Pele Chong

Summary

Affiliation: National Health Research Institutes
Country: Taiwan

Publications

  1. doi request reprint Recombinant Lipoproteins as Novel Vaccines with Intrinsic Adjuvant
    Pele Chong
    Vaccine R and D Center, National Health Research Institutes, Miaoli, Taiwan Electronic address
    Adv Protein Chem Struct Biol 99:55-74. 2015
  2. pmc Purification and characterization of enterovirus 71 viral particles produced from vero cells grown in a serum-free microcarrier bioreactor system
    Chia Chyi Liu
    Vaccine Research and Development Center, National Health Research Institutes, Zhunan Town, Miaoli County, Taiwan
    PLoS ONE 6:e20005. 2011
  3. pmc Formalin-inactivated EV71 vaccine candidate induced cross-neutralizing antibody against subgenotypes B1, B4, B5 and C4A in adult volunteers
    Ai Hsiang Chou
    Vaccine Research and Development Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan Town, Miaoli County, Taiwan
    PLoS ONE 8:e79783. 2013
  4. pmc Production of EV71 vaccine candidates
    Pele Chong
    Vaccine R and D Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan, Taiwan
    Hum Vaccin Immunother 8:1775-83. 2012
  5. pmc Immunological and biochemical characterization of coxsackie virus A16 viral particles
    Pele Chong
    Vaccine R and D Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan Town, Miaoli County, Taiwan
    PLoS ONE 7:e49973. 2012
  6. doi request reprint Identification and characterization of a cross-neutralization epitope of Enterovirus 71
    Chia Chyi Liu
    Vaccine R and D Center, National Health Research Institutes, Zhunan Town, Miaoli County 350, Taiwan
    Vaccine 29:4362-72. 2011
  7. pmc Immunological evaluation and comparison of different EV71 vaccine candidates
    Ai Hsiang Chou
    Vaccine R and D Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan Township, Miaoli County, Taiwan
    Clin Dev Immunol 2012:831282. 2012
  8. pmc Protective efficacy of VP1-specific neutralizing antibody associated with a reduction of viral load and pro-inflammatory cytokines in human SCARB2-transgenic mice
    Hsuen Wen Chang
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan Town, Miaoli County, Taiwan
    PLoS ONE 8:e69858. 2013
  9. doi request reprint Induction of robust immunity by the emulsification of recombinant lipidated dengue-1 envelope protein domain III
    Chen Yi Chiang
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan, ROC
    Microbes Infect 15:719-28. 2013
  10. pmc Human SCARB2 transgenic mice as an infectious animal model for enterovirus 71
    Yi Wen Lin
    Institute of Infectious Disease and Vaccinology, National Health Research Institutes, Zhunan, Miaoli County, Taiwan
    PLoS ONE 8:e57591. 2013

Collaborators

  • Yen Hung Chow
  • Charles Sia
  • Suh Chin Wu
  • Min Shi Lee
  • Ebenezer Chitra
  • Jen Ren Wang
  • Li Wei Lai
  • Chiou Ying Yang
  • Ann Joy Cheng
  • Yu Chao Wang
  • Hsuen Wen Chang
  • Szu Min Hsieh
  • Chia Rui Shen
  • Yi Ming A Chen
  • Shih Jen Liu
  • Hsin Wei Chen
  • Chih Hsiang Leng
  • Ai Hsiang Chou
  • Chia Chyi Liu
  • Ming Hsi Huang
  • Chen Yi Chiang
  • Shu Pei Lien
  • Mei Yu Chen
  • Hsueh Hung Liu
