Ann Lii Cheng

Summary

Affiliation: National Taiwan University
Country: Taiwan

Publications

  1. pmc Radiofrequency ablation is superior to ethanol injection in early-stage hepatocellular carcinoma irrespective of tumor size
    Zhong Zhe Lin
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    PLoS ONE 8:e80276. 2013
  2. pmc Efficacy and tolerability of bevacizumab plus capecitabine as first-line therapy in patients with advanced hepatocellular carcinoma
    C H Hsu
    Department of Oncology, National Taiwan University Hospital, 7 Chung Shan South Road, Taipei, Taiwan
    Br J Cancer 102:981-6. 2010
  3. pmc BCL10GFP fusion protein as a substrate for analysis of determinants required for mucosa-associated lymphoid tissue 1 (MALT1)-mediated cleavage
    Shin Yi Jou
    Graduate Institute of Microbiology, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei 10051, Taiwan
    J Biomed Sci 19:85. 2012
  4. ncbi request reprint Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma according to baseline status: subset analyses of the phase III Sorafenib Asia-Pacific trial
    Ann Lii Cheng
    National Taiwan University Hospital, Taipei, Taiwan
    Eur J Cancer 48:1452-65. 2012
  5. doi request reprint Targeting fibroblast growth factor receptor signaling in hepatocellular carcinoma
    Ann Lii Cheng
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Oncology 81:372-80. 2011
  6. pmc Mechanism-related circulating proteins as biomarkers for clinical outcome in patients with unresectable hepatocellular carcinoma receiving sunitinib
    Charles S Harmon
    Pfizer Oncology, La Jolla, CA, USA
    J Transl Med 9:120. 2011
  7. pmc Significance of Aurora B overexpression in hepatocellular carcinoma. Aurora B Overexpression in HCC
    Zhong Zhe Lin
    Departments of Oncology, National Taiwan University Hospital Yun Lin Branch, No 360, Singjhong Village, Huwei Township, Yun Lin County, 63252, Taiwan
    BMC Cancer 10:461. 2010
  8. ncbi request reprint P53 overexpression predicts poor chemosensitivity to high-dose 5-fluorouracil plus leucovorin chemotherapy for stage IV colorectal cancers after palliative bowel resection
    Jin Tung Liang
    Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
    Int J Cancer 97:451-7. 2002
  9. ncbi request reprint Nuclear expression of BCL10 or nuclear factor kappa B helps predict Helicobacter pylori-independent status of low-grade gastric mucosa-associated lymphoid tissue lymphomas with or without t(11;18)(q21;q21)
    Kun Huei Yeh
    Department of Oncology, National Taiwan University Hospital, No 7, Chung Shan S Rd, Taipei, Taiwan
    Blood 106:1037-41. 2005
  10. ncbi request reprint A phase II study of weekly methotrexate, cisplatin, and 24-hour infusion of high-dose 5-fluorouracil and leucovorin (MP-HDFL) in patients with metastatic and recurrent esophageal cancer-improving toxicity profile by infusional schedule and double biochemi
    Chih Hung Hsu
    Department of Oncology, National Taiwan University Hospital, Cancer Research Center, National Taiwan University College of Medicine, Taiwan
    Anticancer Res 22:3621-7. 2002

Collaborators

Detail Information

Publications140 found, 100 shown here

  1. pmc Radiofrequency ablation is superior to ethanol injection in early-stage hepatocellular carcinoma irrespective of tumor size
    Zhong Zhe Lin
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    PLoS ONE 8:e80276. 2013
    ..However, the survival advantage of RFA needs confirmation in daily practice...
  2. pmc Efficacy and tolerability of bevacizumab plus capecitabine as first-line therapy in patients with advanced hepatocellular carcinoma
    C H Hsu
    Department of Oncology, National Taiwan University Hospital, 7 Chung Shan South Road, Taipei, Taiwan
    Br J Cancer 102:981-6. 2010
    ..This multicentre phase II study involving patients from several Asian countries sought to evaluate the safety and efficacy of bevacizumab plus capecitabine in this population...
  3. pmc BCL10GFP fusion protein as a substrate for analysis of determinants required for mucosa-associated lymphoid tissue 1 (MALT1)-mediated cleavage
    Shin Yi Jou
    Graduate Institute of Microbiology, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei 10051, Taiwan
    J Biomed Sci 19:85. 2012
    ..Here, BCL10GFP was constructed and utilized to examine the specificity and domain determinants for MALT1 cleavage in cells...
  4. ncbi request reprint Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma according to baseline status: subset analyses of the phase III Sorafenib Asia-Pacific trial
    Ann Lii Cheng
    National Taiwan University Hospital, Taipei, Taiwan
    Eur J Cancer 48:1452-65. 2012
    ..We performed a series of exploratory subset analyses to determine whether baseline status affected response to sorafenib...
  5. doi request reprint Targeting fibroblast growth factor receptor signaling in hepatocellular carcinoma
    Ann Lii Cheng
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Oncology 81:372-80. 2011
    ..Therefore, this review discusses the molecular implications of FGFR-mediated signaling in HCC and summarizes the clinical evidence for novel FGFR-targeted therapies for HCC currently being studied in clinical trials...
  6. pmc Mechanism-related circulating proteins as biomarkers for clinical outcome in patients with unresectable hepatocellular carcinoma receiving sunitinib
    Charles S Harmon
    Pfizer Oncology, La Jolla, CA, USA
    J Transl Med 9:120. 2011
    ..In a phase II study of sunitinib in advanced HCC, we evaluated the plasma pharmacodynamics of five proteins related to the mechanism of action of sunitinib and explored potential correlations with clinical outcome...
  7. pmc Significance of Aurora B overexpression in hepatocellular carcinoma. Aurora B Overexpression in HCC
    Zhong Zhe Lin
    Departments of Oncology, National Taiwan University Hospital Yun Lin Branch, No 360, Singjhong Village, Huwei Township, Yun Lin County, 63252, Taiwan
    BMC Cancer 10:461. 2010
    ..To investigate the significance of Aurora B expression in hepatocellular carcinoma (HCC)...
