Chien Jen Chen

Summary

Affiliation: National Taiwan University
Country: Taiwan

Publications

  1. pmc Persistence of type-specific human papillomavirus infection and increased long-term risk of cervical cancer
    Hui Chi Chen
    Genomics Research Center, Academia Sinica, 128 Academia Rd Section 2, Nankang, Taipei 11529, Taiwan
    J Natl Cancer Inst 103:1387-96. 2011
  2. doi request reprint Natural history of chronic hepatitis B REVEALed
    Chien Jen Chen
    Genomics Research Center, Academia Sinica, National Taiwan University, Taipei, Taichung, Taiwan
    J Gastroenterol Hepatol 26:628-38. 2011
  3. ncbi request reprint Long-term outcomes in hepatitis B: the REVEAL-HBV study
    Chien Jen Chen
    Genomics Research Center, Academia Sinica, 128 Academia Road Section 2, Nankang, Taipei 115, Taiwan
    Clin Liver Dis 11:797-816, viii. 2007
  4. doi request reprint Carriers of inactive hepatitis B virus are still at risk for hepatocellular carcinoma and liver-related death
    Jin De Chen
    Department of Internal Medicine, Bei Hu Branch, National Taiwan University Hospital, Taipei, Taiwan
    Gastroenterology 138:1747-54. 2010
  5. doi request reprint Nomograms for risk of hepatocellular carcinoma in patients with chronic hepatitis B virus infection
    Hwai I Yang
    Genomics Research Center, Academia Sinica, Graduate Institute of Epidemiology, College of Public Health and Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Toronto, Ontario, Canada
    J Clin Oncol 28:2437-44. 2010
  6. ncbi request reprint Polymorphisms in XRCC1 and glutathione S-transferase genes and hepatitis B-related hepatocellular carcinoma
    Ming Whei Yu
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    J Natl Cancer Inst 95:1485-8. 2003
  7. ncbi request reprint Increased risk for hepatitis B-related liver cirrhosis in relatives of patients with hepatocellular carcinoma in northern Taiwan
    Ming Whei Yu
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    Int J Epidemiol 31:1008-15. 2002
  8. ncbi request reprint Hepatitis B virus genotype and DNA level and hepatocellular carcinoma: a prospective study in men
    Ming Whei Yu
    Department of Public Health, Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    J Natl Cancer Inst 97:265-72. 2005
  9. doi request reprint Hepatitis C virus seromarkers and subsequent risk of hepatocellular carcinoma: long-term predictors from a community-based cohort study
    Mei Hsuan Lee
    National Taiwan University, Taipei, Taiwan
    J Clin Oncol 28:4587-93. 2010
  10. ncbi request reprint Arsenic exposure, urinary arsenic speciation, and peripheral vascular disease in blackfoot disease-hyperendemic villages in Taiwan
    Chin Hsiao Tseng
    Department of Internal Medicine, Division of Endocrinology and Metabolism, National Taiwan University Hospital, Taipei, Taiwan
    Toxicol Appl Pharmacol 206:299-308. 2005

Collaborators

Detail Information

Publications132 found, 100 shown here

  1. pmc Persistence of type-specific human papillomavirus infection and increased long-term risk of cervical cancer
    Hui Chi Chen
    Genomics Research Center, Academia Sinica, 128 Academia Rd Section 2, Nankang, Taipei 11529, Taiwan
    J Natl Cancer Inst 103:1387-96. 2011
    ..We followed a large-scale community-based cohort for 16 years to investigate the role of genotype-specific HPV persistence in predicting cervical cancer including invasive and in situ carcinoma...
  2. doi request reprint Natural history of chronic hepatitis B REVEALed
    Chien Jen Chen
    Genomics Research Center, Academia Sinica, National Taiwan University, Taipei, Taichung, Taiwan
    J Gastroenterol Hepatol 26:628-38. 2011
    ..Serum HBV DNA level at study entry is a major predictor of spontaneous seroclearance of HBeAg, HBV DNA and HBsAg. These findings may inform the effective and efficient management of chronic hepatitis B...
  3. ncbi request reprint Long-term outcomes in hepatitis B: the REVEAL-HBV study
    Chien Jen Chen
    Genomics Research Center, Academia Sinica, 128 Academia Road Section 2, Nankang, Taipei 115, Taiwan
    Clin Liver Dis 11:797-816, viii. 2007
    ....
  4. doi request reprint Carriers of inactive hepatitis B virus are still at risk for hepatocellular carcinoma and liver-related death
    Jin De Chen
    Department of Internal Medicine, Bei Hu Branch, National Taiwan University Hospital, Taipei, Taiwan
    Gastroenterology 138:1747-54. 2010
    ..The risk and the predictors of liver disease progression in carriers of inactive hepatitis B virus (HBV) are unclear...
