Shan Hui Hsu

Summary

Affiliation: National Taiwan University
Country: Taiwan

Publications

  1. ncbi request reprint Substrate-dependent modulation of 3D spheroid morphology self-assembled in mesenchymal stem cell-endothelial progenitor cell coculture
    Shan Hui Hsu
    Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei, Taiwan Electronic address
    Biomaterials 35:7295-307. 2014
  2. pmc Antibacterial properties of silver nanoparticles in three different sizes and their nanocomposites with a new waterborne polyurethane
    Hung Li Liu
    Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan, Republic of China
    Int J Nanomedicine 5:1017-28. 2010
  3. pmc Spheroid formation and enhanced cardiomyogenic potential of adipose-derived stem cells grown on chitosan
    Bing Hsien Liu
    Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan
    Biores Open Access 2:28-39. 2013
  4. ncbi request reprint Substrate-dependent gene regulation of self-assembled human MSC spheroids on chitosan membranes
    Hsi Yi Yeh
    Institute of Polymer Science and Engineering, National Taiwan University, and the Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei, Taiwan
    BMC Genomics 15:10. 2014
  5. doi request reprint Microwell chips for selection of bio-macromolecules that increase the differentiation capacities of mesenchymal stem cells
    Shan Hui Hsu
    No 1, Sec 4 Roosevelt Road, Institute of Polymer Science and Engineering, National Taiwan University, Taipei 10617, Taiwan
    Macromol Biosci 13:1100-9. 2013
  6. doi request reprint Novel nanostructured biodegradable polymer matrices fabricated by phase separation techniques for tissue regeneration
    S H Hsu
    No 1, Sec 4, Roosevelt Road, Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan
    Acta Biomater 9:6915-27. 2013
  7. doi request reprint Substrate-dependent Wnt signaling in MSC differentiation within biomaterial-derived 3D spheroids
    Shan Hui Hsu
    Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan, ROC
    Biomaterials 34:4725-38. 2013
  8. doi request reprint Air plasma treated chitosan fibers-stacked scaffolds
    Shan Hui Hsu
    Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Republic of China
    Biofabrication 4:015002. 2012
  9. doi request reprint Nanoparticle uptake and gene transfer efficiency for MSCs on chitosan and chitosan-hyaluronan substrates
    Shan Hui Hsu
    Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan
    Biomaterials 33:3639-50. 2012
  10. doi request reprint Mediation of the migration of endothelial cells and fibroblasts on polyurethane nanocomposites by the activation of integrin-focal adhesion kinase signaling
    Huey Shan Hung
    Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan, Republic of China
    J Biomed Mater Res A 100:26-37. 2012

Collaborators

Detail Information

Publications90

  1. ncbi request reprint Substrate-dependent modulation of 3D spheroid morphology self-assembled in mesenchymal stem cell-endothelial progenitor cell coculture
    Shan Hui Hsu
    Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei, Taiwan Electronic address
    Biomaterials 35:7295-307. 2014
    ..This study reveals the possibility to modulate the self-assembled morphology as well as the effect of cocultured cells by changing the cell culture substratum. ..
  2. pmc Antibacterial properties of silver nanoparticles in three different sizes and their nanocomposites with a new waterborne polyurethane
    Hung Li Liu
    Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan, Republic of China
    Int J Nanomedicine 5:1017-28. 2010
    ..Addition of smaller or larger AgNPs did not produce as substantial an effect in PEU, especially for the larger AgNPs...
  3. pmc Spheroid formation and enhanced cardiomyogenic potential of adipose-derived stem cells grown on chitosan
    Bing Hsien Liu
    Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan
    Biores Open Access 2:28-39. 2013
    ....
  4. ncbi request reprint Substrate-dependent gene regulation of self-assembled human MSC spheroids on chitosan membranes
    Hsi Yi Yeh
    Institute of Polymer Science and Engineering, National Taiwan University, and the Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei, Taiwan
    BMC Genomics 15:10. 2014
    ....
  5. doi request reprint Microwell chips for selection of bio-macromolecules that increase the differentiation capacities of mesenchymal stem cells
    Shan Hui Hsu
    No 1, Sec 4 Roosevelt Road, Institute of Polymer Science and Engineering, National Taiwan University, Taipei 10617, Taiwan
    Macromol Biosci 13:1100-9. 2013
    ..MSC spheroids expressing the highest N-cadherin level also show the greatest osteogenic potential. The microwell chip may be used as an efficient platform to screen bio-macromolecules that enhance the differentiation potential of MSCs...
  6. doi request reprint Novel nanostructured biodegradable polymer matrices fabricated by phase separation techniques for tissue regeneration
    S H Hsu
    No 1, Sec 4, Roosevelt Road, Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan
    Acta Biomater 9:6915-27. 2013
    ..Antimicrobial nanofibers were further obtained by plasma-assisted coating of chitosan on PLA nanofibers. This study reveals a platform for fabricating novel biodegradable nanofibrous architecture, with potential in tissue regeneration...
