Ching Chow Chen

Summary

Affiliation: National Taiwan University
Country: Taiwan

Publications

  1. ncbi request reprint Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: structure-activity relationships
    Ching Chow Chen
    Department of Pharmacology, College of Medicine, National Taiwan University, No 1, Jen Ai Road, Section 1, Taipei 10018, Taiwan
    Mol Pharmacol 66:683-93. 2004
  2. ncbi request reprint Conjugated polyhydroxybenzene derivatives block tumor necrosis factor-alpha-mediated nuclear factor-kappaB activation and cyclooxygenase-2 gene transcription by targeting IkappaB kinase activity
    C C Chen
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Pharmacol 60:1439-48. 2001
  3. ncbi request reprint Protein kinase calpha but not p44/42 mitogen-activated protein kinase, p38, or c-Jun NH(2)-terminal kinase is required for intercellular adhesion molecule-1 expression mediated by interleukin-1beta: involvement of sequential activation of tyrosine kinase,
    C C Chen
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Pharmacol 58:1479-89. 2000
  4. ncbi request reprint TNF-alpha-induced cyclooxygenase-2 expression in human lung epithelial cells: involvement of the phospholipase C-gamma 2, protein kinase C-alpha, tyrosine kinase, NF-kappa B-inducing kinase, and I-kappa B kinase 1/2 pathway
    C C Chen
    Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Immunol 165:2719-28. 2000
  5. ncbi request reprint Signal transduction pathways of inflammatory gene expressions and therapeutic implications
    Ching Chow Chen
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Curr Pharm Des 12:3497-508. 2006
  6. ncbi request reprint Tumor necrosis factor alpha-induced activation of downstream NF-kappaB site of the promoter mediates epithelial ICAM-1 expression and monocyte adhesion. Involvement of PKCalpha, tyrosine kinase, and IKK2, but not MAPKs, pathway
    C Chen
    Department of Pharmacology, College of Medicine, National Taiwan University, Number 1, Jen Ai Road, First Section, 10018, Taipei, Taiwan, ROC
    Cell Signal 13:543-53. 2001
  7. ncbi request reprint p38 but not p44/42 mitogen-activated protein kinase is required for nitric oxide synthase induction mediated by lipopolysaccharide in RAW 264.7 macrophages
    C C Chen
    Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Pharmacol 55:481-8. 1999
  8. ncbi request reprint Antisense oligonucleotides targeting protein kinase C-alpha, -beta I, or -delta but not -eta inhibit lipopolysaccharide-induced nitric oxide synthase expression in RAW 264.7 macrophages: involvement of a nuclear factor kappa B-dependent mechanism
    C C Chen
    Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei
    J Immunol 161:6206-14. 1998
  9. ncbi request reprint Interferon-gamma-induced epithelial ICAM-1 expression and monocyte adhesion. Involvement of protein kinase C-dependent c-Src tyrosine kinase activation pathway
    Ya Jen Chang
    Department of Pharmacology, College of Medicine, National Taiwan University, No 1 Jen Ai Road, 1st Section, Taipei 10018, Taiwan
    J Biol Chem 277:7118-26. 2002
  10. ncbi request reprint Mechanisms for Helicobacter pylori CagA-induced cyclin D1 expression that affect cell cycle
    Ya Jen Chang
    Department of Pharmacology, College of Medicine, National Taiwan University, National Taiwan University Hospital, Taipei, Taiwan
    Cell Microbiol 8:1740-52. 2006

Collaborators

Detail Information

Publications63

  1. ncbi request reprint Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: structure-activity relationships
    Ching Chow Chen
    Department of Pharmacology, College of Medicine, National Taiwan University, No 1, Jen Ai Road, Section 1, Taipei 10018, Taiwan
    Mol Pharmacol 66:683-93. 2004
    ..Finally, our results suggested that AP-1 seems to play a more significant role than NF-kappaB in the flavonoid-induced ICAM-1 inhibition...
  2. ncbi request reprint Conjugated polyhydroxybenzene derivatives block tumor necrosis factor-alpha-mediated nuclear factor-kappaB activation and cyclooxygenase-2 gene transcription by targeting IkappaB kinase activity
    C C Chen
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Pharmacol 60:1439-48. 2001
    ....
