Chiun Hsu

Summary

Affiliation: National Taiwan University
Country: Taiwan

Publications

  1. ncbi request reprint Body size as a factor in different ages and breast cancer risk in Taiwan
    W C Chie
    School of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan
    Anticancer Res 18:565-70. 1998
  2. ncbi request reprint Oral contraceptives and breast cancer risk in Taiwan, a country of low incidence of breast cancer and low use of oral contraceptives
    W C Chie
    School of Public Health, College of Public Health, National Taiwan University, Taipei
    Int J Cancer 77:219-23. 1998
  3. ncbi request reprint Quality of life in patients of nasopharyngeal carcinoma: validation of the Taiwan Chinese version of the EORTC QLQ-C30 and the EORTC QLQ-H&N35
    W C Chie
    School of Public Health and Graduate Institute of Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
    Qual Life Res 12:93-8. 2003
  4. ncbi request reprint Quality of life of breast cancer patients in Taiwan: validation of the Taiwan Chinese version of the EORTC QLQ-C30 and EORTC QLQ-BR23
    Wei Chu Chie
    School of Public Health and Graduate Institute of Preventive Medicine, College of Public Health, National Taiwan University, Taiwan
    Psychooncology 12:729-35. 2003
  5. ncbi request reprint Quality of life of lung cancer patients: validation of the Taiwan Chinese version of the EORTC QLQ-C30 and QLQ-LC13
    Wei Chu Chie
    School of Public Health and Graduate Institute of Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
    Qual Life Res 13:257-62. 2004
  6. ncbi request reprint Gemcitabine plus conventional-dose epirubicin versus gemcitabine plus cisplatin as first-line chemotherapy for stage IIIB/IV non-small cell lung carcinoma--a randomized phase II trial
    Chiun Hsu
    Department of Oncology, National Taiwan University Hospital, 7, Chung Shan South Road, Taipei, 100, Taiwan
    Lung Cancer 62:334-43. 2008
  7. ncbi request reprint A phase II trial of weekly paclitaxel and high-dose 5-fluorouracil plus leucovorin in patients with chemotherapy-pretreated metastatic breast cancer
    Chia Chi Lin
    Departments of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Anticancer Res 27:641-5. 2007
  8. doi request reprint Dynamic contrast-enhanced magnetic resonance imaging biomarkers predict survival and response in hepatocellular carcinoma patients treated with sorafenib and metronomic tegafur/uracil
    Chao Yu Hsu
    Department of Radiology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Hepatol 55:858-65. 2011
  9. ncbi request reprint Phase II study of combining sorafenib with metronomic tegafur/uracil for advanced hepatocellular carcinoma
    Chih Hung Hsu
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    J Hepatol 53:126-31. 2010
  10. ncbi request reprint Multifractionated paclitaxel and cisplatin combined with 5-fluorouracil and leucovorin in patients with metastatic or recurrent esophageal squamous cell carcinoma
    Chia Chi Lin
    Department of Oncology, National Taiwan University, Taipei, Taiwan, ROC
    Anticancer Drugs 18:703-8. 2007

Detail Information

Publications70

  1. ncbi request reprint Body size as a factor in different ages and breast cancer risk in Taiwan
    W C Chie
    School of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan
    Anticancer Res 18:565-70. 1998
    ..The results of this study imply that adipose tissue may interfere with ovarian endocrine in the younger age group, and that there is increased hormonal production after obvious weight gain...
  2. ncbi request reprint Oral contraceptives and breast cancer risk in Taiwan, a country of low incidence of breast cancer and low use of oral contraceptives
    W C Chie
    School of Public Health, College of Public Health, National Taiwan University, Taipei
    Int J Cancer 77:219-23. 1998
    ..Our results support the notion that OC use in early life for younger women and in early calendar years increase breast cancer risk...
  3. ncbi request reprint Quality of life in patients of nasopharyngeal carcinoma: validation of the Taiwan Chinese version of the EORTC QLQ-C30 and the EORTC QLQ-H&N35
    W C Chie
    School of Public Health and Graduate Institute of Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
    Qual Life Res 12:93-8. 2003
    ....
