Wen Fei Chiou

Summary

Affiliation: National Research Institute of Chinese Medicine
Country: Taiwan

Publications

  1. pmc Evodia rutaecarpa and Three Major Alkaloids Abrogate Influenza A Virus (H1N1)-Induced Chemokines Production and Cell Migration
    Wen Fei Chiou
    National Research Institute of Chinese Medicine, Taipei 112, Taiwan
    Evid Based Complement Alternat Med 2011:750513. 2011
  2. pmc 8-Prenylkaempferol Suppresses Influenza A Virus-Induced RANTES Production in A549 Cells via Blocking PI3K-Mediated Transcriptional Activation of NF-κB and IRF3
    Wen Fei Chiou
    National Research Institute of Chinese Medicine, Taipei 112, Taiwan
    Evid Based Complement Alternat Med 2011:920828. 2011
  3. pmc 3,4-Di-O-Caffeoylquinic Acid Inhibits Angiotensin-II-Induced Vascular Smooth Muscle Cell Proliferation and Migration by Downregulating the JNK and PI3K/Akt Signaling Pathways
    Wen Fei Chiou
    National Research Institute of Chinese Medicine, Taipei 112, Taiwan
    Evid Based Complement Alternat Med 2011:634502. 2011
  4. pmc Mechanisms of suppression of inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells by andrographolide
    W F Chiou
    National Research Institute of Chinese Medicine, Taipei, Taiwan
    Br J Pharmacol 129:1553-60. 2000
  5. ncbi C5a differentially stimulates the ERK1/2 and p38 MAPK phosphorylation through independent signaling pathways to induced chemotactic migration in RAW264.7 macrophages
    Wen Fei Chiou
    National Research Institute of Chinese Medicine, 155 1, Li Nung Street Section 2, Shih Pai, Taipei 112, Taiwan
    Int Immunopharmacol 4:1329-41. 2004
  6. ncbi Effect of Abeta exposure on the mRNA expression patterns of voltage-sensitive calcium channel alpha 1 subunits (alpha 1A-alpha 1D) in human SK-N-SH neuroblastoma
    Wen Fei Chiou
    Division of Basic Chinese Medical Research, National Research Institute of Chinese Medicine, NO 155 1, Sec 2, Li Nung St, Shipai, Taipei 112, Taiwan, ROC
    Neurochem Int 49:256-61. 2006
  7. doi Abnormal protein expression in the corpus cavernosum impairs erectile function in type 2 diabetes
    Wen Fei Chiou
    National Research Institute of Chinese Medicine, Taipei, Taiwan
    BJU Int 105:674-80. 2010
  8. ncbi Anti-inflammatory properties of piperlactam S: modulation of complement 5a-induced chemotaxis and inflammatory cytokines production in macrophages
    Wen Fei Chiou
    National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC
    Planta Med 69:9-14. 2003
  9. ncbi Tetrandrine selectively protects against amyloid-beta protein - but not against MPTP-induced cytotoxicity in SK-N-SH neuroblastoma cells
    Wen Fei Chiou
    National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC
    Planta Med 72:1300-4. 2006
  10. ncbi Piperlactam S suppresses macrophage migration by impeding F-actin polymerization and filopodia extension
    Wen Fei Chiou
    National Research Institute of Chinese Medicine, NO 155 1, Li Nung Street Section 2, Shih Pai, 112, Taipei, Taiwan
    Eur J Pharmacol 458:217-25. 2003

Collaborators

Detail Information

Publications47

  1. pmc Evodia rutaecarpa and Three Major Alkaloids Abrogate Influenza A Virus (H1N1)-Induced Chemokines Production and Cell Migration
    Wen Fei Chiou
    National Research Institute of Chinese Medicine, Taipei 112, Taiwan
    Evid Based Complement Alternat Med 2011:750513. 2011
    ..As an effective agent to suppress H1N1-induced chemokines production and block chemokine-attracted leukocytes recruitment, E. rutaecarpa and its active components may be useful in influenza virus infection-related inflammatory disorders...
