Jih Hwa Guh

Summary

Affiliation: National Taiwan University
Country: Taiwan

Publications

  1. pmc Reevesioside A, a cardenolide glycoside, induces anticancer activity against human hormone-refractory prostate cancers through suppression of c-myc expression and induction of G1 arrest of the cell cycle
    Wohn Jenn Leu
    School of Pharmacy, National Taiwan University, Taipei, Taiwan
    PLoS ONE 9:e87323. 2014
  2. doi request reprint Tunicamycin induces resistance to camptothecin and etoposide in human hepatocellular carcinoma cells: role of cell-cycle arrest and GRP78
    Jui Ling Hsu
    School of Pharmacy, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei, Taiwan
    Naunyn Schmiedebergs Arch Pharmacol 380:373-82. 2009
  3. ncbi request reprint YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] inhibits endothelial cell functions induced by angiogenic factors in vitro and angiogenesis in vivo models
    Shiow Lin Pan
    Pharmacological Institute, College of Medicine, National Taiwan University, 1 Jen Ai Road, Section 1, Taipei, Taiwan
    J Pharmacol Exp Ther 314:35-42. 2005
  4. ncbi request reprint Induction of Fas clustering and apoptosis by coral prostanoid in human hormone-resistant prostate cancer cells
    Po Cheng Chiang
    School of Pharmacy, College of Medicine, National Taiwan University, No 1, Jen Ai Road, sect 1, Taipei, Taiwan, ROC
    Eur J Pharmacol 542:22-30. 2006
  5. ncbi request reprint CIL-102 interacts with microtubule polymerization and causes mitotic arrest following apoptosis in the human prostate cancer PC-3 cell line
    Yao Ting Huang
    Pharmacological Institute and School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan
    J Biol Chem 280:2771-9. 2005
  6. ncbi request reprint YC-1 [3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl Indazole] exhibits a novel antiproliferative effect and arrests the cell cycle in G0-G1 in human hepatocellular carcinoma cells
    Shih Wei Wang
    Pharmacological Institutes, College of Medicine, National Taiwan University, 1 Jen Ai Road, sect 1, Taipei, Taiwan
    J Pharmacol Exp Ther 312:917-25. 2005
  7. ncbi request reprint Investigation of anticancer mechanism of clavulone II, a coral cyclopentenone prostaglandin analog, in human acute promyelocytic leukemia
    Yu Chun Huang
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Biomed Sci 12:335-45. 2005
  8. ncbi request reprint Investigation of extrinsic and intrinsic apoptosis pathways of new clerodane diterpenoids in human prostate cancer PC-3 cells
    Dong Ming Huang
    Pharmacological Institute, College of Medicine, National Taiwan University, No 1, Jen Ai Road, sect 1, Taipei, Taiwan
    Eur J Pharmacol 503:17-24. 2004
  9. ncbi request reprint YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] inhibits neointima formation in balloon-injured rat carotid through suppression of expressions and activities of matrix metalloproteinases 2 and 9
    Yi Nan Liu
    Pharmacological Institute, College of Medicine, National Taiwan University, 1 Jen Ai Road, sect 1, Taipei, Taiwan
    J Pharmacol Exp Ther 316:35-41. 2006
  10. ncbi request reprint Antitumor mechanism of evodiamine, a constituent from Chinese herb Evodiae fructus, in human multiple-drug resistant breast cancer NCI/ADR-RES cells in vitro and in vivo
    Cho Hwa Liao
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei 100, Taiwan
    Carcinogenesis 26:968-75. 2005

Collaborators

Detail Information

Publications70

  1. pmc Reevesioside A, a cardenolide glycoside, induces anticancer activity against human hormone-refractory prostate cancers through suppression of c-myc expression and induction of G1 arrest of the cell cycle
    Wohn Jenn Leu
    School of Pharmacy, National Taiwan University, Taipei, Taiwan
    PLoS ONE 9:e87323. 2014
    ..G1 arrest is, therefore, induced through E2F1 suppression. Consequently, reevesioside A causes mitochondrial damage and an ultimate apoptosis in human hormone-refractory prostate cancer cells...
  2. doi request reprint Tunicamycin induces resistance to camptothecin and etoposide in human hepatocellular carcinoma cells: role of cell-cycle arrest and GRP78
    Jui Ling Hsu
    School of Pharmacy, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei, Taiwan
    Naunyn Schmiedebergs Arch Pharmacol 380:373-82. 2009
    ....