  3. ncbi request reprint Protein kinase calpha but not p44/42 mitogen-activated protein kinase, p38, or c-Jun NH(2)-terminal kinase is required for intercellular adhesion molecule-1 expression mediated by interleukin-1beta: involvement of sequential activation of tyrosine kinase,
    C C Chen
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Pharmacol 58:1479-89. 2000
    ..However, activation of p44/42 MAPK, p38, and JNK is not involved...
  4. ncbi request reprint TNF-alpha-induced cyclooxygenase-2 expression in human lung epithelial cells: involvement of the phospholipase C-gamma 2, protein kinase C-alpha, tyrosine kinase, NF-kappa B-inducing kinase, and I-kappa B kinase 1/2 pathway
    C C Chen
    Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Immunol 165:2719-28. 2000
    ....
  5. ncbi request reprint Signal transduction pathways of inflammatory gene expressions and therapeutic implications
    Ching Chow Chen
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Curr Pharm Des 12:3497-508. 2006
    ..Furthermore, natural products and novel agents targeting on the transcription factor with potential anti-inflammation and anti-tumor activity are also discussed...
  6. ncbi request reprint Tumor necrosis factor alpha-induced activation of downstream NF-kappaB site of the promoter mediates epithelial ICAM-1 expression and monocyte adhesion. Involvement of PKCalpha, tyrosine kinase, and IKK2, but not MAPKs, pathway
    C Chen
    Department of Pharmacology, College of Medicine, National Taiwan University, Number 1, Jen Ai Road, First Section, 10018, Taipei, Taiwan, ROC
    Cell Signal 13:543-53. 2001
    ..However, activation of p44/42 MAPK, p38, and JNK is not involved in this event...
  7. ncbi request reprint p38 but not p44/42 mitogen-activated protein kinase is required for nitric oxide synthase induction mediated by lipopolysaccharide in RAW 264.7 macrophages
    C C Chen
    Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Pharmacol 55:481-8. 1999
    ..Thus, activation of p38 but not p44/42 MAPK by LPS resulted in the stimulation of NF-kappaB-specific DNA-protein binding and the subsequent expression of inducible form of NO synthase and NO release in RAW 264.7 macrophages...
  8. ncbi request reprint Antisense oligonucleotides targeting protein kinase C-alpha, -beta I, or -delta but not -eta inhibit lipopolysaccharide-induced nitric oxide synthase expression in RAW 264.7 macrophages: involvement of a nuclear factor kappa B-dependent mechanism
    C C Chen
    Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei
    J Immunol 161:6206-14. 1998
    ..PKC isoforms alpha, betaI, and delta were shown to be involved in the regulation of these LPS-induced events...
  9. ncbi request reprint Interferon-gamma-induced epithelial ICAM-1 expression and monocyte adhesion. Involvement of protein kinase C-dependent c-Src tyrosine kinase activation pathway
    Ya Jen Chang
    Department of Pharmacology, College of Medicine, National Taiwan University, No 1 Jen Ai Road, 1st Section, Taipei 10018, Taiwan
    J Biol Chem 277:7118-26. 2002
    ....
  10. ncbi request reprint Mechanisms for Helicobacter pylori CagA-induced cyclin D1 expression that affect cell cycle
    Ya Jen Chang
    Department of Pharmacology, College of Medicine, National Taiwan University, National Taiwan University Hospital, Taipei, Taiwan
    Cell Microbiol 8:1740-52. 2006
    ....
  11. ncbi request reprint Tyrosine phosphorylation of I-kappa B kinase alpha/beta by protein kinase C-dependent c-Src activation is involved in TNF-alpha-induced cyclooxygenase-2 expression
    Wei Chien Huang
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Immunol 170:4767-75. 2003
    ..These two pathways cross-link between c-Src and NIK and converge at IKKalpha/beta, and go on to activate NF-kappaB, via serine phosphorylation and degradation of IkappaB-alpha, and, finally, to initiate COX-2 expression...
  12. ncbi request reprint c-Src-dependent tyrosine phosphorylation of IKKbeta is involved in tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 expression
    Wei Chien Huang
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei 10018, Taiwan
    J Biol Chem 278:9944-52. 2003
    ..These two pathways converge at IKKbeta and go on to activate NF-kappaB, via serine phosphorylation and degradation of IkappaB-alpha, and, finally, to initiate ICAM-1 expression...
