Lih Chu Chiou

Summary

Affiliation: National Taiwan University
Country: Taiwan

Publications

  1. ncbi request reprint Chinese herb constituent beta-eudesmol alleviated the electroshock seizures in mice and electrographic seizures in rat hippocampal slices
    L C Chiou
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei
    Neurosci Lett 231:171-4. 1997
  2. ncbi request reprint [Nphe1,Arg14,Lys15]N/OFQ-NH2 is a competitive antagonist of NOP receptors in the periaqueductal gray
    Lih Chu Chiou
    Department of Pharmacology, College of Medicine, National Taiwan University, No 1, Jen Ai Rd, Section 1, Taipei 100, Taiwan
    Eur J Pharmacol 515:47-53. 2005
  3. ncbi request reprint Pharmacological characterization of nociceptin/orphanin FQ receptors, a novel opioid receptor family, in the midbrain periaqueductal gray
    Lih Chu Chiou
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei 100, Taiwan
    Ann N Y Acad Sci 1025:398-403. 2004
  4. ncbi request reprint Ro 64-6198 [(1S,3aS)-8-(2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one] acts differently from nociceptin/orphanin FQ in rat periaqueductal gray slices
    Lih Chu Chiou
    Department of Pharmacology, College of Medicine, National Taiwan University, 1 Jen Ai Road, Section 1, Taipei 100, Taiwan
    J Pharmacol Exp Ther 311:645-51. 2004
  5. ncbi request reprint Nociceptin/orphanin FQ peptide receptors: pharmacology and clinical implications
    L C Chiou
    Department of Pharmacology, College of Medicine, National Taiwan University, No 1, Jen Ai Rd, Section 1, Taipei 100, Taiwan
    Curr Drug Targets 8:117-35. 2007
  6. ncbi request reprint [Nphe(1)]N/OFQ-(1-13)-NH(2) is a competitive and selective antagonist at nociceptin/orphanin FQ receptors mediating K(+) channel activation in rat periaqueductal gray slices
    Lih Chu Chiou
    Department of Pharmacology, College of Medicine, National Taiwan University, No 1, Jen Ai Rd, Section 1, Taipei 100, Taiwan
    Neuropharmacology 42:246-52. 2002
  7. ncbi request reprint ATP-sensitive K+ channels and cellular actions of morphine in periaqueductal gray slices of neonatal and adult rats
    L C Chiou
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Pharmacol Exp Ther 298:493-500. 2001
  8. pmc [Phe1psi(CH2-NH)Gly2]nociceptin-(1 - 13)-NH2 activation of an inward rectifier as a partial agonist of ORL1 receptors in rat periaqueductal gray
    L C Chiou
    Department of Pharmacology, College of Medicine, National Taiwan University, No 1, Jen Ai Road, Section 1, Taipei 100, Taipei, Taiwan
    Br J Pharmacol 128:103-7. 1999
  9. ncbi request reprint Differential antagonism by naloxone benzoylhydrazone of the activation of inward rectifying K+ channels by nociceptin and a mu-opioid in rat periaqueductal grey slices
    L C Chiou
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei
    Naunyn Schmiedebergs Arch Pharmacol 363:583-9. 2001
  10. ncbi request reprint Pharmacological characterization of the nociceptin receptor, ORL1. Insight from the inward rectifier activation in the periaqueductal gray
    L C Chiou
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Biomed Sci 7:232-40. 2000