  3. ncbi request reprint YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] inhibits endothelial cell functions induced by angiogenic factors in vitro and angiogenesis in vivo models
    Shiow Lin Pan
    Pharmacological Institute, College of Medicine, National Taiwan University, 1 Jen Ai Road, Section 1, Taipei, Taiwan
    J Pharmacol Exp Ther 314:35-42. 2005
    ..YC-1 may be useful for treating angiogenesis-dependent human diseases such as cancer...
  4. ncbi request reprint Induction of Fas clustering and apoptosis by coral prostanoid in human hormone-resistant prostate cancer cells
    Po Cheng Chiang
    School of Pharmacy, College of Medicine, National Taiwan University, No 1, Jen Ai Road, sect 1, Taipei, Taiwan, ROC
    Eur J Pharmacol 542:22-30. 2006
    ..Subsequently, the Fas event causes the activation and interaction of caspase-8/Bid/caspase-9 signaling cascades, and the activation of executor caspase-3...
  5. ncbi request reprint CIL-102 interacts with microtubule polymerization and causes mitotic arrest following apoptosis in the human prostate cancer PC-3 cell line
    Yao Ting Huang
    Pharmacological Institute and School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan
    J Biol Chem 280:2771-9. 2005
    ..CIL-102 causes mitotic arrest, at least partly, by modulating cyclin-dependent kinases and then apoptosis executed by caspase and noncaspase pathways...
  6. ncbi request reprint YC-1 [3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl Indazole] exhibits a novel antiproliferative effect and arrests the cell cycle in G0-G1 in human hepatocellular carcinoma cells
    Shih Wei Wang
    Pharmacological Institutes, College of Medicine, National Taiwan University, 1 Jen Ai Road, sect 1, Taipei, Taiwan
    J Pharmacol Exp Ther 312:917-25. 2005
    ..Because of this, YC-1 is a potential antitumor agent worthy of further investigation...
  7. ncbi request reprint Investigation of anticancer mechanism of clavulone II, a coral cyclopentenone prostaglandin analog, in human acute promyelocytic leukemia
    Yu Chun Huang
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Biomed Sci 12:335-45. 2005
    ....
  8. ncbi request reprint Investigation of extrinsic and intrinsic apoptosis pathways of new clerodane diterpenoids in human prostate cancer PC-3 cells
    Dong Ming Huang
    Pharmacological Institute, College of Medicine, National Taiwan University, No 1, Jen Ai Road, sect 1, Taipei, Taiwan
    Eur J Pharmacol 503:17-24. 2004
    ....
  9. ncbi request reprint YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] inhibits neointima formation in balloon-injured rat carotid through suppression of expressions and activities of matrix metalloproteinases 2 and 9
    Yi Nan Liu
    Pharmacological Institute, College of Medicine, National Taiwan University, 1 Jen Ai Road, sect 1, Taipei, Taiwan
    J Pharmacol Exp Ther 316:35-41. 2006
    ..YC-1 shows therapeutic potential for treatment of restenosis after angioplasty...
  10. ncbi request reprint Antitumor mechanism of evodiamine, a constituent from Chinese herb Evodiae fructus, in human multiple-drug resistant breast cancer NCI/ADR-RES cells in vitro and in vivo
    Cho Hwa Liao
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei 100, Taiwan
    Carcinogenesis 26:968-75. 2005
    ..Evodiamine therefore represents a highly promising chemotherapeutic agent in the treatment of human multiple-drug resistant cancer cells...
  11. ncbi request reprint YC-1 suppresses constitutive nuclear factor-kappaB activation and induces apoptosis in human prostate cancer cells
    Yao Ting Huang
    Pharmacological Institute, College of Medicine, National Taiwan University, No 1, Jen Ai Road, Taipei 100, Taiwan
    Mol Cancer Ther 4:1628-35. 2005
    ..Given these unique actions, further investigations of the effects of YC-1 against hormone-refractory prostate cancer are warranted...
  12. ncbi request reprint Investigation of anti-tumor mechanisms of K2154: characterization of tubulin isotypes, mitotic arrest and apoptotic machinery
    Pin Hsuan Lu
    School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan
    Naunyn Schmiedebergs Arch Pharmacol 374:223-33. 2006
    ..In conclusion, it is suggested that K2154 displays an anticancer activity through a target on microtubules and a subsequent signaling cascade on cell cycle regulation and apoptotic machinery...