  5. doi request reprint Nomograms for risk of hepatocellular carcinoma in patients with chronic hepatitis B virus infection
    Hwai I Yang
    Genomics Research Center, Academia Sinica, Graduate Institute of Epidemiology, College of Public Health and Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Toronto, Ontario, Canada
    J Clin Oncol 28:2437-44. 2010
    ..This study aimed to develop nomograms for predicting hepatocellular carcinoma risk in patients with chronic hepatitis B...
  6. ncbi request reprint Polymorphisms in XRCC1 and glutathione S-transferase genes and hepatitis B-related hepatocellular carcinoma
    Ming Whei Yu
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    J Natl Cancer Inst 95:1485-8. 2003
    ..07, 95% confidence interval = 1.67 to 38.93) than for those with the Arg/Arg genotype. Thus, GST status appears to affect the risk of HCC associated with this XRCC1 polymorphism...
  7. ncbi request reprint Increased risk for hepatitis B-related liver cirrhosis in relatives of patients with hepatocellular carcinoma in northern Taiwan
    Ming Whei Yu
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    Int J Epidemiol 31:1008-15. 2002
    ....
  8. ncbi request reprint Hepatitis B virus genotype and DNA level and hepatocellular carcinoma: a prospective study in men
    Ming Whei Yu
    Department of Public Health, Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    J Natl Cancer Inst 97:265-72. 2005
    ..Although chronic infection with hepatitis B virus (HBV) has been established as a cause of hepatocellular carcinoma (HCC), the roles of viral load and HBV genotype remain unclear...
  9. doi request reprint Hepatitis C virus seromarkers and subsequent risk of hepatocellular carcinoma: long-term predictors from a community-based cohort study
    Mei Hsuan Lee
    National Taiwan University, Taipei, Taiwan
    J Clin Oncol 28:4587-93. 2010
    ..Long-term predictors for HCV-related hepatocellular carcinoma are essential for early intervention. Serum HCV RNA and ALT levels and HCV genotype were assessed for their predictability of hepatocellular carcinoma risk...
  10. ncbi request reprint Arsenic exposure, urinary arsenic speciation, and peripheral vascular disease in blackfoot disease-hyperendemic villages in Taiwan
    Chin Hsiao Tseng
    Department of Internal Medicine, Division of Endocrinology and Metabolism, National Taiwan University Hospital, Taipei, Taiwan
    Toxicol Appl Pharmacol 206:299-308. 2005
    ..05, trend test). It was concluded that individuals with a higher arsenic exposure and a lower capacity to methylate inorganic arsenic to DMA(V) have a higher risk of developing PVD in the BFD-hyperendemic area in Taiwan...
  11. pmc Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma
    Hwai I Yang
    Genomics Research Center, Academia Sinica and Graduate Institute of Epidemiology, National Taiwan University, Taipei, Taiwan
    J Natl Cancer Inst 100:1134-43. 2008
    ..We examined the HCC risk associated with HBV genotypes and common variants in the precore and basal core promoter (BCP) regions...
  12. doi request reprint Prediction models of long-term cirrhosis and hepatocellular carcinoma risk in chronic hepatitis B patients: risk scores integrating host and virus profiles
    Mei Hsuan Lee
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    Hepatology 58:546-54. 2013
    ..Conclusion: The risk prediction models of cirrhosis and HCC by integrating host and HBV profiles have excellent prediction accuracy and discriminatory ability. They may be used for clinical management of chronic hepatitis B patients...
  13. ncbi request reprint Arsenic methylation capability and hypertension risk in subjects living in arseniasis-hyperendemic areas in southwestern Taiwan
    Yung Kai Huang
    Graduate Institute of Medical Sciences, School of Medicine, Taipei Medical University, Taipei, Taiwan
    Toxicol Appl Pharmacol 218:135-42. 2007
    ..This study further explored the association between arsenic methylation capability and hypertension risk among residents of arseniasis-hyperendemic areas in Taiwan considering the effect of CAE and other potential confounders...
  14. doi request reprint Changes in serum levels of HBV DNA and alanine aminotransferase determine risk for hepatocellular carcinoma
    Chuen Fei Chen
    Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, and Department of Internal Medicine, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Gastroenterology 141:1240-8, 1248.e1-2. 2011
    ..It is not clear whether risk for hepatocellular carcinoma can be accurately determined from long-term changes in serum levels of hepatitis B virus (HBV) DNA or alanine aminotransferase (ALT)...