  8. ncbi request reprint P53 overexpression predicts poor chemosensitivity to high-dose 5-fluorouracil plus leucovorin chemotherapy for stage IV colorectal cancers after palliative bowel resection
    Jin Tung Liang
    Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
    Int J Cancer 97:451-7. 2002
    ..05). We thus concluded that the poorer prognosis of stage IV colorectal cancers with p53 overexpression was associated with their poorer chemosensitivity rather than the more biologic aggressiveness...
  9. ncbi request reprint Nuclear expression of BCL10 or nuclear factor kappa B helps predict Helicobacter pylori-independent status of low-grade gastric mucosa-associated lymphoid tissue lymphomas with or without t(11;18)(q21;q21)
    Kun Huei Yeh
    Department of Oncology, National Taiwan University Hospital, No 7, Chung Shan S Rd, Taipei, Taiwan
    Blood 106:1037-41. 2005
    ..In summary, nuclear expression of BCL10 or NF-kappaB is predictive of H pylori-independent status of low-grade gastric MALT lymphoma with or without t(11;18)(q21; q21)...
  10. ncbi request reprint A phase II study of weekly methotrexate, cisplatin, and 24-hour infusion of high-dose 5-fluorouracil and leucovorin (MP-HDFL) in patients with metastatic and recurrent esophageal cancer-improving toxicity profile by infusional schedule and double biochemi
    Chih Hung Hsu
    Department of Oncology, National Taiwan University Hospital, Cancer Research Center, National Taiwan University College of Medicine, Taiwan
    Anticancer Res 22:3621-7. 2002
    ....
  11. doi request reprint Induction of Bim expression contributes to the antitumor synergy between sorafenib and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor CI-1040 in hepatocellular carcinoma
    Da Liang Ou
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Clin Cancer Res 15:5820-8. 2009
    ..This study explored whether the efficacy of sorafenib can be improved by adding the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK) inhibitor CI-1040 to vertically block the Raf/MEK/ERK pathway...
  12. ncbi request reprint Inhibitors of epidermoid growth factor receptor suppress cell growth and enhance chemosensitivity of nasopharyngeal cancer cells in vitro
    Chih Hung Hsu
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Oncology 68:538-47. 2005
    ..Although EGFR inhibitors appear to be effective for some head-and-neck cancers, their efficacy in NPC remains unclear...
  13. ncbi request reprint Steroid-free chemotherapy decreases risk of hepatitis B virus (HBV) reactivation in HBV-carriers with lymphoma
    Ann Lii Cheng
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Hepatology 37:1320-8. 2003
    ..However, further research is needed to evaluate whether steroid-free chemotherapy may confer a less satisfactory control of lymphoma...
  14. ncbi request reprint Predictive and prognostic values of tau and ERCC1 in advanced breast cancer patients treated with paclitaxel and cisplatin
    Yu Yun Shao
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Jpn J Clin Oncol 40:286-93. 2010
    ..We studied tau and excision repair cross-complementing 1 expression to evaluate their predictive values in advanced breast carcinoma patients...
  15. ncbi request reprint Phase II trial combining paclitaxel with 24-hour infusion cisplatin for chemotherapy-naïve patients with locally advanced or metastatic breast carcinoma
    Chiun Hsu
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Cancer 95:2044-50. 2002
    ..A synergistic cytotoxicity of these two drugs has been demonstrated in vitro. This study sought to determine the efficacy of combining these two drugs in the treatment of chemotherapy-naïve patients with breast carcinoma...
  16. pmc Potentiating the efficacy of molecular targeted therapy for hepatocellular carcinoma by inhibiting the insulin-like growth factor pathway
    Da Liang Ou
    Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei, Taiwan
    PLoS ONE 8:e66589. 2013
    ..Our data indicate that the apoptosis-potentiating effects of IGFR inhibition for HCC may be drug-specific. Combination therapy of IGFR inhibitors with other MTA may improve the therapeutic efficacy in HCC. ..
  17. ncbi request reprint Phase II study of combining sorafenib with metronomic tegafur/uracil for advanced hepatocellular carcinoma
    Chih Hung Hsu
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    J Hepatol 53:126-31. 2010
    ..This phase II study evaluated the efficacy and safety of combining metronomic tegafur/uracil with sorafenib in patients with advanced HCC...
  18. doi request reprint Combinations of mTORC1 inhibitor RAD001 with gemcitabine and paclitaxel for treating non-Hodgkin lymphoma
    Chun Te Chiang
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Cancer Lett 298:195-203. 2010
    ..In conclusion, synergistic cytotoxicity was observed with RAD001 plus gemcitabine and paclitaxel in NHL cells. Combination therapy with these three drugs should be examined in patients with refractory or relapsed NHL...
  19. ncbi request reprint Glucocorticoids enhance cytotoxicity of cisplatin via suppression of NF-{kappa}B activation in the glucocorticoid receptor-rich human cervical carcinoma cell line SiHa
    Yen Shen Lu
    Department of Oncology, National Taiwan University Hospital, No 7 Chung Shan South Rd, Taipei 10016, Taiwan
    J Endocrinol 188:311-9. 2006
    ..Our data suggest that the specific action of DEX on GR may enhance the cytotoxicity of cisplatin in selected GR-rich cancer cells by suppressing NF-kappaB activation...
  20. ncbi request reprint Gemcitabine plus conventional-dose epirubicin versus gemcitabine plus cisplatin as first-line chemotherapy for stage IIIB/IV non-small cell lung carcinoma--a randomized phase II trial
    Chiun Hsu
    Department of Oncology, National Taiwan University Hospital, 7, Chung Shan South Road, Taipei, 100, Taiwan
    Lung Cancer 62:334-43. 2008
    ....
  21. ncbi request reprint Multifractionated paclitaxel and cisplatin combined with 5-fluorouracil and leucovorin in patients with metastatic or recurrent esophageal squamous cell carcinoma
    Chia Chi Lin
    Department of Oncology, National Taiwan University, Taipei, Taiwan, ROC
    Anticancer Drugs 18:703-8. 2007
    ..3 and 8.9 months (range 1-50+), respectively. Twice-weekly TP-HDFL has the activity and toxicity profile similar to the previously reported same three-drug combination for advanced esophageal cancer...
