Mei Ru Chen

Summary

Affiliation: National Taiwan University
Country: Taiwan

Publications

  1. pmc The ESCRT machinery is recruited by the viral BFRF1 protein to the nucleus-associated membrane for the maturation of Epstein-Barr Virus
    Chung Pei Lee
    Graduate Institute and Department of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
    PLoS Pathog 8:e1002904. 2012
  2. pmc Epstein-barr virus, the immune system, and associated diseases
    Mei Ru Chen
    Epstein Barr Virus Group, Graduate Institute and Department of Microbiology, National Taiwan University Taipei, Taiwan
    Front Microbiol 2:5. 2011
  3. pmc Epstein-Barr virus BGLF4 kinase retards cellular S-phase progression and induces chromosomal abnormality
    Yu Hsin Chang
    Graduate Institute and Department of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
    PLoS ONE 7:e39217. 2012
  4. doi request reprint Characterization of Epstein-Barr virus BGLF4 kinase expression control at the transcriptional and translational levels
    Jiin Tarng Wang
    Department of Microbiology, National Taiwan University, Taipei, Taiwan, Republic of China
    J Gen Virol 91:2186-96. 2010
  5. ncbi request reprint Genome-wide transcription program and expression of the Rta responsive gene of Epstein-Barr virus
    Chih Chung Lu
    Graduate Institute and Department of Microbiology, College of Medicine, National Taiwan University, No 1, Jen Ai Rd, 1st Section, Taipei 100, Taiwan
    Virology 345:358-72. 2006
  6. ncbi request reprint Detection of Epstein-Barr virus BGLF4 protein kinase in virus replication compartments and virus particles
    Jiin Tarng Wang
    Graduate Institute and Department of Microbiology, College of Medicine, National Taiwan University, No 1 1st Section Jen Ai Road, Taipei, Taiwan
    J Gen Virol 86:3215-25. 2005
  7. pmc Epstein-Barr virus BGLF4 kinase induces premature chromosome condensation through activation of condensin and topoisomerase II
    Chung Pei Lee
    Graduate Institute and Department of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Virol 81:5166-80. 2007
  8. pmc Regulation of microtubule dynamics through phosphorylation on stathmin by Epstein-Barr virus kinase BGLF4
    Po Wen Chen
    Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan
    J Biol Chem 285:10053-63. 2010
  9. pmc Role of the TSG101 gene in Epstein-Barr virus late gene transcription
    Huey Huey Chua
    Graduate Institute of Microbiology, College of Medicine, National Taiwan University, No 1 Jen Ai Road 1st section, Taipei 10051, Taiwan
    J Virol 81:2459-71. 2007
  10. ncbi request reprint Reactivation of Epstein-Barr virus can be triggered by an Rta protein mutated at the nuclear localization signal
    Tsuey Ying Hsu
    Department of Microbiology, College of Medicine, National Taiwan University, Room 722, Number 1, Section 1, Jen Ai Road, Taipei, Taiwan
    J Gen Virol 86:317-22. 2005

Collaborators

  • Ching Hwa Tsai
  • Jen Yang Chen
  • Tsuey Ying Hsu
  • Kenzo Takada
  • Te Huei Yeh
  • Chi long Chen
  • Shin Yi Jou
  • Geir Slupphaug
  • Shu Chun Teng
  • Ting Yun Liu
  • Hsiang Shu Yin
  • Ann Lii Cheng
  • Shao Chun Lu
  • Fu Tong Liu
  • Jiin Tarng Wang
  • Chung Pei Lee
  • Chih Chung Lu
  • Chou Wei Chang
  • Shin Lian Doong
  • Pei Wen Yang
  • Su Fang Lin
  • Yu Hsin Chang
  • Ling Shih Chang
  • Ya Ching Chou
  • Shu Chun Tsai
  • Sue Jane Lin
  • Sheng Wen Yeh
  • Huey Huey Chua
  • Shin C Chang
  • Shih Hsin Chiu
  • Cheng Huang
  • Mei Tzu Su
  • Sheng Yen Huang
  • Jiun Han Lin
  • Ting Ting Chang
  • Meng Chuan Wu
  • Chun Jung Lin
  • Yu Hao Huang
  • Po Wen Chen
  • Ming Fu Chang
  • Kuo Chen Wu
  • Yao Chang
  • Shih Shin Chang
  • Yi Chun Chen
  • Yi Hen Kou
  • Chung Shi Yang
  • Yu Ching Chen
  • Chung Chun Wu
  • John T A Hsu
  • Jia Yin Jiang
  • Yeou Guang Tsay
  • Cheau Jye Lin
  • Huan Yun Chen
  • Meng You Lu
  • Li Min Huang
  • Ya Chi Huang
  • Min Jie Hsieh
  • Jean Lu
  • Hsiu Ni Kung
  • Min Jei Hsieh
  • Ching Yueh Hsieh
  • Yen Ju Chen
  • Po Ting Liu
  • Szu Yu Yeh
  • Chen Chi Hsu
  • Min Chuan Huang
  • Ming Kwang Shyu
  • Hsu Hsiang Cheng
  • Chia Hung Han
  • Kun Liang Chen
  • Ya Ling Chen
  • Yu Chia Chuang
  • Huei Ju Pan
  • Yi Hsin Chao
  • Heng Huan Lee
  • Ai Takemoto
  • Tsai Kun Li
  • Tzu Hao Cheng
  • Ho Ting Huang
  • Keiji Kimura
  • Jiin Tsuey Cheng
  • Shang Min Chou
  • Yu Hsu Huang
  • Shao Yong Huang
  • Mei Ying Liu
  • Yi Ying Jeng
  • Mei Ying Jung
  • Yi Ming Wang
  • Ya Tzu Chang
  • Chia Hong Han