  2. pmc 8-Prenylkaempferol Suppresses Influenza A Virus-Induced RANTES Production in A549 Cells via Blocking PI3K-Mediated Transcriptional Activation of NF-κB and IRF3
    Wen Fei Chiou
    National Research Institute of Chinese Medicine, Taipei 112, Taiwan
    Evid Based Complement Alternat Med 2011:920828. 2011
    ....
  3. pmc 3,4-Di-O-Caffeoylquinic Acid Inhibits Angiotensin-II-Induced Vascular Smooth Muscle Cell Proliferation and Migration by Downregulating the JNK and PI3K/Akt Signaling Pathways
    Wen Fei Chiou
    National Research Institute of Chinese Medicine, Taipei 112, Taiwan
    Evid Based Complement Alternat Med 2011:634502. 2011
    ..The anti-atherosclerotic effect of CQC is achieved either by endothelial cells protection or by VSMC proliferation/migration inhibition, suggesting this compound may be useful in preventing vascular diseases...
  4. pmc Mechanisms of suppression of inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells by andrographolide
    W F Chiou
    National Research Institute of Chinese Medicine, Taipei, Taiwan
    Br J Pharmacol 129:1553-60. 2000
    ..It is also possible that inhibition of iNOS protein expression and NO production under immune stimulation and/or bacteria infection may explain, in part, the beneficial effects of andrographolide as an anti-inflammatory agent...
  5. ncbi C5a differentially stimulates the ERK1/2 and p38 MAPK phosphorylation through independent signaling pathways to induced chemotactic migration in RAW264.7 macrophages
    Wen Fei Chiou
    National Research Institute of Chinese Medicine, 155 1, Li Nung Street Section 2, Shih Pai, Taipei 112, Taiwan
    Int Immunopharmacol 4:1329-41. 2004
    ..That is, ERK1/2 but not p38 MAPK phosphorylation is down stream of P13K/Akt and modulated by PLC. Additionally, beta(2) isoform may be one of the participates in C5a signal and acts more upstream of P13K/Akt...
  6. ncbi Effect of Abeta exposure on the mRNA expression patterns of voltage-sensitive calcium channel alpha 1 subunits (alpha 1A-alpha 1D) in human SK-N-SH neuroblastoma
    Wen Fei Chiou
    Division of Basic Chinese Medical Research, National Research Institute of Chinese Medicine, NO 155 1, Sec 2, Li Nung St, Shipai, Taipei 112, Taiwan, ROC
    Neurochem Int 49:256-61. 2006
    ....
  7. doi Abnormal protein expression in the corpus cavernosum impairs erectile function in type 2 diabetes
    Wen Fei Chiou
    National Research Institute of Chinese Medicine, Taipei, Taiwan
    BJU Int 105:674-80. 2010
    ....
  8. ncbi Anti-inflammatory properties of piperlactam S: modulation of complement 5a-induced chemotaxis and inflammatory cytokines production in macrophages
    Wen Fei Chiou
    National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC
    Planta Med 69:9-14. 2003
    ..We conclude that retardation of macrophage recruitment by interfering with the migration process and suppression of cytokines production might underlie the potential usefulness of piperlactam S as an anti-inflammatory agent...
  9. ncbi Tetrandrine selectively protects against amyloid-beta protein - but not against MPTP-induced cytotoxicity in SK-N-SH neuroblastoma cells
    Wen Fei Chiou
    National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC
    Planta Med 72:1300-4. 2006
    ..These results suggest that TET may mitigate the harmful effects of Abeta on cell survival, probably by interfering via the necrotic signal related to Ca2+ overloading through the L-type calcium channel...
  10. ncbi Piperlactam S suppresses macrophage migration by impeding F-actin polymerization and filopodia extension
    Wen Fei Chiou
    National Research Institute of Chinese Medicine, NO 155 1, Li Nung Street Section 2, Shih Pai, 112, Taipei, Taiwan
    Eur J Pharmacol 458:217-25. 2003
    ..However, the detailed mechanism by which piperlactam S regulates the above processes needs further study...
  11. ncbi Evodia rutaecarpa protects against circulation failure and organ dysfunction in endotoxaemic rats through modulating nitric oxide release
    Wen Fei Chiou
    National Research Institute of Chinese Medicine, NO 155 1, Sec 2, Li Nung Street, Shipai, Taipei, Taiwan
    J Pharm Pharmacol 54:1399-405. 2002
    ..These significant results may offer E. rutaecarpa as a candidate for the treatment of this model of endotoxaemia...