  4. ncbi request reprint Quality of life of breast cancer patients in Taiwan: validation of the Taiwan Chinese version of the EORTC QLQ-C30 and EORTC QLQ-BR23
    Wei Chu Chie
    School of Public Health and Graduate Institute of Preventive Medicine, College of Public Health, National Taiwan University, Taiwan
    Psychooncology 12:729-35. 2003
    ....
  5. ncbi request reprint Quality of life of lung cancer patients: validation of the Taiwan Chinese version of the EORTC QLQ-C30 and QLQ-LC13
    Wei Chu Chie
    School of Public Health and Graduate Institute of Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
    Qual Life Res 13:257-62. 2004
    ..The questionnaires could also detect expected adverse effects of radiotherapy, cisplatin, and paclitaxel...
  6. ncbi request reprint Gemcitabine plus conventional-dose epirubicin versus gemcitabine plus cisplatin as first-line chemotherapy for stage IIIB/IV non-small cell lung carcinoma--a randomized phase II trial
    Chiun Hsu
    Department of Oncology, National Taiwan University Hospital, 7, Chung Shan South Road, Taipei, 100, Taiwan
    Lung Cancer 62:334-43. 2008
    ....
  7. ncbi request reprint A phase II trial of weekly paclitaxel and high-dose 5-fluorouracil plus leucovorin in patients with chemotherapy-pretreated metastatic breast cancer
    Chia Chi Lin
    Departments of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Anticancer Res 27:641-5. 2007
    ..Weekly paclitaxel and infusional high-dose 5-fluorouracil/leucovorin (HDFL) are both effective regimens for metastatic breast cancer (MBC) patients...
  8. doi request reprint Dynamic contrast-enhanced magnetic resonance imaging biomarkers predict survival and response in hepatocellular carcinoma patients treated with sorafenib and metronomic tegafur/uracil
    Chao Yu Hsu
    Department of Radiology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Hepatol 55:858-65. 2011
    ..This study evaluated the correlation of vascular response measured by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and the clinical outcome...
  9. ncbi request reprint Phase II study of combining sorafenib with metronomic tegafur/uracil for advanced hepatocellular carcinoma
    Chih Hung Hsu
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    J Hepatol 53:126-31. 2010
    ..This phase II study evaluated the efficacy and safety of combining metronomic tegafur/uracil with sorafenib in patients with advanced HCC...
  10. ncbi request reprint Multifractionated paclitaxel and cisplatin combined with 5-fluorouracil and leucovorin in patients with metastatic or recurrent esophageal squamous cell carcinoma
    Chia Chi Lin
    Department of Oncology, National Taiwan University, Taipei, Taiwan, ROC
    Anticancer Drugs 18:703-8. 2007
    ..3 and 8.9 months (range 1-50+), respectively. Twice-weekly TP-HDFL has the activity and toxicity profile similar to the previously reported same three-drug combination for advanced esophageal cancer...
  11. pmc Potentiating the efficacy of molecular targeted therapy for hepatocellular carcinoma by inhibiting the insulin-like growth factor pathway
    Da Liang Ou
    Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei, Taiwan
    PLoS ONE 8:e66589. 2013
    ..Our data indicate that the apoptosis-potentiating effects of IGFR inhibition for HCC may be drug-specific. Combination therapy of IGFR inhibitors with other MTA may improve the therapeutic efficacy in HCC. ..
  12. doi request reprint Nuclear overexpression of mitotic regulatory proteins in biliary tract cancer: correlation with clinicopathologic features and patient survival
    Ying Chun Shen
    Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Cancer Epidemiol Biomarkers Prev 18:417-23. 2009
    ..Endogeneity testing suggested that nuclear overexpression of p53 and tumor type may influence patient survival through their interactions with Aurora-A/Aurora-B expression and tumor grade...