  • Jy Ping Tsai
  • Hsiao Yun Shao
  • Yi Wen Lin
  • Chien Hsiung Pan
  • Ying Chyi Song
  • Chiung Yi Huang
  • Kuang Nan Hsiao
  • Alan Yung Chih Hu
  • Chun Hsiang Hsieh
  • Shu Ling Yu
  • Jui Yuan Chang
  • Hung Bo Hsiao
  • Yueh Liang Tsou
  • Shu Ching Hsu
  • Jen Ron Chiang
  • I Hua Chen
  • Mi Hua Tao
  • Meng Shin Guo
  • Yi Shiuan Li
  • Chia Hsin Hsiao
  • Hsin Ju Chao
  • Yan Kwok
  • Yu Fen Tseng
  • Chih Wei Lin
  • Han Hsuan Chung
  • Hui Mei Hu
  • Hsiang Yin Lin
  • Chin Cheng Huang
  • Sheng Kuo Chiang
  • Li Sheng Chang
  • Su Chen Lin
  • Tsai Chuan Weng
  • Fang Feng Chiu
  • Hsin Yu Liu
  • Li Hsiu Lin
  • Yu Wen Chang
  • Chang Ling Lin
  • Wei Cheng Lian
  • Jui Hsin Huang
  • Wei Lin Chen
  • Su I Lin
  • Chyi Sing Hwang
  • Wang Chou Sung
  • Hsiao Yu Lin
  • Li Tzu Wang
  • Hsiu Yu Lai
  • Oscar Kuang Sheng Lee
  • Chien Long Wu
  • Wun Syue Yang
  • Mei Hua Hu
  • Ju Lan Huang
  • Sue Chen Lin
  • Kuan Yin Shen
  • Kate Hsuen Wen Chang
  • Chien Chun Liao
  • Po Wei Chuang
  • Jerry Wang Chou Sung
  • Anna Gu
  • Tzu Yi Huang
  • Nandini Venkatesan
  • Min Han Lin
  • Yu Ju Hsiao
  • Juo Yu Huang
  • Ching Kun Chang
  • Chia Kai Wu
  • Chieh Huang

Detail Information

Publications61

  1. doi request reprint Recombinant Lipoproteins as Novel Vaccines with Intrinsic Adjuvant
    Pele Chong
    Vaccine R and D Center, National Health Research Institutes, Miaoli, Taiwan Electronic address
    Adv Protein Chem Struct Biol 99:55-74. 2015
    ....
  2. pmc Purification and characterization of enterovirus 71 viral particles produced from vero cells grown in a serum-free microcarrier bioreactor system
    Chia Chyi Liu
    Vaccine Research and Development Center, National Health Research Institutes, Zhunan Town, Miaoli County, Taiwan
    PLoS ONE 6:e20005. 2011
    ..Enterovirus 71 (EV71) infections manifest most commonly as a childhood exanthema known as hand-foot-and-mouth disease (HFMD) and can cause neurological disease during acute infection...
  3. pmc Formalin-inactivated EV71 vaccine candidate induced cross-neutralizing antibody against subgenotypes B1, B4, B5 and C4A in adult volunteers
    Ai Hsiang Chou
    Vaccine Research and Development Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan Town, Miaoli County, Taiwan
    PLoS ONE 8:e79783. 2013
    ..In this study we report the cross-neutralizing antibody responses from each volunteer against different subgenotypes of EV71 and CVA16...
  4. pmc Production of EV71 vaccine candidates
    Pele Chong
    Vaccine R and D Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan, Taiwan
    Hum Vaccin Immunother 8:1775-83. 2012
    ..This review also demonstrates the opportunities and challenges that the Asian vaccine industry faces today. ..
  5. pmc Immunological and biochemical characterization of coxsackie virus A16 viral particles
    Pele Chong
    Vaccine R and D Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan Town, Miaoli County, Taiwan
    PLoS ONE 7:e49973. 2012
    ..It manifests most often in childhood exanthema, commonly known as hand-foot-and-mouth disease (HFMD). There are currently no vaccine or effective medical treatments available...