Detail Information

Publications30

  1. pmc The ESCRT machinery is recruited by the viral BFRF1 protein to the nucleus-associated membrane for the maturation of Epstein-Barr Virus
    Chung Pei Lee
    Graduate Institute and Department of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
    PLoS Pathog 8:e1002904. 2012
    ..Overall, data here suggest that BFRF1 recruits the ESCRT components to modulate nuclear envelope for the nuclear egress of EBV...
  2. pmc Epstein-barr virus, the immune system, and associated diseases
    Mei Ru Chen
    Epstein Barr Virus Group, Graduate Institute and Department of Microbiology, National Taiwan University Taipei, Taiwan
    Front Microbiol 2:5. 2011
    ..Instead of an intensive review, this article aims to provide a linkage to recent advances on the interplay between EBV and host immune system and to inspire further studies on EBV related diseases, especially autoimmune diseases...
  3. pmc Epstein-Barr virus BGLF4 kinase retards cellular S-phase progression and induces chromosomal abnormality
    Yu Hsin Chang
    Graduate Institute and Department of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
    PLoS ONE 7:e39217. 2012
    ..Taken together, our study indicates that BGLF4 may directly or indirectly induce a DNA damage signal that eventually interferes with host DNA synthesis and delays S-phase progression...
  4. doi request reprint Characterization of Epstein-Barr virus BGLF4 kinase expression control at the transcriptional and translational levels
    Jiin Tarng Wang
    Department of Microbiology, National Taiwan University, Taipei, Taiwan, Republic of China
    J Gen Virol 91:2186-96. 2010
    ..These results suggested that different promoter usage and 5'UTR-mediated translation enhancement may ensure the proper expression of BGLF4 at various stages of virus replication...
  5. ncbi request reprint Genome-wide transcription program and expression of the Rta responsive gene of Epstein-Barr virus
    Chih Chung Lu
    Graduate Institute and Department of Microbiology, College of Medicine, National Taiwan University, No 1, Jen Ai Rd, 1st Section, Taipei 100, Taiwan
    Virology 345:358-72. 2006
    ..The array data were confirmed by Northern blotting, RT-PCR and reporter assays. All the information here thus provides a better understanding of the control of EBV lytic gene expression...
  6. ncbi request reprint Detection of Epstein-Barr virus BGLF4 protein kinase in virus replication compartments and virus particles
    Jiin Tarng Wang
    Graduate Institute and Department of Microbiology, College of Medicine, National Taiwan University, No 1 1st Section Jen Ai Road, Taipei, Taiwan
    J Gen Virol 86:3215-25. 2005
    ..Finally, possible functional domains at the N terminus of BGLF4 were analysed and it was found that aa 1-26 of BGLF4 are dispensable for EA-D phosphorylation, whereas deletion of aa 27-70 reduced kinase activity...
  7. pmc Epstein-Barr virus BGLF4 kinase induces premature chromosome condensation through activation of condensin and topoisomerase II
    Chung Pei Lee
    Graduate Institute and Department of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Virol 81:5166-80. 2007
    ....
  8. pmc Regulation of microtubule dynamics through phosphorylation on stathmin by Epstein-Barr virus kinase BGLF4
    Po Wen Chen
    Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan
    J Biol Chem 285:10053-63. 2010
    ..In conclusion, we have shown that a viral Ser/Thr kinase can directly modulate the activity of stathmin and this contributes to alteration of cellular MT dynamics and then may modulate the associated cellular processes...
  9. pmc Role of the TSG101 gene in Epstein-Barr virus late gene transcription
    Huey Huey Chua
    Graduate Institute of Microbiology, College of Medicine, National Taiwan University, No 1 Jen Ai Road 1st section, Taipei 10051, Taiwan
    J Virol 81:2459-71. 2007
    ....
  10. ncbi request reprint Reactivation of Epstein-Barr virus can be triggered by an Rta protein mutated at the nuclear localization signal
    Tsuey Ying Hsu
    Department of Microbiology, College of Medicine, National Taiwan University, Room 722, Number 1, Section 1, Jen Ai Road, Taipei, Taiwan
    J Gen Virol 86:317-22. 2005
    ..Thus, the cytoplasmic Rta mutant could induce expression of endogenous Zta and Rta, triggering reactivation of EBV...