  22. ncbi request reprint Doxorubicin activates hepatitis B virus (HBV) replication in HBV-harboring hepatoblastoma cells. A possible novel mechanism of HBV reactivation in HBV carriers receiving systemic chemotherapy
    Chih Hung Hsu
    Department of Oncology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
    Anticancer Res 24:3035-40. 2004
    ..We hypothesized that mechanisms other than immunosuppression, such as direct stimulation of HBV replication by anticancer drugs, might be involved in this type of HBV reactivation...
  23. ncbi request reprint Gemcitabine and ifosfamide as a second-line treatment for cisplatin-refractory metastatic urothelial carcinoma: a phase II study
    Chia Chi Lin
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan, ROC
    Anticancer Drugs 18:487-91. 2007
    ..The gemcitabine and ifosfamide regimen has an acceptable toxicity profile, but shows insufficient clinical activity in patients with cisplatin-refractory urothelial carcinoma to warrant further testing...
  24. ncbi request reprint Phase I study of biweekly gemcitabine followed by oxaliplatin and simplified 48-h infusion of fluorouracil/leucovorin for advanced pancreatic cancer
    Hui Ju Ch'ang
    Division of Cancer Research, National Health Research Institutes, Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    J Gastroenterol Hepatol 21:874-9. 2006
    ..To evaluate the feasibility and maximal tolerated dose (MTD) of oxaliplatin of a triplet regimen consisting of gemcitabine, oxaliplatin and infusional fluorouracil (5-FU)/leucovorin (LV) (GOFL) for advanced pancreatic cancer...
  25. ncbi request reprint Weekly cisplatin plus infusional high-dose 5-fluorouracil and leucovorin (P-HDFL) for metastatic urothelial carcinoma: an effective regimen with low toxicity
    Chia Chi Lin
    Department of Oncology, National Taiwan University Hospital, 7 Chung Shan South Road, Taipei 100, Taiwan
    Cancer 106:1269-75. 2006
    ..The authors developed a regimen that was designed to maintain efficacy, while reducing toxicities...
  26. ncbi request reprint Expression of CD86 and increased infiltration of NK cells are associated with Helicobacter pylori-dependent state of early stage high-grade gastric MALT lymphoma
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital, No 7, Chung Shan South Road, Taipei, Taiwan, China
    World J Gastroenterol 11:4357-62. 2005
    ..To examine whether the expression of co-stimulatory marker CD86 (B7.2) and the infiltration of CD56 (+) natural killer (NK) cells can be useful markers to predict H pylori-dependent status of high-grade gastric MALT lymphoma...
  27. ncbi request reprint Phase II study of weekly paclitaxel and 24-hour infusion of high-dose 5-fluorouracil and leucovorin in the treatment of recurrent or metastatic gastric cancer
    Kun Huei Yeh
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Oncology 69:88-95. 2005
    ..This paclitaxel-HDFL regimen is effective and well tolerated in the treatment of advanced gastric cancer...
  28. ncbi request reprint A phase II trial of weekly paclitaxel and high-dose 5-fluorouracil plus leucovorin in patients with chemotherapy-pretreated metastatic breast cancer
    Chia Chi Lin
    Departments of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Anticancer Res 27:641-5. 2007
    ..Weekly paclitaxel and infusional high-dose 5-fluorouracil/leucovorin (HDFL) are both effective regimens for metastatic breast cancer (MBC) patients...
  29. ncbi request reprint Promoter polymorphisms of tumor necrosis factor-alpha are associated with risk of gastric mucosa-associated lymphoid tissue lymphoma
    Ming Shiang Wu
    Division of Gastroenterology, Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
    Int J Cancer 110:695-700. 2004
    ..The differences in genetic background as well as divergent clinicopathologic features between GAC and maltoma support the notion that fundamental mechanistic differences exist in these 2 well-defined H. pylori-related malignancies...
  30. doi request reprint Clinical significance of ESR1 gene copy number changes in breast cancer as measured by fluorescence in situ hybridisation
    Ching Hung Lin
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    J Clin Pathol 66:140-5. 2013
    ..However, the clinical significance of the ESR1 gene copy number change for breast cancer has not been clarified...
  31. ncbi request reprint HER-2/neu overexpression is rare in hepatocellular carcinoma and not predictive of anti-HER-2/neu regulation of cell growth and chemosensitivity
    Chiun Hsu
    Department of Oncology, National Taiwan University Hospital, Taipei
    Cancer 94:415-20. 2002
    ..However, whether HER-2/neu overexpression plays a similar role in hepatocellular carcinoma (HCC) has not been determined...
  32. doi request reprint Dynamic contrast-enhanced magnetic resonance imaging biomarkers predict survival and response in hepatocellular carcinoma patients treated with sorafenib and metronomic tegafur/uracil
    Chao Yu Hsu
    Department of Radiology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Hepatol 55:858-65. 2011
    ..This study evaluated the correlation of vascular response measured by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and the clinical outcome...
  33. ncbi request reprint Phase II study of combination doxorubicin, interferon-alpha, and high-dose tamoxifen treatment for advanced hepatocellular carcinoma
    Yen Shen Lu
    Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Hepatogastroenterology 51:815-9. 2004
    ..In this study, we sought to clarify if the addition of Interferon-alpha2b to HTD regimen could further improve the control of advanced hepatocellular carcinoma...
  34. ncbi request reprint Induction of DNA damage-inducible gene GADD45beta contributes to sorafenib-induced apoptosis in hepatocellular carcinoma cells
    Da Liang Ou
    National Center of Excellence for Clinical Trial and Research, Department of Oncology, National Taiwan University Hospital, Graduate Institute of Toxicology, Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Cancer Res 70:9309-18. 2010
    ..Together, our findings suggest that GADD45β induction contributes to sorafenib-induced apoptosis in HCC cells, prompting further studies to validate its potential value in predicting sorafenib efficacy...
