Research Topics
Genomes and Genes | Yee Chun ChenSummaryAffiliation: National Taiwan University Country: Taiwan Publications
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Publications
Treatment outcomes in patients receiving conventional amphotericin B therapy: a prospective multicentre study in TaiwanChien Yuan Chen
Department of Internal Medicine, National Taiwan University Hospital, 7 Chung Shan South Road, Taipei, Taiwan 100
J Antimicrob Chemother 57:1181-8. 2006..To evaluate treatment outcomes and healthcare resource use with conventional amphotericin B therapy for invasive fungal infections (IFIs)...- Adult methicillin-resistant Staphylococcus aureus bacteremia in Taiwan: clinical significance of non-multi-resistant antibiogram and Panton-Valentine leukocidin geneJiun Ling Wang
Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan
Diagn Microbiol Infect Dis 59:365-71. 2007..Most PVL-positive MRSA isolates belonged to SCCmec V. PVL-positive CA-MRSA isolates could cause more deep-seated infections in patients presented with non-multi-resistant MRSA bacteremia... 
Influence of genospecies of Acinetobacter baumannii complex on clinical outcomes of patients with acinetobacter bacteremiaYu Chung Chuang
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
Clin Infect Dis 52:352-60. 2011..baumannii (genospecies 2) from other genospecies. Genospecies typing offers a potential tool to determine whether there are major differences in pathogenicity among the genospecies...- Comparison of both clinical features and mortality risk associated with bacteremia due to community-acquired methicillin-resistant Staphylococcus aureus and methicillin-susceptible S. aureusJiun Ling Wang
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
Clin Infect Dis 46:799-806. 2008..No literature has been published on the clinical features and outcomes of adult patients with CA-MRSA bacteremia in comparison with patients with community-acquired methicillin-susceptible S. aureus (CA-MSSA) bacteremia... - Community-onset candidemia at a university hospital, 1995-2005Hsiang Chi Kung
Division of Infectious Diseases, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
J Microbiol Immunol Infect 40:355-63. 2007..This retrospective study was conducted to describe predisposing factors and outcomes of community-onset candidemias... - Microbiological and clinical characteristics of vancomycin-resistant Enterococcus faecium bacteraemia in Taiwan: implication of sequence type for prognosisChing Lan Lu
Department of Internal Medicine, National Taiwan University Hospital, Hsin Chu Branch, Hsin Chu, Taiwan
J Antimicrob Chemother 67:2243-9. 2012..We aimed to examine whether there were newly introduced clones contributing to this increase and to assess the risk factors for mortality in patients with VREfm bacteraemia... 
Clinical characteristics and outcomes of Mycobacterium tuberculosis disease in adult patients with hematological malignanciesChien Yuan Chen
Department of Internal Medicine, Division of Hematology, National TaiwanUniversity Hospital, Taipei, Taiwan
BMC Infect Dis 11:324. 2011..Diseases caused by Mycobacterium tuberculosis (TB) among adult patients with hematological malignancies have rarely been investigated...- Spinal epidural abscess due to Staphylococcus aureus: clinical manifestations and outcomesWan Chin Chen
Division of Infectious Diseases, Department of Internal Medicine, National Taiwan University Hospital College of Medicine, Taipei, Taiwan
J Microbiol Immunol Infect 41:215-21. 2008..In this study, we describe the clinical features and outcomes of patients with spinal epidural abscess due to S. aureus... - Association between contaminated faucets and colonization or infection by nonfermenting gram-negative bacteria in intensive care units in TaiwanJiun Ling Wang
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
J Clin Microbiol 47:3226-30. 2009..The electrokaryotypes of four clinical isolates of C. meningosepticum were similar to those of faucet isolates. Measures directed at making the water supply safe may prevent infection by C. meningosepticum and other waterborne pathogens... - Changing epidemiology of nosocomial bloodstream infections in 11 teaching hospitals in Taiwan between 1993 and 2006Chia Ying Liu
Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan
J Microbiol Immunol Infect 43:416-29. 2010..To understand the changing epidemiology of nosocomial bloodstream infections (BSI) in Taiwan, we retrospectively collected nosocomial infection data from 11 hospitals and examined the trends and changing patterns of nosocomial BSI... - Longitudinal analysis of chlorhexidine susceptibilities of nosocomial methicillin-resistant Staphylococcus aureus isolates at a teaching hospital in TaiwanJann Tay Wang
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
J Antimicrob Chemother 62:514-7. 2008..However, data on longitudinal surveillance of the susceptibility of MRSA isolates to chlorhexidine are limited... - Predictive value of the serum bactericidal test for mortality in patients infected with multidrug-resistant Acinetobacter baumanniiChun Hsing Liao
Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University, 7 Chung Shan South Road, Taipei 100, Taiwan
J Infect 55:149-57. 2007..There are no standard tests to measure outcome in patients infected with these strains. Our aim was to determine whether a serum bactericidal test (SBT) could be used for this purpose... - Validation of a novel severe acute respiratory syndrome scoring systemChan Ping Su
Department of Emergency Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
Ann Emerg Med 43:34-42. 2004..The objective of this study is to validate these scoring systems with a different set of patients... - Longitudinal analysis of Severe Acute Respiratory Syndrome (SARS) coronavirus-specific antibody in SARS patientsShan Chwen Chang
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
Clin Diagn Lab Immunol 12:1455-7. 2005..The serum IgM antibody of most patients became undetectable within 6 months after the onset of SARS. The IgG antibody of all 17 patients, whose serum was checked 1 year after disease onset, remained positive... - Comparative in vitro antimicrobial susceptibilities and synergistic activities of antimicrobial combinations against carbapenem-resistant Acinetobacter species: Acinetobacter baumannii versus Acinetobacter genospecies 3 and 13TUWang Huei Sheng
Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan
Diagn Microbiol Infect Dis 70:380-6. 2011..This knowledge will enable clinicians to select appropriate regimens for treating these infections... - Comparison of an automated repetitive-sequence-based PCR microbial typing system with pulsed-field gel electrophoresis for molecular typing of vancomycin-resistant Enterococcus faeciumYu Chung Chuang
Department of Internal Medicine, National Taiwan University Hospital, No 7 Chung Shan South Road, Taipei, Taiwan
J Clin Microbiol 48:2897-901. 2010..PFGE remains the preferred method to confirm clonal spread... - Mycobacterium tuberculosis bacteremia in HIV-negative patientsYu Shin Chiu
Division of Infectious Disease, Min Sheng General Hospital, Taoyuan, and Division of Infectious Disease, Department of Internal Medicine, Center for Infection Control, National Taiwan University Hospital, Taipei, Taiwan
J Formos Med Assoc 106:355-64. 2007..Limited information exists about the epidemiologic characteristics of HIV-negative patients with Mycobacterium tuberculosis bacteremia (MTB)... - Molecular epidemiology and antifungal susceptibility of Candida parapsilosis sensu stricto, Candida orthopsilosis, and Candida metapsilosis in TaiwanYee Chun Chen
Division of Infectious Diseases, Departments of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
Diagn Microbiol Infect Dis 68:284-92. 2010..orthopsilosis and C. metapsilosis isolates expressed the isoleucine to valine substitution on the hot spot 2 region. However, the amino acid variations in these isolates did not correlate to their MIC values of echinocandin... - Factors associated with development of complications among adults with influenza: a 3-year prospective analysisUn In Wu
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
J Formos Med Assoc 111:364-9. 2012..This prospective study aimed to describe the clinical features, as well as outcomes, of adult patients with influenza of different severity, and to determine the predictors for development of complications... - Ertapenem in the treatment of bacteremia caused by extended-spectrum beta-lactamase-producing Escherichia coli: a propensity score analysisUn In Wu
Department of Internal Medicine, National Taiwan University Hospital, 7 Chung Shan South Road, Taipei, 100, Taiwan
Int J Infect Dis 16:e47-52. 2012..This study assessed the impact of ertapenem and other carbapenems on mortality in patients with monomicrobial extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-EC) bacteremia... - Distribution of Staphylococcal cassette chromosome mec Types and correlation with comorbidity and infection type in patients with MRSA bacteremiaJiun Ling Wang
Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan
PLoS ONE 5:e9489. 2010..However, there is little information regarding the clinical features and outcomes of bacteremia patients with MRSA carrying different SCCmec types... - Detection of circulating galactomannan in serum samples for diagnosis of Penicillium marneffei infection and cryptococcosis among patients infected with human immunodeficiency virusYu Tsung Huang
Department of Internal Medicine, National Taiwan University Hospital, No 7 Chung Shan South Road, Taipei 100, Taiwan
J Clin Microbiol 45:2858-62. 2007..The use of the GM antigen assay may facilitate earlier diagnosis of Penicillium marneffei infection for HIV-infected patients in areas of endemicity... - Stable susceptibility of Candida blood isolates to fluconazole despite increasing use during the past 10 yearsYee Chun Chen
Department of Internal Medicine, National Taiwan University Hospital No 7, and College of Medicine, National Taiwan University, Taipei, Taiwan
J Antimicrob Chemother 52:71-7. 2003..These include low prevalence of C. krusei and C. glabrata, changing patterns of use of antifungal drugs and broad-spectrum antibiotics, and efforts to improve the rational use of antifungal agents at our hospital... - Control of an outbreak of pandrug-resistant Acinetobacter baumannii colonization and infection in a neonatal intensive care unitPei Chun Chan
Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
Infect Control Hosp Epidemiol 28:423-9. 2007..To investigate the potential reservoir and mode of transmission of pandrug-resistant (PDR) Acinetobacter baumannii in a 7-day-old neonate who developed PDR A. baumannii bacteremia that was presumed to be the iceberg of a potential outbreak... - Changing incidence and clinical manifestations of Clostridium difficile-associated diarrhea detected by combination of glutamate dehydrogenase and toxin assay in Northern TaiwanYi Chieh Lee
Division of Infectious Disease, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
J Microbiol Immunol Infect 45:287-95. 2012..This prospective study evaluates the incidence and clinical manifestation of CDAD following a hospital-wide hand hygiene promotion program in a 2,200-bed teaching hospital in northern Taiwan... - A prospective study of antimicrobial-related adverse drug reactions in hospitalized patientsHsin Yun Sun
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
J Microbiol Immunol Infect 41:151-9. 2008..The present study aimed to assess the incidence, risk factors, clinical manifestations, and causative agents of antimicrobial-ADRs in hospitalized patients... - Performance of the BD GeneOhm methicillin-resistant Staphylococcus aureus (MRSA) PCR assay for detecting MRSA nasal colonization in Taiwanese adultsWei Ting Chen
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
J Microbiol Immunol Infect 43:372-7. 2010.... - Safety and efficacy of intravenous colistin (colistin methanesulphonate) for severe multidrug-resistant Gram-negative bacterial infectionsChien Yu Cheng
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
Int J Antimicrob Agents 35:297-300. 2010..Clinical outcomes are associated with the severity of infection and underlying diseases. Compared with previous reports, this study showed a lower incidence of nephrotoxicity and neurotoxicity... - Infections occurring during extracorporeal membrane oxygenation use in adult patientsHsin Yun Sun
Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
J Thorac Cardiovasc Surg 140:1125-32.e2. 2010..The application of extracorporeal membrane oxygenation in adults has been increasing, but infections occurring during extracorporeal membrane oxygenation use are rarely described... - Effectiveness and limitations of hand hygiene promotion on decreasing healthcare-associated infectionsYee Chun Chen
Center for Infection Control, National Taiwan University Hospital, Taipei, Taiwan
PLoS ONE 6:e27163. 2011..We use a quasi-experimental, before and after, study design with prospective hospital-wide surveillance of HAIs to assess the cost effectiveness of HHPs... - In vitro activity of linezolid, tigecycline, and daptomycin on methicillin-resistant Staphylococcus aureus blood isolates from adult patients, 2006-2008: stratified analysis by vancomycin MICTsui Mai Kao