  7. doi request reprint Substrate-dependent Wnt signaling in MSC differentiation within biomaterial-derived 3D spheroids
    Shan Hui Hsu
    Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan, ROC
    Biomaterials 34:4725-38. 2013
    ....
  8. doi request reprint Air plasma treated chitosan fibers-stacked scaffolds
    Shan Hui Hsu
    Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Republic of China
    Biofabrication 4:015002. 2012
    ..These results suggested that fibers-stacked chitosan scaffolds may be produced by liquid-frozen deposition and treated with AP for bone tissue engineering applications...
  9. doi request reprint Nanoparticle uptake and gene transfer efficiency for MSCs on chitosan and chitosan-hyaluronan substrates
    Shan Hui Hsu
    Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan
    Biomaterials 33:3639-50. 2012
    ..The substrate-mediated endocytosis described here may represent a new and potentially attractive approach to facilitate stem cell labeling or to improve gene delivery efficiency without altering cell viability and differentiation...
  10. doi request reprint Mediation of the migration of endothelial cells and fibroblasts on polyurethane nanocomposites by the activation of integrin-focal adhesion kinase signaling
    Huey Shan Hung
    Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan, Republic of China
    J Biomed Mater Res A 100:26-37. 2012
    ....
  11. doi request reprint Isolation of the multipotent MSC subpopulation from human gingival fibroblasts by culturing on chitosan membranes
    Shan Hui Hsu
    Institute of Polymer Science and Engineering, National Taiwan University, Taipei 106, Taiwan, ROC
    Biomaterials 33:2642-55. 2012
    ..This study showed that chitosan membranes could be used for isolation of the spheroid forming subpopulation in human GF that contained multipotent adult stem cells of which the number varied among donors and sites...
  12. doi request reprint Enhanced chondrogenic differentiation potential of human gingival fibroblasts by spheroid formation on chitosan membranes
    Shan Hui Hsu
    Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan
    Tissue Eng Part A 18:67-79. 2012
    ..These changes may contribute to the enhanced chondrogenic differentiation potential of HGF on chitosan...
  13. pmc Quantitative evaluation of motor function before and after engraftment of dopaminergic neurons in a rat model of Parkinson's disease
    Chieh Sen Chuang
    Department of Neurology, Changhua Christian Hospital, Changhua City 500, Taiwan
    J Biomed Sci 17:9. 2010
    ..In addition, the intensity, contact area, and swing speed of the four limbs increased and the distance between the hind paws decreased. Partial recovery of methamphetamine-induced rotational response was also noted...
  14. doi request reprint Peripheral nerve regeneration using a microporous polylactic acid asymmetric conduit in a rabbit long-gap sciatic nerve transection model
    Shan Hui Hsu
    Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan
    Biomaterials 32:3764-75. 2011
    ..The platform established in this study serves to evaluate the regeneration of larger-diameter (>3-mm) nerve across a long-gap bridged by a conduit...
  15. doi request reprint Chondrogenesis from human placenta-derived mesenchymal stem cells in three-dimensional scaffolds for cartilage tissue engineering
    Shan Hui Hsu
    Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan
    Tissue Eng Part A 17:1549-60. 2011
    ..This study also suggested that hPMSCs, when grown in a suitable scaffold, may be a good source of stem cells for building up the tissue-engineered cartilage...
  16. doi request reprint Characterization and biocompatibility of chitosan nanocomposites
    Shan Hui Hsu
    Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan
    Colloids Surf B Biointerfaces 85:198-206. 2011
    ..This study indicated that a small amount of NPs could induce significant changes in the physicochemical properties of chitosan, which may increase its biocompatibility and potential in wound management...
  17. doi request reprint The biocompatibility and antibacterial properties of waterborne polyurethane-silver nanocomposites
    Shan Hui Hsu
    Institute of Polymer Science and Engineering, National Taiwan University, Taipei 10617, Taiwan, ROC
    Biomaterials 31:6796-808. 2010
    ..The dispersion of nano Ag was highly associated with the overall performance...
  18. doi request reprint Antimicrobial activities and cellular responses to natural silicate clays and derivatives modified by cationic alkylamine salts
    Shan Hui Hsu
    Institute of Polymer Science and Engineering, National Taiwan University, Taipei 10617 Taiwan, Republic of China
    ACS Appl Mater Interfaces 1:2556-64. 2009
    ..This study helped to understand the antibacterial potential of NSP and the interaction of natural and modified clays with cellular activities...
  19. pmc The static magnetic field accelerates the osteogenic differentiation and mineralization of dental pulp cells
    Shan Hui Hsu
    Institute of Polymer Science and Engineering, National Taiwan University, No 1, Sec 4, Roosevelt Road, 10617, Taipei, Taiwan, Republic of China
    Cytotechnology 62:143-55. 2010
    ..In summary, SMF exposure in combination of Dex/beta-GP induction could significantly accelerate the osteogenic differentiation and mineralization of DPCs...