  12. ncbi Pharmacological profile of evodiamine in isolated rabbit corpus cavernosum
    Wen Fei Chiou
    National Research Institute of Chinese Medicine, NO 155 1, Section 2, Li Nung Street, Shih Pai, 112, Taipei, Taiwan, ROC
    Eur J Pharmacol 446:151-9. 2002
    ..Furthermore, the physiological effects of evodiamine on the aged animals may implicate a potential for the treatment of erectile dysfunction...
  13. ncbi Camptothecin suppresses nitric oxide biosynthesis in RAW 264.7 macrophages
    W F Chiou
    National Research Institute of Chinese Medicine, Taipei, Taiwan, Republic of China
    Life Sci 69:625-35. 2001
    ..From this observation we propose that inhibition of NO biosynthesis by CPT may underlie, at least in part, the efficacy of this antitumor agent...
  14. ncbi Andrographolide acts through inhibition of ERK1/2 and Akt phosphorylation to suppress chemotactic migration
    Hwei Ru Tsai
    Institute of Traditional Medicine, School of Medicine, National Yang Ming University, No 155, Li Nung Street, Section 2, Shih Pai Taipei 112, Taiwan, ROC
    Eur J Pharmacol 498:45-52. 2004
    ..These results indicate that inhibition of cell migration by interfering with ERK1/2 and PI3K/Akt signal pathways may contribute to the anti-inflammatory activity of andrographolide...
  15. doi Neobavaisoflavone stimulates osteogenesis via p38-mediated up-regulation of transcription factors and osteoid genes expression in MC3T3-E1 cells
    Ming Jaw Don
    National Research Institute of Chinese Medicine, Taipei, Taiwan
    Phytomedicine 19:551-61. 2012
    ..The beneficial effect of NBIF on mineralization demonstrated that NBIF represented as an active component existed in P. corylifolia and might be a potential anabolic agent to treat bone loss-associated diseases...
  16. doi Ugonin K-stimulated osteogenesis involves estrogen receptor-dependent activation of non-classical Src signaling pathway and classical pathway
    Chia Hsin Lee
    Department of Pharmacology, National Yang Ming University, Taipei, Taiwan
    Eur J Pharmacol 676:26-33. 2012
    ..Moreover, a transactivation potential toward estrogen receptor-α through a classical pathway might not be precluded...
  17. ncbi Laxifolone A suppresses LPS/IFN-gamma-induced NO synthesis by attenuating NF-kappaB translocation: role of NF-kappaB p105 level
    Han Chieh Ko
    Division of Basic Chinese Medical Research, National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC
    Planta Med 71:514-9. 2005
    ..In summary, these results suggest that inhibition of NF-kappaB p105 degradation in cytoplasm may participate in the abrogation of LPS/IFN-gamma-induced NF-kappaB translocation and subsequent NO synthesis by laxifolone A...
  18. ncbi Phenylpropanoid glycosides from Orobanche caerulescens
    Lie Chwen Lin
    National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC
    Planta Med 70:50-3. 2004
    ..75 +/- 1.05 microM), a natural phenolic antioxidant isolated from grape, demonstrated that the prolonged effect on lag-time and the damping effect on oxidative rate by compounds 1 - 7 were all more potent...
  19. doi New isoflavonoid glycosides and related constituents from astragali radix ( Astragalus membranaceus ) and their inhibitory activity on nitric oxide production
    Li Jie Zhang
    National Research Institute of Chinese Medicine, Taipei 112, Taiwan, Republic of China
    J Agric Food Chem 59:1131-7. 2011
    ..Furthermore, characteristic peaks for the 11 major compounds in the chromatogram were unambiguously confirmed...
  20. doi Ugonin K promotes osteoblastic differentiation and mineralization by activation of p38 MAPK- and ERK-mediated expression of Runx2 and osterix
    Chia Hsin Lee
    Department of Pharmacology, National Yang Ming University, Taipei, Taiwan
    Eur J Pharmacol 668:383-9. 2011
    ..Take together, the potential anabolic effect of ugonin K on bone might act through activations of p38- and ERK-mediated Runx2 and osterix expressions to induce the synthesis of osteoids and formation of bone nodule...