  11. pmc Epstein-Barr virus protein kinase BGLF4 targets the nucleus through interaction with nucleoporins
    Chou Wei Chang
    Graduate Institute and Department of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Virol 86:8072-85. 2012
    ..Data presented here suggest that BGLF4 employs a novel mechanism through direct interactions with nucleoporins for its nuclear targeting...
  12. pmc Epstein-Barr virus BGLF4 kinase induces disassembly of the nuclear lamina to facilitate virion production
    Chung Pei Lee
    Graduate Institute and Department of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Virol 82:11913-26. 2008
    ..UL kinases of alpha- and betaherpesviruses also induce the disassembly of the nuclear lamina through similar sites on lamin A/C, suggesting a conserved mechanism for the nuclear egress of herpesviruses...
  13. pmc Epstein-Barr virus BGLF4 kinase downregulates NF-κB transactivation through phosphorylation of coactivator UXT
    Ling Shih Chang
    Graduate Institute and Department of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Virol 86:12176-86. 2012
    ..Taking the data together, transcription involving UXT may also be important for EBV lytic protein expression, whereas BGLF4-mediated phosphorylation of UXT at Thr3 plays a critical role in promoting the lytic cycle...
  14. ncbi request reprint EBNA-1 sequence variations reflect active EBV replication and disease status or quiescent latency in lymphocytes
    Jiin Tarng Wang
    Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Med Virol 69:417-25. 2003
    ....
  15. pmc Characterization of the uracil-DNA glycosylase activity of Epstein-Barr virus BKRF3 and its role in lytic viral DNA replication
    Chih Chung Lu
    Graduate Institute and Department of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Virol 81:1195-208. 2007
    ..Taking these results together, we demonstrate the UNG activity of BKRF3 in vitro and in vivo and suggest that UNGs may participate in DNA replication or repair and thereby promote efficient production of viral DNA...
  16. ncbi request reprint Xeroderma pigmentosum C is involved in Epstein Barr virus DNA replication
    Chih Chung Lu
    Graduate Institute and Department of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan 100, PR China
    J Gen Virol 88:3234-43. 2007
    ..Overall, we suggest that the interaction of BGLF4 and XPC may be involved in DNA replication and repair and thereby enhance the efficiency of viral DNA replication...
  17. pmc Epstein-Barr virus BALF3 has nuclease activity and mediates mature virion production during the lytic cycle
    Shih Hsin Chiu
    Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Virol 88:4962-75. 2014
    ..On the basis of these results, we suggest that EBV BALF3 is involved simultaneously in DNA synthesis and packaging and is required for the production of mature virions...
  18. pmc Autocrine CCL3 and CCL4 induced by the oncoprotein LMP1 promote Epstein-Barr virus-triggered B cell proliferation
    Shu Chun Tsai
    Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Virol 87:9041-52. 2013
    ..This study reveals the regulatory mechanism and a novel function of CCL3 and CCL4 in EBV-infected B cells. CCL3 might be useful as a therapeutic target in EBV-associated lymphoproliferative diseases and malignancies. ..
  19. pmc BCL10GFP fusion protein as a substrate for analysis of determinants required for mucosa-associated lymphoid tissue 1 (MALT1)-mediated cleavage
    Shin Yi Jou
    Graduate Institute of Microbiology, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei 10051, Taiwan
    J Biomed Sci 19:85. 2012
    ..Here, BCL10GFP was constructed and utilized to examine the specificity and domain determinants for MALT1 cleavage in cells...
  20. doi request reprint Epstein-Barr virus Rta-mediated transactivation of p21 and 14-3-3σ arrests cells at the G1/S transition by reducing cyclin E/CDK2 activity
    Sheng Yen Huang
    Department of Microbiology, College of Medicine, National Taiwan University, Taipei 100, Taiwan, ROC
    J Gen Virol 93:139-49. 2012
    ..Based on these results, we hypothesize that through the disruption of CDK1 and CDK2 activities, EBV Rta might contribute to cell cycle arrest in EBV-infected epithelial cells during viral reactivation...