  15. ncbi request reprint Hepatitis B e antigen and the risk of hepatocellular carcinoma
    Hwai I Yang
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei
    N Engl J Med 347:168-74. 2002
    ..We conducted a prospective study to determine the relation between positivity for hepatitis B surface antigen (HBsAg) and HBeAg and the development of hepatocellular carcinoma...
  16. doi request reprint EGFR exon 19 in-frame deletion and polymorphisms of DNA repair genes in never-smoking female lung adenocarcinoma patients
    Shi Yi Yang
    Genomics Research Center, Academia Sinica, Taiwan
    Int J Cancer 132:449-58. 2013
    ..002 for trend). Our findings suggest that the in-frame deletion in EGFR exon 19 is associated with polymorphisms in DNA repair and detoxification metabolism genes in never-smoking lung adenocarcinoma patients, especially in females...
  17. ncbi request reprint Urinary arsenic profile affects the risk of urothelial carcinoma even at low arsenic exposure
    Yeong Shiau Pu
    Department of Urology, National Taiwan University College of Medicine, Taipei, Taiwan
    Toxicol Appl Pharmacol 218:99-106. 2007
    ..Subjects who have an unfavorable urinary arsenic profile have an increased UC risk even at low exposure levels...
  18. doi request reprint EGFR polymorphisms, hormone replacement therapy and lung adenocarcinoma risk: analysis from a genome-wide association study in never-smoking women
    Kuan Yu Chen
    Division of Pulmonary Medicine, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei 100, Taiwan
    Carcinogenesis 34:612-9. 2013
    ..0046, respectively). In conclusion, HRT use may modify the association of EGFR SNPs with lung adenocarcinoma risk. The EGFR SNPs have a cumulative effect on decreasing lung adenocarcinoma risk in never-smoking women with HRT use...
  19. ncbi request reprint Genetic polymorphisms of cytochrome p450 2E1, glutathione S-transferase M1 and T1, and susceptibility to gastric carcinoma in Taiwan
    Ming Shiang Wu
    Department of Internal Medicine, National Taiwan University Hospital, No 7 Chung Shan S Rd, Taipei, Taiwan
    Int J Colorectal Dis 17:338-43. 2002
    ....
  20. ncbi request reprint Androgen receptor exon 1 CAG repeat length and risk of hepatocellular carcinoma in women
    Ming Whei Yu
    Department of Public Health and Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, No 1 Jen Ai Road, Section 1, Room 1550, Taipei 100, Taiwan
    Hepatology 36:156-63. 2002
    ..No such relationship was detected among women without the family history. In conclusion, our observations suggest that the AR-CAG alleles may contribute to HCC predisposition among women through a mechanism different from that for men...
  21. ncbi request reprint Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level
    Chien Jen Chen
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    JAMA 295:65-73. 2006
    ..Serum hepatitis B virus (HBV) DNA level is a marker of viral replication and efficacy of antiviral treatment in individuals with chronic hepatitis B...
  22. ncbi request reprint No association between genetic polymorphisms of CYP1A1, GSTM1, GSTT1, GSTP1, NAT2, and nasopharyngeal carcinoma in Taiwan
    Yu Juen Cheng
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, 100 Taiwan
    Cancer Epidemiol Biomarkers Prev 12:179-80. 2003
  23. ncbi request reprint Association of the -160 C --> a promoter polymorphism of E-cadherin gene with gastric carcinoma risk
    Ming Shiang Wu
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Cancer 94:1443-8. 2002
    ..This allelic variation might be a potential genetic marker for identifying individuals at risk for cancer. There remains no report regarding the polymorphism of E-cadherin in gastric carcinoma (GC)...
  24. doi request reprint Arsenic methylation capability, heme oxygenase-1 and NADPH quinone oxidoreductase-1 genetic polymorphisms and the stage and grade of urothelial carcinomas
    Steven K Huang
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Urol Int 80:405-12. 2008
    ..To explore the distribution of the arsenic methylation capability in patients with different stages and grades of UCs, 100 UC cases were recruited between September 2002 and May 2004 for this study...
  25. doi request reprint Arsenic-induced QT dispersion is associated with atherosclerotic diseases and predicts long-term cardiovascular mortality in subjects with previous exposure to arsenic: A 17-Year follow-up study
    Chih Hao Wang
    Department of Cardiology, Cardinal Tien Hospital, Fu Jen Catholic University, Hsintien, Taipei, Taiwan
    Cardiovasc Toxicol 10:17-26. 2010
    ..QTD may be indicated as an early biomarker for atherosclerotic diseases and a significant and strong predictor of cardiovascular mortality in population with chronic arsenic exposure...