  21. doi 8-Prenylkaempferol suppresses inducible nitric oxide synthase expression through interfering with JNK-mediated AP-1 pathway in murine macrophages
    Chien Chih Chen
    National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC
    Eur J Pharmacol 590:430-6. 2008
    ..These findings provided the first molecular basis that 8-prenylkaempferol is an effective agent for attenuating pro-inflammatory NO induction...
  22. ncbi Divergent role of calcium on Abeta- and MPTP-induced cell death in SK-N-SH neuroblastoma
    Wan Shin Lee
    Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei, Taiwan, ROC
    Life Sci 78:1268-75. 2006
    ..Nevertheless, Ca2+ overload seems to solely display a crucial role in Abeta-induced cytotoxicity and over-expressed alpha(1D) may contribute to the disruption of cellular Ca2+ homeostasis...
  23. ncbi A novel NO-production-inhibiting triterpene and cytotoxicity of known alkaloids from Euonymus laxiflorus
    Yao Haur Kuo
    National Research Institute of Chinese Medicine, NO 155 1, Li Nong Street, Section 2, Shih Pai, Taipei, 112, Taiwan, Republic of China
    J Nat Prod 66:554-7. 2003
    ..Structural elucidations of these compounds were established by spectral analysis. Compound 1 displayed significant nitric oxide (NO) inhibitory effect...
  24. ncbi Antioxidant activity of piperlactam S: prevention of copper-induced LDL peroxidation and amelioration of free radical-induced oxidative stress of endothelial cells
    Jeng Yan Tsai
    Institute of Pharmacology, School of Life Sciences, National Yang Ming University, Taipei, ROC
    Planta Med 69:3-8. 2003
    ....
  25. pmc Andrographolide prevents oxygen radical production by human neutrophils: possible mechanism(s) involved in its anti-inflammatory effect
    Yuh Chiang Shen
    National Research Institute of Chinese Medicine, 155 1, Li Nung Street Section 2, Shih Pai, Taipei 112, Taiwan
    Br J Pharmacol 135:399-406. 2002
    ....
  26. ncbi Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes
    Yuh Chiang Shen
    National Research Institute of Chinese Medicine, Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Eur J Pharmacol 465:171-81. 2003
    ....
  27. ncbi Cryptotanshinone inhibits macrophage migration by impeding F-actin polymerization and filopodia extension
    Wen Fei Chiou
    National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC
    Life Sci 81:109-14. 2007
    ..Based on these observations, we suggest that cryptotanshinone exerts anti-migrating activity possibly by impeding F-actin polymerization and filopodia formation...
  28. doi 9-hydroxycanthin-6-one induces penile erection and delays ejaculation
    Wen Fei Chiou
    National Research Institute of Chinese Medicine, Taipei, Taiwan
    J Sex Med 9:1027-36. 2012
    ..longifolia regulates directly the muscle tone of corpus cavernosa and/or seminal vesicle (SV) remains unclear. Even until now, the compositions that could account for its aphrodisiac property are still unknown..
  29. ncbi Ligustilide prevents LPS-induced iNOS expression in RAW 264.7 macrophages by preventing ROS production and down-regulating the MAPK, NF-κB and AP-1 signaling pathways
    Yu Wen Su
    Institute of Biochemistry and Molecular Biology, National Yang Ming University, No 155, Sec 2, Linong Street, Taipei, 112, Taiwan, ROC
    Int Immunopharmacol 11:1166-72. 2011
    ....
  30. doi Psoralidin inhibits LPS-induced iNOS expression via repressing Syk-mediated activation of PI3K-IKK-IκB signaling pathways
    Wen Fei Chiou
    National Research Institute of Chinese Medicine, Taipei, Taiwan
    Eur J Pharmacol 650:102-9. 2011
    ..The present results show that interfering with Syk-mediated PI3K phosphorylation might contribute to the NO inhibitory effect of psoralidin via blocking IKK/IκB signaling propagation in LPS-stimulated RAW 264.7 macrophages...
