Affiliation: National Taiwan Ocean University
Ho T, Paul G, Chen Y, Hsu T. Heat stress upregulates G-T mismatch binding activities in zebrafish (Danio rerio) embryos preexposed and nonexposed to a sublethal level of cadmium (Cd). Chemosphere. 2018;218:179-188 pubmed publisher
..Our results suggested the importance of heat shock response in facilitating the correction of G-T mismatch in developing zebrafish even under Cd exposure. ..
Ho T, Sung S, Huang K, Hsu T. Comparative Effects of Mercury(II) and Cadmium on MutS Homolog 6(MSH6)-Mediated DNA Mismatch Binding Activities in Zebrafish (Danio rerio) Embryos. J Biochem Mol Toxicol. 2015;29:513-20 pubmed publisher
..The weaker response of MSH gene activities to Hg(2+) correlated with the lower oxidative stress-inducing potential of Hg(2+) . Hence, Hg(2+) targets mismatch sensing capacity at protein function rather than at transcription level. ..
Shen Y, Hsu T, Ling L, You W, Liu C. Identification of low-molecular-weight vitellogenin 1 (Vg1)-like proteins as nucleotide excision repair (NER) factors in developing zebrafish (Danio rerio) using a transcription-based DNA repair assay. Fish Physiol Biochem. 2017;43:663-676 pubmed publisher
..Our results identified the participation of Vg1-like factors in NER in developing zebrafish, and these factors may function at post-incison steps of NER. ..
Hsu T, Tsai H, Huang K, Luan M, Hsieh C. Sublethal levels of cadmium down-regulate the gene expression of DNA mismatch recognition protein MutS homolog 6 (MSH6) in zebrafish (Danio rerio) embryos. Chemosphere. 2010;81:748-54 pubmed publisher
..Our results revealed the inhibition of Cd on MSH6 expression at both mRNA and protein levels and this mechanism may play a role in Cd genotoxicity. ..
Lai Y, Hsieh F, Hsu T. Affinity isolation and mass spectral analysis of 1,10-phenanthroline (OP)-stimulated UV-damaged-DNA binding proteins expressed in zebrafish (Danio rerio) embryos. Fish Physiol Biochem. 2012;38:1117-1129 pubmed publisher
..The OP-stimulated fraction produced a much stronger UV-dependent DNA incision activity in the presence than in the absence of OP, suggesting the association of these factors with DNA damage repair under metal-deficient conditions. ..
Ling L, Chang Y, Liu C, Lai P, Hsu T. Oxidative stress intensity-related effects of cadmium (Cd) and paraquat (PQ) on UV-damaged-DNA binding and excision repair activities in zebrafish (Danio rerio) embryos. Chemosphere. 2017;167:10-18 pubmed publisher
Chang Y, Lee W, Lin Y, Hsu T. Mercury (II) impairs nucleotide excision repair (NER) in zebrafish (Danio rerio) embryos by targeting primarily at the stage of DNA incision. Aquat Toxicol. 2017;192:97-104 pubmed publisher
..Our results showed the potential of Hg2+ at environmental relevant levels to disturb NER in zebrafish embryos by targeting primarily at the stage of DNA incision/excision. ..