  20. doi request reprint The effect of laser preexposure on seeding endothelial cells to a biomaterial surface
    Shan Hui Hsu
    Institute of Polymer Science and Engineering, National Taiwan University, Taichung, Taiwan
    Photomed Laser Surg 28:S37-42. 2010
    ..In this study, the possible effect of low-level laser (LLL) on improving the adhesion of endothelial cells (ECs) to a biomaterial substrate was evaluated...
  21. ncbi request reprint Biocompatibility of poly(epsilon-caprolactone)/poly(ethylene glycol) diblock copolymers with nanophase separation
    Shan Hui Hsu
    Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan
    Biomaterials 25:5593-601. 2004
    ..The current study was the first one to demonstrate that surface nanotopography could influence not only cell adhesion and growth but also platelet and monocyte activation...
  22. ncbi request reprint The effect of an RGD-containing fusion protein CBD-RGD in promoting cellular adhesion
    Shan Hui Hsu
    Department of Chemical Engineering, National Chung Hsing University, 250 Kao Kung Road, Taichung 402, Taiwan
    J Biotechnol 111:143-54. 2004
    ..The effect on cellular adhesion correlated with the amount of CBD-RGD physically adsorbed on the material surface...
  23. ncbi request reprint Evaluation of biodegradable polyesters modified by type II collagen and Arg-Gly-Asp as tissue engineering scaffolding materials for cartilage regeneration
    Shan Hui Hsu
    Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan
    Artif Organs 30:42-55. 2006
    ..It was concluded that PLLA/PLGA blended scaffolds modified by type II collagen were a potential tissue engineering scaffold for cartilage regeneration...
  24. ncbi request reprint Biocompatibility and biostability of a series of poly(carbonate)urethanes
    Shan Hui Hsu
    Department of Chemical Engineering, National Chung Hsing University, Taichung 402, Taiwan, ROC
    Colloids Surf B Biointerfaces 36:1-12. 2004
    ..Polyurethanes based on poly(hexyl, ethyl)carbonate diol with MW 2017 in a molar ratio MDI/macrodiol/chain extender of either 3/2/1 or 4/3/1 resulted in greater micro-phase separation as well as superior biocompatibility and biostability...
  25. ncbi request reprint Evaluation of chitosan-alginate-hyaluronate complexes modified by an RGD-containing protein as tissue-engineering scaffolds for cartilage regeneration
    Shan Hui Hsu
    Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan
    Artif Organs 28:693-703. 2004
    ..The defects are completely repaired in 6 months when C1A1HR constructs are implanted. It is concluded that C1A1HR is a potential tissue-engineering scaffold for cartilage regeneration...
  26. doi request reprint Cell orientation and regulation of cell-cell communication in human mesenchymal stem cells on different patterns of electrospun fibers
    Jui Chih Chang
    Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan
    Biomed Mater 8:055002. 2013
    ..It was thus proposed that the promoted osteogenic differentiation of hMSCs may be associated with the fiber-guided and directional induction of GJIC...
  27. ncbi request reprint Fabrication and evaluation of microgrooved polymers as peripheral nerve conduits
    Shan Hui Hsu
    Department of Chemical Engineering, National Chung Hsing University, 250 Kuo Kuang Road, Taichung, 402, Taiwan, Republic of China
    Biomed Microdevices 9:665-74. 2007
    ..The microgrooved conduits were demonstrated to enhance peripheral nerve regeneration as compared to the smooth conduits...
  28. ncbi request reprint In vitro evaluation of degradation and cytotoxicity of a novel composite as a bone substitute
    Bai Shuan Liu
    Department of Radiological Technology, Chungtai Institute of Health Science and Technology, Taichung, Taiwan, Republic of China
    J Biomed Mater Res A 67:1163-9. 2003
    ..In addition, we found that gelatin and calcium continuously were released from the GGT composite in the soaking solution, which promoted differentiation and proliferation of the osteoblasts...
  29. doi request reprint Spheroid formation of mesenchymal stem cells on chitosan and chitosan-hyaluronan membranes
    Guo Shiang Huang
    Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan
    Biomaterials 32:6929-45. 2011
    ..The Rho/Rho-associated kinase (ROCK) signaling pathway may be involved in spheroid formation...
  30. ncbi request reprint The effect of dynamic culture conditions on endothelial cell seeding and retention on small diameter polyurethane vascular grafts
    Shan Hui Hsu
    Department of Chemical Engineering, National Chung Hsing University, 250 Kuo Kuang Road, Taichung, Taiwan 40227, ROC
    Med Eng Phys 27:267-72. 2005
    ..These procedures consistently resulted in a graft covered with confluent vein EC that fully retained on the surface after 6 h of in vitro flushing...
  31. ncbi request reprint The response of articular chondrocytes to type II collagen-Au nanocomposites
    Shan Hui Hsu
    Department of Chemical Engineering, National Chung Hsing University, and Institute of Biomedical Engineering, National Chung Hsing University, Taichung, Taiwan
    Artif Organs 31:854-68. 2007
    ..Au at an appropriate amount could be well dispersed in CII, and enhanced the material modulus, antioxidant effect, as well as the chondrocyte growth and matrix production...