  35. doi request reprint Synergistic interactions between sorafenib and bortezomib in hepatocellular carcinoma involve PP2A-dependent Akt inactivation
    Kuen Feng Chen
    Department of Medical Research, National Taiwan University Hospital, Taiwan
    J Hepatol 52:88-95. 2010
    ..Previously we reported that Akt inactivation determines the sensitivity of hepatocellular carcinoma (HCC) cells to bortezomib. Here we report that combined treatment with sorafenib and bortezomib shows synergistic effects in HCC...
  36. ncbi request reprint Nuclear expression of BCL10 or nuclear factor kappa B predicts Helicobacter pylori-independent status of early-stage, high-grade gastric mucosa-associated lymphoid tissue lymphomas
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medidine, Taipei, Taiwan
    J Clin Oncol 22:3491-7. 2004
    ..This study examined whether nuclear expression of BCL10 or nuclear factor kappa B (NF-kappaB) is useful in predicting H. pylori-independent status in patients with stage IE high-grade gastric MALT lymphomas...
  37. ncbi request reprint Increase of the resistance of human cervical carcinoma cells to cisplatin by inhibition of the MEK to ERK signaling pathway partly via enhancement of anticancer drug-induced NF kappa B activation
    Pei Yen Yeh
    Cancer Research Center, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC
    Biochem Pharmacol 63:1423-30. 2002
    ..The mechanism responsible for the discrepant effect of PD98059 on NF kappa B activation and hence the chemosensitivity of SiHa cells towards cisplatin and doxorubicin remains to be investigated...
  38. ncbi request reprint Involvement of nuclear transcription factor-kappa B in low-dose doxorubicin-induced drug resistance of cervical carcinoma cells
    Pei Yen Yeh
    Cancer Research Center, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC
    Biochem Pharmacol 66:25-33. 2003
    ..These results suggest that even a transient exposure to a small dose of anticancer drugs may induce drug resistance in some cancer cells via upregulation of NF-kappa B activity...
  39. ncbi request reprint Dramatic synergistic anticancer effect of clinically achievable doses of lovastatin and troglitazone
    Chih Jung Yao
    Division of Cancer Research, National Health Research Institutes, Taipei, Taiwan
    Int J Cancer 118:773-9. 2006
    ..With this dramatic combination effect of lovastatin and troglitazone, a promising regimen of cancer therapy may be materialized in the future...
  40. ncbi request reprint Prognostic value of multidrug resistance 1, glutathione-S-transferase-pi and p53 in advanced nasopharyngeal carcinoma treated with systemic chemotherapy
    Chih Hung Hsu
    Department of Oncology, National Taiwan University Hospital, Taipei, ROC
    Oncology 62:305-12. 2002
    ..In this study, we sought to clarify the role of classical drug resistance markers in predicting the chemosensitivity and the prognosis of patients with advanced NPC...
  41. pmc Cancerous inhibitor of protein phosphatase 2A mediates bortezomib-induced autophagy in hepatocellular carcinoma independent of proteasome
    Hui Chuan Yu
    Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan
    PLoS ONE 8:e55705. 2013
    ..In conclusion, bortezomib induces autophagy in HCC through a CIP2A-PP2A-Akt-4EBP1 pathway...
  42. ncbi request reprint Arsenic trioxide in patients with hepatocellular carcinoma: a phase II trial
    Chia Chi Lin
    Department of Oncology, National Taiwan University Hospital, 7 Chung Shan South Road, Taipei, 100 Taiwan
    Invest New Drugs 25:77-84. 2007
    ..Arsenic trioxide induces growth inhibition and apoptosis in human hepatocellular carcinoma (HCC) cell lines. A phase II trial was conducted to evaluate the efficacy and toxicity of single-agent arsenic trioxide in patients with HCC...
  43. doi request reprint Dovitinib induces apoptosis and overcomes sorafenib resistance in hepatocellular carcinoma through SHP-1-mediated inhibition of STAT3
    Wei Tien Tai
    Department of Medical Research, National Taiwan University Hospital, Chung Shan S Rd, Taipei 100, Taiwan
    Mol Cancer Ther 11:452-63. 2012
    ..In conclusion, dovitinib induces significant apoptosis in HCC cells and sorafenib-resistant cells via SHP-1-mediated inhibition of STAT3...
  44. pmc Sorafenib and its derivative SC-49 sensitize hepatocellular carcinoma cells to CS-1008, a humanized anti-TNFRSF10B (DR5) antibody
    Kuen Feng Chen
    Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan
    Br J Pharmacol 168:658-72. 2013
    ..Here, we report that sorafenib and SC-49 sensitize HCC cells to CS-1008, a novel anti-human death receptor 5 (TNFRSF10B) antibody...
  45. ncbi request reprint Prognostic factors for metastatic urothelial carcinoma treated with cisplatin and 5-fluorouracil-based regimens
    Chia Chi Lin
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Urology 69:479-84. 2007
    ..The present study sought to identify factors that predict for patient survival after treatment with P-HDFL-based regimens...
  46. ncbi request reprint Outcome of advanced nonsmall cell lung cancer patients receiving gemcitabine and weekly paclitaxel as first-line treatment
    Zhong Zhe Lin
    Department of Oncology, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
    Lung Cancer 60:215-21. 2008
    ..Combinations of gemcitabine and paclitaxel with various doses and schedules were shown to be effective treatment for these patients. Nevertheless, the survival outcome of these patients is not clear...
  47. ncbi request reprint A pathway for tumor necrosis factor-alpha-induced Bcl10 nuclear translocation. Bcl10 is up-regulated by NF-kappaB and phosphorylated by Akt1 and then complexes with Bcl3 to enter the nucleus
    Pei Yen Yeh
    Cancer Research Center, College of Medicine, National Taiwan University, Taipei
    J Biol Chem 281:167-75. 2006
    ..Either inhibition of Akt1 or depletion of Bcl3 blocks Bcl10 nuclear translocation. In summary, these findings characterize a molecular linkage that directs Bcl10 nuclear translocation in response to TNFalpha treatment...