  13. pmc 2-Phenyl-5-(pyrrolidin-1-yl)-1-(3,4,5-trimethoxybenzyl)-1H-benzimidazole, a benzimidazole derivative, inhibits growth of human prostate cancer cells by affecting tubulin and c-Jun N-terminal kinase
    Wei Ling Chang
    School of Pharmacy, National Taiwan University, Taipei, Taiwan
    Br J Pharmacol 160:1677-89. 2010
    ..A major obstacle to successful development is P-glycoprotein (P-gp)-mediated resistance. Here, we have assessed a compound that inhibited growth of cancer cells, for effects on JNK and tubulin and as a substrate for P-gp...
  14. ncbi request reprint Genistein inversely affects tubulin-binding agent-induced apoptosis in human breast cancer cells
    Cho Hwa Liao
    Pharmacological Institute, College of Medicine, National Taiwan University, No 1, Jen Ai Road, Section 1, Taipei 100, Taiwan
    Biochem Pharmacol 67:2031-8. 2004
    ..In conclusion, genistein inversely affected tubulin-binding agent-induced apoptosis via down-regulation of cyclin B1/CDC2 kinase expression resulting in reduced Bcl-2 phosphorylation...
  15. ncbi request reprint Alisol B acetate, a triterpene from Alismatis rhizoma, induces Bax nuclear translocation and apoptosis in human hormone-resistant prostate cancer PC-3 cells
    Yao Ting Huang
    Pharmacological Institute, College of Medicine, National Taiwan University, No 1, Jen Ai Road, sect 1, Taipei, Taiwan, ROC
    Cancer Lett 231:270-8. 2006
    ..Furthermore, the Bax activation and translocation from the cytosol to nucleus might be a crucial response to the apoptotic effect...
  16. ncbi request reprint A potential role of YC-1 on the inhibition of cytokine release in peripheral blood mononuclear leukocytes and endotoxemic mouse models
    Shiow Lin Pan
    Pharmacological Institutes, College of Medicine, National Taiwan University, Taipei
    Thromb Haemost 93:940-8. 2005
    ..It is suggested that YC-1 may be a potential agent for the therapeutic treatment of sepsis...
  17. ncbi request reprint Induction of mitotic arrest and apoptosis in human prostate cancer pc-3 cells by evodiamine
    Dong Ming Huang
    Department of Pharmacology, School of Pharmacy and Department of Urology, College of Medicine, National Taiwan University, No 1 Jen Ai Road, Taipei 100, Taiwan, Republic of China
    J Urol 173:256-61. 2005
    ..We examined the anticancer activities and action mechanism of evodiamine...
  18. ncbi request reprint Induction of mitotic arrest and apoptosis by evodiamine in human leukemic T-lymphocytes
    Yu Chun Huang
    Pharmacological Institute, College of Medicine, National Taiwan University, No 1, Jen Ai Road, Sec 1, Taipei, Taiwan
    Life Sci 75:35-49. 2004
    ..Furthermore, several biological events including the Bcl-2 phosphorylation, Bax up-regulation and increase of caspase-3 activity could explain evodiamine-induced cell apoptosis...
  19. ncbi request reprint Genistein induces apoptosis in human hepatocellular carcinomas via interaction of endoplasmic reticulum stress and mitochondrial insult
    Ting Chun Yeh
    School of Pharmacy, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei, Taiwan
    Biochem Pharmacol 73:782-92. 2007
    ..Taken together, it is suggested that genistein induces the anticancer effect through a mechanism initiated by ER stress and facilitated by mitochondrial insult in Hep3B cells...
  20. doi request reprint Costunolide induces apoptosis through nuclear calcium2+ overload and DNA damage response in human prostate cancer
    Jui Ling Hsu
    School of Pharmacy, National Taiwan University, Taipei, Taiwan, Republic of China
    J Urol 185:1967-74. 2011
    ..Costunolide is a natural sesquiterpene lactone. We elucidated what to our knowledge is a novel mechanism to highlight its potential in chemotherapy for prostate cancer, particularly androgen refractory prostate cancer...
  21. doi request reprint Methoxychalcone induces cell-cycle arrest and apoptosis in human hormone-resistant prostate cancer cells through PI 3-kinase-independent inhibition of mTOR pathways
    Yu Wei Sun
    School of Pharmacy, National Taiwan University, Taipei, Taiwan
    Prostate 70:1295-306. 2010
    ..Chalcones are contained in fruits and vegetables, and have been suggested to display anticancer activities. In this study, the anticancer mechanism of WJ9708011 (a methoxychalcone derivative) was delineated in human prostate cancer cells...