  13. doi request reprint Induction of DNA damage-inducible gene GADD45beta contributes to sorafenib-induced apoptosis in hepatocellular carcinoma cells
    Da Liang Ou
    National Center of Excellence for Clinical Trial and Research, Department of Oncology, National Taiwan University Hospital, Graduate Institute of Toxicology, Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Cancer Res 70:9309-18. 2010
    ..Together, our findings suggest that GADD45β induction contributes to sorafenib-induced apoptosis in HCC cells, prompting further studies to validate its potential value in predicting sorafenib efficacy...
  14. doi request reprint High circulating endothelial progenitor levels associated with poor survival of advanced hepatocellular carcinoma patients receiving sorafenib combined with metronomic chemotherapy
    Yu Yun Shao
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan, ROC
    Oncology 81:98-103. 2011
    ..We examined whether circulating endothelial progenitor (CEP) and circulating endothelial cell (CEC) levels had associations with the survival of patients who received antiangiogenic therapy for advanced hepatocellular carcinoma (HCC)...
  15. ncbi request reprint Phase II study of weekly paclitaxel and 24-hour infusion of high-dose 5-fluorouracil and leucovorin in the treatment of recurrent or metastatic gastric cancer
    Kun Huei Yeh
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Oncology 69:88-95. 2005
    ..This paclitaxel-HDFL regimen is effective and well tolerated in the treatment of advanced gastric cancer...
  16. doi request reprint Molecular targeted therapy for advanced hepatocellular carcinoma: current status and future perspectives
    Ying Chun Shen
    National Center of Excellence for Clinical Trial and Research, National Taiwan University Hospital, Taipei, Taiwan
    J Gastroenterol 45:794-807. 2010
    ..Patient selection according to the individual molecular signature of the tumor and correlative biomarker studies are encouraged while planning a clinical trial of novel MTT...
  17. doi request reprint Predictive and prognostic values of tau and ERCC1 in advanced breast cancer patients treated with paclitaxel and cisplatin
    Yu Yun Shao
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Jpn J Clin Oncol 40:286-93. 2010
    ..We studied tau and excision repair cross-complementing 1 expression to evaluate their predictive values in advanced breast carcinoma patients...
  18. doi request reprint Inferior survival of advanced pancreatic cancer patients who received gemcitabine-based chemotherapy but did not participate in clinical trials
    Shih Hung Yang
    Department of Oncology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan, ROC
    Oncology 81:143-50. 2011
    ..Advanced pancreatic cancer, even when treated, is highly lethal. The best choice of gemcitabine-based therapy and the prognostic factors affecting the success of treatment remain uncertain...
  19. doi request reprint A pilot study of hepatic arterial infusion of chemotherapy for patients with advanced hepatocellular carcinoma who have failed anti-angiogenic therapy
    Yu Yun Shao
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan
    Liver Int 33:1413-9. 2013
    ..Hepatic arterial infusion of chemotherapy (HAIC) has been reported to achieve substantial treatment responses in HCC patients. We aimed to explore the feasibility of using HAIC as second-line therapy for advanced HCC...
  20. ncbi request reprint Phase I study of biweekly gemcitabine followed by oxaliplatin and simplified 48-h infusion of fluorouracil/leucovorin for advanced pancreatic cancer
    Hui Ju Ch'ang
    Division of Cancer Research, National Health Research Institutes, Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    J Gastroenterol Hepatol 21:874-9. 2006
    ..To evaluate the feasibility and maximal tolerated dose (MTD) of oxaliplatin of a triplet regimen consisting of gemcitabine, oxaliplatin and infusional fluorouracil (5-FU)/leucovorin (LV) (GOFL) for advanced pancreatic cancer...
  21. ncbi request reprint Outcome of advanced nonsmall cell lung cancer patients receiving gemcitabine and weekly paclitaxel as first-line treatment
    Zhong Zhe Lin
    Department of Oncology, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
    Lung Cancer 60:215-21. 2008
    ..Combinations of gemcitabine and paclitaxel with various doses and schedules were shown to be effective treatment for these patients. Nevertheless, the survival outcome of these patients is not clear...
