Ann Shyn Chiang

Summary

Affiliation: National Tsing Hua University
Country: Taiwan

Publications

  1. pmc Insect NMDA receptors mediate juvenile hormone biosynthesis
    Ann Shyn Chiang
    Department of Life Science, National Tsing Hua University, Hsinchu, 300 Taiwan, Republic of China
    Proc Natl Acad Sci U S A 99:37-42. 2002
  2. ncbi request reprint Three-dimensional mapping of brain neuropils in the cockroach, Diploptera punctata
    A S Chiang
    Department of Life Science, National Tsing Hua University, Hsinchu 30013, Taiwan, Republic of China
    J Comp Neurol 440:1-11. 2001
  3. doi request reprint Three-dimensional reconstruction of brain-wide wiring networks in Drosophila at single-cell resolution
    Ann Shyn Chiang
    Brain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan, R O C
    Curr Biol 21:1-11. 2011
  4. ncbi request reprint Ionotropic glutamate receptors mediate juvenile hormone synthesis in the cockroach, Diploptera punctata
    Ann Shyn Chiang
    Department of Life Science, National Tsing Hua University, Hsinchu 300, Taiwan
    Insect Biochem Mol Biol 32:669-78. 2002
  5. ncbi request reprint Glutamate-gated chloride channels inhibit juvenile hormone biosynthesis in the cockroach, Diploptera punctata
    Hsin Ping Liu
    Institute of Biotechnology, National Tsing Hua University, Hsinchu 300, Taiwan, ROC
    Insect Biochem Mol Biol 35:1260-8. 2005
  6. doi request reprint Visualizing long-term memory formation in two neurons of the Drosophila brain
    Chun Chao Chen
    Institute of Biotechnology and Department of Life Science, National Tsing Hua University, Hsinchu 30013, Taiwan
    Science 335:678-85. 2012
  7. ncbi request reprint An octopamine-mushroom body circuit modulates the formation of anesthesia-resistant memory in Drosophila
    Chia Lin Wu
    Brain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan Department of Biochemistry and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Tao Yuan 333, Taiwan
    Curr Biol 23:2346-54. 2013
  8. pmc Drosophila ORB protein in two mushroom body output neurons is necessary for long-term memory formation
    Tsung Pin Pai
    Institute of Biotechnology and Department of Life Science, National Tsing Hua University, Hsinchu 30013, Taiwan
    Proc Natl Acad Sci U S A 110:7898-903. 2013
  9. pmc Serotonin-mushroom body circuit modulating the formation of anesthesia-resistant memory in Drosophila
    Pei Tseng Lee
    Department of Life Science, National Tsing Hua University, Hsinchu 30013, Taiwan
    Proc Natl Acad Sci U S A 108:13794-9. 2011
  10. doi request reprint Heterotypic gap junctions between two neurons in the drosophila brain are critical for memory
    Chia Lin Wu
    Brain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan
    Curr Biol 21:848-54. 2011