  22. doi request reprint Moscatilin, a bibenzyl derivative from the India orchid Dendrobrium loddigesii, suppresses tumor angiogenesis and growth in vitro and in vivo
    An Chi Tsai
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    Cancer Lett 292:163-70. 2010
    ..These results suggest that inhibition of angiogenesis by moscatilin may be a major mechanism in cancer therapy...
  23. ncbi request reprint Investigation of ouabain-induced anticancer effect in human androgen-independent prostate cancer PC-3 cells
    Yao Ting Huang
    Pharmacological Institute, College of Medicine, National Taiwan University, No 1, Jen Ai Road, sect 1, Taipei, Taiwan, ROC
    Biochem Pharmacol 67:727-33. 2004
    ..Low concentrations of ouabain induce the increase of Par-4 expression and sensitize the cytotoxicity; while high concentrations of ouabain induce a loss of Deltapsim, a sustained ROS production and a severe apoptosis in PC-3 cells...
  24. ncbi request reprint Cardiac glycosides induce resistance to tubulin-dependent anticancer drugs in androgen-independent human prostate cancer
    Dong Ming Huang
    Pharmacological Institute, College of Medicine, National Taiwan University, Taiwan, ROC
    J Biomed Sci 9:443-52. 2002
    ..The decline in transport of these drugs into the nucleus may partly explain the action of cardiac glycosides...
  25. ncbi request reprint The indazole derivative YD-3 inhibits thrombin-induced vascular smooth muscle cell proliferation and attenuates intimal thickening after balloon injury
    Chieh Yu Peng
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    Thromb Haemost 92:1232-9. 2004
    ..Moreover, YD-3 also shows a developmental potential in the treatment of atherosclerosis and restenosis after vascular injury...
  26. ncbi request reprint Quinolone analogue inhibits tubulin polymerization and induces apoptosis via Cdk1-involved signaling pathways
    Ying Cheng Chen
    School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan
    Biochem Pharmacol 74:10-9. 2007
    ..Furthermore, participation of cell-cycle regulators, Bcl-2 family of proteins, activation of caspases and release of AIF may mutually cross-regulate the apoptotic signaling cascades induced by 2-phenyl-4-quinolone...
  27. doi request reprint Reevesioside F induces potent and efficient anti-proliferative and apoptotic activities through Na⁺/K⁺-ATPase α3 subunit-involved mitochondrial stress and amplification of caspase cascades
    She Hung Chan
    School of Pharmacy, National Taiwan University, No 1, sect 1, Jen Ai Rd, Taipei 100, Taiwan
    Biochem Pharmacol 86:1564-75. 2013
    ..The loss of ΔΨm and mitochondrial damage are responsible for the activation of caspases. Moreover, the amplification of caspase-3-mediated signaling pathway contributes largely to the execution of apoptosis in leukemic cells...
  28. doi request reprint Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathway
    Jui Ling Hsu
    School of Pharmacy, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei 100, Taiwan
    Biochem Pharmacol 84:59-67. 2012
    ..The novel discovery may provide an anticancer approach of combinatory use between rottlerin and camptothecin for the treatment of HRPCs...
  29. ncbi request reprint Identification of apoptotic and antiangiogenic activities of terazosin in human prostate cancer and endothelial cells
    Shiow Lin Pan
    Pharmacological Institutes, School of Pharmacy and Department of Urology, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
    J Urol 169:724-9. 2003
    ..It has been suggested that terazosin has an inhibitory effect on prostate tumor growth. We determined if terazosin action contributes to direct suppression of the angiogenic effect...
  30. ncbi request reprint CHM-1 inhibits hepatocyte growth factor-induced invasion of SK-Hep-1 human hepatocellular carcinoma cells by suppressing matrix metalloproteinase-9 expression
    Shih Wei Wang
    Pharmacological Institute, College of Medicine, National Taiwan University, No 1, Jen Ai Road, sect 1, Taipei, Taiwan
    Cancer Lett 257:87-96. 2007
    ..Thus, we suggest that CHM-1 is a potential therapeutic agent against tumor invasion...
  31. doi request reprint CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo
    Shih Wei Wang
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Cancer Ther 7:350-60. 2008
    ..CHM-1 is a promising chemotherapeutic agent worthy of further development into a clinical trial candidate for treating cancer, especially hepatocellular carcinoma...