  32. doi request reprint Fabrication of precision scaffolds using liquid-frozen deposition manufacturing for cartilage tissue engineering
    Hung Jen Yen
    Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan
    Tissue Eng Part A 15:965-75. 2009
    ..In contrast, the FDM PLGA scaffolds had low cell numbers and poor matrix production because of heavy swelling. The LFDM system offered a useful way to fabricate scaffolds for cartilage tissue-engineering applications...
  33. ncbi request reprint Effects of unidirectional permeability in asymmetric poly(DL-lactic acid-co-glycolic acid) conduits on peripheral nerve regeneration: an in vitro and in vivo study
    Chen Jung Chang
    Department of Radiological Technology, Central Taiwan University of Science and Technology, Taichung, Taiwan
    J Biomed Mater Res B Appl Biomater 83:206-15. 2007
    ..In this work, the directional transport characteristics were established as an extremely important factor to the design and development of optimal nerve guide conduits in peripheral nerve regeneration...
  34. ncbi request reprint Evaluation of the growth of chondrocytes and osteoblasts seeded into precision scaffolds fabricated by fused deposition manufacturing
    Shan Hui Hsu
    Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan
    J Biomed Mater Res B Appl Biomater 80:519-27. 2007
    ..The results indicated that the highly porous and interconnected structure of precision scaffolds could benefit cell ingrowth...
  35. ncbi request reprint In vitro and in vivo effects of Ginkgo biloba extract EGb 761 on seeded Schwann cells within poly(DL-lactic acid-co-glycolic acid) conduits for peripheral nerve regeneration
    Shan Hui Hsu
    Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan
    J Biomater Appl 19:163-82. 2004
    ..Addition of EGb 761 in Schwann cells-seeded conduit could increase the total number of myelinated axons in nerve regeneration and improve peripheral nerve functional recovery...
  36. doi request reprint Comparison between two different methods of immobilizing NGF in poly(DL-lactic acid-co-glycolic acid) conduit for peripheral nerve regeneration by EDC/NHS/MES and genipin
    Shu Chih Hsieh
    Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan, Republic of China
    J Biomed Mater Res A 99:576-85. 2011
    ..Therefore, the results confirm that GP/EDCs groups with good cell compatibility and effective release of NGF can considerably improve peripheral nerve regeneration...
  37. doi request reprint The biocompatibility and antimicrobial activity of nanocomposites from polyurethane and nano silicate platelets
    Hsiang Jung Tseng
    Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan, Republic of China
    J Biomed Mater Res A 99:192-202. 2011
    ..This may be associated with the different surface structure. PU-NSP and PU-NSP-S showed strong bacteriostatic effects, which suggested that the nano clay in the polymer matrix may still interact with the microbes...
  38. doi request reprint Bacterial cellulose and bacterial cellulose-chitosan membranes for wound dressing applications
    Wen Chun Lin
    Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan
    Carbohydr Polym 94:603-11. 2013
    ..Histological examinations revealed that wounds treated with BC-Ch epithelialized and regenerated faster than those treated with BC or Tegaderm. Therefore, BC-Ch was considered as a potential candidate for wound dressing materials...
  39. ncbi request reprint Biocompatibility and biodegradation of a bone composite containing tricalcium phosphate and genipin crosslinked gelatin
    Chun Hsu Yao
    Department of Radiological Technology, Chungtai Institute of Health Science and Technology, Taichung, Taiwan
    J Biomed Mater Res A 69:709-17. 2004
    ..We found that the GGT composites containing 0.5 wt % of the genipin had an excellent biocompatibility and could produce osteoconduction for the regenerating bone tissues...
  40. ncbi request reprint The effect of ultrasound stimulation versus bioreactors on neocartilage formation in tissue engineering scaffolds seeded with human chondrocytes in vitro
    Shan Hui Hsu
    Department of Chemical Engineering, National Chung Hsing University, Taichung 402, Taiwan, ROC
    Biomol Eng 23:259-64. 2006
    ..The beneficial effect of ultrasound on neocartilage formation only last 28 days, shorter than that of bioreactors...
  41. doi request reprint Characterization, antimicrobial activities, and biocompatibility of organically modified clays and their nanocomposites with polyurethane
    Ming Chien Wang
    Department of Chemical Engineering, National Chung Hsing University, Taichung, 40227 Taiwan, ROC
    ACS Appl Mater Interfaces 4:338-50. 2012
    ..These results proposed the safety and potential antimicrobial applications of surfactant-modified delaminated clays and their nanocomposites with PU polymer...
  42. doi request reprint Evaluation of chondrocyte growth in the highly porous scaffolds made by fused deposition manufacturing (FDM) filled with type II collagen
    Hung Jen Yen
    Department of Chemical Engineering, National Chung Hsing University, Taichung City, Taiwan, 40227, Republic of China
    Biomed Microdevices 11:615-24. 2009
    ..The study also suggested that a low processing temperature may be required to produce PLGA precision scaffolds using FDM...