Division of Infectious Diseases, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
J Microbiol Immunol Infect 44:346-51. 2011.... - Invasive fungal sinusitis in patients with hematological malignancy: 15 years experience in a single university hospital in TaiwanChien Yuan Chen
Department of Internal Medicine, Division of Hematology, National Taiwan University Hospital, Taipei, Taiwan
BMC Infect Dis 11:250. 2011..Risk factors and outcomes in hematological patients who acquire invasive fungal sinusitis (IFS) are infrequently reported in the modern medical era... - Bacteremia in previously hospitalized patients: prolonged effect from previous hospitalization and risk factors for antimicrobial-resistant bacterial infectionsShey Ying Chen
Department of Emergency Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
Ann Emerg Med 51:639-46. 2008..Our objectives are to determine the time from previous hospital discharge that affects subsequent antimicrobial susceptibility pattern and risk factors for antimicrobial-resistant infection in bacteremia in recently discharged patients... - Cluster of parvovirus infection among hospital staff working in coronary care unitsYee Chun Chen
Department of Internal Medicine, National Taiwan University Hospital, Taiwan
J Formos Med Assoc 109:886-94. 2010..The virus is relatively conserved and nucleotide identity is expected in viruses that are epidemiologically related. Here, we describe the first cluster of parvovirus infection among hospital staff documented in Taiwan... - Incidence of and risk factors for infection or colonization of vancomycin-resistant enterococci in patients in the intensive care unitSung Ching Pan
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
PLoS ONE 7:e47297. 2012..Strategies to reduce the duration of ICU stay and prudent usage of broad-spectrum antibiotics are the keys to controlling VRE transmission... - Severity of pandemic H1N1 2009 influenza virus infection may not be directly correlated with initial viral load in upper respiratory tractUn In Wu
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
Influenza Other Respi Viruses 6:367-73. 2012..We hypothesized that viral load in upper respiratory specimens obtained on presentation may not be correlated with disease severity... - Prospective randomized study of efficacy of 1-day versus 3-day antibiotic prophylaxis for preventing surgical site infection after coronary artery bypass graftMei Hsin Lin
Department of Pharmacy, National Taiwan University Hospital, Taipei, Taiwan
J Formos Med Assoc 110:619-26. 2011..This study compared the efficacy of 1-day versus 3-day antibiotic prophylaxis in preventing surgical site infection (SSI) in patients undergoing coronary artery bypass graft (CABG)... - Risk factors for bloodstream infections due to extended-spectrum beta-lactamase-producing Escherichia coliUn In Wu
Department of Internal Medicine, National Taiwan University Hospital, 7 Chung Shan South Road, Taipei, Taiwan
J Microbiol Immunol Infect 43:310-6. 2010..A case-control study was undertaken to identify the risk factors associated with bloodstream infections caused by ESBL producing E. coli... - Clinical presentations, laboratory results and outcomes of patients with Kikuchi's disease: emphasis on the association between recurrent Kikuchi's disease and autoimmune diseasesChien Yu Cheng
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
J Microbiol Immunol Infect 43:366-71. 2010..Kikuchi's disease (KD), also known as histiocytic necrotizing lymphadenitis, is a benign and self-limiting disease of unknown etiology that mainly affects young women. There is limited data on the long-term prognosis of patients with KD... - Using 18-fluoro-2-deoxyglucose positron emission tomography in detecting infectious endocarditis/endoarteritis: a preliminary reportRuoh Fang Yen
Department of Nuclear Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, No 7, Chung Shan South Road, Taipei 10016, Taiwan
Acad Radiol 11:316-21. 2004..We evaluated the effectiveness of positron emission tomography (PET) with 18-fluoro-2-deoxyglucose (FDG) in the detection of infectious endocarditis/endoarteritis... - Predictive model of antimicrobial-resistant gram-negative bacteremia at the EDWen Chu Chiang
Department of Emergency Medicine, National Taiwan University Hospital, Taipei 100, Taiwan
Am J Emerg Med 25:597-607. 2007.... - Causes, clinical symptoms, and outcomes of infectious diseases associated with hemophagocytic lymphohistiocytosis in Taiwanese adultsYu Tzu Tseng