  22. ncbi request reprint Difference in the incidence trend of nasopharyngeal and oropharyngeal carcinomas in Taiwan: implication from age-period-cohort analysis
    Chiun Hsu
    Department of Oncology and Internal Medicine, National Taiwan University Hospital, No 7, Chung Shan South Road, Taipei, Taiwan
    Cancer Epidemiol Biomarkers Prev 15:856-61. 2006
    ..67 for men and 2.69 for women. Change in lifestyle seemed to be an important factor for the difference in the incidence trend between nasopharyngeal and oropharyngeal carcinomas and between men and women...
  23. pmc Factors impacting prognosis prediction in BCLC stage C and Child-Pugh class A hepatocellular carcinoma patients in prospective clinical trials of systemic therapy
    Zhong Zhe Lin
    Department of Oncology, National Taiwan University, Taipei, Taiwan
    Oncologist 17:970-7. 2012
    ..The purpose of this study was to determine the prognostic significance of clinical factors and staging systems for survival of hepatocellular carcinoma (HCC) patients who are candidates for therapeutic clinical trials...
  24. doi request reprint Serum vascular endothelial growth factor/soluble vascular endothelial growth factor receptor 1 ratio is an independent prognostic marker in pancreatic cancer
    Yu Ting Chang
    Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
    Pancreas 37:145-50. 2008
    ....
  25. doi request reprint Early alpha-fetoprotein response predicts treatment efficacy of antiangiogenic systemic therapy in patients with advanced hepatocellular carcinoma
    Yu Yun Shao
    Department of Oncology, National Taiwan University Hospital, and Cancer Research Center, National Taiwan University School of Medicine, Taipei, Taiwan
    Cancer 116:4590-6. 2010
    ..In this study, the authors investigated levels of alpha-fetoprotein (AFP) as a potential biomarker for treatment efficacy of antiangiogenic therapy...
  26. ncbi request reprint Adjuvant interferon therapy after curative therapy for hepatocellular carcinoma (HCC): a meta-regression approach
    Ying Chun Shen
    Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Hepatol 52:889-94. 2010
    ..Adjuvant anti-viral therapy after curative therapy for HCC has been studied extensively but the true clinical benefit and the predictors of efficacy remain unclear...
  27. doi request reprint Induction of Bim expression contributes to the antitumor synergy between sorafenib and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor CI-1040 in hepatocellular carcinoma
    Da Liang Ou
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Clin Cancer Res 15:5820-8. 2009
    ..This study explored whether the efficacy of sorafenib can be improved by adding the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK) inhibitor CI-1040 to vertically block the Raf/MEK/ERK pathway...
  28. pmc Bortezomib overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway
    Kuen Feng Chen
    Department of Medical Research, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    J Biol Chem 284:11121-33. 2009
    ..Together, bortezomib overcame TRAIL resistance at clinically achievable concentrations in hepatocellular carcinoma cells, and this effect is mediated at least partly via inhibition of the PI3K/Akt pathway...
  29. ncbi request reprint Survival outcome and predictors of gefitinib antitumor activity in East Asian chemonaive patients with advanced nonsmall cell lung cancer
    Chih Hsin Yang
    Department of Oncology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
    Cancer 107:1873-82. 2006
    ..The survival outcome and the predictors for antitumor activity in chemonaive patients who received gefitinib as first-line treatment are unclear...
  30. doi request reprint A critical evaluation of the preventive effect of antiviral therapy on the development of hepatocellular carcinoma in patients with chronic hepatitis C or B: a novel approach by using meta-regression
    Ying Chun Shen
    Graduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC
    Oncology 82:275-89. 2012
    ..The extent of the effect of antiviral therapy and its predictors in preventing hepatocellular carcinoma (HCC) development in patients with chronic hepatitis C (CHC) or B (CHB) remain unclear...