Collaborators

Detail Information

Publications38

  1. pmc Insect NMDA receptors mediate juvenile hormone biosynthesis
    Ann Shyn Chiang
    Department of Life Science, National Tsing Hua University, Hsinchu, 300 Taiwan, Republic of China
    Proc Natl Acad Sci U S A 99:37-42. 2002
    ..Our results suggest that the NMDAR has a role in regulating JH synthesis and that ionotropic-subtype glutamate receptors became specialized early in animal evolution...
  2. ncbi request reprint Three-dimensional mapping of brain neuropils in the cockroach, Diploptera punctata
    A S Chiang
    Department of Life Science, National Tsing Hua University, Hsinchu 30013, Taiwan, Republic of China
    J Comp Neurol 440:1-11. 2001
    ..This is the first 3D map at submicron resolution of an entire animal's brain that measures more than 500 microm in thickness...
  3. doi request reprint Three-dimensional reconstruction of brain-wide wiring networks in Drosophila at single-cell resolution
    Ann Shyn Chiang
    Brain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan, R O C
    Curr Biol 21:1-11. 2011
    ..Comprehensive brain wiring maps are thus needed in order to formulate hypotheses about information flow and also to guide genetic manipulations aimed at understanding how genes and circuits orchestrate complex behaviors...
  4. ncbi request reprint Ionotropic glutamate receptors mediate juvenile hormone synthesis in the cockroach, Diploptera punctata
    Ann Shyn Chiang
    Department of Life Science, National Tsing Hua University, Hsinchu 300, Taiwan
    Insect Biochem Mol Biol 32:669-78. 2002
    ..The metabotropic-subtype and ionotropic AMPA-subtype L-glutamate receptors are unlikely to be present on active CA cells...
  5. ncbi request reprint Glutamate-gated chloride channels inhibit juvenile hormone biosynthesis in the cockroach, Diploptera punctata
    Hsin Ping Liu
    Institute of Biotechnology, National Tsing Hua University, Hsinchu 300, Taiwan, ROC
    Insect Biochem Mol Biol 35:1260-8. 2005
    ..These results indicate a novel function of GluCl channels in the inhibition of JH synthesis that could be a potential pathway for developing a new generation of insecticides...
  6. doi request reprint Visualizing long-term memory formation in two neurons of the Drosophila brain
    Chun Chao Chen
    Institute of Biotechnology and Department of Life Science, National Tsing Hua University, Hsinchu 30013, Taiwan
    Science 335:678-85. 2012
    ..These findings suggest an extra-MB memory circuit in Drosophila: LTM consolidation (MB to DAL), storage (DAL), and retrieval (DAL to MB)...
  7. ncbi request reprint An octopamine-mushroom body circuit modulates the formation of anesthesia-resistant memory in Drosophila
    Chia Lin Wu
    Brain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan Department of Biochemistry and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Tao Yuan 333, Taiwan
    Curr Biol 23:2346-54. 2013
    ..Octopamine (OA), an invertebrate analog of norepinephrine, is involved in appetitive conditioning, but its role in aversive memory remains uncertain...
  8. pmc Drosophila ORB protein in two mushroom body output neurons is necessary for long-term memory formation
    Tsung Pin Pai
    Institute of Biotechnology and Department of Life Science, National Tsing Hua University, Hsinchu 30013, Taiwan
    Proc Natl Acad Sci U S A 110:7898-903. 2013
    ....
  9. pmc Serotonin-mushroom body circuit modulating the formation of anesthesia-resistant memory in Drosophila
    Pei Tseng Lee
    Department of Life Science, National Tsing Hua University, Hsinchu 30013, Taiwan
    Proc Natl Acad Sci U S A 108:13794-9. 2011
    ..Thus, in addition to the Amnesiac peptide required for anesthesia-sensitive memory formation, the two DPM neurons also release 5HT acting on MB neurons for ARM formation...
  10. doi request reprint Heterotypic gap junctions between two neurons in the drosophila brain are critical for memory
    Chia Lin Wu
    Brain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan
    Curr Biol 21:848-54. 2011
    ..Our results reveal that the heterotypic gap junctions between the APL and DPM neurons are an essential part of the MB circuitry for memory formation, potentially constituting a recurrent neural network to stabilize ASM...
  11. ncbi request reprint A map of olfactory representation in the Drosophila mushroom body
    Hui Hao Lin
    Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan, ROC
    Cell 128:1205-17. 2007
    ..Our data suggest that olfactory coding at the AL is decoded in the MB and then transferred via distinct lobes to separate higher brain centers...
  12. doi request reprint Anatomical characterization of thermosensory AC neurons in the adult Drosophila brain
    Hsiang Wen Shih
    Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan
    J Neurogenet 25:1-6. 2011
    ..In conclusion, by morphological analysis of the AC neurons, the authors show a general strategy for predicting brain circuits orchestrating thermosensory behaviors...
  13. pmc Specific requirement of NMDA receptors for long-term memory consolidation in Drosophila ellipsoid body
    Chia Lin Wu