  6. doi request reprint Identification and characterization of a cross-neutralization epitope of Enterovirus 71
    Chia Chyi Liu
    Vaccine R and D Center, National Health Research Institutes, Zhunan Town, Miaoli County 350, Taiwan
    Vaccine 29:4362-72. 2011
    ..Thus, VP2-28 could be used as the surrogate biomarker in the potency testing of candidate EV71 vaccines...
  7. pmc Immunological evaluation and comparison of different EV71 vaccine candidates
    Ai Hsiang Chou
    Vaccine R and D Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan Township, Miaoli County, Taiwan
    Clin Dev Immunol 2012:831282. 2012
    ..Therefore, the best formulation for producing cost-effective HFMD vaccine is a combination of formalin-inactivated EV71 and CAV16 virions...
  8. pmc Protective efficacy of VP1-specific neutralizing antibody associated with a reduction of viral load and pro-inflammatory cytokines in human SCARB2-transgenic mice
    Hsuen Wen Chang
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan Town, Miaoli County, Taiwan
    PLoS ONE 8:e69858. 2013
    ..These results indicate N3 could be useful in treating severe EV71 infections and the hSCARB2-transgenic mouse could be used to evaluate the protective efficacy of potential anti-enterovirus agent candidates. ..
  9. doi request reprint Induction of robust immunity by the emulsification of recombinant lipidated dengue-1 envelope protein domain III
    Chen Yi Chiang
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan, ROC
    Microbes Infect 15:719-28. 2013
    ..This approach is a promising strategy for the development of subunit vaccines that induce robust immunity. ..
  10. pmc Human SCARB2 transgenic mice as an infectious animal model for enterovirus 71
    Yi Wen Lin
    Institute of Infectious Disease and Vaccinology, National Health Research Institutes, Zhunan, Miaoli County, Taiwan
    PLoS ONE 8:e57591. 2013
    ..These results indicate that hSCARB2-transgenic mice are a useful model for assessing anti-EV71 medications and for studying the pathogenesis induced by EV71...
  11. doi request reprint Recombinant lipidated dengue-4 envelope protein domain III elicits protective immunity
    Chen Yi Chiang
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, 35 Keyan Road, Zhunan 350, Miaoli, Taiwan, ROC
    Vaccine 32:1346-53. 2014
    ..The study demonstrates that lipidated dengue-4 envelope protein domain III is immunogenic and may be a potential dengue vaccine candidate. Furthermore, the lipidation strategy can be applied to other serotypes of dengue virus...
  12. doi request reprint Development of a quantitative enzyme linked immunosorbent assay for monitoring the Enterovirus 71 vaccine manufacturing process
    Chia Chyi Liu
    Vaccine R and D Center, National Health Research Institutes, Zhunan Town, Miaoli County 350, Taiwan
    J Virol Methods 176:60-8. 2011
    ....
  13. pmc Pilot scale production of highly efficacious and stable enterovirus 71 vaccine candidates
    Ai Hsiang Chou
    Vaccine R and D Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan, Taiwan
    PLoS ONE 7:e34834. 2012
    ..Based on the success of inactivated poliovirus vaccine, a prototype chemically inactivated EV71 vaccine candidate has been developed and currently in human phase 1 clinical trial...
  14. pmc Human SCARB2-mediated entry and endocytosis of EV71
    Yi Wen Lin
    National Institutes of Infectious Disease and Vaccinology, National Health Research Institutes, Taiwan, Republic of China
    PLoS ONE 7:e30507. 2012
    ..This study on the receptor and endocytic mechanisms of EV71 infection is useful for the development of effective medications and prophylactic treatment against the enterovirus...
  15. doi request reprint A novel technology for the production of a heterologous lipoprotein immunogen in high yield has implications for the field of vaccine design
    Hsin Wei Chen
    Vaccine Research and Development Center, National Health Research Institutes, Zhunan Town, Miaoli 350, Taiwan, ROC
    Vaccine 27:1400-9. 2009
    ..These results have successfully demonstrated the merit of lipo-immunogens for novel vaccine development...
