old. This TSLS demonstrated a successful establishment of an efficient research infrastructure to collect a large nation-wise sample of schizophrenic family for genetic linkage study... - Linkage of schizophrenia with chromosome 1q loci in Taiwanese familiesH G Hwu
Department of Psychiatry, National Taiwan University Hospital and National Taiwan University College of Medicine, National Taiwan University, Taipei, Taiwan
Mol Psychiatry 8:445-52. 2003..The marker D1S2836 also had a maximal proportion (0.57, P=0.05) of shared IBD under the broad model. These findings may provide guidance for positional cloning studies on candidate genes in the 1q22-31 and 1q41-44 regions... - A single nucleotide polymorphism fine mapping study of chromosome 1q42.1 reveals the vulnerability genes for schizophrenia, GNPAT and DISC1: Association with impairment of sustained attentionYu Li Liu
Division of Mental Health and Substance Abuse Research, National Health Research Institutes, Taipei, Taiwan
Biol Psychiatry 60:554-62. 2006..The marker D1S251 of chromosome 1q42.1 showed significant association with schizophrenia in a Taiwanese sample. We used single nucleotide polymorphism (SNP) fine mapping to search for the vulnerability genes of schizophrenia... - Evaluation of RGS4 as a candidate gene for schizophreniaYu Li Liu
Department of Psychiatry, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
Am J Med Genet B Neuropsychiatr Genet 141:418-20. 2006..Our results fail to support the RGS4 as a candidate gene for schizophrenia when evaluated from these three SNP markers... - No association of G72 and D-amino acid oxidase genes with schizophreniaYu Li Liu
Division of Mental Health and Substance Abuse Research, National Health Research Institutes, Taipei, Taiwan
Schizophr Res 87:15-20. 2006..These results suggest that the DAAO and G72 genes are not susceptibility genes for schizophrenia in a Taiwanese sample... - Absence of significant associations between four AKT1 SNP markers and schizophrenia in the Taiwanese populationYu Li Liu
Department of Psychiatry, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
Psychiatr Genet 16:39-41. 2006..Both single locus and haplotypes analyses showed no association of these single-nucleotide polymorphisms with schizophrenia. These findings fail to support AKT1 as a susceptibility gene for schizophrenia in the Taiwanese population... 
Medium-term course and outcome of schizophrenia depicted by the sixth-month subtype after an acute episodeChen Chung Liu
Department of Psychiatry, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
J Formos Med Assoc 111:265-74. 2012..This article attempts to simplify this complexity using a hypothetical tripartite based on the profile of symptoms at 6 months after acute treatment...- Differentiation of schizophrenia patients from healthy subjects by mismatch negativity and neuropsychological testsYi Ting Lin
Department of Psychiatry, National Taiwan University Hospital Yun Lin Branch, Dou Liou City, Yun Lin, Taiwan
PLoS ONE 7:e34454. 2012.... - Familial aggregation in skin flush response to niacin patch among schizophrenic patients and their nonpsychotic relativesSheng Hsiang Lin
Institute of Epidemiology, College of Public Health, National Taiwan University, 17 Xuzhou Road, Taipei 100, Taiwan
Schizophr Bull 33:174-82. 2007..These findings provide support for the potential of niacin flush response as a vulnerability indicator to schizophrenia... - Neuregulin 1 gene and variations in perceptual aberration of schizotypal personality in adolescentsHsiao Fan Lin
Institute of Epidemiology, College of Public Health, National Taiwan University, 1 Jen Ai Road, Sec 1, Taipei 100, Taiwan
Psychol Med 35:1589-98. 2005..We test the hypothesis that the neuregulin 1 (NRG1 ) gene at chromosome 8p22-p12, which has been implicated as a susceptibility gene to schizophrenia, is associated with variations in schizotypal personality in non-clinical populations... - ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes at chromosome 10q22 associated with the subgroup of schizophrenia with deficits in attention and executive functionChih Min Liu
Department of Psychiatry, National Taiwan University Hospital, Yun Lin branch, Yunlin, Taiwan
Biol Psychiatry 70:51-8. 2011..A genome scan of Taiwanese schizophrenia families suggested linkage to chromosome 10q22.3. We aimed to find the candidate genes in this region... - A genome-wide linkage scan for distinct subsets of schizophrenia characterized by age at onset and neurocognitive deficitsYin Ju Lien