  26. ncbi request reprint Effects of arsenic exposure and genetic polymorphisms of p53, glutathione S-transferase M1, T1, and P1 on the risk of carotid atherosclerosis in Taiwan
    Yuan Hung Wang
    School of Public Health, Taipei Medical University, Taipei, Taiwan
    Atherosclerosis 192:305-12. 2007
    ..Our study showed the joint effects on the risk of carotid atherosclerosis between the genetic polymorphisms of GSTP1 and p53, and arsenic exposure...
  27. doi request reprint Polymorphisms in arsenic metabolism genes, urinary arsenic methylation profile and cancer
    Chi Jung Chung
    Graduate Institute of Public Health, Taipei Medical University, Taipei, Taiwan
    Cancer Causes Control 20:1653-61. 2009
    ..Our results show that MMA% might be a potential predictor of cancer risk. The change in MMA% was linked to individual cancer susceptibility related to AS3MT rs3740393...
  28. doi request reprint Arsenic in drinking water and risk of urinary tract cancer: a follow-up study from northeastern Taiwan
    Chi Ling Chen
    Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    Cancer Epidemiol Biomarkers Prev 19:101-10. 2010
    ..12; 95% CI, 1.48-11.5) had a significantly increased risk of urinary cancer. When restricted to urothelial carcinoma, all risk estimates including concentration and characteristics of well water consumption were higher...
  29. ncbi request reprint Long-term tracking of hepatitis B viral load and the relationship with risk for hepatocellular carcinoma in men
    Chih Feng Wu
    Research Center for Genes, Environment and Human Health and Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Xuzhou Road Zhongzheng District, Taipei 10055, Taiwan
    Carcinogenesis 29:106-12. 2008
    ..46-5.51) accounted for 43.5, 57.2 and 24.9% of HCCs, respectively. The results suggest that maintenance of viral load <4.39 log copies/ml was associated with sustained normalization of ALT levels and decreased risk of HCC...
  30. doi request reprint Use of arsenic-induced palmoplantar hyperkeratosis and skin cancers to predict risk of subsequent internal malignancy
    Ling I Hsu
    Genomics Research Center, Academia Sinica, Taipei, Taiwan
    Am J Epidemiol 177:202-12. 2013
    ..35, 5.67). A significant interactive effect on lung cancer risk between hyperkeratosis and cigarette smoking was identified, which suggests that patients with hyperkeratosis who have been exposed to arsenic should cease smoking...
  31. doi request reprint Community and personal risk factors for hepatitis C virus infection: a survey of 23,820 residents in Taiwan in 1991-2
    Mei Hsuan Lee
    Genomics Research Center, Academia Sinica, Nankang, Taipei 11529, Taiwan
    Gut 60:688-94. 2011
    ....
  32. pmc Predictability of liver-related seromarkers for the risk of hepatocellular carcinoma in chronic hepatitis B patients
    Yu Ju Lin
    Institute of Microbiology and Immunology, School of Life Sciences, National Yang Ming University, Taipei, Taiwan
    PLoS ONE 8:e61448. 2013
    ..This study aimed to assess the predictability of HCC risk in chronic hepatitis B patients, using a combination of liver-related seromarkers combined with or without HBV seromarkers...
  33. pmc GT-repeat polymorphism in the heme oxygenase-1 gene promoter and the risk of carotid atherosclerosis related to arsenic exposure
    Meei Maan Wu
    School of Public Health, Taipei Medical University, Taipei, Taiwan
    J Biomed Sci 17:70. 2010
    ..In this study, we investigated the relationship between HO-1 genetic polymorphism and the risk of atherosclerosis related to arsenic...
  34. ncbi request reprint Role of reproductive factors in hepatocellular carcinoma: Impact on hepatitis B- and C-related risk
    Ming Whei Yu
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    Hepatology 38:1393-400. 2003
    ..0053). In conclusion, increased exposure to estrogen during adulthood may provide a protective effect against HCC. Nevertheless, an early menarche, which results in early estrogen exposure, does not confer protection for HBsAg carriers...
  35. ncbi request reprint Ingested arsenic, cigarette smoking, and lung cancer risk: a follow-up study in arseniasis-endemic areas in Taiwan
    Chi Ling Chen
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    JAMA 292:2984-90. 2004
    ..Arsenic has been documented as a lung carcinogen in humans in only a few follow-up studies, which were limited by a small number of cases or the lack of information on cigarette smoking...
  36. ncbi request reprint Long-term trends and geographic variations in the survival of patients with hepatocellular carcinoma: analysis of 11,312 patients in Taiwan
    Chien Hung Chen
    Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    J Gastroenterol Hepatol 21:1561-6. 2006
    ..The survival rates of patients with hepatocellular carcinoma (HCC) were investigated over the past 20 years to clarify the long-term survival trend...