  31. ncbi Dual regulatory effect of plant extracts of Forsythia suspense on RANTES and MCP-1 secretion in influenza A virus-infected human bronchial epithelial cells
    Han Chieh Ko
    Division of Basic Chinese Medical Research, National Research Institute of Chinese Medicine, Li Nung St, Shipai, Taipei, Taiwan, ROC
    J Ethnopharmacol 102:418-23. 2005
    ..6-3.7 times. These results suggested that Forsythia suspense consisted of both negative and positive regulatory components on RANTES and MCP-1 secretion in H1N1-infected A549 cells, respectively...
  32. doi (+)-Vitisin A inhibits influenza A virus-induced RANTES production in A549 alveolar epithelial cells through interference with Akt and STAT1 phosphorylation
    Yu Ling Huang
    National Research Institute of Chinese Medicine, Taipei, Taiwan
    Planta Med 74:156-62. 2008
    ..These results suggested that (+)-vitisin A might be a potent anti-inflammatory agent that inhibits influenza A virus-induced RANTES production by interfering with Akt- and STAT (1)-related signal pathways...
  33. ncbi The effect of medicinal plants used in Chinese folk medicine on RANTES secretion by virus-infected human epithelial cells
    Han Chieh Ko
    Division of Basic Chinese Medical Research, National Research Institute of Chinese Medicine, Shipai, Taipei, Taiwan, ROC
    J Ethnopharmacol 107:205-10. 2006
    ..2 +/- 0.4 microg/ml while the next two were Glycyrrhiza uralensis and Forsythia suspensa (IC(50) ranging from 35 to 48 microg/ml)...
  34. doi 1,3,5-trihydroxy-4-prenylxanthone represses lipopolysaccharide-induced iNOS expression via impeding posttranslational modification of IRAK-1
    Wen Fei Chiou
    National Research Institute of Chinese Medicine, Taipei, Taiwan
    Biochem Pharmacol 81:752-60. 2011
    ....
  35. doi Inhibitory effects of Mannich bases of heterocyclic chalcones on NO production by activated RAW 264.7 macrophages and superoxide anion generation and elastase release by activated human neutrophils
    M Vijaya Bhaskar Reddy
    Department of Chemistry, National Cheng Kung University, Tainan, Taiwan, ROC
    Bioorg Med Chem 19:2751-6. 2011
    ..Therefore, these four compounds may be new leads for development of anti-inflammatory activities. The structure-activity relationships are also discussed...
  36. ncbi Selective COX-2 inhibitors. Part 1: synthesis and biological evaluation of phenylazobenzenesulfonamides
    Wei Jern Tsai
    Division of Medicinal Chemistry, National Research Institute of Chinese Medicine, Taipei, Taiwan
    Bioorg Med Chem Lett 16:4440-3. 2006
    ..28 microM; COX-2: 2.04 microM), being active but less COX-2 selective than celecoxib...
  37. doi 8-Prenylkaempferol accelerates osteoblast maturation through bone morphogenetic protein-2/p38 pathway to activate Runx2 transcription
    Wen Fei Chiou
    National Research Institute of Chinese Medicine, Taipei, Taiwan
    Life Sci 88:335-42. 2011
    ..In this study, we investigated the effect of 8-prenylkaempferol (8-PK), a prenyl-flavonoid isolated from Sophora flavescens, on osteoblast differentiation and maturation...
  38. doi Synthesis, in vitro anti-inflammatory and cytotoxic evaluation, and mechanism of action studies of 1-benzoyl-β-carboline and 1-benzoyl-3-carboxy-β-carboline derivatives
    Mei Lin Yang
    Department of Chemistry, National Cheng Kung University, Tainan, Taiwan, ROC
    Bioorg Med Chem 19:1674-82. 2011
    ..Therefore, the synthetic 1-benzoyl-3-carboxy β-carboline analogs may have great potential to be developed as anti-inflammatory agents...
  39. ncbi Astragalus membranaceus flavonoids (AMF) ameliorate chronic fatigue syndrome induced by food intake restriction plus forced swimming
    Yao Haur Kuo
    National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC
    J Ethnopharmacol 122:28-34. 2009
    ..Alteration of immune function may be associated with chronic fatigue syndrome (CFS) and this study reveals the immunoregulatory effect of Astragalus membranaceus flavonoids (AMF)...