College of Public Health, Research Center for Genes and Institute of Epidemiology and Preventive Medicine, Environment and Human Health, National Taiwan University, Taipei, Taiwan
PLoS ONE 6:e24103. 2011..The aim of the study is to evaluate the genetic linkage evidence for schizophrenia in subsets of families with earlier age at onset or greater neurocognitive deficits... - More severe sustained attention deficits in nonpsychotic siblings of multiplex schizophrenia families than in those of simplex onesHui Chun Tsuang
Institute of Epidemiology, College of Public Health, National Taiwan University, Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan, ROC
Schizophr Res 87:172-80. 2006.... - No association evidence between schizophrenia and dystrobrevin-binding protein 1 (DTNBP1) in Taiwanese familiesChih Min Liu
Department of Psychiatry, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
Schizophr Res 93:391-8. 2007..We failed to replicate the association evidence between DTNBP1 and schizophrenia and this gene may not play a major role in the etiology of schizophrenia in this Taiwanese family sample... - Follow-up of subjects with suspected pre-psychotic state in TaiwanChen Chung Liu
Department of Psychiatry, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
Schizophr Res 126:65-70. 2011..To describe the outcomes of subjects with suspected pre-psychotic state in Taiwan... - Symptom patterns and subgrouping of schizophrenic patients: significance of negative symptoms assessed on admissionHai Gwo Hwu
Department of Psychiatry, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
Schizophr Res 56:105-19. 2002..Thus, the GONEG might comprise patients having a pure paranoid syndrome with quick and better treatment response, while the GWNEG comprises patients with the blunt-disorganization syndrome having a poorer outcome... - Outcome of severe obsessive-compulsive disorder with schizotypal features: a pilot studyLung Cheng Huang
Department of Psychiatry, Chi Mei Medical Center, Tainan, Taiwan
J Formos Med Assoc 110:85-92. 2011..Long-term outcome of patients with severe obsessive-compulsive disorder (OCD) and schizotypal features has been rarely studied. We investigated this issue in this retrospective pilot study... - Development of a brief self-report questionnaire for screening putative pre-psychotic statesChen Chung Liu
Department of Psychiatry, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
Schizophr Res 143:32-7. 2013..This study developed a questionnaire using data covering a wide range of clinical characteristics... - Creating a platform to bridge service and research for early psychosisChen Chung Liu
Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan
J Formos Med Assoc 109:543-9. 2010..It seems that setting up a special clinic to provide a service for at risk subjects, combined with certain campaigns, could facilitate their engagement in a longitudinal prospective study for early psychosis... - Correlates of gender dysphoria in Taiwanese university studentsMeng Chuan Lai
Department of Psychiatry, National Taiwan University Hospital, No 7, Chung Shan South Road, 10002, Taipei, Taiwan
Arch Sex Behav 39:1415-28. 2010..This implies the importance of attention and specific measures to offset psychiatric conditions and to promote mental well-being of this population... - Association between the dopamine transporter gene and the inattentive subtype of attention deficit hyperactivity disorder in TaiwanChi Yung Shang
Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan
Prog Neuropsychopharmacol Biol Psychiatry 35:421-8. 2011..012). Our finding of the haplotype rs27048 (C)/rs429699 (T) as a novel genetic marker in the inattentive ADHD subtype suggests that variation in the DAT1 gene may primarily affect the inattentive subtype of ADHD... - Rapid response to antipsychotic treatment on psychotic prodrome: implications from a case seriesChen Chung Liu
Department of Psychiatry, National Taiwan University Hospital, No 7 Chung Shan S Road, Taipei 10002, Taiwan
Psychiatry Clin Neurosci 64:202-6. 2010..We urge specific attention to monitor the dissolution of psychotic-like symptoms carefully in order to have a better understanding of the pathogenesis and pharmacotherapy in the inception of psychosis... - RASD2, MYH9, and CACNG2 genes at chromosome 22q12 associated with the subgroup of schizophrenia with non-deficit in sustained attention and executive functionYu Li Liu
Division of Mental Health and Substance Abuse Research, National Health Research Institutes, Taipei, Taiwan