  32. doi request reprint Anticancer activity of a cyclooxygenase inhibitor, CX9051, in human prostate cancer cells: the roles of NF-kappaB and crosstalk between the extrinsic and intrinsic apoptotic pathways
    Chiung Hua Huang
    School of Pharmacy, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei 100, Taiwan
    Naunyn Schmiedebergs Arch Pharmacol 382:159-69. 2010
    ..Taken together, our data suggest that CX9051 induces TRAIL up-regulation and activation of extrinsic apoptotic signaling, which in turn activates mitochondria-mediated intrinsic apoptotic signaling, leading to cancer cell apoptosis...
  33. doi request reprint The indazole derivative YD-3 specifically inhibits thrombin-induced angiogenesis in vitro and in vivo
    Chieh Yu Peng
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    Shock 34:580-5. 2010
    ..YD-3 may have benefit in elucidating pathophysiology induced by thrombin-induced angiogenesis...
  34. doi request reprint Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: a crucial role of AMPK and mTOR pathways
    Po Cheng Chiang
    School of Pharmacy, National Taiwan University, No 1, sect 1, Jen Ai Rd, Taipei 100, Taiwan
    Biochem Pharmacol 79:162-71. 2010
    ..In summary, the data suggest that antroquinonol displays anticancer activity against HCCs through AMPK activation and inhibition of mTOR translational pathway, leading to G1 arrest of the cell-cycle and subsequent cell apoptosis...
  35. doi request reprint Moscatilin repressed lipopolysaccharide-induced HIF-1alpha accumulation and NF-kappaB activation in murine RAW264.7 cells
    Yi Nan Liu
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    Shock 33:70-5. 2010
    ..7. Furthermore, the inhibition of moscatilin seemed to be dependent on the repression of HIF-1alpha accumulation and NF-kappaB activation...
  36. ncbi request reprint Moniliformediquinone induces in vitro and in vivo antitumor activity through glutathione involved DNA damage response and mitochondrial stress in human hormone refractory prostate cancer
    Jui Ling Hsu
    School of Pharmacy, National Taiwan University, Taipei, Taiwan, Republic of China
    J Urol 191:1429-38. 2014
    ..Hormone refractory metastatic prostate cancer is a major obstacle in clinical treatment. The key focus of this study was the discovery and development of a potential agent for this disease...
  37. ncbi request reprint Induction of endoplasmic reticulum stress and apoptosis by a marine prostanoid in human hepatocellular carcinoma
    Po Cheng Chiang
    School of Pharmacy, College of Medicine, National Taiwan University, No 1, Jen Ai Road, sect 1, Taipei, Taiwan, ROC
    J Hepatol 43:679-86. 2005
    ..We isolated a marine prostanoid, bromovulone III, from soft coral Clavularia viridis and found that it displayed effective anti-tumor activity in human hepatocellular carcinoma. The anti-tumor mechanism has been delineated in this study...
  38. ncbi request reprint Denbinobin-mediated anticancer effect in human K562 leukemia cells: role in tubulin polymerization and Bcr-Abl activity
    Yu Chun Huang
    Pharmacological Institute, No 1, Jen Ai Road, sect 1, Taipei, Taiwan
    J Biomed Sci 12:113-21. 2005
    ..Our data demonstrate that denbinobin could be a potential anticancer lead compound for further development...
  39. ncbi request reprint Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway
    Pin Hsuan Lu
    School of Pharmacy, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei, Taiwan
    Eur J Pharmacol 556:45-54. 2007
    ..In summary, it is suggested that ilimaquinone induces the anti-proliferative effect through the G(1) arrest of the cell cycle and the up-regulation and nuclear translocation of CHOP/GADD153...
  40. ncbi request reprint Modulation of anti-adhesion molecule MUC-1 is associated with arctiin-induced growth inhibition in PC-3 cells
    Dong Ming Huang
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    Prostate 59:260-7. 2004
    ..We postulated that arctiin modulates the attachment/detachment of PC-3 cells and we investigated the role of arctiin on MUC-1 expression...
  41. ncbi request reprint Investigation of anticancer mechanism of thiadiazole-based compound in human non-small cell lung cancer A549 cells
    Jui Yi Chou
    School of Pharmacy, College of Medicine, National Taiwan University, No 1, Jen Ai Road, sect 1, Taipei, Taiwan
    Biochem Pharmacol 66:115-24. 2003
    ..It induced the early-phase apoptosis in A549 cells via the Bcl-X(L) down-regulation, and that of the late-phase through up-regulation of Bax expression as well as inhibition of Akt/PKB activation...