Division of Infectious Diseases, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
J Microbiol Immunol Infect 44:191-7. 2011..Few systematic reviews have been published on the clinical manifestations, causes, and indicators for prognosis of HLH caused by infections... - Certainties and uncertainties facing emerging respiratory infectious diseases: lessons from SARSYee Chun Chen
Department of Internal Medicine, and Center for Infection Control, National Taiwan University Hospital, 7 Chung Shan South Road, Taipei, Taiwan
J Formos Med Assoc 107:432-42. 2008..Herein, we relate our perspective on useful lessons derived from a review of the SARS epidemic that may be useful to physicians, especially when looking ahead to the next epidemic... - Human immunodeficiency virus testing among patients with tuberculosis at a university hospital in Taiwan, 2000 to 2006Hsiang Chi Kung
Department of Internal Medicine, National Taiwan University Hospital, Yun Lin branch, Yun Lin, Taiwan
J Formos Med Assoc 108:320-7. 2009..This study assessed the frequency and results of HIV testing among patients diagnosed with TB at a university hospital from 2000 to 2006... - Characteristics and outcomes of community-onset septic arthritis in adultsYu Chung Chuang
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
J Microbiol Immunol Infect 42:258-64. 2009..This study compared the demographic characteristics, risk factors, and outcomes of patients with community-onset septic arthritis due to Gram-positive and Gram-negative bacteria... - Identification of distinct ciprofloxacin susceptibility in Acinetobacter spp. by detection of the gyrA gene mutation using real-time PCRWang Huei Sheng
Division of Infectious Diseases, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
Mol Cell Probes 23:154-6. 2009..5 degrees C. The assay can rapidly and accurately identify the mutated QRDR of gyrA gene in CipR Acinetobacter spp., and potentially increase the rate of the appropriate therapy for Acinetobacter infections... - Functional characterization and localization of acetyl-CoA hydrolase, Ach1p, in Saccharomyces cerevisiaeLeh Miauh Buu
Institute of Molecular Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, 7 Chung Shan South Road, Taipei 100, Taiwan
J Biol Chem 278:17203-9. 2003..We infer that Ach1p may be involved in a novel acetyl-CoA biogenesis and/or acetate utilization in mitochondria and thereby indirectly affect pseudohyphal development in yeast... - Staphylococcal cassette chromosome mec in MRSA, TaiwanJann Tay Wang
National Taiwan University Hospital, Taipei, Taiwan, Republic of China
Emerg Infect Dis 13:494-7. 2007..We found a shift from type IV to type III SCCmec element during 1992-2003, perhaps caused by selective pressure from indiscriminate use of antimicrobial drugs... - The first case of severe novel H1N1 influenza successfully rescued by extracorporeal membrane oxygenation in TaiwanTsui Mai Kao
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
J Formos Med Assoc 108:894-8. 2009..Hospital course was uneventful and he was discharged 26 days after transfer to Hospital B. This experience showed that ECMO can be life-saving for severe novel H1N1 infection... - Combination antifungal therapy for disseminated fusariosis in immunocompromised patients : a case report and literature reviewJyh You Liu
Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
Med Mycol 49:872-8. 2011..Among 19 published cases in the last 10 years plus this patient, the patients in 14 cases (70%) responded positively to combination antifungal therapy. A clinical response was achieved in seven cases before resolution of neutropenia... - In vitro activities of 16 antimicrobial agents against clinical isolates of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in two regional hospitals in TaiwanChun Hsing Liao
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
J Microbiol Immunol Infect 39:59-66. 2006.... - Clinical experience of 17 cases of imported malaria at a Taiwan university hospital, 1999-2005Hsing Chun Chung
Division of Infectious Diseases, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
J Microbiol Immunol Infect 40:209-15. 2007..Malaria had been eradicated in Taiwan since 1965, but there are currently 30 to 50 imported cases annually. The management of imported malaria continues to be challenging due to evolving drug resistance of Plasmodium parasites...