Wei J Chen

..The PAS differed from the Cognitive-Perceptual factor in its consistent association with poorer attention in both samples. These have important implications for the scales in the early detection of the schizotypy in various cultures...

..5%). For adolescent twins, if DNA diagnostic workups were limited to those with discordant reports either from themselves or from their parents, the accuracy rate increased to 100% for parental reports and 98% for self-reports...

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..The results highlight the potential of adolescents for future investigation on certain common causes underlying atypical cerebral lateralisation and positive schizotypy...

..A method for estimating sibling recurrence risk with correction for complete ascertainment was used to estimate the numerator, and the prevalence in the whole cohort was used as the denominator of lambdas...

..The marker D1S251 of chromosome 1q42.1 showed significant association with schizophrenia in a Taiwanese sample. We used single nucleotide polymorphism (SNP) fine mapping to search for the vulnerability genes of schizophrenia...

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..We failed to replicate the association evidence between DTNBP1 and schizophrenia and this gene may not play a major role in the etiology of schizophrenia in this Taiwanese family sample...

..The authors aimed to identify potential laboratory indices and clinical characteristics associated with natural death through a two-phase study...

..With the backdrop of a global ecstasy epidemic, this study sought to examine the trend, correlates, and onset sequence of ecstasy use among adolescents in Taiwan, where a well-established gateway drug such as marijuana is much less popular...

..Our results fail to support the RGS4 as a candidate gene for schizophrenia when evaluated from these three SNP markers...

..These results suggest that the DAAO and G72 genes are not susceptibility genes for schizophrenia in a Taiwanese sample...

..For patients with schizophrenia, aggravation of symptoms and the likelihood of being crowded out of the use of health care services by those with other physical or mental illnesses after a catastrophe warrant our attention...

..This article attempts to simplify this complexity using a hypothetical tripartite based on the profile of symptoms at 6 months after acute treatment...

..Only one study has investigated the association between NGFR polymorphisms and the risk of AD in an Italian population. Type 2 diabetes mellitus (DM) may modify this association based on previous animal and epidemiologic studies...

..The niacin skin test for schizophrenia had 49.2% sensitivity and 92.5% specificity compared with controls. This study found that absent response to niacin skin patch was specific to schizophrenia and independent of smoking status...

..The study aimed to evaluate the risk of hepatitis C virus (HCV) infection on hepatic and extrahepatic deaths...

..Current staging methods are inadequate for predicting the outcome of treatment of non-small-cell lung cancer (NSCLC). We developed a five-gene signature that is closely associated with survival of patients with NSCLC...

..We concluded that there is substantial heterogeneity in schizophrenia patients' long term pattern in sustained attention deficits and those with severe impairment might represent a subgroup with stable vulnerability to schizophrenia...

..Both single locus and haplotypes analyses showed no association of these single-nucleotide polymorphisms with schizophrenia. These findings fail to support AKT1 as a susceptibility gene for schizophrenia in the Taiwanese population...

..Gender differences in heritability exist for various CBCL-based competence and behavioral/emotional problems...

..Long-term predictors for HCV-related hepatocellular carcinoma are essential for early intervention. Serum HCV RNA and ALT levels and HCV genotype were assessed for their predictability of hepatocellular carcinoma risk...

..However, information concerning the developmental continuity between supported stepping and walking is limited...

..In a previous linkage study of schizophrenia that included Taiwanese samples, the marker D22S278 (22q12.3) was significantly linked to schizophrenia (p = .001)...

..The aim of the study is to evaluate the genetic linkage evidence for schizophrenia in subsets of families with earlier age at onset or greater neurocognitive deficits...

..Our results provide empirical support for the applicability of the NS and the HA scales of the TPQ in adolescents, particularly in relation to behavioral problems...

..These findings provide support for the potential of niacin flush response as a vulnerability indicator to schizophrenia...

..More importantly, only a small portion of the genetic influences on adiponectin and leptin was attributed to BMI. Our findings provided more insight into the complex regulation of adiponectin and leptin in obesity...

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..Future prevention programs may target this high-risk group to reduce possible drug-related negative consequences in developmental and health domains in Taiwan...

..CONCLUSIONS: Stringent cut-off criteria of CPT deficits with adjustment for demographic features leads to recurrence risk ratios greater than those based on schizophrenia alone in both parents and siblings of schizophrenic patients...

..Whether their impacts on social dysfunction are independent to those caused by deficits in basic neurocognition and clinical symptoms needs to be further delineated...

..This study examines the relationship between the availability of public facilities for habitual physical activity in the community and metabolic syndrome in northern Taiwan, one of most densely populated countries in the world...

..Methamphetamine use leads to increased likelihood of premature death. The authors investigated the causes of death and risk of mortality in a large cohort of patients with methamphetamine dependence...

