Hsien Yeh Hsu

Summary

Affiliation: National Yang-Ming University
Country: Taiwan

Publications

  1. doi request reprint Immunostimulatory bioactivity of algal polysaccharides from Chlorella pyrenoidosa activates macrophages via Toll-like receptor 4
    Hsien Yeh Hsu
    Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, Taipei, Taiwan
    J Agric Food Chem 58:927-36. 2010
  2. doi request reprint Heme oxygenase-1 mediates the anti-inflammatory effect of Curcumin within LPS-stimulated human monocytes
    Hsien Yeh Hsu
    Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, Taipei, Taiwan
    J Cell Physiol 215:603-12. 2008
  3. ncbi request reprint Ligands of macrophage scavenger receptor induce cytokine expression via differential modulation of protein kinase signaling pathways
    H Y Hsu
    Faculty of Medical Technology, Institute of Biotechnology in Medicine, National Yang Ming University, Taipei 112, Taiwan
    J Biol Chem 276:28719-30. 2001
  4. ncbi request reprint Geldanamycin interferes with the 90-kDa heat shock protein, affecting lipopolysaccharide-mediated interleukin-1 expression and apoptosis within macrophages
    Hsien Yeh Hsu
    Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, 155 Li Nong Street, Shih Pai Taipei, Taiwan
    Mol Pharmacol 71:344-56. 2007
  5. ncbi request reprint Extract of Reishi polysaccharides induces cytokine expression via TLR4-modulated protein kinase signaling pathways
    Hsien Yeh Hsu
    Faculty of Medical Technology, Institute of Biotechnology in Medicine, National Yang Ming University, 155 Li Nong Street, Shih Pai, Taipei, Taiwan
    J Immunol 173:5989-99. 2004
  6. ncbi request reprint Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression
    Hsien Yeh Hsu
    Faculty of Medical Technology, Institute of Biotechnology in Medicine, National Yang Ming University, 112 Taipei, Taiwan
    J Biol Chem 277:22131-9. 2002
  7. ncbi request reprint Ganoderma lucidum polysaccharides enhance CD14 endocytosis of LPS and promote TLR4 signal transduction of cytokine expression
    Kuo Feng Hua
    Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, Taipei, Taiwan
    J Cell Physiol 212:537-50. 2007
  8. ncbi request reprint LTA and LPS mediated activation of protein kinases in the regulation of inflammatory cytokines expression in macrophages
    Shih Chi Su
    Biotechnology and Laboratory Science in Medicine, Institute of Biotechnology in Medicine, National Yang Ming University, 155 Li Nong Street, Shih Pai, Taipei 112, Taiwan
    Clin Chim Acta 374:106-15. 2006
  9. ncbi request reprint Study on the antiinflammatory activity of methanol extract from seagrass Zostera japonica
    Kuo Feng Hua
    Faculty of Biotechnology and Laboratory Science in Medicine, Institute of Biotechnology in Medicine, National Yang Ming University, Taipei 112, Taiwan
    J Agric Food Chem 54:306-11. 2006
  10. doi request reprint Reishi immuno-modulation protein induces interleukin-2 expression via protein kinase-dependent signaling pathways within human T cells
    Hsien Yeh Hsu
    Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, Taipei, Taiwan
    J Cell Physiol 215:15-26. 2008