  31. ncbi request reprint Phase II study of combination doxorubicin, interferon-alpha, and high-dose tamoxifen treatment for advanced hepatocellular carcinoma
    Yen Shen Lu
    Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Hepatogastroenterology 51:815-9. 2004
    ..In this study, we sought to clarify if the addition of Interferon-alpha2b to HTD regimen could further improve the control of advanced hepatocellular carcinoma...
  32. ncbi request reprint Survival of stage IIIB/IV non-small cell lung cancer patients who received chemotherapy but did not participate in clinical trials
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, No 7, Chung Shan South Rd, Taipei, Taiwan
    Lung Cancer 48:275-80. 2005
    ..36; progression-free survival: P=0.57). Our data suggest that the survival of patients who received chemotherapy but did not participate in clinical trials was similar to patients participated in clinical trials...
  33. pmc Radiofrequency ablation is superior to ethanol injection in early-stage hepatocellular carcinoma irrespective of tumor size
    Zhong Zhe Lin
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    PLoS ONE 8:e80276. 2013
    ..However, the survival advantage of RFA needs confirmation in daily practice...
  34. doi request reprint Bevacizumab with erlotinib as first-line therapy in Asian patients with advanced hepatocellular carcinoma: a multicenter phase II study
    Chih Hung Hsu
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Oncology 85:44-52. 2013
    ..This multicenter study across several Asian countries was to evaluate the safety and efficacy of the combination in this population...
  35. doi request reprint The Aurora kinase inhibitor VE-465 has anticancer effects in pre-clinical studies of human hepatocellular carcinoma
    Zhong Zhe Lin
    National Center of Excellence for Clinical Trial and Research, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan
    J Hepatol 50:518-27. 2009
    ..Recently, aberrant expression of Aurora kinases has been reported in various human cancers including HCC. We sought to investigate the potential of a potent and selective Aurora kinase inhibitor, VE-465, for targeted therapy of HCC...
  36. doi request reprint Vandetanib in patients with inoperable hepatocellular carcinoma: a phase II, randomized, double-blind, placebo-controlled study
    Chiun Hsu
    Department of Oncology and Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    J Hepatol 56:1097-103. 2012
    ..The present study evaluated the efficacy and safety of vandetanib, an oral inhibitor of both VEGFR and EGFR, in patients with unresectable advanced HCC...
  37. pmc Diabetes mellitus is associated with increased mortality in patients receiving curative therapy for hepatocellular carcinoma
    Wen Yi Shau
    Division of Health Technology Assessment, Center for Drug Evaluation, Taipei, Taiwan
    Oncologist 17:856-62. 2012
    ..Diabetes mellitus (DM) is closely associated with hepatocarcinogenesis. This study explores the prognostic impact of DM in patients who received curative therapy for localized hepatocellular carcinoma (HCC)...
  38. ncbi request reprint Weekly cisplatin, infusional high-dose 5-fluorouracil and leucovorin for advanced, recurrent and metastatic cervical carcinoma
    Sheng Mou Hsiao
    Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Pan Chiao, Taipei, Taiwan
    Anticancer Res 28:1887-91. 2008
    ....
  39. ncbi request reprint Predictors of toxicity of weekly docetaxel in chemotherapy-treated non-small cell lung cancers
    Jo Pai Chen
    Department of Oncology, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
    Lung Cancer 60:92-7. 2008
    ..It should be given cautiously in elderly patients and in patients with chronic viral hepatitis or low white blood cell counts...
  40. ncbi request reprint Phase I-II trial of weekly gemcitabine plus high-dose 5-fluorouracil and leucovorin in advanced pancreatic cancer
    Her Shyong Shiah
    Division of Cancer Research, National Health Research Institutes, Veterans General Hospital, Taipei, Taiwan
    J Gastroenterol Hepatol 21:531-6. 2006
    ..The purpose of the present study was to determine the maximum tolerated dose (MTD) of 5-FU and the efficacy and toxicity profile of weekly gemcitabine plus infusional 5-FU/leucovorin in advanced pancreatic cancer...