  13. ncbi request reprint Inhibition of ICAM-1 gene expression, monocyte adhesion and cancer cell invasion by targeting IKK complex: molecular and functional study of novel alpha-methylene-gamma-butyrolactone derivatives
    Wei Chien Huang
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei 10018, Taiwan
    Carcinogenesis 25:1925-34. 2004
    ..These agents may be effective in the anti-inflammatory and anticancer therapy...
  14. ncbi request reprint Tumor necrosis factor-alpha-induced cyclooxygenase-2 expression via sequential activation of ceramide-dependent mitogen-activated protein kinases, and IkappaB kinase 1/2 in human alveolar epithelial cells
    C C Chen
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Pharmacol 59:493-500. 2001
    ....
  15. ncbi request reprint Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappaB and pp38 mitogen-activated protein kinase
    Jui Hsiang Hung
    Department of Biochemistry, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan, Republic of China
    J Biol Chem 279:46384-92. 2004
    ..Our results provide important insights into cellular carcinogenesis associated with latent endoplasmic reticulum stress...
  16. ncbi request reprint A novel anticancer effect of thalidomide: inhibition of intercellular adhesion molecule-1-mediated cell invasion and metastasis through suppression of nuclear factor-kappaB
    Yi Chu Lin
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Clin Cancer Res 12:7165-73. 2006
    ..In this study, we further investigated the role of ICAM-1 in tumorigenesis, including tumor formation and metastasis. ICAM-1 as a molecular target for cancer and the anticancer effect of thalidomide were investigated...
  17. ncbi request reprint Helicobacter pylori-Induced invasion and angiogenesis of gastric cells is mediated by cyclooxygenase-2 induction through TLR2/TLR9 and promoter regulation
    Ya Jen Chang
    Department of Pharmacology, National Taiwan University, Taipei, Taiwan
    J Immunol 175:8242-52. 2005
    ..These intracellular networks drive the COX-2-dependent PGE2 release and contribute to cell invasion and angiogenesis...
  18. pmc Akt phosphorylation of p300 at Ser-1834 is essential for its histone acetyltransferase and transcriptional activity
    Wei Chien Huang
    Department of Pharmacology, College of Medicine, National Taiwan University, No 1 Jen Ai Road, 1st Section, Taipei 10018, Taiwan
    Mol Cell Biol 25:6592-602. 2005
    ..Our study provides a new insight into the molecular mechanism by which Akt promotes the transcriptional potential of p300...
  19. doi request reprint Inhibition of autophagy enhances anticancer effects of atorvastatin in digestive malignancies
    Pei Ming Yang
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Cancer Res 70:7699-709. 2010
    ..Combinations of atorvastatin with bafilomycin A1 provide a novel and promising strategy to improve the treatment of digestive malignancies...
  20. doi request reprint Loss of IKKbeta activity increases p53 stability and p21 expression leading to cell cycle arrest and apoptosis
    Pei Ming Yang
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Cell Mol Med 14:687-98. 2010
    ..These results suggest that loss of IKKbeta activation is important for the enhancement of p53 stability, leading to p21 expression and cell cycle arrest and apoptosis of tumour cells...
  21. ncbi request reprint Differential role of Janus family kinases (JAKs) in interferon-gamma-induced lung epithelial ICAM-1 expression: involving protein interactions between JAKs, phospholipase Cgamma, c-Src, and STAT1
    Ya Jen Chang
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Pharmacol 65:589-98. 2004
    ..One is the JAK1/2-dependent PLC-gamma pathway inducing the activations of PKCalpha, c-Src, and STAT1, and the other is the direct activation of STAT1 by JAK1/2...
  22. ncbi request reprint Induction of IL-8 release in lung cells via activator protein-1 by recombinant baculovirus displaying severe acute respiratory syndrome-coronavirus spike proteins: identification of two functional regions
    Ya Jen Chang
    Department of Pharmacology, College of Medicine, National Taiwan University and National Taiwan University Hospital, Taipei, Taiwan
    J Immunol 173:7602-14. 2004
    ..The identification of the functional domain for IL-8 release will provide for the drug design on targeting specific sequence domains of S protein responsible for initiating the inflammatory response...
  23. ncbi request reprint Distinct gene expression profiles in gastric epithelial cells induced by different clinical isolates of Helicobacter pylori--implication of bacteria and host interaction in gastric carcinogenesis
    Yu Ting Chang
    Department of Internal Medicine, National Taiwan University Hospital College of Medicine, National Taiwan University, Taipei
    Hepatogastroenterology 53:484-90. 2006
    ..pylori-related diseases. We aimed to examine simultaneously dynamic changes of multiple molecular pathways of infection affected by different H. pylori strains by cDNA microarrays...