  37. ncbi request reprint Determinants of inorganic arsenic methylation capability among residents of the Lanyang Basin, Taiwan: arsenic and selenium exposure and alcohol consumption
    Yu Mei Hsueh
    Department of Public Health, School of Medicine, Taipei Medical University, No 250, Wu Hsin Street, 110, Taipei, Taiwan
    Toxicol Lett 137:49-63. 2003
    ..It appeared that urinary selenium levels increased the metabolism by methylation of arsenic, a finding that requires further investigation...
  38. doi request reprint Arsenic exposure, urinary arsenic speciation, and the incidence of urothelial carcinoma: a twelve-year follow-up study
    Yung Kai Huang
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Cancer Causes Control 19:829-39. 2008
    ..There was a significant association between inefficient arsenic methylation and the development of UC in the residents in the high CAE exposure strata in an area of southwestern Taiwan endemic for arseniasis...
  39. pmc Familial tendency and risk of nasopharyngeal carcinoma in taiwan: effects of covariates on risk
    Wan Lun Hsu
    Genomics Research Center, Academia Sinica, Taipei, Taiwan
    Am J Epidemiol 173:292-9. 2011
    ....
  40. ncbi request reprint Epidemiologic evidence of diabetogenic effect of arsenic
    Chin Hsiao Tseng
    Department of Internal Medicine, National Taiwan University Hospital, No 7, Chung Shan South Road, Taipei, Taiwan, ROC
    Toxicol Lett 133:69-76. 2002
    ....
  41. doi request reprint GT-repeat polymorphism in the heme oxygenase-1 gene promoter is associated with cardiovascular mortality risk in an arsenic-exposed population in northeastern Taiwan
    Meei Maan Wu
    School of Public Health, Taipei Medical University, Taipei, Taiwan
    Toxicol Appl Pharmacol 248:226-33. 2010
    ..Shorter (GT)n repeats in the HO-1 gene promoter may confer protective effects against cardiovascular mortality related to arsenic exposure...
  42. ncbi request reprint Association of cytokine and DNA repair gene polymorphisms with hepatitis B-related hepatocellular carcinoma
    Chun Chieh Chen
    Department of Family Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan
    Int J Epidemiol 34:1310-8. 2005
    ..We investigated the mechanisms underlying the inflammatory hepatocarcinogenesis by examining whether genetic variations in cytokines, antioxidant enzymes, and DNA repair genes affect the HCC risk...
  43. doi request reprint Ingested arsenic, characteristics of well water consumption and risk of different histological types of lung cancer in northeastern Taiwan
    Chi Ling Chen
    Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, 7 Chung Shan S Road, 100 Taipei, Taiwan
    Environ Res 110:455-62. 2010
    ....
  44. ncbi request reprint The association between frequencies of mitomycin C-induced sister chromatid exchange and cancer risk in arseniasis
    Saou Hsing Liou
    Department of Public Health, National Defense Medical Center, National Defense University, Nei Hu, Taipei, Taiwan, ROC
    Toxicol Lett 129:237-43. 2002
    ..These results suggest that SCEs, either spontaneous or mitomycin C-induced, might not be good markers to predict cancer risk...
  45. ncbi request reprint Modification effects of GSTM1, GSTT1 and CYP2E1 polymorphisms on associations between raw salted food and incomplete intestinal metaplasia in a high-risk area of stomach cancer
    Shu Yuan Chen
    Division of Biostatistics and Bioinformatics, National Health Research Institutes, Taipei, Taiwan
    Int J Cancer 108:606-12. 2004
    ..Our study suggests the importance of gene-environment interaction on the development of incomplete IM...
  46. doi request reprint Unique variants of human papillomavirus genotypes 52 and 58 and risk of cervical neoplasia
    Ya Ju Chang
    Graduate Institute of Epidemiology, National Taiwan University, Taipei, Taiwan
    Int J Cancer 129:965-73. 2011
    ..The association between C variant of HPV 52 and prevalence of cervical neoplasia needs further validation...
  47. ncbi request reprint Nasopharyngeal carcinoma and genetic polymorphisms of DNA repair enzymes XRCC1 and hOGG1
    En Yu Cho
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei 10018, Taiwan
    Cancer Epidemiol Biomarkers Prev 12:1100-4. 2003
    ..5-177). Polymorphisms of the DNA repair genes hOGG1 (codon 326) and XRCC1 (codon 280) are associated with an altered risk of NPC. Carriers of multiple putative high-risk genotypes have the highest risk of developing NPC...