  41. doi request reprint Lack of efficacy to systemic chemotherapy for treatment of metaplastic carcinoma of the breast in the modern era
    I C Chen
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Breast Cancer Res Treat 130:345-51. 2011
    ..Tumor response to systemic chemotherapy remains generally poor for MCB patients. Taxanes may have modest activity, but need to be validated in further studies...
  42. pmc Hepatitis B and C viruses are not risks for pancreatic adenocarcinoma
    Ming Chu Chang
    Ming Chu Chang, Chien Hung Chen, Ja Der Liang, Jau Min Wong, Yu Ting Chang, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei 101, Taiwan
    World J Gastroenterol 20:5060-5. 2014
    ..To investigate whether hepatitis B virus (HBV) and hepatitis C virus (HCV) increase risk of pancreatic ductal adenocarcinoma (PDAC)...
  43. pmc Vertical blockade of the IGFR- PI3K/Akt/mTOR pathway for the treatment of hepatocellular carcinoma: the role of survivin
    Da Liang Ou
    Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Cancer 13:2. 2014
    ..To explore whether combining inhibitors that target the insulin-like growth factor receptor (IGFR)/PI3K/Akt/mTOR signaling pathway (vertical blockade) can improve treatment efficacy for hepatocellular carcinoma (HCC)...
  44. ncbi request reprint Unexpected rapid progression of metastatic adenoid cystic carcinoma during treatment with imatinib mesylate
    Ching Hung Lin
    Department of Oncology, National Taiwan University Hospital, National Taiwan University, No 7, Chung Shan South Rd, Taipei 10016, Taiwan
    Head Neck 27:1022-7. 2005
    ..We studied the efficacy of imatinib mesylate, a potent inhibitor of KIT tyrosine kinase, in patients with KIT-positive metastatic ACC...
  45. doi request reprint Issues and controversies of hepatocellular carcinoma-targeted therapy clinical trials in Asia: experts' opinion
    Pei Jer Chen
    National Taiwan University Hospital, Taipei, Taiwan
    Liver Int 30:1427-38. 2010
    ....
  46. ncbi request reprint Clinicopathological and prognostic significances of EGFR, KRAS and BRAF mutations in biliary tract carcinomas in Taiwan
    Yu Ting Chang
    Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Gastroenterol Hepatol 29:1119-25. 2014
    ..The aims of this study were to analyze the EGFR, KRAS and BRAF mutations in BTCs and their association with clinical outcomes...
  47. doi request reprint Overexpression of 14-3-3ε predicts tumour metastasis and poor survival in hepatocellular carcinoma
    Bor Sheng Ko
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Histopathology 58:705-11. 2011
    ..However, it is not clear whether 14-3-3ε plays a role in tumour metastasis and patient outcome. The aim of this study was to determine whether 14-3-3ε is a marker for predicting hepatocellular carcinoma (HCC) metastasis and survival...
  48. ncbi request reprint Dynamic MRI signals in the second week of radiotherapy relate to treatment outcomes of hepatocellular carcinoma: a preliminary result
    Po Chin Liang
    Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan
    Liver Int 27:516-28. 2007
    ..5 T before therapy, at 2 weeks of therapy, and 1 month (week 9) later. Initial first-pass enhancement slopes (slope) and peak enhancement ratios (peak) were measured...
  49. ncbi request reprint ACCOMP: Augmented cell competition algorithm for breast lesion demarcation in sonography
    Jie Zhi Cheng
    Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Number 1, Section 1, Jen Ai Road, Taipei 100, Taiwan
    Med Phys 37:6240-52. 2010
    ..This article aims to develop an image segmentation algorithm that provides quality delineation of breast lesions in sonography with a simple and friendly semiautomatic scheme...
  50. doi request reprint Dose variation and regimen modification of adjuvant chemotherapy in daily practice affect survival of stage I-II and operable stage III Taiwanese breast cancer patients
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Breast 17:646-53. 2008
    ..032) and OS (HR=0.54; P=0.025) than those treated with non-standard adjuvant chemotherapy. Breast cancer patients receiving standard adjuvant chemotherapy have a better DFS and OS than those receiving non-standard adjuvant chemotherapy...