Collaborators

  • Ling Ling Hwang
  • Ing Kang Ho
  • Remo Guerrini
  • Girolamo Calo'
  • Geng Chang Yeh
  • Sung Tsang Hsieh
  • James W Hu
  • Shuu Jiun Wang
  • Jong Ling Fuh
  • Li Jen Lee
  • Yan Yu Liao
  • Jen Kun Cheng
  • Yu Cheng Ho
  • Pi Chuan Fan
  • Jia Rung Yang
  • Chien Chuan Chen
  • Hon Lie Chen
  • Shu Hao Wei
  • Ping Hung Kuo
  • Hsin Jung Lee
  • Shu Fang Teng
  • Shang Cheng Huang
  • Chia Ju Kuo
  • Tzu Ling Li
  • Ya Chun Huang
  • Jung Chieh Du
  • Cynthia Wei Sheng Lee
  • Shu Hui Chang
  • Wei Jan Huang
  • Yuan Ling Ku
  • Jui Feng Chou
  • Jou Kou Wang
  • Eric P Prinssen
  • Hsin Tzu Liao
  • Li Wei Tung
  • Faming Jiang
  • Szu Ying Fu
  • Li Chun Lin
  • Ken Mackie
  • Sabine Kolczewski
  • Yu Wen E Dai
  • Yen Hsien Lee
  • Claudio Trapella
  • Chia Shiang Lin
  • Jing Ru Hsieh
  • You Shuei Lin
  • Chien Hua Wang
  • Sun Zhi Lee
  • Po Wu Gean
  • Robert Chang Chih Chou