  16. pmc Dengue-1 envelope protein domain III along with PELC and CpG oligodeoxynucleotides synergistically enhances immune responses
    Chen Yi Chiang
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan
    PLoS Negl Trop Dis 6:e1645. 2012
    ..PELC plus CpG oligodeoxynucleotides is a promising adjuvant for recombinant protein based vaccination against dengue virus...
  17. pmc Immunoprotectivity of HLA-A2 CTL peptides derived from respiratory syncytial virus fusion protein in HLA-A2 transgenic mouse
    Hsiao Yun Shao
    Institute of Infectious Disease and Vaccinology, National Health Research Institutes, Miaoli County, Taiwan, Republic of China
    PLoS ONE 6:e25500. 2011
    ..Our results suggest that HLA-A2-restricted epitopes of RSV F protein could be useful for the development of epitope-based RSV vaccine...
  18. doi request reprint Development of multi-phase emulsions based on bioresorbable polymers and oily adjuvant
    Ming Hsi Huang
    Vaccine Research and Development Center, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli, 35053, Taiwan
    Pharm Res 26:1856-62. 2009
    ....
  19. doi request reprint A consensus envelope protein domain III can induce neutralizing antibody responses against serotype 2 of dengue virus in non-human primates
    Hsin Wei Chen
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli, Taiwan
    Arch Virol 158:1523-31. 2013
    ..These data provide evidence that a protective neutralizing antibody response was successfully elicited in non-human primates by the dengue subunit vaccine with aluminum phosphate adjuvant. ..
  20. doi request reprint Biochemical characterizations of Escherichia coli-expressed protective antigen Ag473 of Neisseria meningitides group B
    Jerry Wang Chou Sung
    Vaccine Research and Development Center, National Health Research Institutes, Zhunan Town, Miaoli County 350, Taiwan
    Vaccine 28:8175-82. 2010
    ..In addition, the solubility of rAg473 (5mg/mL) was not affected after several freeze-thaw cycles. These biophysical and immunological properties make rAg473 a good vaccine candidate against NmB...
  21. doi request reprint A recombinant lipoprotein containing an unsaturated fatty acid activates NF-kappaB through the TLR2 signaling pathway and induces a differential gene profile from a synthetic lipopeptide
    Chih Hsiang Leng
    Vaccine Research and Development Center, National Health Research Institutes, Taiwan
    Mol Immunol 47:2015-21. 2010
    ..Taken together, these results demonstrate that different TLR2 ligands can promote various immune responses by inducing different levels of biological cytokines and chemokines...
  22. doi request reprint Enhancement of potent antibody and T-cell responses by a single-dose, novel nanoemulsion-formulated pandemic influenza vaccine
    Ming Hsi Huang
    Vaccine Research and Development Center, National Health Research Institutes, Taiwan, ROC
    Microbes Infect 11:654-60. 2009
    ..These results indicate that PELC can be used for effective single-dose immunization and could thus play an important role in influenza pandemic preparedness...
  23. pmc Production of inactivated influenza H5N1 vaccines from MDCK cells in serum-free medium
    Alan Yung Chih Hu
    Vaccine Research and Development Center, National Health Research Institutes, Zhunan, Taiwan Authority
    PLoS ONE 6:e14578. 2011
    ..This study presents an improved high-yield manufacturing process for the inactivated influenza H5N1 vaccines using Madin-Darby canine kidney (MDCK) cells grown in a serum-free (SF) medium microcarrier cell culture system...
  24. pmc Lipidated dengue-2 envelope protein domain III independently stimulates long-lasting neutralizing antibodies and reduces the risk of antibody-dependent enhancement
    Chen Yi Chiang
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan, Republic of China
    PLoS Negl Trop Dis 7:e2432. 2013
    ..New approaches to dengue vaccine development are urgently needed. Our approach represents a promising method of dengue vaccine development and may even complement the deficiencies of the CYD tetravalent dengue vaccine...