Biol Psychiatry 64:789-96. 2008..In a previous linkage study of schizophrenia that included Taiwanese samples, the marker D22S278 (22q12.3) was significantly linked to schizophrenia (p = .001)... - Applicability of the Chinese version of the Prodromal QuestionnaireShu Chen Chiu
School of Nursing, College of Medicine, National Taiwan University, Taipei, Taiwan
J Formos Med Assoc 109:647-55. 2010..Early detection and intervention of psychosis is clinically important. This study aimed to test the applicability of the Chinese version of the Prodromal Questionnaire (CPQ) for identifying prodromal states of psychosis... - Absent response to niacin skin patch is specific to schizophrenia and independent of smokingChih Min Liu
Department of Psychiatry, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
Psychiatry Res 152:181-7. 2007..The niacin skin test for schizophrenia had 49.2% sensitivity and 92.5% specificity compared with controls. This study found that absent response to niacin skin patch was specific to schizophrenia and independent of smoking status... - Psychiatric nurses' anxiety and cognition in managing psychiatric patients' aggressionShing Chia Chen
Department of Nursing, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan
Arch Psychiatr Nurs 19:141-9. 2005..An important outcome of this study is the added understanding of cognitive appraisal, trait anxiety, and attitudes, that influence the anxiety of psychiatric nurses... - Aripiprazole for drug-naive or antipsychotic-short-exposure subjects with ultra-high risk state and first-episode psychosis: an open-label studyChen Chung Liu
From the Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan
J Clin Psychopharmacol 33:18-23. 2013.... - Auditory event-related potential of subjects with suspected pre-psychotic state and first-episode psychosisMing H Hsieh
Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan
Schizophr Res 140:243-9. 2012..This study explores 3 sets of auditory-related event potentials in subjects with different risk levels of psychosis... - The multidimensionality of schizotypy in nonpsychotic relatives of patients with schizophrenia and its applications in ordered subsets linkage analysis of schizophreniaYin Ju Lien
Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
Am J Med Genet B Neuropsychiatr Genet 153:1-9. 2010..Their differential relations to linkage signals have etiological implications and provide further evidence for their validity... - Risk factors for suicide in Taiwanese college studentsSusan Shur Fen Gau
Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan
J Am Coll Health 57:135-42. 2008..The authors investigated the personality characteristics, psychopathology, parenting style, and family function among Taiwanese college students with high, moderate, and low suicidal risks... - Clinical manifestations of aggressive acts by schizophrenic inpatients: a prospective studyShing Chia Chen
Department of Nursing, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan
Perspect Psychiatr Care 47:110-6. 2011..The purpose of this study was to explore the clinical manifestations of aggressive acts by schizophrenic patients during hospitalization... - Genetic copy number variants in sib pairs both affected with schizophreniaChia Huei Lee
Department of Psychiatry, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
J Biomed Sci 17:2. 2010..Schizophrenia is a complex disorder with involvement of multiple genes... - MicroRNA expression aberration as potential peripheral blood biomarkers for schizophreniaChi Yu Lai
Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
PLoS ONE 6:e21635. 2011..The results indicated that the mononuclear leukocyte-based miRNA profiling is a feasible way to identify biomarkers for schizophrenia, and the seven-miRNA signature warrants further investigation... - Sustained attention deficits in nonpsychotic relatives of schizophrenic patients: a recurrence risk ratio analysisWei J Chen
Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
Biol Psychiatry 55:995-1000. 2004..CONCLUSIONS: Stringent cut-off criteria of CPT deficits with adjustment for demographic features leads to recurrence risk ratios greater than those based on schizophrenia alone in both parents and siblings of schizophrenic patients... - Autonomic modulation and health-related quality of life among schizophrenic patients treated with non-intensive case managementLi Ren Chang
Department of Psychiatry, National Taiwan University Hospital, Yun Lin branch, Yunlin, Taiwan