  24. pmc CD1d induction in solid tumor cells by histone deacetylase inhibitors through inhibition of HDAC1/2 and activation of Sp1
    Pei Ming Yang
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Epigenetics 7:390-9. 2012
    ..These results indicate that TSA and SAHA could up-regulate CD1d expression in tumor cells through inhibition of HDAC1/2 and activation of Sp1...
  25. pmc Degradation of epidermal growth factor receptor mediates dasatinib-induced apoptosis in head and neck squamous cell carcinoma cells
    Yu Chin Lin
    Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan
    Neoplasia 14:463-75. 2012
    ..In conclusion, degradation of EGFR is a novel mechanism responsible for dasatinib-induced apoptosis in HNSCC cells...
  26. ncbi request reprint Induction of cyclooxygenase-2 overexpression in human gastric epithelial cells by Helicobacter pylori involves TLR2/TLR9 and c-Src-dependent nuclear factor-kappaB activation
    Ya Jen Chang
    Department of Pharmacology, College of Medicine, National Taiwan University and National Taiwan University Hospital, Taipei, Taiwan
    Mol Pharmacol 66:1465-77. 2004
    ..The COX-2 overexpression may contribute to the carcinogenesis in patients colonized with these strains...
  27. pmc Transcriptional regulation of cyclooxygenase-2 in response to proteasome inhibitors involves reactive oxygen species-mediated signaling pathway and recruitment of CCAAT/enhancer-binding protein delta and CREB-binding protein
    Jun Jie Chen
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei 10018, Taiwan
    Mol Biol Cell 16:5579-91. 2005
    ..These findings reveal that the induction of COX-2 transcription induced by proteasome inhibitors requires ROS-dependent protein kinases activation and the subsequent recruitments of C/EBPdelta and CBP...
  28. pmc Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB
    Wei Chien Huang
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei 10018, Taiwan Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cell 26:75-87. 2007
    ..Our results suggest that phosphorylation of CBP by IKKalpha regulates the CBP-mediated crosstalk between NF-kappaB and p53 and thus may be a critical factor in the promotion of cell proliferation and tumor growth...
  29. doi request reprint Statins increase p21 through inhibition of histone deacetylase activity and release of promoter-associated HDAC1/2
    Yi Chu Lin
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei 10018, Taiwan
    Cancer Res 68:2375-83. 2008
    ..Therefore, statins might serve as novel HDAC inhibitors for cancer therapy and chemoprevention...
  30. pmc HDAC inhibition decreases the expression of EGFR in colorectal cancer cells
    Chia Wei Chou
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    PLoS ONE 6:e18087. 2011
    ..Our data suggested that HDACi could serve as a single agent to block both EGFR and HDAC, and may bring more benefits to the development of CRC therapy...
  31. pmc Zebularine inhibits tumorigenesis and stemness of colorectal cancer via p53-dependent endoplasmic reticulum stress
    Pei Ming Yang
    1 Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan 2 The Ph D Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan 3
    Sci Rep 3:3219. 2013
    ..Zeb downregulates GRP78 and p62, and upregulates a pro-apoptotic CHOP. Our results reveal a novel mechanism for the anticancer activity of Zeb. ..
  32. doi request reprint Inhibition of histone deacetylase activity is a novel function of the antifolate drug methotrexate
    Pei Ming Yang
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei 10018, Taiwan
    Biochem Biophys Res Commun 391:1396-9. 2010
    ..The global acetylation of histone H3 was also induced by MTX. Moreover, MTX inhibited immunoprecipitated HDAC1/2 activity but not their protein levels. This study provides evidence that MTX inhibits HDAC activity...
  33. doi request reprint Design and synthesis of dual-action inhibitors targeting histone deacetylases and 3-hydroxy-3-methylglutaryl coenzyme A reductase for cancer treatment
    Jhih Bin Chen
    Department of Chemistry, National Taiwan University, Taipei 106, Taiwan
    J Med Chem 56:3645-55. 2013
    ..These compounds also effectively reduced the HMGR activity as well as promoted the acetylations of histone and tubulin in cancer cells, but were not toxic to normal cells...