  48. ncbi request reprint Long-term results of anti-Helicobacter pylori therapy in early-stage gastric high-grade transformed MALT lymphoma
    Li Tzong Chen
    Division of Cancer Research, National Health Research Institutes, Taipei, Taiwan
    J Natl Cancer Inst 97:1345-53. 2005
    ..Several independent clinical studies have reported that Helicobacter pylori eradication therapy could achieve complete remission in some patients with H. pylori-positive early-stage gastric mucosa-associated lymphoid tissue (MALT) lymphoma...
  49. ncbi request reprint Prognostic factors of metastatic or recurrent esophageal squamous cell carcinoma in patients receiving three-drug combination chemotherapy
    Wei Wu Chen
    Department of Oncology, National Taiwan University Hospital, 7 Chung Shan South Road, Taipei 10002, Taiwan, R O C
    Anticancer Res 33:4123-8. 2013
    ..The study sought to identify factors associated with outcomes of metastatic ESCC in patients who were treated with three-drug combinations...
  50. doi request reprint High circulating endothelial progenitor levels associated with poor survival of advanced hepatocellular carcinoma patients receiving sorafenib combined with metronomic chemotherapy
    Yu Yun Shao
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan, ROC
    Oncology 81:98-103. 2011
    ..We examined whether circulating endothelial progenitor (CEP) and circulating endothelial cell (CEC) levels had associations with the survival of patients who received antiangiogenic therapy for advanced hepatocellular carcinoma (HCC)...
  51. ncbi request reprint Gefitinib reverses chemotherapy resistance in gefitinib-insensitive multidrug resistant cancer cells expressing ATP-binding cassette family protein
    Chih Hsin Yang
    Department of Oncology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    Cancer Res 65:6943-9. 2005
    ..Our results suggest that the interaction of gefitinib and chemotherapeutic agents does occur in cells expressing one of these two proteins...
  52. ncbi request reprint Low-dose thalidomide treatment for advanced hepatocellular carcinoma
    Chiun Hsu
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan, ROC
    Oncology 65:242-9. 2003
    ..To analyze the efficacy of oral thalidomide in the treatment of advanced hepatocellular carcinoma (HCC)...
  53. doi request reprint Efficacy, safety, and potential biomarkers of thalidomide plus metronomic chemotherapy for advanced hepatocellular carcinoma
    Yu Yun Shao
    Department of Oncology, National Taiwan University Hospital, Taipei City, Taiwan, ROC
    Oncology 82:59-66. 2012
    ..We initiated a phase II study to determine the safety and efficacy of adding metronomic chemotherapy to thalidomide as first-line therapy...
  54. doi request reprint Lack of compensatory pAKT activation and eIF4E phosphorylation of lymphoma cells towards mTOR inhibitor, RAD001
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital, Taiwan
    Eur J Cancer 47:1244-57. 2011
    ..These findings indicate that the basis for enhanced activity of mTOR inhibitors in NHL may be the lack of compensatory activation of AKT and eIF4E phosphorylation in lymphoma cells...
  55. doi request reprint Prognostic molecular markers in women aged 35 years or younger with breast cancer: is there a difference from the older patients?
    Ching Hung Lin
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    J Clin Pathol 64:781-7. 2011
    ..Women aged ≤ 35 years with breast cancer have a poor prognosis, but their prognostic factors have not been clearly defined...
  56. ncbi request reprint Effects of glucocorticoids on the growth and chemosensitivity of carcinoma cells are heterogeneous and require high concentration of functional glucocorticoid receptors
    Yen Shen Lu
    Department of Oncology, National Taiwan University Hospital, Taipei 10016, Taiwan, China
    World J Gastroenterol 11:6373-80. 2005
    ..To determine how glucocorticoids (GCs) may affect the growth and chemosensitivity of common carcinoma cells...
  57. ncbi request reprint Differential clinical characteristics, treatment response and prognosis of locally advanced adenocarcinoma/adenosquamous carcinoma and squamous cell carcinoma of cervix treated with definitive radiotherapy
    Jenny Ling Yu Chen
    Department of Oncology, National Taiwan University Hospital Yun Lin Branch, Yun Lin, Taiwan
    Acta Obstet Gynecol Scand 93:661-8. 2014
    ..To compare tumor characteristics and clinical outcome of patients with cervical locally advanced adenocarcinoma (AC)/adenosquamous carcinoma (ASC) and squamous cell carcinoma (SCC)...
  58. pmc Diabetes mellitus is associated with increased mortality in patients receiving curative therapy for hepatocellular carcinoma
    Wen Yi Shau
    Division of Health Technology Assessment, Center for Drug Evaluation, Taipei, Taiwan
    Oncologist 17:856-62. 2012
    ..Diabetes mellitus (DM) is closely associated with hepatocarcinogenesis. This study explores the prognostic impact of DM in patients who received curative therapy for localized hepatocellular carcinoma (HCC)...
  59. doi request reprint Helicobacter pylori eradication therapy is effective in the treatment of early-stage H pylori-positive gastric diffuse large B-cell lymphomas
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Blood 119:4838-44; quiz 5057. 2012
    ..Similar to DLBCL(MALT), a substantial portion of early-stage HP-positive gastric pure (de novo) DLBCLs remains HP-dependent and responds to antibiotic treatment. Prospective studies to validate the findings are warranted...
  60. doi request reprint Phosphorylated insulin-like growth factor-1 receptor (pIGF1R) is a poor prognostic factor in brain metastases from lung adenocarcinomas
    Pei Fang Wu
    National Center of Excellence for Clinical Trial and Research, National Taiwan University Hospital, No 7, Chung Shan South Rd, Taipei, 100, Taiwan
    J Neurooncol 115:61-70. 2013
    ..Our study results showed that high membranous/cytoplasmic pIGF1R expression in brain metastases was a poor prognostic factor, more significantly in patients with EGFR mutations than in those with wild-type EGFRs. ..
  61. doi request reprint Sorafenib enhances radiation-induced apoptosis in hepatocellular carcinoma by inhibiting STAT3
    Chao Yuan Huang
    Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Int J Radiat Oncol Biol Phys 86:456-62. 2013
    ..Lack of efficient therapy for advanced HCC is a pressing problem worldwide. This study aimed to determine the efficacy and mechanism of combined sorafenib and radiation therapy treatment for HCC...