  48. doi request reprint Comparative genomic hybridization study of arsenic-exposed and non-arsenic-exposed urinary transitional cell carcinoma
    Ling I Hsu
    The Genomics Research Center, Academia Sinica, Taipei, Taiwan
    Toxicol Appl Pharmacol 227:229-38. 2008
    ..The findings suggest that long-term arsenic exposure may increase the chromosome abnormality in TCC, and 17p loss plays an important role in arsenic-induced urinary carcinogenesis...
  49. ncbi request reprint Arsenic cancer risk posed to human health from tilapia consumption in Taiwan
    Chung Min Liao
    Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei 10617, Taiwan, ROC
    Ecotoxicol Environ Saf 70:27-37. 2008
    ..We conclude that, by integrating the bioaccumulation concept and epidemiological investigation of humans exposed to arsenic, we can provide a scientific basis for risk analysis to enhance risk management strategies...
  50. ncbi request reprint Prevalence of metabolically healthy obesity and its impacts on incidences of hypertension, diabetes and the metabolic syndrome in Taiwan
    Lee Ching Hwang
    Department of Family Medicine, Mackay Memorial Hospital, Taipei, Taiwan, Republic of China
    Asia Pac J Clin Nutr 21:227-33. 2012
    ..Our data provide further evidence that opposes the notion of metabolically healthy obese as harmless conditions...
  51. pmc Genetic polymorphisms in glutathione S-transferase (GST) superfamily and risk of arsenic-induced urothelial carcinoma in residents of southwestern Taiwan
    Ling I Hsu
    Genomics Research Center, Academia Sinica, No 128 Academia road, Sec 2, Nankang, Taipei 115, Taiwan
    J Biomed Sci 18:51. 2011
    ..Variations in capacity of xenobiotic detoxification and arsenic methylation might explain individual variation in susceptibility to arsenic-induced cancers...
  52. doi request reprint SNPs of GSTM1, T1, P1, epoxide hydrolase and DNA repair enzyme XRCC1 and risk of urinary transitional cell carcinoma in southwestern Taiwan
    Ling I Hsu
    Genomics Research Center, Academia Sinica, 128 Academia Road Section 2, Nankang, Taipei, Taiwan
    Toxicol Appl Pharmacol 228:144-55. 2008
    ..These observations implied that impaired metabolism of carcinogenic exposure as well as impaired DNA repair function play an important role in arsenic-related urinary transitional cell carcinogenesis...
  53. doi request reprint Prevalence of genotype-specific human papillomavirus infection and cervical neoplasia in Taiwan: a community-based survey of 10,602 women
    Hui Chi Chen
    Genomics Research Center, Academia Sinica, Taipei, Taiwan
    Int J Cancer 128:1192-203. 2011
    ..Up to 40% more could be prevented by targeting HPV58, HPV52, HPV33 and HPV31, arguing for the introduction of vaccines including more types...
  54. ncbi request reprint The MTHFR C677T polymorphism, estrogen exposure and breast cancer risk: a nested case-control study in Taiwan
    Wei Yu Lin
    School of Public Health, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Anticancer Res 24:3863-8. 2004
    ..We evaluated the effects of the MTHFR C677T polymorphism and its interaction with estrogen exposure on breast cancer risk in a nested case-control study conducted in Taiwan...
  55. ncbi request reprint Biomarkers of exposure, effect, and susceptibility of arsenic-induced health hazards in Taiwan
    Chien Jen Chen
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, 1 Jen Ai Road Section1, Taipei 10018, Taiwan, ROC
    Toxicol Appl Pharmacol 206:198-206. 2005
    ..Gene-gene and gene-environment interactions are involved in arsenic-induced health hazards through toxicological mechanisms including genomic instability and oxidative stress...
  56. doi request reprint Androgen receptor gene CAG repeats, estrogen exposure status, and breast cancer susceptibility
    Mei Hsuan Wu
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    Eur J Cancer Prev 17:317-22. 2008
    ..25-1.59) was detected. These data suggest that longer AR (CAG)n repeat alleles may confer an increased risk of breast cancer among particular subsets of individuals, although these findings need replication in other populations...
  57. ncbi request reprint Incidence and cofactors of hepatitis C virus-related hepatocellular carcinoma: a prospective study of 12,008 men in Taiwan
    Chien An Sun
    School of Public Health, National Defense Medical Center, Taipei, Taiwan
    Am J Epidemiol 157:674-82. 2003
    ..The results of this study suggest that HCV plays a significant role in hepatocarcinogenesis in an area endemic for chronic HBV infection...