  34. ncbi request reprint Autophagy potentiates the anti-cancer effects of the histone deacetylase inhibitors in hepatocellular carcinoma
    Yuan Ling Liu
    Department of Pharmacology, College of Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Autophagy 6:1057-65. 2010
    ..Our results show that the combination of autophagy inducers with SAHA might be attractive for the treatment of HCC and pharmacological targeting of autophagy provides promise for the management of cancer therapy...
  35. doi request reprint Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2
    Wen Yu Huang
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei 10018, Taiwan
    Biochem Pharmacol 81:510-7. 2011
    ..Therefore, the anticancer mechanism of MTX acts through initiation of p53-dependent apoptosis and restoration of E-cadherin expression by downregulation of HDAC/EZH2...
  36. ncbi request reprint AID downregulation is a novel function of the DNMT inhibitor 5-aza-deoxycytidine
    Chiou Tsun Tsai
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Oncotarget 5:211-23. 2014
    ..The study not only displays the association of AID and DNMT1 and identifies a novel biological function of AID, but also provides novel information regarding the use of DNMT inhibitors to treat AID-positive hematopoietic cancers. ..
  37. ncbi request reprint Proteasome inhibitors enhance TRAIL-induced apoptosis through the intronic regulation of DR5: involvement of NF-kappa B and reactive oxygen species-mediated p53 activation
    Jun Jie Chen
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Immunol 180:8030-9. 2008
    ....
  38. ncbi request reprint Life or death? Autophagy in anticancer therapies with statins and histone deacetylase inhibitors
    Pei Ming Yang
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Autophagy 7:107-8. 2011
    ..Here, we will discuss the differential signaling pathways elicited by statins and HDACi. We find that AMPK, cytoplasmic p21 and Akt signaling are crucial determinants of cell fates (i.e., life or death) while autophagy is induced...
  39. pmc Ring down artefacts on abdominal sonography to predict pulmonary abnormalities in the emergency department
    C L Tsai
    Department of Emergency Medicine, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan
    Emerg Med J 22:747-8. 2005
    ..Ring down artefacts on ultrasound may be used to predict pulmonary abnormalities. Awareness of this sonographic finding may assist in accurate diagnosis and administration of appropriate treatment without delay...
  40. ncbi request reprint Protein kinase C eta mediates lipopolysaccharide-induced nitric-oxide synthase expression in primary astrocytes
    C C Chen
    Institutes of Pharmacology, College of Medicine, National Taiwan University, No 1, Jen Ai Road, 1st Section, Taipei 10018, Taiwan
    J Biol Chem 273:19424-30. 1998
    ..This is further evidence demonstrating that different members of the PKC family within a single cell are involved in specific physiological responses...
  41. ncbi request reprint Isolation of immunoglobulin from egg yolk by anionic polysaccharides
    H M Chang
    Graduate Institute of Food Science and Technology, National Taiwan University, Taipei 106, Taiwan
    J Agric Food Chem 48:995-9. 2000
    ..The interactions between polysaccharides and lipoproteins were mainly ionic bonds, hydrophobic interactions, and hydrogen bonds as determined by the addition (0-2.0 M) of NaSCN or urea to the polysaccharide-lipoprotein precipitates...
  42. pmc Combined treatment with denbinobin and Fas ligand has a synergistic cytotoxic effect in human pancreatic adenocarcinoma BxPC-3 cells
    C R Yang
    School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan
    Br J Pharmacol 157:1175-85. 2009
    ..In the present study, we evaluated the anti-cancer activity of a natural compound, denbinobin (5-hydroxy-3,7-dimethoxy-1,4-phenanthraquinone), through decreasing DcR3 levels in human pancreatic adenocarcinoma cell lines...
  43. ncbi request reprint TPA induces translocation but not down-regulation of new PKC isoform eta in macrophages, MDCK cells and astrocytes
    C C Chen
    Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei
    FEBS Lett 412:30-4. 1997
    ..Stimulation of the cells with TPA resulted in translocation to the plasma membrane. This translocation of PKC eta was still apparent after 24 h treatment with TPA...
  44. doi request reprint ERK1/2 activation regulates the wound healing process of rabbit corneal endothelial cells
    Wei Li Chen
    Department of Ophthalmology and Center of Corneal Tissue Engineering and Stem Cell Biology, National Taiwan University Hospital, Taipei, Taiwan
    Curr Eye Res 34:103-11. 2009
    ..To evaluate the activation of ERK, a MAP kinase, in the regulation of proliferation and migration of rabbit corneal endothelial cells during the healing process after scrape wound injury...