    Institute of Biotechnology and Department of Life Science, National Tsing Hua University, 101, Section 2, Kuang Fu Road, Hsinchu 30013, Taiwan
    Nat Neurosci 10:1578-86. 2007
    ....
  14. ncbi request reprint radish encodes a phospholipase-A2 and defines a neural circuit involved in anesthesia-resistant memory
    Ann Shyn Chiang
    National Tsing Hua University, Institute of Biotechnology, Hsinchu, Taiwan
    Curr Biol 14:263-72. 2004
    ..In contrast, LTM is normal in radish mutants but is disrupted in CREB repressor transgenic flies. To date, nothing is known about the molecular, genetic, or cell biological pathways underlying ARM...
  15. doi request reprint A comprehensive wiring diagram of the protocerebral bridge for visual information processing in the Drosophila brain
    Chih Yung Lin
    Institute of Biotechnology and Department of Life Science, National Tsing Hua University, Hsinchu 30013, Taiwan
    Cell Rep 3:1739-53. 2013
    ..This layout of PB neuronal circuitry may provide guidelines for further investigations on transformation of sensory (e.g., visual) input into locomotor commands in fly brains...
  16. doi request reprint Parallel neural pathways mediate CO2 avoidance responses in Drosophila
    Hui Hao Lin
    Institute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan
    Science 340:1338-41. 2013
    ..Channeling a sensory input into distinct neural pathways allows the perception of an odor to be further modulated by both stimulus intensity and context...
  17. doi request reprint Genes and circuits for olfactory-associated long-term memory in Drosophila
    Chia Lin Wu
    Brain Research Center, Institute of Biotechnology and Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan
    J Neurogenet 22:257-84. 2008
    ..This review will focus on recent discoveries of genes and circuits involved in the formation of olfactory-associated LTM in Drosophila...
  18. pmc Three-dimensional optical method for integrated visualization of mouse islet microstructure and vascular network with subcellular-level resolution
    Ya Yuan Fu
    National Tsing Hua University, Department of Chemical Engineering, Hsinchu, Taiwan
    J Biomed Opt 15:046018. 2010
    ..We thus provide a useful imaging approach to change our conventional planar view of the islet structure into a 3-D panorama for better understanding of the islet physiology...
  19. pmc Auditory circuit in the Drosophila brain
    Jason Sih Yu Lai
    Institute of Biotechnology and Department of Life Science, National Tsing Hua University, Hsinchu 30013, Taiwan
    Proc Natl Acad Sci U S A 109:2607-12. 2012
    ..Our findings delineate an auditory processing pathway involving AMMC→IVLP→VLP in the Drosophila brain...
  20. pmc Optogenetic control of selective neural activity in multiple freely moving Drosophila adults
    Ming Chin Wu
    Department of Power Mechanical Engineering, Institute of Biotechnology, Brain Research Center, Institute of Photonics Technologies, Department of Electrical Engineering, and Institute of NanoEngineering and MicroSystems, National Tsing Hua University, Hsinchu 30013, Taiwan
    Proc Natl Acad Sci U S A 111:5367-72. 2014
    ..Given its capacity for optogenetic manipulation to transiently and independently activate/inactivate selective neurons, ALTOMS offers opportunities to systematically map brain circuits that orchestrate specific Drosophila behaviors. ..
  21. doi request reprint Retention of features on a mapped Drosophila brain surface using a Bézier-tube-based surface model averaging technique
    Guan Yu Chen
    Department of Electrical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan
    IEEE Trans Biomed Eng 59:3314-26. 2012
    ..The comparisons show that the proposed method could generate a more representative average surface than both ISA and VIB methods...
  22. ncbi request reprint A reliable surface reconstruction system in biomedicine
    Ying Cheng Chen
    Department of Electrical Engineering, National Tsing Hua University, Hsinchu 300, Taiwan, ROC
    Comput Methods Programs Biomed 86:141-52. 2007
    ..For degenerate cases and branches, intermediate contours are introduced by means of contour interpolation to enhance the reconstruction results. The surface area and volume are also calculated to facilitate the practical applications...
  23. pmc High-throughput computer method for 3D neuronal structure reconstruction from the image stack of the Drosophila brain and its applications
    Ping Chang Lee
    Department of Computer Science, National Chiao Tung University, Hsinchu, Taiwan
    PLoS Comput Biol 8:e1002658. 2012
    ..This study also shows that further analysis based on the reconstruction results can be performed to gather more information on the neural network...
  24. pmc Pathogenic VCP/TER94 alleles are dominant actives and contribute to neurodegeneration by altering cellular ATP level in a Drosophila IBMPFD model
    Ya Chu Chang
    Institute of Biotechnology, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan
    PLoS Genet 7:e1001288. 2011
    ..Taken together, our analyses have defined the nature of IBMPFD-causing VCP mutations and made an unexpected link between cellular ATP level and IBMPFD pathogenesis...