  42. doi request reprint Paclitaxel induces apoptosis through activation of nuclear protein kinase C-δ and subsequent activation of Golgi associated Cdk1 in human hormone refractory prostate cancer
    Pin Hsuan Lu
    School of Pharmacy, National Taiwan University, Taipei, Taiwan, Republic of China
    J Urol 186:2434-41. 2011
    ..We characterized the effect of paclitaxel (Sigma®) on Golgi involved apoptosis in human hormone refractory prostate cancer...
  43. pmc Prazosin displays anticancer activity against human prostate cancers: targeting DNA and cell cycle
    Ssu Chia Lin
    School of Pharmacy, National Taiwan University, Taipei, Taiwan
    Neoplasia 9:830-9. 2007
    ..Subsequently, mitochondria-mediated caspase cascades are triggered to induce apoptosis in PC-3 cells...
  44. doi request reprint Ardisianone, a natural benzoquinone, efficiently induces apoptosis in human hormone-refractory prostate cancers through mitochondrial damage stress and survivin downregulation
    Chia Chun Yu
    School of Pharmacy, National Taiwan University, Taipei, Taiwan
    Prostate 73:133-45. 2013
    ..Therefore, development of anticancer agents targeting mitochondria and survivin is a potential strategy...
  45. doi request reprint A unique P-glycoprotein interacting agent displays anticancer activity against hepatocellular carcinoma through inhibition of GRP78 and mTOR pathways
    Ting Chun Kuo
    School of Pharmacy, National Taiwan University, No 1, sect 1, Jen Ai Road, Taipei 100, Taiwan
    Biochem Pharmacol 81:1136-44. 2011
    ..The data support that KNG-I-322 is a selective anticancer agent against P-gp-overexpressed other than P-gp-deficient cancer cells...
  46. doi request reprint Elucidation of susceptible factors to endoplasmic reticulum stress-mediated anticancer activity in human hepatocellular carcinoma
    Po Cheng Chiang
    School of Pharmacy, National Taiwan University, Taipei, Taiwan
    Naunyn Schmiedebergs Arch Pharmacol 377:167-77. 2008
    ..These data provide evidence that cell-cycle regulators are susceptible factors in hepatocellular carcinoma (HCC) responsive to ER stress...
  47. doi request reprint Pim-1 knockdown potentiates paclitaxel-induced apoptosis in human hormone-refractory prostate cancers through inhibition of NHEJ DNA repair
    Jui Ling Hsu
    School of Pharmacy, National Taiwan University, No 1, sect 1, Jen Ai Road, Taipei 100, Taiwan
    Cancer Lett 319:214-22. 2012
    ..The data suggest that Pim-1 plays a crucial role in the regulation of NHEJ repair. In the absence of Pim-1, the ability of DNA repair significantly decreases when exposed to paclitaxel, leading to severe DNA damage and apoptosis...
  48. doi request reprint Moscatilin induces apoptosis in human colorectal cancer cells: a crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage
    Tzu Hsuan Chen
    Pharmacological Institute and School of Pharmacy, College of Medicine, National Taiwan University, Taiwan, Republic of China
    Clin Cancer Res 14:4250-8. 2008
    ..To study the effect of moscatilin (purified from the stem of orchid Dendrobrium loddigesii) on the proliferation of human colorectal cancer HCT-116 cells in vitro and in vivo...
  49. doi request reprint A novel hydroxysuberamide derivative potentiates MG132-mediated anticancer activity against human hormone refractory prostate cancers--the role of histone deacetylase and endoplasmic reticulum stress
    Yi Cheng Chen
    College of Medicine, School of Pharmacy, National Taiwan University, Taipei, Taiwan
    Prostate 73:1270-80. 2013
    ..Histone deacetylase (HDAC) inhibitors are successful for treatment of advanced cutaneous T-cell lymphoma but only show modest effect in solid tumors. Approaches for HDAC inhibitors to improve activity against solid tumors are necessary...
  50. ncbi request reprint Esculetin inhibits Ras-mediated cell proliferation and attenuates vascular restenosis following angioplasty in rats
    Shiow Lin Pan
    Pharmacological Institute, College of Medicine, National Taiwan University, No 1 Jen Ai Road, sect 1, Taipei, Taiwan, ROC
    Biochem Pharmacol 65:1897-905. 2003
    ..It also inhibits intimal hyperplasia after balloon vascular injury in the rat, indicating the therapeutic potential for treating restenosis after arterial injury...