  25. doi request reprint Formulation and immunological evaluation of novel vaccine delivery systems based on bioresorbable poly(ethylene glycol)-block-poly(lactide-co-epsilon-caprolactone)
    Ming Hsi Huang
    Vaccine Research and Development Center, National Health Research Institutes, Zhunan, Miaoli 35053, Taiwan
    J Biomed Mater Res B Appl Biomater 90:832-41. 2009
    ..These features are of great interest for applications in delivery systems of prophylactic and therapeutic vaccine candidates...
  26. pmc Recombinant lipidated HPV E7 induces a Th-1-biased immune response and protective immunity against cervical cancer in a mouse model
    Chiung Yi Huang
    National Institute of Infectious Disease and Vaccinology, National Health Research Institutes, Zhunan Town, Miaoli, Taiwan, Republic of China
    PLoS ONE 7:e40970. 2012
    ..In addition, we demonstrated that the CD8+ T cells play a major role in anti-tumor immunity when administration of rlipo-E7m. These results demonstrate that rlipo-E7m could be a promising candidate for treating HPV-associated tumors...
  27. ncbi request reprint Identification of synthetic vaccine candidates against SARS CoV infection
    Shu Pei Lien
    Vaccine Research and Development Center, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli 350, Taiwan, ROC
    Biochem Biophys Res Commun 358:716-21. 2007
    ..The highly immunogenic D2 peptide contains both neutralizing and Th cell epitopes. These results suggest that synthetic peptide D2 would be useful as a component of SARS vaccine candidates...
  28. pmc Emulsified nanoparticles containing inactivated influenza virus and CpG oligodeoxynucleotides critically influences the host immune responses in mice
    Ming Hsi Huang
    Vaccine Research and Development Center, National Health Research Institutes, Zhunan Town, Taiwan
    PLoS ONE 5:e12279. 2010
    ..We assessed the immunogenicity of an inactivated H5N1 whole-virion vaccine (A/Vietnam/1194/2004 NIBRG-14, clade 1) formulated with emulsified nanoparticles and investigated whether it can induce cross-clade protecting immunity...
  29. doi request reprint A novel dengue vaccine candidate that induces cross-neutralizing antibodies and memory immunity
    Chih Hsiang Leng
    Vaccine Research and Development Center, National Health Research Institute, No 35 Keyan Road, Zhunan Town, Miaoli County 350, Taiwan
    Microbes Infect 11:288-95. 2009
    ..These results demonstrate the possibility of developing a single tetravalent vaccine against dengue viral infections...
  30. doi request reprint Generation of murine monoclonal antibodies which cross-neutralize human enterovirus genogroup B isolates
    Hsuen Wen Chang
    Vaccine Research and Development Center, National Health Research Institutes, Zhunan Township, Miaoli County 350, Taiwan
    J Virol Methods 173:189-95. 2011
    ..It was also observed the monoclonal antibodies acted cooperatively in neutralizing the EV71/E59 virus...
  31. pmc A novel single-dose dengue subunit vaccine induces memory immune responses
    Chen Yi Chiang
    Vaccine Research and Development Center, National Health Research Institutes, Zhunan, Miaoli, Taiwan
    PLoS ONE 6:e23319. 2011
    ..These results demonstrate the promising possibility of a future successful tetravalent vaccine against dengue viral infections that utilizes one-dose vaccination with LcED III...
  32. pmc Adaptation of high-growth influenza H5N1 vaccine virus in Vero cells: implications for pandemic preparedness
    Yu Fen Tseng
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan
    PLoS ONE 6:e24057. 2011
    ..In conclusion, one high-growth H5N1 vaccine virus was generated in Vero cells, which can be used to manufacture influenza H5N1 vaccines and prepare reassortant vaccine viruses for other influenza A subtypes...