Detail Information

Publications34

  1. ncbi request reprint Chinese herb constituent beta-eudesmol alleviated the electroshock seizures in mice and electrographic seizures in rat hippocampal slices
    L C Chiou
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei
    Neurosci Lett 231:171-4. 1997
    ..5 microM)-induced electrographic seizure activity. The potential of beta-eudesmol to serve as an antiepileptic or a conjuvant in phenytoin therapy is suggested...
  2. ncbi request reprint [Nphe1,Arg14,Lys15]N/OFQ-NH2 is a competitive antagonist of NOP receptors in the periaqueductal gray
    Lih Chu Chiou
    Department of Pharmacology, College of Medicine, National Taiwan University, No 1, Jen Ai Rd, Section 1, Taipei 100, Taiwan
    Eur J Pharmacol 515:47-53. 2005
    ..It is concluded that UFP-101 is a potent and competitive peptide antagonist of NOP receptors that mediate GIRK channel activation in ventrolateral periaqueductal gray neurons...
  3. ncbi request reprint Pharmacological characterization of nociceptin/orphanin FQ receptors, a novel opioid receptor family, in the midbrain periaqueductal gray
    Lih Chu Chiou
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei 100, Taiwan
    Ann N Y Acad Sci 1025:398-403. 2004
    ..Our functional studies of NOP receptor ligands at native brain NOP receptors reveal that some of them act differently from those at expressed receptors of cell cultures...
  4. ncbi request reprint Ro 64-6198 [(1S,3aS)-8-(2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one] acts differently from nociceptin/orphanin FQ in rat periaqueductal gray slices
    Lih Chu Chiou
    Department of Pharmacology, College of Medicine, National Taiwan University, 1 Jen Ai Road, Section 1, Taipei 100, Taiwan
    J Pharmacol Exp Ther 311:645-51. 2004
    ..The possibility was discussed that two subsets of NOP receptors exist in ventrolateral PAG neurons, and Ro 64-6198 activates only one subset but N/OFQ activates both of them...
  5. ncbi request reprint Nociceptin/orphanin FQ peptide receptors: pharmacology and clinical implications
    L C Chiou
    Department of Pharmacology, College of Medicine, National Taiwan University, No 1, Jen Ai Rd, Section 1, Taipei 100, Taiwan
    Curr Drug Targets 8:117-35. 2007
    ..This review summarizes the pharmacological characteristics of, and studies with, the available NOP receptor ligands and their possible clinical implications...
  6. ncbi request reprint [Nphe(1)]N/OFQ-(1-13)-NH(2) is a competitive and selective antagonist at nociceptin/orphanin FQ receptors mediating K(+) channel activation in rat periaqueductal gray slices
    Lih Chu Chiou
    Department of Pharmacology, College of Medicine, National Taiwan University, No 1, Jen Ai Rd, Section 1, Taipei 100, Taiwan
    Neuropharmacology 42:246-52. 2002
    ..It is concluded that Nphe acts as a pure, selective and competitive antagonist at native NOP receptors of ventrolateral PAG neurons...
  7. ncbi request reprint ATP-sensitive K+ channels and cellular actions of morphine in periaqueductal gray slices of neonatal and adult rats
    L C Chiou
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Pharmacol Exp Ther 298:493-500. 2001
    ..The correlation between the insensitivity in K+ channel activation and the less antinociceptive response to morphine in adults was discussed...
  8. pmc [Phe1psi(CH2-NH)Gly2]nociceptin-(1 - 13)-NH2 activation of an inward rectifier as a partial agonist of ORL1 receptors in rat periaqueductal gray
    L C Chiou
    Department of Pharmacology, College of Medicine, National Taiwan University, No 1, Jen Ai Road, Section 1, Taipei 100, Taipei, Taiwan
    Br J Pharmacol 128:103-7. 1999
    ..5 It is suggested that Phepsi acts as a partial agonist of ORL1 that mediates the activation of inwardly rectifying K+ channels in ventrolateral neurons of rat periaqueductal gray...
  9. ncbi request reprint Differential antagonism by naloxone benzoylhydrazone of the activation of inward rectifying K+ channels by nociceptin and a mu-opioid in rat periaqueductal grey slices
    L C Chiou
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei
    Naunyn Schmiedebergs Arch Pharmacol 363:583-9. 2001
    ..It acts not only as a competitive antagonist at ORL1, but also as a more potent and non-competitive antagonist at mu-opioid receptors...
  10. ncbi request reprint Pharmacological characterization of the nociceptin receptor, ORL1. Insight from the inward rectifier activation in the periaqueductal gray
    L C Chiou
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Biomed Sci 7:232-40. 2000
    ..It indicates that a potent and selective ORL1 antagonist is expecting to elucidate the physiological role of OFQ/N...
  11. ncbi request reprint Characterization of synaptic transmission in the ventrolateral periaqueductal gray of rat brain slices
    L C Chiou
    Department of Pharmacology, College of Medicine, National Taiwan University, No 1, Jen Ai Rd, Section 1, Taipei, Taiwan
    Neuroscience 100:829-34. 2000
    ..The excitatory transmission is mediated by glutamate acting on alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate as well as N-methyl-D-aspartate receptors...