  58. ncbi request reprint Breast cancer risk associated with multigenotypic polymorphisms in folate-metabolizing genes: a nested case-control study in Taiwan
    Cheng Ping Yu
    Department of Pathology, Tri Service General Hospital, Taipei, Taiwan, ROC
    Anticancer Res 27:1727-32. 2007
    ..The purpose of this study was to test the hypothesis that multigenotypic polymorphisms in the folate metabolic pathway, which may result in genomic instability and inbalance of estrogen metabolism, were associated with breast cancer risk...
  59. ncbi request reprint Genetic polymorphisms of oxidative and antioxidant enzymes and arsenic-related hypertension
    Yu Mei Hsueh
    Department of Public Health, School of Medicine, Taipei Medical University, Taipei, Taiwan
    J Toxicol Environ Health A 68:1471-84. 2005
    ..These results suggested that the NADPH oxidase, MnSOD, and e-NOS polymorphisms, but not catalase, might play a role in the development of arsenic-related hypertension, especially in subjects with high triglyceride levels...
  60. ncbi request reprint Long-term arsenic exposure and ischemic heart disease in arseniasis-hyperendemic villages in Taiwan
    Chin Hsiao Tseng
    Department of Internal Medicine, National Taiwan University Hospital, No 7, Chung Shan South Road, Taipei, Taiwan, ROC
    Toxicol Lett 137:15-21. 2003
    ..0 mg/l-years, when compared with those lacking drinking water exposure to arsenic after multivariate adjustment. It is concluded that IHD in the arseniasis-hyperendemic villages in Taiwan was associated with long-term arsenic exposure...
  61. doi request reprint Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C infection: a follow-up study in Taiwan
    Chi Ling Chen
    Graduate Institute of Clinical Medicine, College of Medicine, College of Public Health, National Taiwan University, Taipei
    Gastroenterology 135:111-21. 2008
    ....
  62. ncbi request reprint The mortality risks of smokers in Taiwan: Part I: cause-specific mortality
    Chi Pang Wen
    Division of Health Policy Research, National Health Research Institute, Taipei, Taiwan
    Prev Med 39:528-35. 2004
    ..This study aims to quantify cause-specific mortality risks among cigarette smokers in Taiwan...
  63. ncbi request reprint Plasma matrix metalloproteinase-9 level is better than serum matrix metalloproteinase-9 level to predict gastric cancer evolution
    Chun Ying Wu
    Graduate Institute of Clinical Medicine, College of Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
    Clin Cancer Res 13:2054-60. 2007
    ..Matrix metalloproteinase-9 (MMP-9) in blood is a promising new tumor marker. The aims of the present study are to compare the usefulness of plasma and serum MMP-9 levels for predicting gastric cancer development, invasion, and survival...
  64. doi request reprint Circulating interleukin-6 level is a prognostic marker for survival in advanced nonsmall cell lung cancer patients treated with chemotherapy
    Chin Hao Chang
    Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan, Republic of China
    Int J Cancer 132:1977-85. 2013
    ..Patients with high circulating IL-6 also responded poorly to chemotherapy. Therefore, a high level of circulating IL-6 was associated with an inferior response and survival outcome in NSCLC patients treated with chemotherapy...
  65. pmc Nationwide surveillance in uterine cancer: survival analysis and the importance of birth cohort: 30-year population-based registry in Taiwan
    Chia Yen Huang
    Gynecologic Cancer Center, Cathay General Hospital, Taipei, Taiwan
    PLoS ONE 7:e51372. 2012
    ..Uterine cancer was the most rapidly increasing malignancy and the second most common gynecologic malignancy in Taiwan...
  66. ncbi request reprint Do young hepatocellular carcinoma patients have worse prognosis? The paradox of age as a prognostic factor in the survival of hepatocellular carcinoma patients
    Chien Hung Chen
    Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Liver Int 26:766-73. 2006
    ..Thus, it seems that age has a paradoxical influence on the prognosis. To further clarify the issue of age on HCC prognosis, we initiated this study...
  67. doi request reprint Incidence and determinants of spontaneous seroclearance of hepatitis B e antigen and DNA in patients with chronic hepatitis B
    Hwai I Yang
    Molecular and Genomic Epidemiology Center, China Medical University Hospital, Taichung, Taiwan
    Clin Gastroenterol Hepatol 10:527-34.e1-2. 2012
    ..We performed a long-term cohort study to elucidate the incidence and determinants of HBeAg and HBV DNA seroclearance in patients with chronic hepatitis B...
  68. doi request reprint Clinicopathological characteristics and survival outcome of arsenic related bladder cancer in taiwan
    Chung Hsin Chen
    Department of Urology, National Taiwan University College of Medicine and Hospital, Division of Urology, Taoyuan General Hospital, Taipei, Taiwan
    J Urol 181:547-52; discussion 553. 2009
    ..We compared clinicopathological characteristics and outcomes in patients with bladder cancer who were exposed to graded arsenic levels in drinking water...