  62. doi request reprint Translocation of Helicobacter pylori CagA into Human B lymphocytes, the origin of mucosa-associated lymphoid tissue lymphoma
    Wei Cheng Lin
    Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Cancer Res 70:5740-8. 2010
    ..pylori and is associated with the development of MALT lymphomas...
  63. ncbi request reprint Phase II trial of weekly paclitaxel, cisplatin plus infusional high dose 5-fluorouracil and leucovorin for metastatic urothelial carcinoma
    Chia Chi Lin
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    J Urol 177:84-9; discussion 89. 2007
    ..We tested the efficacy and toxicity of adding paclitaxel to that regimen...
  64. ncbi request reprint Effect of thalidomide in hepatocellular carcinoma: assessment with power doppler US and analysis of circulating angiogenic factors
    Chiun Hsu
    Department of Oncology, National Taiwan University Hospital, 7 Chung Shan South Road, Taipei, Taiwan 100
    Radiology 235:509-16. 2005
    ..To prospectively evaluate the feasibility of using power Doppler ultrasonography (US) and measurement of circulating angiogenic factors to assess the antiangiogenic effect of thalidomide in hepatocellular carcinoma...
  65. doi request reprint Signal transducer and activator of transcription 3 is a major kinase-independent target of sorafenib in hepatocellular carcinoma
    Wei Tien Tai
    National Center of Excellence for Clinical Trial and Research, National Taiwan University Hospital, Taipei, Taiwan
    J Hepatol 55:1041-8. 2011
    ..Here, we report that sorafenib inhibits HCC via a kinase-independent mechanism: SHP-1 dependent STAT3 inactivation...
  66. ncbi request reprint Phase I-II trial of weekly gemcitabine plus high-dose 5-fluorouracil and leucovorin in advanced pancreatic cancer
    Her Shyong Shiah
    Division of Cancer Research, National Health Research Institutes, Veterans General Hospital, Taipei, Taiwan
    J Gastroenterol Hepatol 21:531-6. 2006
    ..The purpose of the present study was to determine the maximum tolerated dose (MTD) of 5-FU and the efficacy and toxicity profile of weekly gemcitabine plus infusional 5-FU/leucovorin in advanced pancreatic cancer...
  67. doi request reprint Activation of phosphatidylinositol 3-kinase/Akt signaling pathway mediates acquired resistance to sorafenib in hepatocellular carcinoma cells
    Kuen Feng Chen
    Department of Medical Research, National Taiwan University Hospital, No 7, Chung Shan S Rd, Taipei, Taiwan
    J Pharmacol Exp Ther 337:155-61. 2011
    ..In conclusion, activation of PI3K/Akt signaling pathway mediates acquired resistance to sorafenib in HCC, and the combination of sorafenib and MK-2206, an Akt inhibitor, overcomes the resistance at clinical achievable concentrations...
  68. doi request reprint Sorafenib overcomes TRAIL resistance of hepatocellular carcinoma cells through the inhibition of STAT3
    Kuen Feng Chen
    Department of Medical Research, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Clin Cancer Res 16:5189-99. 2010
    ..However, many hepatocellular carcinoma (HCC) cells show resistance to TRAIL-induced apoptosis. Here, we report that sorafenib improves the antitumor effect of TRAIL-related agents in resistant HCC...
  69. ncbi request reprint Pre-clinical and early-phase clinical studies of curcumin as chemopreventive agent for endemic cancers in Taiwan
    Chih Hung Hsu
    Department of Oncology, National Taiwan University Hospital, Taipei
    Gan To Kagaku Ryoho 29:194-200. 2002
  70. ncbi request reprint Induction of Epstein-Barr virus (EBV) reactivation in Raji cells by doxorubicin and cisplatin
    Chih Hung Hsu
    Department of Oncology, National Taiwan University Hospital, Cancer Research Center, National Taiwan University College of Medicine, Taipei, Taiwan
    Anticancer Res 22:4065-71. 2002
    ..EBV reactivation has been clinically observed in patients receiving systemic chemotherapy. This study sought in vitro evidence to suggest whether anticancer drugs may directly contribute to the EBV reactivation...
  71. doi request reprint Specific EGFR mutations predict treatment outcome of stage IIIB/IV patients with chemotherapy-naive non-small-cell lung cancer receiving first-line gefitinib monotherapy
    Chih Hsin Yang
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    J Clin Oncol 26:2745-53. 2008
    ..To explore predictive factors for time to treatment failure (TTF) in chemotherapy-naive non-small-cell lung cancer (NSCLC) patients receiving gefitinib treatment...
  72. doi request reprint Serum insulin-like growth factor-1 levels predict outcomes of patients with advanced hepatocellular carcinoma receiving antiangiogenic therapy
    Yu Yun Shao
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Clin Cancer Res 18:3992-7. 2012
    ..We evaluated whether IGF-1 levels were associated with the outcomes of patients with advanced HCC treated with systemic antiangiogenic therapy...
  73. doi request reprint Inhibition of CIP2A determines erlotinib-induced apoptosis in hepatocellular carcinoma
    Hui Chuan Yu
    Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan
    Biochem Pharmacol 85:356-66. 2013
    ..In conclusion, inhibition of CIP2A determines the effects of erlotinib on apoptosis in HCC. CIP2A may be useful as a therapeutic biomarker for predicting clinical response to erlotinib in HCC treatment...
  74. doi request reprint Inferior survival of advanced pancreatic cancer patients who received gemcitabine-based chemotherapy but did not participate in clinical trials
    Shih Hung Yang
    Department of Oncology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan, ROC
    Oncology 81:143-50. 2011
    ..Advanced pancreatic cancer, even when treated, is highly lethal. The best choice of gemcitabine-based therapy and the prognostic factors affecting the success of treatment remain uncertain...
  75. ncbi request reprint Survival outcome of inoperable non-small cell lung cancer patients receiving conventional dose epirubicin and Paclitaxel as first-line treatment
    Chih Hsin Yang
    Department of Oncology and Cancer Research Center, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Oncology 68:350-5. 2005
    ..A phase II study was designed to test the effectiveness of combining paclitaxel with a conventional dose of epirubicin in inoperable NSCLC patients...