  12. ncbi request reprint Antiallodynic effects of intrathecal orexins in a rat model of postoperative pain
    Jen Kun Cheng
    Department of Pharmacology, College of Medicine, National Taiwan University, 1, Jen Ai Rd, Section 1, Taipei 100, Taiwan
    J Pharmacol Exp Ther 307:1065-71. 2003
    ..Endogenous orexin might be released after incision injury to activate the spinal OX1 receptors as an endogenous analgesic protector...
  13. pmc Activation of orexin 1 receptors in the periaqueductal gray of male rats leads to antinociception via retrograde endocannabinoid (2-arachidonoylglycerol)-induced disinhibition
    Yu Cheng Ho
    Graduate Institute and Department of Pharmacology, and Graduate Institute of Brain and Mind Sciences, College of Medicine, Graduate Institute of Zoology, Neurobiology and Cognitive Science Center, National Taiwan University, Taipei 100, Taiwan
    J Neurosci 31:14600-10. 2011
    ....
  14. ncbi request reprint Does ethanol activate G-protein coupled inwardly rectifying K+ channels?
    Lih Chu Chiou
    Department of Pharmacology, Medical College, National Taiwan University, Taipei
    Neuroreport 13:163-5. 2002
    ..In neurons unresponsive to ethanol, baclofen, the mu-opioid or nociceptin successfully activated GIRK channels. It is suggested that GIRK channels of the ventrolateral PAG are unlikely to be targets of the analgesic action of ethanol...
  15. doi request reprint Functional heterogeneity of nociceptin/orphanin FQ receptors revealed by (+)-5a Compound and Ro 64-6198 in rat periaqueductal grey slices
    Yan Yu Liao
    Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Int J Neuropsychopharmacol 14:977-89. 2011
    ..These results further support the presence of functional heterogeneity of NOP receptors in the midbrain PAG...
  16. ncbi request reprint Does gabapentin act as an agonist at native GABA(B) receptors?
    Jen Kun Cheng
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC
    J Biomed Sci 11:346-55. 2004
    ..It is concluded that gabapentin is not an agonist at GABA(B) receptors that are functional in baclofen-induced antiallodynia in the postoperative pain model in vivo and in GIRK channel activation in ventrolateral PAG neurons in vitro...
  17. ncbi request reprint Quantitative study of [(pF)Phe4,Arg14,Lys15]nociceptin/orphanin FQ-NH2 (UFP-102) at NOP receptors in rat periaqueductal gray slices
    Chia Ju Kuo
    Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Eur J Pharmacol 579:110-5. 2008
    ..7. These results suggest that UFP-102 is a full agonist at the postsynaptic NOP receptors of the midbrain of rats and is 5 fold more potent than N/OFQ...
  18. doi request reprint Hypofunction of glutamatergic neurotransmission in the periaqueductal gray contributes to nerve-injury-induced neuropathic pain
    Yu Cheng Ho
    Graduate Institute, Department of Pharmacology, Graduate Institute of Brain and Mind Sciences, College of Medicine, Neurobiology and Cognitive Science Center, National Taiwan University, Taipei 10051, Taiwan
    J Neurosci 33:7825-36. 2013
    ..Long-term hypoglutamatergic function in the vlPAG may lead to persistent reduction of descending pain inhibition, resulting in chronic neuropathic pain...
  19. doi request reprint 1-Benzyl-N-[3-[spiroisobenzofuran-1(3H),4'-piperidin-1-yl]propyl]pyrrolidine-2-carboxamide (Compound 24) antagonizes NOP receptor-mediated potassium channel activation in rat periaqueductal gray slices
    Yan Yu Liao
    Graduate Institute, National Taiwan University, Taipei, Taiwan
    Eur J Pharmacol 606:84-9. 2009
    ..It is concluded that Compound 24 acts as a pure antagonist at the native NOP receptors in the vlPAG with moderate potency and selectivity...
  20. ncbi request reprint Mechanisms of the antinociceptive action of gabapentin
    Jen Kun Cheng
    Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei
    J Pharmacol Sci 100:471-86. 2006
    ....
  21. ncbi request reprint CompB (J-113397), selectively and competitively antagonizes nociceptin activation of inwardly rectifying K(+) channels in rat periaqueductal gray slices
    Lih Chu Chiou
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Neuropharmacology 42:987-92. 2002
    ..It appears that CompB, at nanomolar concentrations, is a pure, selective and competitive antagonist of postsynaptic NOP receptors that mediate inwardly rectifying K(+) channel activation in ventrolateral PAG neurons...
  22. ncbi request reprint Prenatal morphine exposure decreases analgesia but not K+ channel activation
    Lih Chu Chiou
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Republic of China
    Neuroreport 14:239-42. 2003
    ....
  23. ncbi request reprint The antiallodynic action target of intrathecal gabapentin: Ca2+ channels, KATP channels or N-methyl-d-aspartic acid receptors?
    Jen Kun Cheng
    Department of Anesthesiology, Mackay Memorial Hospital, Taipei, Taiwan
    Anesth Analg 102:182-7. 2006