Collaborators

Detail Information

Publications23

  1. doi request reprint Immunostimulatory bioactivity of algal polysaccharides from Chlorella pyrenoidosa activates macrophages via Toll-like receptor 4
    Hsien Yeh Hsu
    Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, Taipei, Taiwan
    J Agric Food Chem 58:927-36. 2010
    ..8%), glucose (20.42%), galactose (10.28%), mannose (5.23%), and xylose (1.27%). This study is the first to report the molecular mechanism of immune-modulated signal transduction in vitro from the polysaccharides of Chlorella pyrenoidosa...
  2. doi request reprint Heme oxygenase-1 mediates the anti-inflammatory effect of Curcumin within LPS-stimulated human monocytes
    Hsien Yeh Hsu
    Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, Taipei, Taiwan
    J Cell Physiol 215:603-12. 2008
    ..Collectively, our results suggest that Curcumin inhibits cytokines secretion within LPS-stimulated monocytes through a mechanism that involves the action of HO-1...
  3. ncbi request reprint Ligands of macrophage scavenger receptor induce cytokine expression via differential modulation of protein kinase signaling pathways
    H Y Hsu
    Faculty of Medical Technology, Institute of Biotechnology in Medicine, National Yang Ming University, Taipei 112, Taiwan
    J Biol Chem 276:28719-30. 2001
    ..Our current results indicate and suggest a model for MSR ligands differentially modulating specific PK signal transduction pathways, which regulate atherogenesis-related inflammatory cytokines TNF and IL-1...
  4. ncbi request reprint Geldanamycin interferes with the 90-kDa heat shock protein, affecting lipopolysaccharide-mediated interleukin-1 expression and apoptosis within macrophages
    Hsien Yeh Hsu
    Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, 155 Li Nong Street, Shih Pai Taipei, Taiwan
    Mol Pharmacol 71:344-56. 2007
    ....
  5. ncbi request reprint Extract of Reishi polysaccharides induces cytokine expression via TLR4-modulated protein kinase signaling pathways
    Hsien Yeh Hsu
    Faculty of Medical Technology, Institute of Biotechnology in Medicine, National Yang Ming University, 155 Li Nong Street, Shih Pai, Taipei, Taiwan
    J Immunol 173:5989-99. 2004
    ..Our findings establish that EORP-mediated signaling pathways are involved in the pro-IL-1/IL-1 regulation: PTK/protein kinase C/MEK1/ERK and PTK/Rac1/p21-activated kinase/p38...
  6. ncbi request reprint Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression
    Hsien Yeh Hsu
    Faculty of Medical Technology, Institute of Biotechnology in Medicine, National Yang Ming University, 112 Taipei, Taiwan
    J Biol Chem 277:22131-9. 2002
    ....
  7. ncbi request reprint Ganoderma lucidum polysaccharides enhance CD14 endocytosis of LPS and promote TLR4 signal transduction of cytokine expression
    Kuo Feng Hua
    Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, Taipei, Taiwan
    J Cell Physiol 212:537-50. 2007
    ..Our current results could provide a potential EORP-associated protection mechanism for bacteria infection by enhancing IL-1 expression and the clearance of contaminated LPS by macrophages...
  8. ncbi request reprint LTA and LPS mediated activation of protein kinases in the regulation of inflammatory cytokines expression in macrophages
    Shih Chi Su
    Biotechnology and Laboratory Science in Medicine, Institute of Biotechnology in Medicine, National Yang Ming University, 155 Li Nong Street, Shih Pai, Taipei 112, Taiwan
    Clin Chim Acta 374:106-15. 2006
    ..We investigated the LTA-induced signal transduction and biological effects, as well as to compare the effect of LTA with that of LPS...
  9. ncbi request reprint Study on the antiinflammatory activity of methanol extract from seagrass Zostera japonica
    Kuo Feng Hua
    Faculty of Biotechnology and Laboratory Science in Medicine, Institute of Biotechnology in Medicine, National Yang Ming University, Taipei 112, Taiwan
    J Agric Food Chem 54:306-11. 2006
    ..This study is the first to report the antiinflammatory activity of extracts obtained from the seagrass Z. japonica...
  10. doi request reprint Reishi immuno-modulation protein induces interleukin-2 expression via protein kinase-dependent signaling pathways within human T cells
    Hsien Yeh Hsu
    Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, Taipei, Taiwan
    J Cell Physiol 215:15-26. 2008
    ..Our current results of analyzing rLZ-8-mediated signal transduction in T cells might provide a potential application for rLZ-8 as a pharmacological immune-modulating agent...
  11. ncbi request reprint TLR-independent induction of human monocyte IL-1 by phosphoglycolipids from thermophilic bacteria
    Feng Ling Yang
    Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
    Glycoconj J 25:427-39. 2008
    ..thermophilus and M. ruber consists of a low percentage of C15 (<10%) and a high percentage of C17 (>75%). It suggests, the C15 percentage of PGL may play a critical role in PGL-mediated proIL-1 induction...