  40. pmc (+)-Vitisin A Inhibits Osteoclast Differentiation by Preventing TRAF6 Ubiquitination and TRAF6-TAK1 Formation to Suppress NFATc1 Activation
    Wen Fei Chiou
    National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei, Taiwan, ROC Department of Biotechnology, Hungkuang University, Taichung, Taiwan, ROC
    PLoS ONE 9:e89159. 2014
    ..Furthermore, action through negative regulation of the proteolytic activity of MMP-9 and cathepsin K might also contribute to the anti-resorption effect of (+)-vitisin A. ..
  41. ncbi Oligostilbenes from the roots of Vitis thunbergii
    Wen Fei Chiou
    National Research Institute of Chinese Medicine, Taipei, Taiwan
    Planta Med 75:856-9. 2009
    ..led to the isolation of three new resveratrol derivatives, vitisinols E-G (1-3), together with 14 known compounds. The structures of compounds 1-3 were established by application of spectroscopic analyses (NMR, MS, UV, and IR)...
  42. ncbi Protective effects of tetramethylpyrazine on kainate-induced excitotoxicity in hippocampal culture
    Yang Hsin Shih
    Department of Neurosurgery, Neurological Institute, Veterans General Hospital, Taipei, Taiwan
    Neuroreport 13:515-9. 2002
    ....
  43. pmc Anti-inflammatory and anti-infectious effects of Evodia rutaecarpa (Wuzhuyu) and its major bioactive components
    Jyh Fei Liao
    Institute of Pharmacology, National Yang Ming University, No 155, Sec 2, Linong Road, Taipei 112, Taiwan
    Chin Med 6:6. 2011
    ..Stimulation of calcitonin gene-related peptide release may partially explain the analgesic, cardiovascular and gastrointestinal protective, anti-obese activities of Evodia rutaecarpa and its major bioactive components...
  44. pmc A Special Ingredient (VtR) Containing Oligostilbenes Isolated from Vitis thunbergii Prevents Bone Loss in Ovariectomized Mice: In Vitro and In Vivo Study
    Yu Ling Huang
    National Research Institute of Chinese Medicine, NO 155 1, Section 2, Li Nong Street, Beitou District, Taipei 11221, Taiwan Department of Cosmetic Science, Chang Gung University of Science and Technology, No 261, Wen Hwa 1st Road, Kwei Shan, Taoyuan 333, Taiwan
    Evid Based Complement Alternat Med 2013:409421. 2013
    ..The results suggested VtR composed of diverse components to reciprocally drive osteoblastogenesis and interdict osteoclastogenesis may serve as a potential botanic drug for osteoporosis therapy...
  45. ncbi Acteoside protects endothelial cells against free radical-induced oxidative stress
    Wen Fei Chiou
    National Research Institute of Chinese Medicine, NO 155 1, Sec 2, Li Nung Street, Shipai, Taipei, Taiwan
    J Pharm Pharmacol 56:743-8. 2004
    ..These data suggested that acteoside protects the cell from oxidative stress and that scavenging of free radicals could be a key mechanism contributing to the cytoprotective effect of acteoside...
  46. ncbi Synthesis and vasorelaxant activity of 4-(cyclic amido)-2H-naphtho[1,2-b]pyrans
    Wen Fei Chiou
    National Research Institute of Chinese Medicine, Taipei 112, Taiwan, ROC
    Eur J Med Chem 37:69-75. 2002
    ..The relaxant mechanism of 3a was found not through ATP-sensitive K(+) channels as cromakalim, but through opening voltage-sensitive K(+) channels...
  47. doi Design, synthesis, and biological evaluation of Mannich bases of heterocyclic chalcone analogs as cytotoxic agents
    M Vijaya Bhaskar Reddy
    Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan
    Bioorg Med Chem 16:7358-70. 2008
    ..Out of the 39 chalcones synthesized, 31 compounds showed potent activity against at least one cell line with IC(50) values ranging from 0.03 to 3.80 microg/mL. Structure-activity relationships (SAR) are also discussed...