  51. doi request reprint The CYP19 TTTA repeat polymorphism is related to the prognosis of premenopausal stage I-II and operable stage III breast cancers
    Chiun Sheng Huang
    Department of Surgery, National Taiwan University Hospital, No 7, Chung Shan South Road, Taipei, Taiwan
    Oncologist 13:751-60. 2008
    ....
  52. ncbi request reprint Chemotherapy-induced hepatitis B reactivation in lymphoma patients with resolved HBV infection: A prospective study
    Chiun Hsu
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan
    Hepatology 59:2092-100. 2014
    ..Serological breakthrough (i.e., reappearance of HBsAg) is the most important predictor of HBV-related hepatitis flare. (Hepatology 2014;59:2092-2100). ..
  53. doi request reprint Diagnostic value of 18F-FDG-PET/CT in indeterminate infiltrative hepatic lesions in an endemic area of viral hepatitis
    Mei Fang Cheng
    Department of Nuclear Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Nucl Med Commun 32:252-9. 2011
    ....
  54. ncbi request reprint Significant difference in the trends of female breast cancer incidence between Taiwanese and Caucasian Americans: implications from age-period-cohort analysis
    Ying Chun Shen
    Division of Medical Oncology and Hematology, Department of Internal Medicine, Far Eastern Memorial Hospital and Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan
    Cancer Epidemiol Biomarkers Prev 14:1986-90. 2005
    ..These findings indicate that a continued shift in the incidence and age distribution pattern of FIBC in Taiwanese toward that of Caucasian Americans should be anticipated...
  55. ncbi request reprint Survival-weighted health profile for long-term survivors of acute myelogenous leukemia
    Chiun Hsu
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Qual Life Res 12:503-17. 2003
    ..SWPS may be useful to evaluate the efficacy of different treatment strategies for AML. Confirmation of the relative merit of BMT vs. chemotherapy alone from prospective studies is needed...
  56. ncbi request reprint Should adjuvant radiotherapy to the supraclavicular fossa be routinely given in patients with breast conservative treatment?
    Chun Wei Wang
    Division of Radiation Oncology, Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    J Surg Oncol 96:144-50. 2007
    ..To analyze the overall outcome, supraclavicular fossa (SCF) recurrence rate, and pattern of failure in breast cancer patients treated with conservative surgery and adjuvant radiotherapy excluding SCF treatment...
  57. ncbi request reprint Expression of the caudal-type homeodomain transcription factor CDX2 is related to clinical outcome in biliary tract carcinoma
    Yu Ting Chang
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    J Gastroenterol Hepatol 22:389-94. 2007
    ..The clinicopathological significance of CDX2 expression has hitherto remained unclear in biliary tract carcinoma (BTC). The aim of this study was to determine whether CDX2 expression in BTC indicates clinical outcome...
  58. ncbi request reprint Low-dose thalidomide treatment for advanced hepatocellular carcinoma
    Chiun Hsu
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan, ROC
    Oncology 65:242-9. 2003
    ..To analyze the efficacy of oral thalidomide in the treatment of advanced hepatocellular carcinoma (HCC)...
  59. ncbi request reprint Phase II trial combining paclitaxel with 24-hour infusion cisplatin for chemotherapy-naïve patients with locally advanced or metastatic breast carcinoma
    Chiun Hsu
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Cancer 95:2044-50. 2002
    ..A synergistic cytotoxicity of these two drugs has been demonstrated in vitro. This study sought to determine the efficacy of combining these two drugs in the treatment of chemotherapy-naïve patients with breast carcinoma...
  60. ncbi request reprint Could Kinesio tape replace the bandage in decongestive lymphatic therapy for breast-cancer-related lymphedema? A pilot study
    Han Ju Tsai
    School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Zhongzheng District, Taipei 100, Taiwan, Republic of China
    Support Care Cancer 17:1353-60. 2009
    ....