  33. doi request reprint Microcarrier-based MDCK cell culture system for the production of influenza H5N1 vaccines
    Alan Yung Chih Hu
    Vaccine R and D Center, National Health Research Institutes, Zhunan, Miaoli, Taiwan
    Vaccine 26:5736-40. 2008
    ....
  34. doi request reprint Immunological study of HA1 domain of hemagglutinin of influenza H5N1 virus
    Fang Feng Chiu
    Vaccine Research and Development Center, National Health Research Institutes, Zhunan, Miaoli, Taiwan, ROC
    Biochem Biophys Res Commun 383:27-31. 2009
    ....
  35. doi request reprint The Immunodominance Change and Protection of CD4+ T-Cell Responses Elicited by an Envelope Protein Domain III-Based Tetravalent Dengue Vaccine in Mice
    Hsin Wei Chen
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan
    PLoS ONE 10:e0145717. 2015
    ..Our findings shed light on how ED3-based tetravalent dengue vaccines sharpen host CD4 T-cell responses and contribute to protection against dengue virus. ..
  36. pmc Toll-like receptor 9-mediated protection of enterovirus 71 infection in mice is due to the release of danger-associated molecular patterns
    Hung Bo Hsiao
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan, Miaoli, Taiwan
    J Virol 88:11658-70. 2014
    ..Therefore, our study provides new insights into EV71-induced apoptosis, which stimulates TLR9 in EV71-associated infections...
  37. pmc Long-term immunogenicity studies of formalin-inactivated enterovirus 71 whole-virion vaccine in macaques
    Chia Chyi Liu
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan Town, Miaoli County, Taiwan
    PLoS ONE 9:e106756. 2014
    ..In summary, our results indicate that EV71vac elicits dose-dependent T-cell and antibody responses in macaques that could be a good animal model for evaluating the long-term immune responses elicited by EV71 vaccines. ..
  38. doi request reprint Disintegration and cancer immunotherapy efficacy of a squalane-in-water delivery system emulsified by bioresorbable poly(ethylene glycol)-block-polylactide
    Wei Lin Chen
    Graduate Institute of Life Sciences, National Defense Medical Center, 11466 Taipei, Taiwan National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, 35053 Miaoli, Taiwan
    Biomaterials 35:1686-95. 2014
    ..Accordingly, these advances may be a potential immunoregulatory strategy in manipulating the immune responses induced by tumor-associated antigens...
  39. pmc Recombinant adeno-vaccine expressing enterovirus 71-like particles against hand, foot, and mouth disease
    Yueh Liang Tsou
    Institute of Infectious Disease and Vaccinology, National Health Research Institutes, Zhunan, Taiwan Graduate Program of Biotechnology in Medicine, Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, Taiwan
    PLoS Negl Trop Dis 9:e0003692. 2015
    ..These results suggest that Ad-EVVLP can enhance neutralizing antibody and protective cellular immune responses to prevent EV71 infection and cellular immune responses against CV infection. ..
  40. doi request reprint Presentation of lipopeptide by dendritic cells induces anti-tumor responses via an endocytosis-independent pathway in vivo
    Ying Chyi Song
    Vaccine Research and Development Center, National Health Research Institutes, Zhunan, Miaoli County, Taiwan
    J Leukoc Biol 90:323-32. 2011
    ..Taken together, our results demonstrate that DCs present lipidated peptides through an endocytosis-independent pathway to promote strong anti-tumor effects in vivo...
  41. doi request reprint Recombinant lipoprotein-based vaccine candidates against C. difficile infections
    Jui Hsin Huang
    Vaccine R and D Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan Town, Miaoli County, Taiwan
    J Biomed Sci 22:65. 2015
    ..difficile spores. To develop an effective recombinant subunit vaccine against CDI, A-rRBD was lipidated (rlipoA-RBD) as a rational design to contain an intrinsic adjuvant, a toll-like receptor 2 agonist and expressed in Escherichia coli...