  76. ncbi request reprint Survival of stage IIIB/IV non-small cell lung cancer patients who received chemotherapy but did not participate in clinical trials
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, No 7, Chung Shan South Rd, Taipei, Taiwan
    Lung Cancer 48:275-80. 2005
    ..36; progression-free survival: P=0.57). Our data suggest that the survival of patients who received chemotherapy but did not participate in clinical trials was similar to patients participated in clinical trials...
  77. pmc Dynamics of circulating endothelial cells and endothelial progenitor cells in breast cancer patients receiving cytotoxic chemotherapy
    Yu Hsuan Kuo
    Department of Oncology, Chi Mei Hospital, Tainan, Taiwan
    BMC Cancer 12:620. 2012
    ..We studied their dynamic change during consecutive cycles of chemotherapy...
  78. ncbi request reprint Geographic difference in safety and efficacy of systemicchemotherapy for advanced gastric or gastroesophagealcarcinoma: a meta-analysis and meta-regression
    Chiun Hsu
    Department of Oncology, National Taiwan University Hospital, 7 Chung Shan South Road, Zhongzheng District, Taipei 100, Taiwan
    Gastric Cancer 15:265-80. 2012
    ..This study aimed to explore predictors of safety and efficacy of chemotherapy for patients with advanced or metastatic gastric cancer...
  79. doi request reprint Dovitinib sensitizes hepatocellular carcinoma cells to TRAIL and tigatuzumab, a novel anti-DR5 antibody, through SHP-1-dependent inhibition of STAT3
    Kuen Feng Chen
    Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan
    Biochem Pharmacol 83:769-77. 2012
    ..In conclusion, dovitinib sensitizes resistant HCC cells to TRAIL- and tigatuzumab-induced apoptosis through a novel machinery: SHP-1 dependent STAT3 inhibition...
  80. ncbi request reprint Glucocorticoid receptor expression in advanced non-small cell lung cancer: clinicopathological correlation and in vitro effect of glucocorticoid on cell growth and chemosensitivity
    Yen Shen Lu
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Lung Cancer 53:303-10. 2006
    ..The effect of GC treatment on the chemosensitivity in NSCLC patients remains to be established...
  81. ncbi request reprint Somatic mutations in epidermal growth factor receptor underlying complete responsiveness to gefitinib in a Taiwanese female patient with metastatic adenocarcinoma of lung
    Kun Huei Yeh
    Division of Oncology and Hematology, Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan
    Anticancer Drugs 16:739-42. 2005
    ..Our patient supports the proposition that somatic mutation L858R in exon 21 of the EGFR gene accounts for complete responsiveness to gefitinib in a Taiwanese female patient with metastatic adenocarcinoma of lung...
  82. doi request reprint Establishment of a novel MALT lymphoma cell line, ma-1, from a patient with t(14;18)(q32;q21)-positive Helicobacter pylori-independent gastric MALT lymphoma
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei
    Genes Chromosomes Cancer 50:908-21. 2011
    ....
  83. ncbi request reprint High-dose tamoxifen modulates drug resistance to doxorubicin, dacarbazine and ifosfamide in metastatic uterine leiomyosarcoma
    Kun Huei Yeh
    Division of Oncology, Department of Internal Medicine, Far Eastern Memorial Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
    Anticancer Res 23:5133-7. 2003
    ..The excellent tumor response by simple addition of high-dose tamoxifen into a previously inactive ADI regimen advocates further investigation for the development of chemotherapy in metastatic uterine leiomyosarcoma...
  84. doi request reprint Long-term follow-up of gastrectomized patients with mucosa-associated lymphoid tissue lymphoma: need for a revisit of surgical treatment
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
    Ann Surg 247:265-9. 2008
    ....
  85. ncbi request reprint Vinorelbine plus 24-hour infusion of high-dose 5-fluorouracil and leucovorin as effective palliative chemotherapy for breast cancer patients with acute disseminated intravascular coagulation
    Po Han Lin
    Department of Oncology, National Taiwan University Hospital, No 7, Chung Shan South Road, Taipei 100, Taiwan, R O C
    Anticancer Res 30:3087-91. 2010
    ..Acute DIC in breast cancer is a rare condition and is not well studied. Therefore, we designed this study to determine the clinical characteristics and effective treatment for breast cancer patients with acute DIC...
  86. doi request reprint Hospital volume of percutaneous radiofrequency ablation is closely associated with treatment outcomes for patients with hepatocellular carcinoma
    Li Chun Lu
    Department of Oncology, National Taiwan University Hospital, Yun Lin branch, Yunlin, Taiwan
    Cancer 119:1210-6. 2013
    ..In this study, the authors explored the influence of hospital radiofrequency ablation (RFA) volume on the prognosis of patients who received RFA for hepatocellular carcinoma (HCC)...
  87. pmc KRAS mutation is a predictor of oxaliplatin sensitivity in colon cancer cells
    Yu lin Lin
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    PLoS ONE 7:e50701. 2012
    ..Overall, our findings suggest that KRAS mutation is a predictor of oxaliplatin sensitivity in colon cancer cells by the mechanism of ERCC1 downregulation...
  88. pmc Factors impacting prognosis prediction in BCLC stage C and Child-Pugh class A hepatocellular carcinoma patients in prospective clinical trials of systemic therapy
    Zhong Zhe Lin
    Department of Oncology, National Taiwan University, Taipei, Taiwan
    Oncologist 17:970-7. 2012
    ..The purpose of this study was to determine the prognostic significance of clinical factors and staging systems for survival of hepatocellular carcinoma (HCC) patients who are candidates for therapeutic clinical trials...
  89. ncbi request reprint Impact of baseline hepatitis B viral DNA levels on survival of patients with advanced hepatocellular carcinoma
    Yu Yun Shao
    Department of Oncology, National Taiwan University Hospital, 7 Chung Shan South Road, Taipei 10002, Taiwan, ROC
    Anticancer Res 31:4007-11. 2011
    ..Hepatitis B virus (HBV) infection is one of the main etiologies of hepatocellular carcinoma (HCC). We explored the impact of HBV DNA levels on the prognosis of patients with advanced HCC...