    ..These results provide correlative evidence to support the contention that N-type Ca2+ channels, but not K(ATP) channels or NMDA or GABA(A) receptors, might be involved in the antiallodynic effect of intrathecal gabapentin...
  24. doi request reprint Quantitative study of the antagonistic effect of (-)-cis-1-Methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol (SB-612111) on nociceptin/orphanin FQ-mediated potassium channel activation in rat periaqueducta
    Yan Yu Liao
    Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Eur J Pharmacol 657:84-8. 2011
    ..It is concluded that SB-612111 is a pure, potent and selective antagonist of NOP receptors that mediate GIRK channel activation in the vlPAG neurons...
  25. doi request reprint Orexins depolarize rostral ventrolateral medulla neurons and increase arterial pressure and heart rate in rats mainly via orexin 2 receptors
    Shang Cheng Huang
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    J Pharmacol Exp Ther 334:522-9. 2010
    ..We concluded that orexins directly excite RVLM neurons, which include bulbospinal vasomotor neurons, and regulate cardiovascular function mainly via the OX(2)R, with a smaller contribution from the OX(1)R...
  26. doi request reprint Quantitative study of [Tyr10]nociceptin/orphanin FQ (1-11) at NOP receptors in rat periaqueductal gray and expressed NOP receptors in HEK293 cells
    Yan Yu Liao
    Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, No 1 Jen Ai Road, Taipei, Taiwan
    Life Sci 90:306-12. 2012
    ..We also examined if [Tyr(10)]N/OFQ(1-11) distinguished heteromeric NOP-MOP receptors from homomeric NOP receptors...
  27. doi request reprint Sex differences in high-fat diet-induced obesity, metabolic alterations and learning, and synaptic plasticity deficits in mice
    Ling Ling Hwang
    Department of Physiology, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Obesity (Silver Spring) 18:463-9. 2010
    ..Our results suggest that male mice are more vulnerable than the females to the impacts of HFD on weight gains, metabolic alterations and deficits of learning, and hippocampal synaptic plasticity...
  28. ncbi request reprint Electrophysiological study on the effects of leptin in rat dorsal motor nucleus of the vagus
    Tzu Ling Li
    Department of Physiology, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Am J Physiol Regul Integr Comp Physiol 292:R2136-43. 2007
    ..These results suggest that the DMNV is one of the central target sites of leptin, and leptin can regulate parasympathetic outflow from the DMNV by directly acting on the parasympathetic preganglionic neurons of the DMNV...
  29. ncbi request reprint Different trigemino-vascular responsiveness between adolescent and adult rats in a migraine model
    Pi Chuan Fan
    Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, No 1 Jen Ai Rd, Taipei 100, Taiwan
    Cephalalgia 32:979-90. 2012
    ..c.) instillation of capsaicin in adolescent and adult rats...
  30. pmc Clerodendrum inerme Leaf Extract Alleviates Animal Behaviors, Hyperlocomotion, and Prepulse Inhibition Disruptions, Mimicking Tourette Syndrome and Schizophrenia
    Hon Lie Chen
    Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, No 1, Jen Ai Road, Section 1, Taipei 100, Taiwan
    Evid Based Complement Alternat Med 2012:284301. 2012
    ..These results suggest that CI extract can relieve hyperlocomotion and improve sensorimotor gating deficit, supporting the therapeutic potential of CI for TS and schizophrenia...
  31. doi request reprint Calcitonin gene-related peptide and size of the atrial septal defect in new-onset migraine after transcatheter closure: results of a preliminary study
    Shu Hao Wei
    Departments of Pediatrics, E Da Hospital and I Shou University, Kaohsiung, Taiwan
    Headache 52:985-92. 2012
    ..Plasma calcitonin gene-related peptide (CGRP), which plays a crucial role in migraine pathophysiology, has shown to be released from specific cardiac tissues...
  32. ncbi request reprint Effects of intrathecal injection of T-type calcium channel blockers in the rat formalin test
    Jen Kun Cheng
    Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Behav Pharmacol 18:1-8. 2007
    ..It is suggested that spinal T-type Ca2+ channels may play a role in formalin-induced inflammatory pain. The ineffectiveness of ethosuximide is discussed...
  33. ncbi request reprint Orexins/hypocretins: pain regulation and cellular actions
    Lih Chu Chiou
    Department of Pharmacology, College of Medicine, National Taiwan University No 1, Jen Ai Rd, Section 1, Taipei 100, Taiwan
    Curr Pharm Des 16:3089-100. 2010
    ..Further studies are required to elucidate the receptor subtype-specific mechanism(s) and clinical implications of orexin-induced antinociception...
  34. ncbi request reprint Mediation of amphetamine-induced long-term depression of synaptic transmission by CB1 cannabinoid receptors in the rat amygdala
    Ya Chun Huang
    Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan
    J Neurosci 23:10311-20. 2003
    ..The finding that endocannabinoids underlie the synaptic actions of amphetamine may open a new avenue for the treatment of psychostimulants addiction...