Huei Sheng Huang

Summary

Affiliation: National Cheng Kung University
Country: Taiwan

Publications

  1. doi request reprint TG-interacting factor-induced superoxide production from NADPH oxidase contributes to the migration/invasion of urothelial carcinoma
    Huei Sheng Huang
    Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Free Radic Biol Med 53:769-78. 2012
  2. ncbi request reprint Involvement of reactive oxygen species in arsenite-induced downregulation of phospholipid hydroperoxide glutathione peroxidase in human epidermoid carcinoma A431 cells
    Huei Sheng Huang
    Department of Medical Technology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Free Radic Biol Med 33:864-73. 2002
  3. ncbi request reprint Opposite effect of ERK1/2 and JNK on p53-independent p21WAF1/CIP1 activation involved in the arsenic trioxide-induced human epidermoid carcinoma A431 cellular cytotoxicity
    Huei Sheng Huang
    Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    J Biomed Sci 13:113-25. 2006
  4. doi request reprint Involvement of glycogen synthase kinase-3β in arsenic trioxide-induced p21 expression
    Huei Sheng Huang
    Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Toxicol Sci 121:101-9. 2011
  5. ncbi request reprint Blockage of JNK pathway enhances arsenic trioxide-induced apoptosis in human keratinocytes
    Huei Sheng Huang
    Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Toxicol Appl Pharmacol 244:234-41. 2010
  6. ncbi request reprint As2O3-induced c-Src/EGFR/ERK signaling is via Sp1 binding sites to stimulate p21WAF1/CIP1 expression in human epidermoid carcinoma A431 cells
    Zi Miao Liu
    Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Cell Signal 18:244-55. 2006
  7. ncbi request reprint NADPH oxidase-produced superoxide mediates EGFR transactivation by c-Src in arsenic trioxide-stimulated human keratinocytes
    Hong Yu Tseng
    Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Arch Toxicol 86:935-45. 2012
  8. ncbi request reprint Depletion of phospholipid hydroperoxide glutathione peroxidase up-regulates arachidonate metabolism by 12S-lipoxygenase and cyclooxygenase 1 in human epidermoid carcinoma A431 cells
    Ching Jiunn Chen
    Department of Pharmacology, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan 704, Taiwan
    FASEB J 17:1694-6. 2003
  9. ncbi request reprint Functional role of extracellular signal-regulated kinase activation and c-Jun induction in phorbol ester-induced promoter activation of human 12(S)-lipoxygenase gene
    Ben Kuen Chen
    Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC
    J Biomed Sci 9:156-65. 2002
  10. doi request reprint Arsenic trioxide phosphorylates c-Fos to transactivate p21(WAF1/CIP1) expression
    Zi Miao Liu
    Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Toxicol Appl Pharmacol 233:297-307. 2008