  43. ncbi request reprint Synthesis of water-dispersible zinc oxide quantum dots with antibacterial activity and low cytotoxicity for cell labeling
    Shan Hui Hsu
    Institute of Polymer Science and Engineering, National Taiwan University, Taipei 10617, Taiwan, Republic of China Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei 10617, Taiwan, Republic of China
    Nanotechnology 24:475102. 2013
    ..Therefore, we conclude that the water-dispersible ZnO QDs developed in this study have antibacterial activity, low cytotoxicity, and proper labeling efficiency, and can be used to label a variety of cells including stem cells. ..
  44. ncbi request reprint Improved retention of endothelial cells seeded on polyurethane small-diameter vascular grafts modified by a recombinant RGD-containing protein
    Shan Hui Hsu
    Department of Chemical Engineering and Institute of Veterinary Microbiology, National Chung Hsing University, Taichung, Taiwan, Republic of China
    Artif Organs 27:1068-78. 2003
    ..The modified surface was also shown to help canine external jugular vein endothelial cells to maintain the round cell morphology in vitro...
  45. ncbi request reprint Cell attachment and proliferation on poly(carbonate urethanes) with various degrees of nanophase separation
    Shan Hui Hsu
    Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan, Republic of China
    Macromol Biosci 4:891-900. 2004
    ..The degree of nanophase separation correlated very well with endothelial cell attachment and proliferation on PCU...
  46. ncbi request reprint Sciatic nerve regeneration by cocultured Schwann cells and stem cells on microporous nerve conduits
    Lien Guo Dai
    Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan
    Cell Transplant 22:2029-39. 2013
    ..It was concluded that coculture of SCs with ASCs or DPSCs in a conduit promoted peripheral nerve regeneration over a critical gap defect. ..
  47. ncbi request reprint The effects of low-intensity ultrasound on peripheral nerve regeneration in poly(DL-lactic acid-co-glycolic acid) conduits seeded with Schwann cells
    Chen Jung Chang
    Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan
    Ultrasound Med Biol 30:1079-84. 2004
    ..Nevertheless, the applying of US may not allow incorporation with the silicone rubber as a material from which to form nerve guidance conduits...
  48. ncbi request reprint Biocompatibility of poly(ether)urethane-gold nanocomposites
    Shan Hui Hsu
    Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan, Republic of China
    J Biomed Mater Res A 79:759-70. 2006
    ..The oxidative degradation in PU-Au 43.5 ppm was also inhibited. The increased oxidative stability corresponded to the greater free radical scavenging ability of the nanocomposites...
  49. ncbi request reprint Oriented Schwann cell growth on microgrooved surfaces
    Shan Hui Hsu
    Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan, R O C
    Biotechnol Bioeng 92:579-88. 2005
    ..05). Coating this surface with laminin enhanced cell alignment only in short term (67% vs. 62% at 24 h, P < 0.05). The cell alignment guided by surface microgrooves was time dependent...
  50. ncbi request reprint The effect of high outflow permeability in asymmetric poly(dl-lactic acid-co-glycolic acid) conduits for peripheral nerve regeneration
    Chen Jung Chang
    Department of Radiological Technology, Chung Tai Institute of Health Science and Technology, Taichung, Taiwan
    Biomaterials 27:1035-42. 2006
    ..The asymmetric structure could be adequately employed in the future as optimal nerve conduits in peripheral nerve regeneration...
  51. ncbi request reprint In vitro biocompatibility of PTMO-based polyurethanes and those containing PDMS blocks
    Shan Hui Hsu
    Department of Chemical Engineering, National Chung Hsing University, 250 Kuo Kuang Road, Taichung, Taiwan 402, ROC
    J Biomater Appl 19:135-46. 2004
    ..75: 0.5: 1 in synthesis was favorable due to a combination of enhanced mechanical properties, biostability, cellular affinity as well as platelet nonadherence...
  52. doi request reprint Surface modification of poly(ε-caprolactone) porous scaffolds using gelatin hydrogel as the tracheal replacement
    Chen Huan Lin
    Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan, Republic of China
    J Tissue Eng Regen Med 5:156-62. 2011
    ..Genipin could be an effective treatment to reduce granulation tissue formation at the tracheal anastomoses...
  53. doi request reprint A scaffold-bioreactor system for a tissue-engineered trachea
    Chen Huan Lin
    Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan, ROC
    Biomaterials 30:4117-26. 2009
    ..This successful initial step would allow us to make further improvement in applying tissue-engineering techniques to regenerate tracheas for practical use...
  54. ncbi request reprint Evaluation of cellular affinity and compatibility to biodegradable polyesters and Type-II collagen-modified scaffolds using immortalized rat chondrocytes
    Shan Hui Hsu
    Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan
    Artif Organs 26:647-58. 2002
    ..Scaffolds made of blended materials by freeze-drying procedure with the surface modified by cross-linked Type-II collagen were demonstrated as the ideal templates for chondrocyte seeding in our study...