  45. doi request reprint HDAC inhibition upregulates the expression of angiostatic ADAMTS1
    Chia Wei Chou
    Department of Pharmacology, College of Medicine, National Taiwan University, No 1, Jen Ai Road, 1st Section Taipei 10018, Taiwan
    FEBS Lett 582:4059-65. 2008
    ..Decreased binding of SP1 and HDAC6 to the ADAMTS1 promoter after TSA treatment was also seen. These data suggest the involvement of HDAC6 and SP1 in the HDACi-induced expression of angiostatic ADAMTS1...
  46. doi request reprint CIP2A-mediated Akt activation plays a role in bortezomib-induced apoptosis in head and neck squamous cell carcinoma cells
    Yu Chin Lin
    Department of Oncology, National Taiwan University Hospital, No 7 Chung Shan S Rd, Taipei, Taiwan
    Oral Oncol 48:585-93. 2012
    ..Furthermore, xenograft model showed that bortezomib down-regulated CIP2A and p-Akt in SAS tumor cells. CIP2A is demonstrated to be a new therapeutic target of bortezomib in HNSCC...
  47. ncbi request reprint Epimedium brevicornum Maxim extract relaxes rabbit corpus cavernosum through multitargets on nitric oxide/cyclic guanosine monophosphate signaling pathway
    J H Chiu
    Institute of Traditional Medicine, School of Medicine, National Yang Ming University, Peitou, Taipei, Taiwan, ROC
    Int J Impot Res 18:335-42. 2006
    ..We concluded that extract of EbM relax the CC smooth muscle through multitargets in NO/cGMP/PDE 5 pathway and might bring into perspective the treatment strategy for those patients with erectile dysfunction...
  48. ncbi request reprint TNF-alpha suppressed TGF-beta-induced CTGF expression by switching the binding preference of p300 from Smad4 to p65
    Fun Yu
    Department of Pharmacology, College of Medicine, National Taiwan University, No 1 Jen Ai Road, Taipei, Taiwan
    Cell Signal 21:867-72. 2009
    ..Overall, our data showed that suppression of TNF-alpha on TGF-beta-induced CTGF expression is due to the competition of p300 by p65 and Smad4...
  49. ncbi request reprint Microarray profiling of gene expression patterns in bladder tumor cells treated with genistein
    C C Chen
    Institute of Molecular Medicine, National Cheng Kung University, Medical College, Tainan, Taiwan, ROC
    J Biomed Sci 8:214-22. 2001
    ..These genes warrant further investigation as regards their roles in the susceptibility of the tumor cell line to the antitumor drug...
  50. ncbi request reprint Anti-tumor effects of d-dicentrine from the root of Lindera megaphylla
    R L Huang
    National Research Institute of Chinese Medicine, Taipei, Taiwan, R O C
    Planta Med 64:212-5. 1998
    ..All these data indicated that d-dicentrine has potential anti-tumor applications...
  51. ncbi request reprint Antileukemic activity of Bidens pilosa L. var. minor (Blume) Sherff and Houttuynia cordata Thunb
    J S Chang
    Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan
    Am J Chin Med 29:303-12. 2001
    ..1. B. pilosa var. minor was more effective than H. cordata in inhibiting most of the leukemic cells in our study. We suggest that B. pilosa L. var. minor (Blume) Sherff may prove to be a useful medicinal plant for treating leukemia...
  52. ncbi request reprint Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis
    R L Huang
    Department of Pharmacology, National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC
    Planta Med 66:694-8. 2000
    ..Wogonin deserves to be further evaluated for the treatment of human HBV infection...
  53. ncbi request reprint Cloning and expression of the genes associated with lipid metabolism in Tsaiya ducks
    C F Yen
    Department of Animal Science, National Taiwan University, Taipei, Taiwan
    Poult Sci 84:67-74. 2005
    ..Therefore, laying may affect particular aspects of lipid metabolism, especially biochemical pathways that involved apoVLDL-II and HMG-CoA reductase...