  42. doi request reprint Depletion of regulatory T-cells leads to moderate B-cell antigenicity in respiratory syncytial virus infection
    Hsiao Yun Shao
    Institute of Infectious Disease and Vaccinology, National Health Research Institutes, Room No R1 7033, No 35, Keyan Road, Zhunan Town, Miaoli County 350, Taiwan Graduate Program of Biotechnology in Medicine, Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan
    Int J Infect Dis 41:56-64. 2015
    ..The regulation of the immunopathology of respiratory syncytial virus (RSV) by regulatory T-cells (CD4(+)CD25(+)Foxp3(+); Tregs) is not understood...
  43. doi request reprint Immunogenic properties of RSV-B1 fusion (F) protein gene-encoding recombinant adenoviruses
    Hsiao Yun Shao
    Vaccine R and D Center, National Health Research Institutes, Zhunan Town, Miaoli County 350, Taiwan, ROC
    Vaccine 27:5460-71. 2009
    ..Results from these studies suggest that rAd-F0DeltaTM or rAd-F0 possess immunogenic properties that meet the requirements expected from potential RSV vaccine candidates...
  44. pmc A purified recombinant lipopeptide as adjuvant for cancer immunotherapy
    Ying Chyi Song
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan, Miaoli 35053, Taiwan
    Biomed Res Int 2014:349783. 2014
    ..We demonstrated that the lipo-Nter of a bacterial-derived recombinant lipoprotein is a novel adjuvant that could be used for the development of a new generation of vaccines...
  45. ncbi request reprint Identification of HLA-A11-restricted CTL epitopes derived from HPV type 18 using DNA immunization
    Hsin Wei Chen
    Vaccine Research and Development Center, National Health Research Institutes, Zhunan, Miaoli, Taiwan
    Cancer Biol Ther 8:2025-32. 2009
    ..Our results demonstrate that the antigenic E6 peptides derived from HPV18 are potential candidates for the treatment of HPV 18-associated tumors in HLA-A11(+) populations...
  46. doi request reprint Mesenchymal stem cells tune the development of monocyte-derived dendritic cells toward a myeloid-derived suppressive phenotype through growth-regulated oncogene chemokines
    Hsin Wei Chen
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan, Miaoli 35053, Taiwan
    J Immunol 190:5065-77. 2013
    ....
  47. pmc Challenges to licensure of enterovirus 71 vaccines
    Min Shi Lee
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Taiwan
    PLoS Negl Trop Dis 6:e1737. 2012
    ..Prospective cohort studies are warranted to clarify clinical and epidemiological significances of the antigenic and genetic variations between different EV71 genogroups, which is critical for vaccine design...
  48. pmc Delivery of human EV71 receptors by adeno-associated virus increases EV71 infection-induced local inflammation in adult mice
    Hung Bo Hsiao
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan, Miaoli 35053, Taiwan
    Biomed Res Int 2014:878139. 2014
    ..However, neurological disease was not observed in these animals. Taken together, we successfully infected adult mice with live EV71 and induced local inflammation using an AAV delivery system. ..
  49. pmc Immunogenicity studies of bivalent inactivated virions of EV71/CVA16 formulated with submicron emulsion systems
    Chih Wei Lin
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan Town, Miaoli County 35053, Taiwan
    Biomed Res Int 2014:670506. 2014
    ..The current results are important for the design and development of prophylactic vaccines against HFMD and other emerging infectious diseases...
  50. doi request reprint A novel emulsion-type adjuvant containing CpG oligodeoxynucleotides enhances CD8+ T-cell-mediated anti-tumor immunity
    Ying Chyi Song
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan
    J Control Release 173:158-65. 2014
    ..These results demonstrated that peptide antigen formulated with PELC/CpG nanoparticles is feasible for cancer immunotherapy. ..