  55. doi request reprint Evaluation of type II collagen scaffolds reinforced by poly(epsilon-caprolactone) as tissue-engineered trachea
    Chen Huan Lin
    Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan, ROC
    Tissue Eng Part C Methods 14:69-77. 2008
    ..The stent-sponge composite facilitated the proliferation of chondrocytes and was expected to provide adequate mechanical strength, and therefore was a promising material for use in trachea tissue engineering...
  56. ncbi request reprint Low-intensity-ultrasound-accelerated nerve regeneration using cell-seeded poly(D,L-lactic acid-co-glycolic acid) conduits: an in vivo and in vitro study
    Chen Jung Chang
    Department of Radiological Technology, Chung Tai Institute of Health Science and Technology, Taichung, Taiwan, Republic of China
    J Biomed Mater Res B Appl Biomater 75:99-107. 2005
    ..Ultrasonic stimulation on silicone groups was found to induce a mass of fibrous tissues that covered the nerve conduits and retarded axon regeneration...
  57. ncbi request reprint Enhanced biocompatibility in biostable poly(carbonate)urethane
    Shan Hui Hsu
    Department of Chemical Engineering, National Chung Hsing University, Taichung, 402, Taiwan
    Macromol Biosci 4:464-70. 2004
    ..The total number of adherent monocytes (nonactivated and activated) on the bare sample surfaces, albumin pre-adsorbed sample surfaces, and fibrinogen pre-adsorbed sample surfaces...
  58. doi request reprint The calcium-dependent regulation of spheroid formation and cardiomyogenic differentiation for MSCs on chitosan membranes
    Hsi Yi Yeh
    Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan, ROC
    Biomaterials 33:8943-54. 2012
    ..Spheroids formed on the acetylated chitosan or polyvinyl alcohol membranes failed to show such behavior. The properties of MSC spheroids were therefore determined by the culture substrate...
  59. ncbi request reprint Primary adipose-derived stem cells enriched by growth factor treatment improves cell adaptability toward cardiovascular differentiation in a rodent model of acute myocardial infarction
    Jui Chih Chang
    Department of Life Sciences, National Chung Hsing University, 250 Kuo Kuang Road, Taichung 40227, Taiwan
    J Stem Cells 6:21-37. 2011
    ..These data suggested that ADAS-GFs with a higher proangiogenic potential may restore the cardiac function of infarcted myocardium via the direct cardiomyocyte differentiation as well as angiogenesis recruitment...
  60. ncbi request reprint Microvessel scaffold with circular microchannels by photoresist melting
    Gou Jen Wang
    Department of Mechanical Engineering, National Chung Hsing University, Taichung, 402, Taiwan
    Biomed Microdevices 9:657-63. 2007
    ..Finally, the bovine endothelial cells (BEC) are cultured into the scaffold. Encouraging results by semi-dynamic seeding have been observed in this context, depicting the survival of the cells in the scaffold for up to 4 weeks...
  61. doi request reprint The promotion of chondrogenesis in adipose-derived adult stem cells by an RGD-chimeric protein in 3D alginate culture
    Jui Chih Chang
    Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan, Republic of China
    Biomaterials 30:6265-75. 2009
    ..It was concluded that the CBD-RGD-alginate culture system promoted the chondrogenesis of mesenchymal stem cells coordinated with TGF-beta3 induction in an RGD dose-dependent manner...
  62. doi request reprint The fabrication of PLGA microvessel scaffolds with nano-patterned inner walls
    Gou Jen Wang
    Department of Mechanical Engineering, National Chung Hsing University, Taichung 40227, Taiwan
    Biomed Microdevices 12:841-8. 2010
    ..Observations show that the BECs grew more separately in a nano-patterned microvessel scaffold than they did in a smooth surface scaffold...
  63. pmc Biocompatibility and favorable response of mesenchymal stem cells on fibronectin-gold nanocomposites
    Huey Shan Hung
    Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan, ROC
    PLoS ONE 8:e65738. 2013
    ..These results suggest that the FN-Au nanocomposite thin film coating may serve as a potential and simple solution for the surface modification of blood-contacting devices such as vascular grafts. ..
  64. doi request reprint Fabrication of bioactive conduits containing the fibroblast growth factor 1 and neural stem cells for peripheral nerve regeneration across a 15 mm critical gap
    Hsiao Chiang Ni
    Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan, Republic of China
    Biofabrication 5:035010. 2013
    ....
  65. ncbi request reprint Ultrasound preexposure improves endothelial cell binding and retention on biomaterial surfaces
    Shan Hui Hsu
    Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan, Republic of China
    J Biomed Mater Res B Appl Biomater 76:85-92. 2006
    ..Finally, polyurethane small-diameter vascular grafts seeded with ultrasound-preexposed endothelial cells showed enhanced cell retention on graft surfaces upon flushing...