  12. doi request reprint Fucoidan induces changes in the epithelial to mesenchymal transition and decreases metastasis by enhancing ubiquitin-dependent TGFβ receptor degradation in breast cancer
    Hsien Yeh Hsu
    Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, Taipei, Taiwan
    Carcinogenesis 34:874-84. 2013
    ..Our current findings indicate that fucoidan is a potential therapeutic agent for breast cancer and acts via an ubiquitin-dependent degradation pathway that affects the TGFR/Smad/Snail, Slug, Twist and EMT axes...
  13. doi request reprint Ganoderma lucidum polysaccharides prevent platelet-derived growth factor-stimulated smooth muscle cell proliferation in vitro and neointimal hyperplasia in the endothelial-denuded artery in vivo
    Shu Huei Wang
    Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Cell Physiol 227:3063-71. 2012
    ..Thus, EORP may represent a safe and effective novel approach to the prevention and treatment of vascular proliferative diseases...
  14. ncbi request reprint Lysophosphatidic acid-induced interleukin-1 beta expression is mediated through Gi/Rho and the generation of reactive oxygen species in macrophages
    Chi Lun Chang
    Institute of Zoology, National Taiwan University, Taipei, Taiwan
    J Biomed Sci 15:357-63. 2008
    ..In addition, IL-1 beta induction by LPA was also observed in human primary macrophages. In summary, LPA is involved in the processes of inflammation by affecting macrophage behavior...
  15. doi request reprint Ling Zhi-8 mediates p53-dependent growth arrest of lung cancer cells proliferation via the ribosomal protein S7-MDM2-p53 pathway
    Chien Ting Wu
    Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, 155 Li Nong Street, Shih Pai Road, Taipei 11221, Taiwan
    Carcinogenesis 32:1890-6. 2011
    ..Our current results suggest that rLZ-8 may have potential as a therapeutic intervention for the treatment of cancers that contain wild-type p53 and high expression of MDM2...
  16. doi request reprint Lysophosphatidic acid-induced oxidized low-density lipoprotein uptake is class A scavenger receptor-dependent in macrophages
    Chi Lun Chang
    Institute of Zoology, National Taiwan University, Taipei, Taiwan, ROC
    Prostaglandins Other Lipid Mediat 87:20-5. 2008
    ..Our results suggest that LPA-enhanced OxLDL uptake is mediated via LPA(3)-G(i) activation and subsequent SR-A expression...
  17. ncbi request reprint Fiber optic biosensor for the detection of C-reactive protein and the study of protein binding kinetics
    Chien Chou
    National Yang Ming University, Institute of Biophotonic Engineering, and Institute of Radiological Sciences, Taipei 112, Taiwan
    J Biomed Opt 12:024025. 2007
    ..The feasibility of our current approach to measure the association and dissociation rate constants of the reaction between tested CRP isoforms was successfully demonstrated...
  18. ncbi request reprint Cinnamaldehyde inhibits pro-inflammatory cytokines secretion from monocytes/macrophages through suppression of intracellular signaling
    Louis Kuoping Chao
    Department of Cosmeceutics, China Medical University, Taichung 404, Taiwan
    Food Chem Toxicol 46:220-31. 2008
    ..Our current results have demonstrated the anti-oxidation and anti-inflammatory properties of Cinnamaldehyde that could provide the possibility for Cinnamaldehyde's future pharmaceutical application in the realm of immuno-modulation...
  19. ncbi request reprint Anti-inflammatory activity of sugiol, a diterpene isolated from Calocedrus formosana bark
    Kuo Ping Chao
    Department of Biological Science and Technology, Chung Hwa College of Medical Technology, Tainan, Taiwan, Republic of China
    Planta Med 71:300-5. 2005
    ..Our studies suggest that sugiol's efficacy in inhibiting the inflammatory cytokines of IL-1beta and TNF-alpha could be attributed to a reduction of the ROS that leads to a decrease in the phosphorylation of MAPKs...
  20. ncbi request reprint Study on the antiinflammatory activity of essential oil from leaves of Cinnamomum osmophloeum
    Louis Kuoping Chao
    Department of Biological Science and Technology, Chung Hwa College of Medical Technology, Tainan 717, Taiwan
    J Agric Food Chem 53:7274-8. 2005
    ..This study is the first to report antiinflammatory activity of extracts obtained from the leaf essential oil of C. osmophloeum...
  21. ncbi request reprint Lysophospholipids increase ICAM-1 expression in HUVEC through a Gi- and NF-kappaB-dependent mechanism
    Hsinyu Lee
    Department of Life Science and Institute of Zoology, National Taiwan University, Taipei, Taiwan 106, ROC
    Am J Physiol Cell Physiol 287:C1657-66. 2004
    ....
  22. ncbi request reprint Bioactivity assay of extracts from Calocedrus macrolepis var. formosana bark
    Louis Kuoping Chao
    Department of Biological Science and Technology, Chung Hwa College of Medical Technology, Tainan, Taiwan
    Bioresour Technol 97:2462-5. 2006
    ..1%, H5ppt 81.1%), which at dosages of 10 microg/ml inhibited proIL-1beta protein production completely. Furthermore, the T1 also exhibited anti-inflammatory activity, and its major constituent was ferruginol (above 85.6%)...