  51. doi request reprint Mesenchymal stem cells promote neutrophil activation by inducing IL-17 production in CD4+ CD45RO+ T cells
    Shu Ching Hsu
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan
    Immunobiology 218:90-5. 2013
    ..These results suggest that MSCs regulate the functional activation of neutrophils via their role in modulating IL-17 from CD4(+) CD45RO(+) memory T cells...
  52. doi request reprint Rapid isolation and characterization of bacterial lipopeptides using liquid chromatography and mass spectrometry analysis
    Yan Kwok
    Vaccine Research and Development Center, National Health Research Institutes, Zhunan Town, Miaoli County, Taiwan, ROC
    Proteomics 11:2620-7. 2011
    ..For diacyl lipoprotein, the saturated palmitoyl fatty acid group is absent at sn1 position of glycerol-derived lipid residue of lipopeptide...
  53. doi request reprint Review of enterovirus 71 vaccines
    Pele Chong
    Vaccine Research and Development Center, National Health Research Institutes, Zhunan Town Graduate Institute of Immunology, China Medical University, Taichung, Taiwan
    Clin Infect Dis 60:797-803. 2015
    ....
  54. doi request reprint A poorly neutralizing IgG2a/c response elicited by a DNA vaccine protects mice against Japanese encephalitis virus
    Hsin Wei Chen
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli County, Taiwan Graduate Institute of Immunology, China Medical University, Taichung, Taiwan
    J Gen Virol 95:1983-90. 2014
    ....
  55. doi request reprint Tonsillar CD4+FOXP3+ T-regulatory cell dynamics in primary EBV infection
    Yen Hung Chow
    Vaccine Research and Development Center, National Health Research Institutes, Zhunan Township, Miaoli County, Taiwan
    Immunol Res 50:97-101. 2011
    ....
  56. doi request reprint Recombinant bacterial lipoproteins as vaccine candidates
    Chih Hsiang Leng
    a Vaccine R and D Center, National Health Research Institutes, Zhunan Town, Miaoli 350, Taiwan
    Expert Rev Vaccines 14:1623-32. 2015
    ....
  57. doi request reprint Prospect and challenges for the development of multivalent vaccines against hand, foot and mouth diseases
    Chia Chyi Liu
    Vaccine R and D Center, National Health Research Institutes, Zhunan Town 350, Miaoli County, Taiwan
    Vaccine 32:6177-82. 2014
    ....
  58. pmc The Development and Application of HLA Tetramers in the Detection, Characterization and Therapy of Type 1 Diabetes Mellitus
    Hsin Wei Chen
    Vaccine Center, National Health Research Institutes, 35 Keyan Road, Zhunan Township, Miaoli County, Taiwan
    Rev Diabet Stud 4:56-61. 2007
    ..This observation even opens up a potential application of HLA class II tetramers as therapeutic agents for immune intervention in T1DM...
  59. doi request reprint CD4+ T cells disarm or delete cytotoxic T lymphocytes under IL-17-polarizing conditions
    Jy Ping Tsai
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli 350, Taiwan
    J Immunol 189:1671-9. 2012
    ..Taken together, these results reveal an intriguing mechanism in which Tc17 cells are controlled by a finely tuned collaboration between the different types of CD4(+) T cells in distinct tumor microenvironments...
  60. ncbi request reprint Immunological characterizations of the nucleocapsid protein based SARS vaccine candidates
    Shih Jen Liu
    Vaccine Research and Development Center, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli 350, Taiwan ROC
    Vaccine 24:3100-8. 2006
    ..This information is very important for the development SARS diagnostic kits and a vaccine...
  61. pmc The cross-regulatory relationship between human dendritic and regulatory T cells and its role in type 1 diabetes mellitus
    Hsuen Wen Chang
    Vaccine Center, National Health Research Institutes, Zhunan Township, Miaoli County, Taiwan 350
    Rev Diabet Stud 4:68-76. 2007
    ..This review aims to supply an update on the progress made in these aspects of T1DM research...