Wen Mei Fu
Affiliation: National Taiwan University
Tu H, Kang K, Ho S, Liou H, Liou H, Lin C, et al
. Leukemia inhibitory factor (LIF) potentiates antinociception activity and inhibits tolerance induction of opioids. Br J Anaesth. 2016;117:512-520 pubmed publisher
..LIF might be a novel drug candidate for inhibiting opioid tolerance induction. ..
Hung S, Huang W, Liou H, Fu W. LC3 overexpression reduces AÎ² neurotoxicity through increasing Î±7nAchR expression and autophagic activity in neurons and mice. Neuropharmacology. 2015;93:243-51 pubmed publisher
..LC3 overexpression thus exerts neuroprotection through increasing Î±7nAChR expression for eAÎ² binding and further enhancing autophagic activity for AÎ² clearance inÂ vitro and inÂ vivo. ..
Liu Y, Tsai Y, Tang S, Liou H, Kang K, Liou H, et al
. Cytokine MIF Enhances Blood-Brain Barrier Permeability: Impact for Therapy in Ischemic Stroke. Sci Rep. 2018;8:743 pubmed publisher
..In contrast, administration of MIF antagonist ISO-1 has the profound neuroprotective effect. Our results demonstrate that MIF might be a good drug target for the therapy of stroke. ..
Chien C, Lee M, Liou H, Liou H, Fu W. Growth hormone is increased in the lungs and enhances experimental lung metastasis of melanoma in DJ-1 KO mice. BMC Cancer. 2016;16:871 pubmed
..These results indicate that up-regulation of GH in the lungs of DJ-1 KO mice may enhance the malignancy of B16F10 cells and nodule formation in pulmonary metastasis of melanoma. ..
Lin T, Yang R, Tu H, Liou H, Lin Y, Chuang W, et al
. Inhibition of osteoporosis by the ?v?3 integrin antagonist of rhodostomin variants. Eur J Pharmacol. 2017;804:94-101 pubmed publisher
..These results indicate that the highly selective and long-acting ?v?3 integrin antagonists could be developed as effective drugs for postmenopausal osteoporosis. ..
Hung S, Fu W. Drug candidates in clinical trials for Alzheimer's disease. J Biomed Sci. 2017;24:47 pubmed publisher
..We here systemically review the findings from recent clinical trials to provide a comprehensive review of novel therapeutic compounds in the treatment and prevention of AD. ..