  90. ncbi request reprint Weekly paclitaxel and high-dose 5-fluorouracil plus leucovorin in hormone-refractory prostate cancer: in vitro combined effects and a phase II trial
    Chia Chi Lin
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Urol Oncol 25:207-13. 2007
    ..In vitro data suggest that the combined cytotoxicity may be sequence dependent. Thus, we explored the combined effects of the 2 agents, both in vitro and in vivo...
  91. doi request reprint Targeting epidermal growth factor receptor/human epidermal growth factor receptor 2 signalling pathway by a dual receptor tyrosine kinase inhibitor afatinib for radiosensitisation in murine bladder carcinoma
    Yu Chieh Tsai
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Eur J Cancer 49:1458-66. 2013
    ..Afatinib has therapeutic value as a radiosensitiser of murine bladder cancer cells. The synergism between afatinib and radiation likely enhances DNA damage, leading to increased cell apoptosis...
  92. ncbi request reprint CIP2A-mediated Akt activation plays a role in bortezomib-induced apoptosis in head and neck squamous cell carcinoma cells
    Yu Chin Lin
    Department of Oncology, National Taiwan University Hospital, No 7 Chung Shan S Rd, Taipei, Taiwan
    Oral Oncol 48:585-93. 2012
    ..Furthermore, xenograft model showed that bortezomib down-regulated CIP2A and p-Akt in SAS tumor cells. CIP2A is demonstrated to be a new therapeutic target of bortezomib in HNSCC...
  93. ncbi request reprint Inhibition of Bcl-2 improves effect of LCL161, a SMAC mimetic, in hepatocellular carcinoma cells
    Kuen Feng Chen
    Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan
    Biochem Pharmacol 84:268-77. 2012
    ..In conclusion, targeting Bcl-2 with SC-2001 overcomes drug resistance to LCL161 in HCC cells thus suggesting a new anti-IAP combinational therapy for HCC...
  94. ncbi request reprint Bortezomib enhances radiation-induced apoptosis in solid tumors by inhibiting CIP2A
    Chao Yuan Huang
    Department of Oncology, National Taiwan University Hospital, Taipei 10002, Taiwan
    Cancer Lett 317:9-15. 2012
    ..Finally, our in vivo data showed that bortezomib and radiation combination treatment decreased tumor growth significantly. Thus, bortezomib sensitized solid tumor cells to radiation through the inhibition of CIP2A...
  95. doi request reprint O(6)-Methylguanine-DNA methyltransferase expression and prognostic value in brain metastases of lung cancers
    Pei Fang Wu
    Graduate Institute of Clinical Medicine, National Taiwan University, College of Medicine, Taipei, Taiwan
    Lung Cancer 68:484-90. 2010
    ..5 versus 3.5 months, P<0.001). In conclusion, MGMT expression was enhanced in brain metastases as compared with the primary lung cancers. MGMT expression in brain metastases was significantly correlated with better survival...
  96. pmc Fractionated evaluation of immunohistochemical hormone receptor expression enhances prognostic prediction in breast cancer patients treated with tamoxifen as adjuvant therapy
    Ching Hung Lin
    Department of Oncology, National Taiwan University Hospital, Taiwan, Taipei 10016
    J Zhejiang Univ Sci B 11:1-9. 2010
    ..To compare the prognostic prediction between dichotomized and fractionated evaluations of hormone receptor expressions...
  97. ncbi request reprint Synergistic effect of radiation and interleukin-6 on hepatitis B virus reactivation in liver through STAT3 signaling pathway
    Chia Hung Chou
    Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan Cancer Research Center, National Taiwan University College of Medicine, Taipei, Taiwan Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Int J Radiat Oncol Biol Phys 75:1545-52. 2009
    ..Our previous in vitro culture study identified interleukin-6 (IL-6) as the main bystander mediator of RT-induced HBV replication. We attempted to examine the molecular mechanism in HBV-transgenic mice...
  98. doi request reprint Early alpha-fetoprotein response predicts treatment efficacy of antiangiogenic systemic therapy in patients with advanced hepatocellular carcinoma
    Yu Yun Shao
    Department of Oncology, National Taiwan University Hospital, and Cancer Research Center, National Taiwan University School of Medicine, Taipei, Taiwan
    Cancer 116:4590-6. 2010
    ..In this study, the authors investigated levels of alpha-fetoprotein (AFP) as a potential biomarker for treatment efficacy of antiangiogenic therapy...
  99. ncbi request reprint High-frequency microsatellite instability predicts better chemosensitivity to high-dose 5-fluorouracil plus leucovorin chemotherapy for stage IV sporadic colorectal cancer after palliative bowel resection
    Jin Tung Liang
    Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
    Int J Cancer 101:519-25. 2002
    ..05). Thus, the better prognosis of stage IV sporadic colorectal cancers with MSI-H may be associated with better chemosensitivity, rather than lower aggressiveness in biologic behavior...
  100. doi request reprint Phase I, pharmacokinetic, and bone marrow drug-level studies of tri-monthly 48-h infusion of high-dose 5-fluorouracil and leucovorin in patients with metastatic colorectal cancers
    Yunn Fang Ho
    Graduate Institute of Clinical Pharmacy, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China
    Anticancer Drugs 22:290-8. 2011
    ..63-fold concentration gradient between plasma and BM compartments at steady state. The recommended 5-FU dose for use in future trials was 3500 mg/m²/48 h/week, with a fixed dose of LV at 300 mg/m²/48 h/week...
  101. doi request reprint E2A-positive gastric MALT lymphoma has weaker plasmacytoid infiltrates and stronger expression of the memory B-cell-associated miR-223: possible correlation with stage and treatment response
    Ting Yun Liu
    Department of Pathology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan, ROC
    Mod Pathol 23:1507-17. 2010
    ..A prospective study would be necessary to verify the association between E2A expression and a poor response to Helicobacter eradication therapy...