Li Chung Hsu

Summary

Affiliation: National Taiwan University
Country: Taiwan

Publications

  1. ncbi request reprint Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing
    Shin Maeda
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
    Science 307:734-8. 2005
  2. pmc TNFalpha induces ABCA1 through NF-kappaB in macrophages and in phagocytes ingesting apoptotic cells
    Marie Christine Gerbod-Giannone
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:3112-7. 2006
  3. pmc A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide
    Li Chung Hsu
    Departments of Pharmacology and Pathology, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 105:7803-8. 2008
  4. pmc IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ
    Li Chung Hsu
    Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    Nat Immunol 12:144-50. 2011
  5. ncbi request reprint Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression
    Jun Li Luo
    Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cancer Cell 6:297-305. 2004
  6. ncbi request reprint The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4
    Li Chung Hsu
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0636, USA
    Nature 428:341-5. 2004
  7. pmc TLR-induced PAI-2 expression suppresses IL-1β processing via increasing autophagy and NLRP3 degradation
    Shih Yi Chuang
    Institute of Molecular Medicine, National Taiwan University, Taipei 10002, Taiwan
    Proc Natl Acad Sci U S A 110:16079-84. 2013
  8. pmc I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss
    Maria Grazia Ruocco
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 201:1677-87. 2005
  9. pmc Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis
    Annabel F Valledor
    Department of Cellular and Molecular Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 101:17813-8. 2004
  10. pmc Streptolysin O promotes group A Streptococcus immune evasion by accelerated macrophage apoptosis
    Anjuli M Timmer
    Department of Pediatrics, Biomedical Sciences Graduate Program, Laboratory of Signal Transduction, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 284:862-71. 2009

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing
    Shin Maeda
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
    Science 307:734-8. 2005
    ..These effects are linked to increased susceptibility to bacterial-induced intestinal inflammation and identify NOD2 as a positive regulator of NF-kappaB activation and IL-1beta secretion...
  2. pmc TNFalpha induces ABCA1 through NF-kappaB in macrophages and in phagocytes ingesting apoptotic cells
    Marie Christine Gerbod-Giannone
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:3112-7. 2006
    ..In atherosclerotic plaques, this process may help phagocytic macrophages to efflux excess lipids derived from the ingestion of cholesterol-rich apoptotic corpses...
  3. pmc A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide
    Li Chung Hsu
    Departments of Pharmacology and Pathology, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 105:7803-8. 2008
    ..Thus, NOD2 plays a key role in the B. anthracis-induced inflammatory response by being a critical mediator of IL-1beta secretion...
  4. pmc IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ
    Li Chung Hsu
    Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    Nat Immunol 12:144-50. 2011
    ....
  5. ncbi request reprint Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression
    Jun Li Luo
    Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cancer Cell 6:297-305. 2004
    ..The latter response is TNFalpha-independent, but depends on another member of the TNF superfamily, TRAIL, whose receptor is induced in NF-kappaB-deficient cancer cells...
  6. ncbi request reprint The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4
    Li Chung Hsu
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0636, USA
    Nature 428:341-5. 2004
    ..The pro-apoptotic actions of PKR are mediated both through inhibition of protein synthesis and activation of interferon response factor 3...
  7. pmc TLR-induced PAI-2 expression suppresses IL-1β processing via increasing autophagy and NLRP3 degradation
    Shih Yi Chuang
    Institute of Molecular Medicine, National Taiwan University, Taipei 10002, Taiwan
    Proc Natl Acad Sci U S A 110:16079-84. 2013
    ....
  8. pmc I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss
    Maria Grazia Ruocco
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 201:1677-87. 2005
    ..IKKbeta also protects osteoclasts and their progenitors from tumor necrosis factor alpha-induced apoptosis, and its loss in hematopoietic cells prevents inflammation-induced bone loss...
  9. pmc Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis
    Annabel F Valledor
    Department of Cellular and Molecular Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 101:17813-8. 2004
    ....
  10. pmc Streptolysin O promotes group A Streptococcus immune evasion by accelerated macrophage apoptosis
    Anjuli M Timmer
    Department of Pediatrics, Biomedical Sciences Graduate Program, Laboratory of Signal Transduction, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 284:862-71. 2009
    ..We conclude that accelerated, caspase-dependent macrophage apoptosis induced by the pore-forming cytolysin SLO contributes to GAS immune evasion and virulence...
  11. pmc Transcription of Tnfaip3 is regulated by NF-κB and p38 via C/EBPβ in activated macrophages
    Ting Yu Lai
    Institute of Molecular Medicine, National Taiwan University, Taipei, Taiwan
    PLoS ONE 8:e73153. 2013
    ..These results identify a novel regulatory mechanism in TLR4-mediated innate immunity. ..
  12. ncbi request reprint Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
    Hans Hacker
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nature 439:204-7. 2006
    ....
  13. pmc NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta
    Florian R Greten
    Second Department of Medicine, Klinikum rechts der Isar, Technical University Munich, 81675 Germany
    Cell 130:918-31. 2007
    ..These results unravel an unanticipated role for IKKbeta-dependent NF-kappaB signaling in the negative control of IL-1beta production and highlight potential complications of long-term IKKbeta inhibition...