  54. ncbi request reprint Ribosomal phosphoprotein P0 interacts with GCIP and overexpression of P0 is associated with cellular proliferation in breast and liver carcinoma cells
    T W Chang
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Oncogene 27:332-8. 2008
    ..Together, these data indicate that P0 overexpression may cause tumorigenesis in breast and liver tissues at least in part by inhibiting GCIP-mediated tumor suppression...
  55. ncbi request reprint Regulation of herpes simplex virus type 1 replication in Vero cells by Psychotria serpens: relationship to gene expression, DNA replication, and protein synthesis
    Y C Kuo
    National Research Institute of Chinese Medicine, NO 155 1, Sec 2, Li Nung St Shih Pai, 112, Taipei, Taiwan, ROC
    Antiviral Res 51:95-109. 2001
    ..Plans are underway for the isolation of pure compounds from PS-A-6 and elucidation of their mechanism of action...
  56. ncbi request reprint Effects of age and hypertension on endothelium-dependent vasodilating responses
    H Chen
    Department of Physiology, National Cheng Kung University Medical College, Tainan, Taiwan, ROC
    Chin J Physiol 40:157-64. 1997
    ..In conclusion, basal release of EDRF decreases before hypertension is well established, and the impairment of ACh-evoked vasorelaxation in adult SHR is mainly due to the release of contracting factors...
  57. ncbi request reprint Characterization of the antiplatelet effects of (2S)-5-methoxy-6-methylflavan-7-ol from Draconis Resina
    W J Tsai
    National Research Institute of Chinese Medicine, Taipei, Taiwan
    Eur J Pharmacol 346:103-10. 1998
    ..This study provided evidence that MMF is an antiplatelet agent whose activity is likely related to cyclooxygenase inhibition and suppression of [Ca2+]i increase...
  58. ncbi request reprint Resection of triple synchronous tumors--gastric adenocarcinoma, gallbladder adenocarcinoma and stromal tumor of the stomach
    J H Chen
    Department of Medicine, Taipei Veterans General Hospital, Taiwan, ROC
    Zhonghua Yi Xue Za Zhi (Taipei) 64:655-60. 2001
    ..Pathological findings revealed gastric adenocarcinoma, gallbladder adenocarcinoma and stromal cell tumor of the stomach. The postoperative course was smooth...
  59. pmc Contact-induced structure transformation in transmembrane prion propagation
    D M Ou
    Department of Physics, National Taiwan Normal University, Taipei, Taiwan
    Biophys J 92:2704-10. 2007
    ..By comparing with the experimental correlation curve between incubation time and injected dose of scrapie prions, we conclude that cooperative dimerization may play an important role in the pathological mechanism of prion diseases...
  60. doi request reprint Influences of surgical decompression on the dorsal horn after chronic constriction injury: changes in peptidergic and delta-opioid receptor (+) nerve terminals
    T J Tseng
    Department of Anatomy and Cell Biology, National Taiwan University College of Medicine, Taipei, Taiwan
    Neuroscience 156:758-68. 2008
    ..These findings suggest that CCI and decompression cause different patterns in peptidergic and DOR (+) nerve terminals in the dorsal horn...
  61. pmc Combined modalities of resistance in an oxaliplatin-resistant human gastric cancer cell line with enhanced sensitivity to 5-fluorouracil
    C C Chen
    National Institute of Cancer Research, National Health Research Institutes, Taipei 114, Taiwan, ROC
    Br J Cancer 97:334-44. 2007
    ..Downregulation of thymidylate synthase in S3 cells renders them more susceptible to 5-fluorouracil-induced cytotoxicity. These findings could pave ways for future efforts to overcome oxaliplatin resistance...
  62. ncbi request reprint Optimization of separation and migration behavior of chloropyridines in micellar electrokinetic chromatography
    C E Lin
    Department of Chemistry, National Taiwan University, Taipei, Taiwan
    J Chromatogr A 910:165-71. 2001
    ..However, electrostatic interactions may also play a significant role in the determination of the migration order of the positional isomers of chloropyridines...
  63. ncbi request reprint Synergistic effect of arachidonic acid and cyclic AMP on glucose transport in 3T3-L1 adipocytes
    J C Fong
    Institute of Biochemistry, National Yang Ming University, Taipei, Taiwan, Republic of China
    Cell Signal 11:53-8. 1999
    ..Thus the present study seems to indicate that arachidonic acid may act with cAMP in a synergistic way to increase glucose transport by a PKC-dependent mechanism. The increased activity may be accounted for by increased GLUT1 synthesis...