Collaborators

Detail Information

Publications17

  1. doi request reprint TG-interacting factor-induced superoxide production from NADPH oxidase contributes to the migration/invasion of urothelial carcinoma
    Huei Sheng Huang
    Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Free Radic Biol Med 53:769-78. 2012
    ....
  2. ncbi request reprint Involvement of reactive oxygen species in arsenite-induced downregulation of phospholipid hydroperoxide glutathione peroxidase in human epidermoid carcinoma A431 cells
    Huei Sheng Huang
    Department of Medical Technology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Free Radic Biol Med 33:864-73. 2002
    ..Therefore, we concluded that reactive oxygen species were involved in arsenite-induced downregulation of PHGPx, upregulation of p21(WAF1/CIP1), and apoptosis in A431 cells...
  3. ncbi request reprint Opposite effect of ERK1/2 and JNK on p53-independent p21WAF1/CIP1 activation involved in the arsenic trioxide-induced human epidermoid carcinoma A431 cellular cytotoxicity
    Huei Sheng Huang
    Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    J Biomed Sci 13:113-25. 2006
    ..Therefore, we conclude that in A431 cells the ERK1/2 and JNK pathways might differentially contribute to As2O3-induced p21 expression and then due to cellular cytotoxicity...
  4. doi request reprint Involvement of glycogen synthase kinase-3β in arsenic trioxide-induced p21 expression
    Huei Sheng Huang
    Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Toxicol Sci 121:101-9. 2011
    ..We suggest that, taken together, ATO-induced ERK phosphorylation could inhibit GSK-3β activity to dephosphorylate the C-terminus (Ser243) of c-Jun to increase p21 expression and resultant cell death...
  5. ncbi request reprint Blockage of JNK pathway enhances arsenic trioxide-induced apoptosis in human keratinocytes
    Huei Sheng Huang
    Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Toxicol Appl Pharmacol 244:234-41. 2010
    ..Thus, the domains of TGIF that carried out its inhibitory effects on p21 were identified. Finally, treatment with JNK inhibitor SP600125 could enhance ATO-induced apoptosis of HaCaT keratinocytes by using flow cytometry...
  6. ncbi request reprint As2O3-induced c-Src/EGFR/ERK signaling is via Sp1 binding sites to stimulate p21WAF1/CIP1 expression in human epidermoid carcinoma A431 cells
    Zi Miao Liu
    Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Cell Signal 18:244-55. 2006
    ..EGF-induced p21 expression may involve similar mechanisms as those that operate in the As2O3-mediated reactions in A431 cells...
  7. ncbi request reprint NADPH oxidase-produced superoxide mediates EGFR transactivation by c-Src in arsenic trioxide-stimulated human keratinocytes
    Hong Yu Tseng
    Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Arch Toxicol 86:935-45. 2012
    ..Collectively, we suggest that NADPH oxidase was involved in the ATO-induced arrest/apoptosis of keratinocytes, which was regulated by c-Src activation...
  8. ncbi request reprint Depletion of phospholipid hydroperoxide glutathione peroxidase up-regulates arachidonate metabolism by 12S-lipoxygenase and cyclooxygenase 1 in human epidermoid carcinoma A431 cells
    Ching Jiunn Chen
    Department of Pharmacology, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan 704, Taiwan
    FASEB J 17:1694-6. 2003
    ....
  9. ncbi request reprint Functional role of extracellular signal-regulated kinase activation and c-Jun induction in phorbol ester-induced promoter activation of human 12(S)-lipoxygenase gene
    Ben Kuen Chen
    Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC
    J Biomed Sci 9:156-65. 2002
    ....
  10. doi request reprint Arsenic trioxide phosphorylates c-Fos to transactivate p21(WAF1/CIP1) expression
    Zi Miao Liu
    Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Toxicol Appl Pharmacol 233:297-307. 2008
    ....
  11. doi request reprint Inhibitory role of TGIF in the As2O3-regulated p21 WAF1/CIP1 expression
    Zi Miao Liu
    Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan
    J Biomed Sci 15:333-42. 2008
    ..That is, TGIF is involved in As(2)O(3)-inhibited p21 expression, and then blocks the cell cycle arrest...
  12. ncbi request reprint Overexpression of TG-interacting factor is associated with worse prognosis in upper urinary tract urothelial carcinoma
    Bi Wen Yeh
    Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Am J Pathol 181:1044-55. 2012
    ..It may serve as an attractive therapeutic or prognostic target for selected patients with upper urinary tract UC...
  13. ncbi request reprint Inhibition of arachidonate metabolism in human epidermoid carcinoma a431 cells overexpressing phospholipid hydroperoxide glutathione peroxidase
    Ching Jiunn Chen
    Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC
    J Biomed Sci 9:453-9. 2002
    ..These results support the hypothesis that PHGPx plays a pivotal role in the regulation of arachidonate metabolism in A431 cells...
  14. ncbi request reprint Suppression of TG-interacting factor sensitizes arsenic trioxide-induced apoptosis in human hepatocellular carcinoma cells
    Zi Miao Liu
    Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Biochem J 438:349-58. 2011
    ..Blockage of the PI3K/Akt pathway or TGIF expression combined with ATO treatment may be a promising strategy for HCC therapy...
  15. pmc Role of macrophage CCAAT/enhancer binding protein delta in the pathogenesis of rheumatoid arthritis in collagen-induced arthritic mice
    Ling Hua Chang
    Institute of Basic Medical Sciences, College of Medicine, Tainan, Taiwan
    PLoS ONE 7:e45378. 2012
    ..However, the role of macrophage CEBPD in the pathogenesis of RA is unclear...
  16. ncbi request reprint Serine hydroxymethyltransferase isoforms are differentially inhibited by leucovorin: characterization and comparison of recombinant zebrafish serine hydroxymethyltransferases
    Wen Ni Chang
    Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, No 1, University Road, Tainan 701, Taiwan
    Drug Metab Dispos 35:2127-37. 2007
    ..Together with the previous report on zebrafish cytosolic SHMT, we suggest that zSHMTs can be used in in vitro assays for folate-related investigation and antifolate drug discovery...
  17. ncbi request reprint Proteomic analysis of pycnogenol effects in RAW 264.7 macrophage reveals induction of cathepsin D expression and enhancement of phagocytosis
    Ting Feng Wu
    Department of Biotechnology, Southern Taiwan University, 1 Nan Tai Street, Yung Kang City, Tainan County, Tainan, Taiwan
    J Agric Food Chem 55:9784-91. 2007
    ..These results reveal the novel effects of pycnogenol on protein expression and phagocytic functions and illustrate the advantage of proteomics-based strategy in unveiling the molecular basis of phytochemicals...