  25. ncbi request reprint Human connexin30.2/31.3 (GJC3) does not form functional gap junction channels but causes enhanced ATP release in HeLa cells
    Wei Guang Liang
    Department of Biomedical Sciences, Chung Shan Medical University, Taichung, Taiwan, Republic of China
    Cell Biochem Biophys 61:189-97. 2011
    ..2/CX31.3. Based on these findings, we suggest that CX30.2/CX31.3 shares functional properties with pannexin (hemi) channels rather than gap junction channels of other CXs...
  26. ncbi request reprint Cell size control by ovarian factors regulates juvenile hormone synthesis in corpora allata of the cockroach, Diploptera punctata
    Ling Wen Chang
    Department of Life Science, Institute of Biotechnology, National Tsing Hua University, 101, Section 2 Kuang Fu Road, Hsinchu 30043, Taiwan
    Insect Biochem Mol Biol 35:41-50. 2005
    ..As a result of the depletion of cellular machinery, CA glands exhibit long-term depression in JH synthesis...
  27. doi request reprint Template-driven segmentation of confocal microscopy images
    Ying Cheng Chen
    Department of Electrical Engineering, National Tsing Hua University, Hsinchu 300, Taiwan, ROC
    Comput Methods Programs Biomed 89:239-47. 2008
    ..The proposed method increases the accuracy of the snake algorithm because of better initial contours. Besides, it can provide smoother segmented results in 3D visualization...
  28. ncbi request reprint High-resolution confocal imaging and three-dimensional rendering
    Yee Chien Liu
    Department of Life Science, National Tsing Hua University, Hsinchu 30043, Taiwan
    Methods 30:86-93. 2003
    ..Practical uses and limitations of these techniques are discussed...
  29. pmc Loss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau
    Ting Han Wu
    Department of Medical Science, Institute of Systems Neuroscience, National Tsing Hua University, 101, Section 2 Kuang Fu Road, Hsinchu, 30013, Taiwan
    Acta Neuropathol 125:711-25. 2013
    ....
  30. ncbi request reprint Internal representations of smell in the Drosophila brain
    Hui Hao Lin
    Institute of Biotechnology and Department of Life Science, National Tsing Hua University, Hsinchu, 30013, Taiwan, ROC
    J Biomed Sci 14:453-9. 2007
    ..Here, we review current progress in mapping Drosophila olfactory circuits and discuss their relationships with innate olfactory behaviors...
  31. doi request reprint Impaired Cd14 and Cd36 expression, bacterial clearance, and Toll-like receptor 4-Myd88 signaling in caveolin-1-deleted macrophages and mice
    Tsung Huang Tsai
    Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan, Republic of China
    Shock 35:92-9. 2011
    ..Cav-1 may be a therapeutic target in the treatment of sepsis...
  32. pmc Microtome-free 3-dimensional confocal imaging method for visualization of mouse intestine with subcellular-level resolution
    Ya Yuan Fu
    Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan
    Gastroenterology 137:453-65. 2009
    ..We therefore attempted to develop a microtome-free 3-dimensional (3D) confocal imaging method for characterization of mouse intestine...
  33. pmc NMDA receptors mediate olfactory learning and memory in Drosophila
    Shouzhen Xia
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Curr Biol 15:603-15. 2005
    ..Moreover, a role for NMDARs in memory consolidation remains controversial...
  34. ncbi request reprint Neural substrates of memory: from synapse to system
    Josh Dubnau
    Cold Spring Harbor Laboratories, 1 Bungtown Rd, Cold Spring Harbor, New York 11724, USA
    J Neurobiol 54:238-53. 2003
    ..Our objective here is to offer a conceptually unifying perspective and to discuss this perspective in relation to an experiment analysis of memory in Drosophila...
  35. ncbi request reprint Gradients of the Drosophila Chinmo BTB-zinc finger protein govern neuronal temporal identity
    Sijun Zhu
    Department of Cell and Developmental Biology, University of Illinois, Urbana, 61801, USA
    Cell 127:409-22. 2006
    ..Taken together, we suggest that a temporal gradient of Chinmo (Chinmo(high) --> Chinmo(low)) helps specify distinct birth order-dependent cell fates in an extended neuronal lineage...
  36. ncbi request reprint Neural stem and progenitor cells in nestin-GFP transgenic mice
    John L Mignone
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Comp Neurol 469:311-24. 2004
    ....
  37. ncbi request reprint Development of the Drosophila mushroom bodies: elaboration, remodeling and spatial organization of dendrites in the calyx
    Sijun Zhu
    Department of Molecular and Integrative Physiology, University of Illinois, Urbana, IL 61801, USA
    Development 130:2603-10. 2003
    ..Taken together, subregional differences exist in the adult Drosophila MB calyx, where processing and integration of distinct types of sensory information begin...
  38. pmc Imaging of an early memory trace in the Drosophila mushroom body
    Yalin Wang
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 28:4368-76. 2008
    ..Our results suggest that increased Ca(2+) activity in response to a conditioned olfactory stimulus may be a neural correlate of early memory in the MB...