  51. ncbi request reprint Characterization of some novel alpha 1-adrenoceptor antagonists in human hyperplastic prostate
    Shih Chieh Chueh
    Department of Urology, College of Medicine, National Taiwan University, No 1, Jen Ai Road, sect 1, Taipei, Taiwan
    Eur J Pharmacol 445:125-31. 2002
    ..These data show FH-71 to be a potent and selective alpha(1A)-adrenoceptor antagonist with activity in human hyperplastic prostate...
  52. ncbi request reprint Inhibition of Ras-mediated cell proliferation by benzyloxybenzaldehyde
    Shiow Lin Pan
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC
    J Biomed Sci 9:622-30. 2002
    ....
  53. doi request reprint Antroquinonol, a natural ubiquinone derivative, induces a cross talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells
    Chia Chun Yu
    School of Pharmacy, National Taiwan University, Taipei 100, Taiwan
    J Nutr Biochem 23:900-7. 2012
    ..The translational inhibition causes G1 arrest of the cell cycle and an ultimate mitochondria-dependent apoptosis. Moreover, autophagic cell death and accelerated senescence also explain antroquinonol-mediated anticancer effect...
  54. doi request reprint ICAM-1 and AMPK regulate cell detachment and apoptosis by N-methyl-N'-nitro-N-nitrosoguanidine, a widely spread environmental chemical, in human hormone-refractory prostate cancers
    Yi Cheng Chen
    School of Pharmacy, College of Medicine, National Taiwan University, No 1, sect 1, Jen Ai Rd, Taipei 100, Taiwan
    Toxicol Appl Pharmacol 257:412-9. 2011
    ....
  55. doi request reprint Terfenadine induces anti-proliferative and apoptotic activities in human hormone-refractory prostate cancer through histamine receptor-independent Mcl-1 cleavage and Bak up-regulation
    Wei Ting Wang
    School of Pharmacy, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei, 100, Taiwan
    Naunyn Schmiedebergs Arch Pharmacol 387:33-45. 2014
    ....
  56. doi request reprint WJ9708012 exerts anticancer activity through PKC-α related crosstalk of mitochondrial and endoplasmic reticulum stresses in human hormone-refractory prostate cancer cells
    Ting Chun Kuo
    School of Pharmacy, National Taiwan University, Taipei, Taiwan, China
    Acta Pharmacol Sin 32:89-98. 2011
    ..To investigate the anticancer mechanism of a methoxyflavanone derivative, WJ9708012, highlighting its role on a crosstalk between endoplasmic reticulum (ER) and mitochondrial stress...
  57. ncbi request reprint A novel small molecule hybrid of vorinostat and DACA displays anticancer activity against human hormone-refractory metastatic prostate cancer through dual inhibition of histone deacetylase and topoisomerase I
    Chia Chun Yu
    School of Pharmacy, National Taiwan University, No 1, sect 1, Jen Ai Rd, Taipei 100, Taiwan
    Biochem Pharmacol 90:320-30. 2014
    ..Ultimately, WJ35435 inhibits cell proliferation and induces apoptosis of HRMPCs. ..
  58. doi request reprint Cryptocaryone, a natural dihydrochalcone, induces apoptosis in human androgen independent prostate cancer cells by death receptor clustering in lipid raft and nonraft compartments
    Yi Cheng Chen
    School of Pharmacy, National Taiwan University, Taipei, Taiwan, Republic of China
    J Urol 183:2409-18. 2010
    ..Treatment approaches to prostate cancer are based on various mechanisms that cause malignant cell apoptosis. Of these strategies the anticancer effect of triggering death receptors is well substantiated...
  59. doi request reprint Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines
    Chun Han Chen
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, ROC
    Cancer Lett 315:1-11. 2012
    ..In conclusion, the data suggest that protopine is a novel microtubule stabilizer with anticancer activity in HRPC cells through apoptotic pathway by modulating Cdk1 activity and Bcl-2 family of proteins...
  60. doi request reprint Anti-angiogenic effects and mechanism of prazosin
    Chun Hou Liao
    Department of Surgery, Fu Jen Catholic University, Taipei, Taiwan
    Prostate 71:976-84. 2011
    ..Prazosin induces apoptosis in three prostate cancer cell lines. We hypothesized that prazosin, a more potent alpha1-adrenoceptor antagonist with a distinct mechanism, exhibits anti-angiogenic activity...