PLoS ONE 6:e26378. 2011..Besides, autonomic modulation and its association with health-related quality of life (HRQoL) in this population remain unexplored... - Differential propensity in recognition of prepsychotic phenomena among psychiatrists, clinical psychologists and school counsellorsChen Chung Liu
Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan
Early Interv Psychiatry 4:275-82. 2010..This study was conducted to assess differences among three types of mental health professionals in the recognition of prepsychotic phenomena... - Psychometric evaluation of Chinese version of Violence Scale for objective rating among inpatients with schizophreniaShing Chia Chen
Department of Nursing, National Taiwan University College of Medicine, 1, Jen Ai Road, Sec 1, Taipei 100, Taiwan, ROC
J Clin Nurs 18:1889-96. 2009..The psychometric properties of the Chinese version of Violence Scale in clinical service setting were examined... - Association of the 3' region of COMT with schizophrenia in TaiwanYi Ling Chien
Department of Psychiatry, National Taiwan University Hospital, Yun Lin branch, Yunlin, Taiwan
J Formos Med Assoc 108:301-9. 2009..This study aims to clarify the association between these three SNPs and their haplotypes with schizophrenia and neurocognitive functioning, using both case-control and family-based designs... - Individual and family correlates for cigarette smoking among Taiwanese college studentsSusan Shur Fen Gau
Department of Psychiatry, National Taiwan University Hospital, Taipei 10002, Taiwan
Compr Psychiatry 50:276-85. 2009..This college-based questionnaire survey aimed to explore the individual, family, and peer correlates for cigarette smoking among first-year college students... - Genome-wide association study of treatment refractory schizophrenia in Han ChineseYing Jay Liou
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
PLoS ONE 7:e33598. 2012..This study suggests that rs28362691 in NFKB1 might be involved in the development of TRS... - Association between sleep problems and symptoms of attention-deficit/hyperactivity disorder in young adultsSusan S F Gau
Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Chung Shan South Road, Taipei, Taiwan
Sleep 30:195-201. 2007..To examine the association between sleep-related problems and symptoms of attention-deficit/hyperactivity disorder (ADHD) in a community sample of young adults in Taiwan... - Brain responses of explicit and implicit memory: An event-related potential studyMing Jang Chiu
Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
Neuroreport 17:1483-6. 2006.... - Aripiprazole and haloperidol: beneficial combination antipsychotic therapy for a schizophrenic patientJoseph Kuo
Department of Psychiatry, Lotung St Mary s Hospital, Ilan, Taiwan
Clin Neuropharmacol 31:173-5. 2008..Its partial agonism is said to protect the patient from the side effects caused by full antagonists at the same time that its antagonism treats the schizophrenia effectively... - Morbidity risk of psychiatric disorders among the first degree relatives of schizophrenia patients in TaiwanChing-Jui Chang
Department of Psychiatry, College of Medicine, National Taiwan University, Taipei
Schizophr Bull 28:379-92. 2002..0 to 5.9) was greater than that of schizophrenia alone (9.3 to 14.4). Thus, including schizophrenia-related personality disorders in the spectrum did not increase power for linkage analysis of schizophrenia... - Linkage evidence of schizophrenia to loci near neuregulin 1 gene on chromosome 8p21 in Taiwanese familiesChih-Min Liu
Department of Psychiatry, National Taiwan University Hospital, and College of Medicine, National Taiwan University, Taipei, Taiwan
Am J Med Genet B Neuropsychiatr Genet 134:79-83. 2005..The results provide suggestive linkage evidence of schizophrenia to loci near NRG1 on chromosome 8p21 in an ethnically distinct Taiwanese sample. Further exploration of the candidate gene and nearby chromosome regions is warranted... - Brief alcoholism screening questionnaire: establishment and validity in TaiwaneseHai-Gwo Hwu
Department of Psychiatry, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
J Formos Med Assoc 102:250-6. 2003..1 to 90.3%) in diverse clinical settings. CONCLUSIONS: A 4-item BASQ was established with adequate validity for clinical and public health application in the early detection of alcoholism in Taiwanese subjects... - Re-examining sustained attention deficits as vulnerability indicators for schizophrenia: stability in the long term courseShi K Liu