  66. doi request reprint Characterization of chitosan-gelatin scaffolds for dermal tissue engineering
    Hsiang Jung Tseng
    Department of Chemical Engineering, National Chung Hsing University, Taichung, 40227, Taiwan
    J Tissue Eng Regen Med 7:20-31. 2013
    ..Such a combination could help regenerate skin with integrated dermal and epidermal layers and a have potential use in tissue-engineered skin...
  67. doi request reprint The behavior of endothelial cells on polyurethane nanocomposites and the associated signaling pathways
    Huey Shan Hung
    Center of Tissue Engineering and Stem Cells Research, National Chung Hsing University, Taichung, Taiwan, ROC
    Biomaterials 30:1502-11. 2009
    ..5 ppm was observed in FAK-GFP transfected ECs. It was concluded that PU-Au nanocomposites activated FAK and the PI3K/Akt signaling pathway in ECs, leading to proliferation and migration of ECs on these surfaces...
  68. ncbi request reprint Sciatic nerve repair by microgrooved nerve conduits made of chitosan-gold nanocomposites
    Yi Lo Lin
    Center of Tissue Engineering and Stem Cells Research, National Chung Hsing University, Taichung 402, Taiwan, ROC
    Surg Neurol 70:S1:9-18. 2008
    ..To better direct the repair of peripheral nerve after injury, an implant consisting of a multicomponent micropatterned conduit seeded with NSC was designed...
  69. ncbi request reprint The use of peptide-delivery to protect human adipose-derived adult stem cells from damage caused by the internalization of quantum dots
    Jui Chih Chang
    Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan, ROC
    Biomaterials 29:925-36. 2008
    ..The results also suggested that the endo-/lysosome degradation of QDs may depend on different surface coatings and critically influence the differentiation of hADAS...
  70. ncbi request reprint Cell migration rate on poly(epsilon-caprolactone)/poly(ethylene glycol) diblock copolymers and correlation with the material sliding angle
    Shan Hui Hsu
    Center of Tissue Engineering and Stem Cells Research, National Chung Hsing University, Taichung, Taiwan, Republic of China
    Macromol Biosci 7:482-90. 2007
    ..The cell migration rate was examined under a real-time optical microscope. It was found that a greater cell migration rate correlated with the smaller sliding angle of the substrate...
  71. ncbi request reprint Evaluation of the antibacterial activity and biocompatibility for silver nanoparticles immobilized on nano silicate platelets
    Jiang Jen Lin
    Institute of Polymer Science and Engineering, National Taiwan University, No 1, Sec 4, Roosevelt Road, Taipei, Taiwan, ROC
    ACS Appl Mater Interfaces 5:433-43. 2013
    ..9%). PEU containing the same amount of free AgNPs did not display such an effect. Our results verify the better biosafety of the AgNPs/NSP hybrids and their polymer nanocomposites for further clinical use...
  72. doi request reprint Sciatic nerve regeneration by microporous nerve conduits seeded with glial cell line-derived neurotrophic factor or brain-derived neurotrophic factor gene transfected neural stem cells
    Keng Yen Fu
    Institute of Polymer Science and Engineering, National Taiwan University, Taipei
    Artif Organs 35:363-72. 2011
    ..It was concluded that the genetically modified NSCs may have potential applications in promoting nerve regeneration and functional recovery...
  73. ncbi request reprint Calvarial bone response to a tricalcium phosphate-genipin crosslinked gelatin composite
    Chun Hsu Yao
    Department of Radiological Technology, Institute of Biomedical Engineering and Material Science, Chung Tai Institute of Health Science and Technology, Takun, Taichung, Taiwan
    Biomaterials 26:3065-74. 2005
    ..Therefore, the GGT composite could serve as a useful bone substitute for repairing bone defects...
  74. ncbi request reprint The properties of gelatin-poly (gamma-glutamic acid) hydrogels as biological glues
    Shan Hui Hsu
    Department of Chemical Engineering, Institute of Biomedical Engineering, National Chung Hsing University, Taichung, Taiwan, ROC
    Biorheology 44:17-28. 2007
    ..Rheological characterization was essential in the evaluation of biological glues...
  75. doi request reprint Gold nanoparticles induce surface morphological transformation in polyurethane and affect the cellular response
    Shan Hui Hsu
    Department of Chemical Engineering, Institute of Biomedical Engineering, National Chung Hsing University, Taichung, Taiwan, ROC
    Biomacromolecules 9:241-8. 2008
    ..The different cellular response on PU-Au nanocomposites was attributed to the extensively modified surface morphology and phase separation in the presence of a small amount of Au nanoparticles...
  76. ncbi request reprint Endothelial cell attachment to the gamma irradiated small diameter polyurethane vascular grafts
    Shan Hui Hsu
    Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan, ROC
    Biomed Mater Eng 16:397-404. 2006
    ..5 Mrad). The positive cellular effect remained after storage. Based on these results, freeze-drying followed by gamma irradiation at 2.5 Mrad is a proper way to process and store these vascular grafts...