  21. doi request reprint Effect of phosphorylation on the transactivation activity of Epstein-Barr virus BMRF1, a major target of the viral BGLF4 kinase
    Pei Wen Yang
    Graduate Institute, Department of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC
    J Gen Virol 89:884-95. 2008
    ..Our findings suggest that BGLF4 may modulate the activation of the oriLyt BHLF1 promoter coordinately through multiple mechanisms to facilitate optimal oriLyt-dependent viral DNA replication...
  22. pmc Epstein-Barr virus BGLF4 kinase suppresses the interferon regulatory factor 3 signaling pathway
    Jiin Tarng Wang
    Graduate Institute and Department of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Virol 83:1856-69. 2009
    ..The data presented here thus suggest a novel mechanism by which herpesviral protein kinases suppress host innate immune responses and facilitate virus replication...
  23. doi request reprint Involvement of recepteur d'origine nantais receptor tyrosine kinase in Epstein-Barr virus-associated nasopharyngeal carcinoma and its metastasis
    Ya Ching Chou
    Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Am J Pathol 181:1773-81. 2012
    ..These results suggest an important role of RON in the tumorigenesis and metastasis of NPC and RON may be a novel therapeutic target for EBV-associated NPC...
  24. doi request reprint Glycogen synthase kinase 3 negatively regulates IFN regulatory factor 3 transactivation through phosphorylation at its linker region
    Jiin Tarng Wang
    1Graduate Institute and Department of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Innate Immun 20:78-87. 2014
    ..In vitro, both GSK3α and GSK3β phosphorylate IRF3 at the linker region. Collectively, data here suggest GSK3 phosphorylates IRF3 linker region in a way similar to viral kinase BGLF4. ..
  25. pmc Nuclear export signal-interacting protein forms complexes with lamin A/C-Nups to mediate the CRM1-independent nuclear export of large hepatitis delta antigen
    Cheng Huang
    Institute of Biochemistry and Molecular Biology, National Taiwan University College of Medicine, Taipei, Taiwan
    J Virol 87:1596-604. 2013
    ..These data indicate that by forming complexes with lamin A/C and nucleoporins, NESI facilitates the CRM1-independent nuclear export of HDAg-L...
  26. ncbi request reprint Epstein-Barr virus nuclear antigen 1 is a DNA-binding protein with strong RNA-binding activity
    Chih Chung Lu
    Graduate Institute of Microbiology, College of Medicine, No 1, Jen Ai Road, 1st Section, National Taiwan University, Taipei, Taiwan
    J Gen Virol 85:2755-65. 2004
    ..These results revealed that EBNA-1 is a DNA-binding protein with strong binding activity to a relatively broad spectrum of RNA and suggested an additional biological impact of EBNA-1 through its ability to bind to RNA...
  27. ncbi request reprint Hepatitis C virus NS4A inhibits cap-dependent and the viral IRES-mediated translation through interacting with eukaryotic elongation factor 1A
    Yi Hen Kou
    Institute of Microbiology, National Taiwan University College of Medicine, No 1, Sec 1, Jen Ai Road, Taipei, Taiwan, Republic of China
    J Biomed Sci 13:861-74. 2006
    ..Taken together, NS4A inhibits host and viral translation through interacting with eEF1A, implying a possible mechanism by which NS4A is involved in the pathogenesis and chronic infection of HCV...
  28. doi request reprint Escape of herpesviruses from the nucleus
    Chung Pei Lee
    Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Rev Med Virol 20:214-30. 2010
    ....
  29. doi request reprint Hypoxia-mediated down-regulation of OCTN2 and PPARα expression in human placentas and in BeWo cells
    Ting Ting Chang
    School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan
    Mol Pharm 8:117-25. 2011
    ..WY14643, a PPARα agonist, caused an increase in OCTN2 expression in BeWo cells under hypoxic conditions. In conclusion, under hypoxic conditions, placental OCTN2 is down-regulated through PPARα-mediated pathways...
  30. doi request reprint Change in P-glycoprotein and caveolin protein expression in brain striatum capillaries in New Zealand obese mice with type 2 diabetes
    Kuo Chen Wu
    School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan
    Life Sci 85:775-81. 2009
    ..To investigate the expression of P-gp and caveolins in brain striatum capillaries in inbred mice with type 2 diabetes...