Department of Psychiatry, National Taiwan University Hospital and College of Medicine, National Taiwan University, 7 Chung-Shan South Road, Taipei 100, Taiwan
J Psychiatr Res 40:613-21. 2006..We concluded that there is substantial heterogeneity in schizophrenia patients' long term pattern in sustained attention deficits and those with severe impairment might represent a subgroup with stable vulnerability to schizophrenia... - Memory impairment and auditory evoked potential gating deficit in schizophreniaMing H Hsieh
Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan
Psychiatry Res 130:161-9. 2004..The modality-specific impairment of implicit learning in schizophrenia may reflect a failure of adaptive filtering on the flooding input from color patterns... - Patterns and clinical correlates of neuropsychologic deficits in patients with schizophreniaShi-Kai Liu
Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan
J Formos Med Assoc 105:978-91. 2006..Despite evidence suggesting that disease chronicity entailed a decline in selective cognitive domains, the trajectory of the neuropsychologic deficits remains to be examined by further longitudinal studies... - Prevalence and determinants of workplace violence of health care workers in a psychiatric hospital in TaiwanWen Ching Chen
Yu Li Hospital, Department of Health, Executive Yuan, Taiwan
J Occup Health 50:288-93. 2008..A high anxiety level was associated with the occurrence of PV. These results need to be corroborated by future investigation. A training program may be required for high risk groups to reduce workplace violence... - Deficits in sustained attention in schizophrenia and affective disorders: stable versus state-dependent markersShi K Liu
Department of Psychiatry, National Taiwan University Hospital, Tapei
Am J Psychiatry 159:975-82. 2002..CONCLUSIONS: Continuous Performance Test deficits are stable vulnerability indicators for schizophrenia, mediating indicators for bipolar disorder, and state-dependent indicators for major depression... - HTF9C gene of 22q11.21 region associates with schizophrenia having deficit-sustained attentionYu Li Liu
Division of Mental Health and Substance Abuse Research, National Health Research Institute, Taiwan
Psychiatr Genet 17:333-8. 2007.... - Health-related quality of life of Chinese people with schizophrenia in Hong Kong and Taipei: a cross-sectional analysisSally Wai chi Chan
The Nethersole School of Nursing, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
Res Nurs Health 30:261-9. 2007..Schizophrenia has an impact on many aspects of a person's functioning. A rehabilitation model that takes into account symptoms, financial situation, family support, and social functioning is required... - Genome scan of Han Chinese schizophrenia families from Taiwan: confirmation of linkage to 10q22.3Stephen V Faraone
Department of Psychiatry, SUNY Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA
Am J Psychiatry 163:1760-6. 2006..To address this issue, the authors ascertained 606 Han Chinese families comprising 1,234 affected members... - Teachers' knowledge, beliefs and attitudes concerning schizophrenia- a cross-cultural approach in Japan and TaiwanTakahiro Kurumatani
Osaka Juvenile Classification Home, Osaka, Japan
Soc Psychiatry Psychiatr Epidemiol 39:402-9. 2004.... - Efficacy and safety of aripiprazole in the acute treatment of schizophrenia in Chinese patients with risperidone as an active control: a randomized trialHung Yu Chan
Taoyuan Mental Hospital, Taoyuan County, Taiwan
J Clin Psychiatry 68:29-36. 2007..Studies of aripiprazole in Asian populations are scarce. This study aimed to investigate the efficacy, safety, and tolerability of aripiprazole in Chinese patients with acute schizophrenia or schizoaffective disorder... - Effects of olanzapine plasma concentrations on depressive symptoms in schizophrenia: a pilot studyHsien-Yuan Lane
J Clin Psychopharmacol 22:530-2. 2002 - Changing needs and new perspectives for psychiatry and mental health services in TaiwanHai-Gwo Hwu
Department of Psychiatry, College of Medicine and National Taiwan University Hospital
Seishin Shinkeigaku Zasshi 108:1167-73. 2006 - Factors related to perceived needs of primary caregivers of patients with schizophreniaLing Ling Yeh
Institute of Long Term Care, College of Health Science, Asia University, Taichung, Taiwan
J Formos Med Assoc 107:644-52. 2008..The present study was designed to assess the perceived needs of caregivers so that adequate services can be provided for them in the community...