  77. doi request reprint The response of endothelial cells to polymer surface composed of nanometric micelles
    Huey Shan Hung
    Center of Tissue Engineering and Stem Cells Research, National Chung Hsing University, Taichung, Taiwan, ROC
    N Biotechnol 25:235-43. 2009
    ..It was concluded that the nanometric micelles on PU surface may interact with ECs and accelerate their migration by increasing cytoplasmic Ca(2+) and stimulating the PI3K/Akt/eNOS signaling pathway...
  78. doi request reprint The cellular responses and antibacterial activities of silver nanoparticles stabilized by different polymers
    Jiang Jen Lin
    Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan
    Nanotechnology 23:065102. 2012
    ..Overall, SMA-AgNPs demonstrated better safety in vitro and greater antibacterial effects than POEM-AgNPs and PVA-AgNPs. This study suggested that polymer stabilizers may play an important role in determining the toxicity of AgNPs...
  79. doi request reprint Low-energy laser irradiation increases endothelial cell proliferation, migration, and eNOS gene expression possibly via PI3K signal pathway
    Chung Huang Chen
    Institute of Biomedical Science, National Chung Hsing University, Taichung, Taiwan, Republic of China
    Lasers Surg Med 40:46-54. 2008
    ....
  80. ncbi request reprint Characterization and biocompatibility of a titanium dental implant with a laser irradiated and dual-acid etched surface
    Shan Hui Hsu
    Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan
    Biomed Mater Eng 17:53-68. 2007
    ..Rabbit tibia implantation also proved that TA implant had greater removal torque value. These results suggested that TA had good osteoconductivity and was a potential material for dental implantation...
  81. ncbi request reprint Biostability and biocompatibility of poly(ether)urethane containing gold or silver nanoparticles in a porcine model
    Chih Wei Chou
    Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan, Republic of China
    J Biomed Mater Res A 84:785-94. 2008
    ..The interdependency among antioxidation/biostability/biocompatibility of PU was demonstrated in this porcine model...
  82. pmc Efficacy and safety of nanohybrids comprising silver nanoparticles and silicate clay for controlling Salmonella infection
    Shu Her Chiao
    Department of Life Sciences, Agricultural Biotechnology Center, National Chung Hsing University, Taichung, Taiwan
    Int J Nanomedicine 7:2421-32. 2012
    ..These in vivo results illustrated that both NSP and AgNP/NSP nanohybrid represent potential agents for controlling enteric bacterial infections...
  83. doi request reprint The regulation of the gap junction of human mesenchymal stem cells through the internalization of quantum dots
    Jui Chih Chang
    Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan, ROC
    Biomaterials 30:1937-46. 2009
    ..The study also suggested that the regulation of gap junction may play a key role in QD cytotoxicity...
  84. ncbi request reprint Transplantation of bone marrow stromal cells for peripheral nerve repair
    Chun Jung Chen
    Department of Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan
    Exp Neurol 204:443-53. 2007
    ..These results taken together, in addition to documented Schwann cell-like differentiation, provide evidence indicating the strong association of neurotrophic factor production and the regenerative potential of implanted BMSCs...
  85. doi request reprint Fabrication of the microgrooved/microporous polylactide substrates as peripheral nerve conduits and in vivo evaluation
    Shan Hui Hsu
    Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan, Province of China
    Tissue Eng Part A 15:1381-90. 2009
    ..Based on the study, the combination of microgrooves and asymmetric microporous structure could be employed in the design of nerve conduits for peripheral nerve regeneration in the future...
  86. ncbi request reprint The effects of Ginkgo biloba extracts on the memory and motor functions of rats with chronic cerebral insufficiency
    Chou Ching K Lin
    Department of Neurology, National Cheng Kung University Hospital, 138 Sheng Li Road, Tainan 701, Taiwan, ROC
    Neuropsychobiology 47:47-51. 2003
    ..The results indicate that both EGb 761 and LGb improved spatial memory from the second week after operation, but only EGb 761 delayed deterioration of motor functions from the fifth week after operation...
  87. doi request reprint Transplantation of endothelial progenitor cells as therapeutics for cardiovascular diseases
    Huey Shan Hung
    Center for Neuropsychiatry, China Medical University and Hospital, Taichung, Taiwan
    Cell Transplant 18:1003-12. 2009
    ..Based on past experience and actual knowledge, future strategies for EPC therapy will be proposed in order to fully exploit the potential of EPC transplantation with clinical relevance for cardiovascular disease applications...
  88. doi request reprint A novel approach to align adult neural stem cells on micropatterned conduits for peripheral nerve regeneration: a feasibility study
    Shan Hui Hsu
    Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan
    Artif Organs 33:26-35. 2009
    ..This model can be used to study the role of adult NSCs in peripheral-nerve regeneration in the future...
  89. ncbi request reprint Preparation of controlled release ophthalmic drops, for glaucoma therapy using thermosensitive poly-N-isopropylacrylamide
    Ging Ho Hsiue
    Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan, Republic of China
    Biomaterials 23:457-62. 2002
    ..These results suggest the use of thermosensitive polymer solutions or hydrogels is potential in controlled release antiglaucoma ophthalmic drugs...