..75) and without (SSLR=0.61, 5.09, and 10.42) impairment requirement. CONCLUSIONS: The CES-D is useful in screening for major depressive disorder among nonreferred adolescents. Three strata are recommended for its practical application...

..This study assessed the association between pharmacokinetic- and pharmacodynamic-related genes and individual responses to low-density lipoprotein cholesterol (LDL-C) change by statins in a Chinese population...

..Perseveration might act as a moderator on the relations of life events to depressive symptoms and lowering perseveration may be a plausible way to decrease the impact of negative life events on adolescent depressive symptoms...

..Our proposed method (Bayesian regression using uncertainty-coding matrix, BRUCM) is shown to perform better and the implementation in R is freely available...

..We concluded that WCST performance might be an indicator more for environmental insult than for genetic influences on frontal lobe function...

..The type of early alcohol involvement in adolescence may exert differential effects on emotions and behaviors expressed across and within syndromes; these may warrant distinctions in informing etiological research and preventive efforts...

..This study aimed to identify clinical characteristics associated with suicide mortality in patients with methamphetamine dependence by means of a nested case-control design...

..Their differential relations to linkage signals have etiological implications and provide further evidence for their validity...

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..Such a combination of detailed psychological assessments and metabolic function tests is expected to help shed light on the interrelation of psychological well-being and metabolic functioning...

..Apo A1 concentrations were measured by turbidimetric immunoassay methods. After adjustment for gender, age, body mass index, smoking and drinking status, residual values of Apo A1 were subjected to subsequent analyses...

..CONCLUSIONS: Web SAQ leads to higher reporting rates of commonly used substances in adolescents compared with those of paper SAQ...

..The results indicated that the mononuclear leukocyte-based miRNA profiling is a feasible way to identify biomarkers for schizophrenia, and the seven-miRNA signature warrants further investigation...

..1 years old. This TSLS demonstrated a successful establishment of an efficient research infrastructure to collect a large nation-wise sample of schizophrenic family for genetic linkage study...

..These findings indicate that there might be modifier or susceptibility-modifier genes at 14q32.12 for schizophrenia-related attenuation of flush response to niacin...

..The Bayesian inference based on the full likelihood is flexible with any phenotype, and easy to implement computationally. This model has a wide applicability and may help unravel the complexity in development of complex diseases...

..05). Our data have provided important epidemiologic information to assist in clinical assessment and management of preschoolers' behavioral and emotional problems in an Eastern society...

..This study aimed to investigate the prevalence and correlates of EDs in Taiwanese high-school students...

..To describe the outcomes of subjects with suspected pre-psychotic state in Taiwan...

..CONCLUSIONS: Adolescents who use substance have specific individual features that are readily assessable by existing instruments. This bears important implications for the early intervention of substance abuse in adolescents...

..The authors investigated the association between asthma and suicide mortality in a large population-based cohort of young people...

..03 and 0.007, respectively). In conclusion, the influence of IL-13 genetic variants on cIgE elevation was modified by male sex and prenatal ETS...

..01, 0.42, and 0.91, respectively. CONCLUSIONS: The AUDIT is a valid screening tool for alcohol use disorders, and the three strata derived from the SSLR analysis are informative and readily applicable in clinical practice...

..We test the hypothesis that the neuregulin 1 (NRG1 ) gene at chromosome 8p22-p12, which has been implicated as a susceptibility gene to schizophrenia, is associated with variations in schizotypal personality in non-clinical populations...

..Via the capture-recapture approach, the present study aimed to offer insights into the size of heroin and methamphetamine male user population in the northern Taiwan during the period from 1999 to 2002...

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..To investigate whether variation may exist in betel nut- and ecstasy-involved adolescents in terms of sociobehavioral characteristics, the experience of psychoactive substance use, and behavioral/emotional problems...

..Implications of the findings for the prevention of AUDs and their physical complications are discussed...

..3, 54,2, and 117.2 mg/dl. CONCLUSION: Variations of Apo B levels in the normal range among adolescent families are controlled by major gene, and further identification of this gene locus will be mandatory...

..These findings may help form programs to identify or monitor youths at risk...

..The association between hepatitis C virus (HCV) infection and cerebrovascular disease remains controversial. This study aimed to assess the risk of lethal cerebrovascular diseases associated with chronic HCV infection...

..The emergency response to this event-consisting of TMSSs, a buddy system, and a communication system-should be considered in planning for future disaster events in Taiwan...

..This equal-contribution assumption cannot account for the possible dependence among subjects who associate similarly to the disease, and may restrict the selection of influential genes...

..CONCLUSION: The accuracy of maternal recall on obstetric complications varied depending on the nature of complications examined, whereas that on birth characteristics was high...