  61. doi request reprint Synthesis and anti-cancer activity of a glycosyl library of N-acetylglucosamine-bearing oleanolic acid
    Yi Bing Zeng
    School of Pharmacy, College of Medicine, National Taiwan University, 1 Jen Ai Road, Section 1, Taipei, 100, Taiwan
    Mol Divers 18:13-23. 2014
    ..The study revealed that the activity decreased following the order of 3' > 4' > 6' glycosyl modifications. GNTS that incorporated (D/L)-xylose and L-arabinose at positions 3' and 4' were more potent than those bearing other sugars...
  62. doi request reprint Bioactive diterpenes from Callicarpa longissima
    Yuan Wei Liu
    School of Pharmacy, College of Medicine, National Taiwan University, Jen Ai Road, Section 1, Taipei 100, Taiwan
    J Nat Prod 75:689-93. 2012
    ..The structure of compound 1 was confirmed by X-ray crystallographic analysis. Cytotoxicity against a human prostate cancer cell line (PC3) and anti-inflammatory activities of the isolated compounds were evaluated...
  63. doi request reprint Pycnidione, a fungus-derived agent, induces cell cycle arrest and apoptosis in A549 human lung cancer cells
    Che Jen Hsiao
    School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Chem Biol Interact 197:23-30. 2012
    ..Therefore, testing of its effects in vivo is warranted to evaluate its potential as a therapeutic agent against lung cancer...
  64. doi request reprint Synthesis of a chlorogenin glycoside library using an orthogonal protecting group strategy
    Ying Hsin Wang
    School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan
    Carbohydr Res 375:118-35. 2013
    ..These compounds were found to be weakly-cytotoxic toward leukemia cell lines CCRF and HL-20, indicating that the chacotriose moiety is important for anticancer activity...
  65. ncbi request reprint Synthesis, DNA binding, and cytotoxicity of 1,4-bis(2-amino-ethylamino)anthraquinone-amino acid conjugates
    Ling Wei Hsin
    Institute of Pharmaceutical Sciences, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Room 1336, Taipei 10018, Taiwan, ROC
    Bioorg Med Chem 16:1006-14. 2008
    ..The primary mechanism of cytotoxicity for MAC 16 was most likely through TOP2 poisoning. Therefore, MAC 16 may provide a lead for the development of novel generations of anthraquinone-type antitumor agents...
  66. doi request reprint YC-1 induces heat shock protein 70 expression and prevents oxidized LDL-mediated apoptosis in vascular smooth muscle cells
    Yi Nan Liu
    Phamacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    Shock 30:274-9. 2008
    ..According to our observations, YC-1 would be an effectively pharmacological hsp70 inducer that can be used as a cytoprotective agent in vascular diseases...
  67. doi request reprint Denbinobin induces apoptosis by apoptosis-inducing factor releasing and DNA damage in human colorectal cancer HCT-116 cells
    Tzu Hsuan Chen
    Pharmacological Institute, College of Medicine, National Taiwan University, No 1, Jen Ai Road, sect 1, Taipei, Taiwan
    Naunyn Schmiedebergs Arch Pharmacol 378:447-57. 2008
    ..Taken together, our findings suggest that denbinobin induces apoptosis of human colorectal cancer HCT-116 cells via DNA damage and an AIF-mediated pathway. These results indicate that denbinobin has potential as a novel anticancer agent...
  68. doi request reprint Evodiamine represses hypoxia-induced inflammatory proteins expression and hypoxia-inducible factor 1alpha accumulation in RAW264.7
    Yi Nan Liu
    Phamacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    Shock 32:263-9. 2009
    ..Therefore, evodiamine could be an effective therapeutic agent against inflammatory diseases involving hypoxia...
  69. doi request reprint Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress
    Che Jen Hsiao
    School of Pharmacy, National Taiwan University, Taipei, Taiwan
    Naunyn Schmiedebergs Arch Pharmacol 378:599-608. 2008
    ..Data provide evidence that the anticancer strategy of dual-action targets could be a potential anticancer approach...
  70. doi request reprint Baicalein attenuates intimal hyperplasia after rat carotid balloon injury through arresting cell-cycle progression and inhibiting ERK, Akt, and NF-kappaB activity in vascular smooth-muscle cells
    Chieh Yu Peng
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    Naunyn Schmiedebergs Arch Pharmacol 378:579-88. 2008
    ..It also inhibits intimal hyperplasia after balloon vascular injury in the rat, indicating the therapeutic potential for treating restenosis after arterial injury...