  61. doi request reprint Molecular subtypes of breast cancer emerging in young women in Taiwan: evidence for more than just westernization as a reason for the disease in Asia
    Ching Hung Lin
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Cancer Epidemiol Biomarkers Prev 18:1807-14. 2009
    ..As a first step to investigate the possible etiology, we examined the molecular subtypes of female breast cancer in Taiwan...
  62. doi request reprint Unique features of breast cancer in Asian women--breast cancer in Taiwan as an example
    Chiun Sheng Huang
    Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    J Steroid Biochem Mol Biol 118:300-3. 2010
    ..The frequency of the luminal-A subtype of breast cancer, characterized by estrogen receptor expression, is similar to that in breast cancer in Caucasian, supporting the usefulness of hormone-based therapy in Asian breast cancer...
  63. ncbi request reprint Breast cancer risk associated with genotype polymorphism of the catechol estrogen-metabolizing genes: a multigenic study on cancer susceptibility
    Ting Chih Cheng
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Int J Cancer 113:345-53. 2005
    ....
  64. ncbi request reprint Radio-guided sentinel lymph node biopsy using periareolar injection technique for patients with early breast cancer
    Ruoh Fang Yen
    Department of Nuclear Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
    J Formos Med Assoc 106:44-50. 2007
    ..This study aimed to evaluate the accuracy of radio-guided sentinel LN (SLN) biopsy (SLNB) using the periareolar injection technique for predicting the histopathologic status of axillary LNs in early breast cancer patients...
  65. doi request reprint Clinicopathologic features and treatment outcome of non-Hodgkin lymphoma of the breast--a review of 42 primary and secondary cases in Taiwanese patients
    Yu Chin Lin
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Leuk Lymphoma 50:918-24. 2009
    ..Further investigation of underlying mechanisms of young age- and stage IIE disease-related poor prognosis in patients with PBL is needed...
  66. doi request reprint A revisit of prophylactic lamivudine for chemotherapy-associated hepatitis B reactivation in non-Hodgkin's lymphoma: a randomized trial
    Chiun Hsu
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Hepatology 47:844-53. 2008
    ..When compared with an equivalent group of lamivudine-naïve lymphoma patients who underwent chemotherapy, therapeutic use of lamivudine neither reduced the severity of HBV-related hepatitis nor changed the patterns of HBV reactivation...
  67. doi request reprint Comprehensive locoregional treatment and systemic therapy for postmastectomy isolated locoregional recurrence
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Int J Radiat Oncol Biol Phys 72:1456-64. 2008
    ..To assess the impact of comprehensive locoregional therapy and systemic therapy on disease control and survival for postmastectomy patients with isolated locoregional recurrence (ILRR)...
  68. ncbi request reprint Breast cancer risk associated with genotypic polymorphism of the genes involved in the estrogen-receptor-signaling pathway: a multigenic study on cancer susceptibility
    Jyh Cherng Yu
    Departments of Surgery, Tri Service General Hospital, Taipei, Taiwan
    J Biomed Sci 13:419-32. 2006
    ..These epidemiological findings highlight the role of newly identified novel ER-related pathways in breast cancer development and provide a more comprehensive picture of the tumorigenic effect of estrogen in breast cancer development...
  69. ncbi request reprint Increased expression of SRp40 affecting CD44 splicing is associated with the clinical outcome of lymph node metastasis in human breast cancer
    Chiun Sheng Huang
    Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
    Clin Chim Acta 384:69-74. 2007
    ..Regulation of pre-mRNA splicing by serine-arginine (SR)-rich phosphoprotein is hypothesized to be associated with tumor cell metastasis...
  70. ncbi request reprint Rapid image stitching and computer-aided detection for multipass automated breast ultrasound
    Ruey Feng Chang
    Department of Computer Science and Information Engineering, Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan 10617
    Med Phys 37:2063-73. 2010
    ..In this study, an image stitching technique is proposed for combining multipass images of the whole breast into a series of full-view images, and a fully automatic screening system that works off these images is also presented...