  69. doi request reprint Associations of human leukocyte antigen class II genotypes with human papillomavirus 18 infection and cervical intraepithelial neoplasia risk
    Li Chung Chuang
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan Genomics Research Center, Academia Sinica, Taipei, Taiwan
    Cancer 118:223-31. 2012
    ..This community-based cohort study aimed to assess associations with human leukocyte antigen (HLA) class II genotypes for natural infection of HPV18 and subsequent risk of cervical neoplasia...
  70. pmc Changes in urinary arsenic methylation profiles in a 15-year interval after cessation of arsenic ingestion in southwest Taiwan
    Yung Kai Huang
    Graduate Institute of Medical Sciences, College of Medicine Taipei Medical University, Taipei, Taiwan
    Environ Health Perspect 117:1860-6. 2009
    ..Relatively little information is available regarding changes in As methylation profiles after cessation of As exposure...
  71. pmc Evaluation of human leukocyte antigen-A (HLA-A), other non-HLA markers on chromosome 6p21 and risk of nasopharyngeal carcinoma
    Wan Lun Hsu
    Genomics Research Center, Academia Sinica, Taipei, Taiwan
    PLoS ONE 7:e42767. 2012
    ..It is still unclear, however, whether these findings reflect direct associations with Human Leukocyte Antigen (HLA) genes and/or to other genes in this gene-rich region...
  72. doi request reprint Baseline human papillomavirus infection, high vaginal parity, and their interaction on cervical cancer risks after a follow-up of more than 10 years
    Shu Fen Liao
    Research Center for Genes, Environment and Human Health, and Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
    Cancer Causes Control 23:703-8. 2012
    ..This study aims to disentangle the roles of baseline HPV infection, high vaginal parity (defined as having ≥4 vaginal deliveries), and the interaction between the two in predicting cervical cancer risk...
  73. doi request reprint Chronic hepatitis C virus infection increases mortality from hepatic and extrahepatic diseases: a community-based long-term prospective study
    Mei Hsuan Lee
    Genomics Research Center, Academia Sinica, Taipei, Taiwan
    J Infect Dis 206:469-77. 2012
    ..The study aimed to evaluate the risk of hepatitis C virus (HCV) infection on hepatic and extrahepatic deaths...
  74. doi request reprint Decreased incidence of hepatocellular carcinoma in hepatitis B vaccinees: a 20-year follow-up study
    Mei Hwei Chang
    Department of Pediatrics, National Taiwan University Hospital, Chung Shan S Road, Taipei, Taiwan
    J Natl Cancer Inst 101:1348-55. 2009
    ....
  75. doi request reprint Hepatitis C virus infection and increased risk of cerebrovascular disease
    Mei Hsuan Lee
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    Stroke 41:2894-900. 2010
    ..The association between hepatitis C virus (HCV) infection and cerebrovascular disease remains controversial. This study aimed to assess the risk of lethal cerebrovascular diseases associated with chronic HCV infection...
  76. ncbi request reprint Association of GSTP1 polymorphism and survival for esophageal cancer
    Jang Ming Lee
    Department of Surgery and Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    Clin Cancer Res 11:4749-53. 2005
    ..The clinical significance of this variation is still puzzling. We investigated whether genetic polymorphisms of GST including GSTP1, GSTM1, and GSTT1 affect survival among esophageal cancer patients...
  77. doi request reprint Optimal anthropometric factor cutoffs for hyperglycemia, hypertension and dyslipidemia for the Taiwanese population
    Chin Hsiao Tseng
    National Taiwan University College of Medicine, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Atherosclerosis 210:585-9. 2010
    ..Optimal cutoffs for obesity indices are rarely studied in Asians. We evaluated these cutoffs for diabetes, hypertension, dyslipidemia and any risk factor for the Taiwanese general population...
  78. doi request reprint Epidermal growth factor receptor mutation status in stage I lung adenocarcinoma with different image patterns
    Kuo Hsuan Hsu
    Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
    J Thorac Oncol 6:1066-72. 2011
    ..Nevertheless, the correlation between clinical characteristics, CT image patterns, and EGFR mutation status was indeterminate...
  79. ncbi request reprint A review of the epidemiologic literature on the role of environmental arsenic exposure and cardiovascular diseases
    Chih Hao Wang
    Department of Cardiology, Cardinal Tien Hospital and College of Medicine, Fu Jen Catholic University, Taipei, Taiwan
    Toxicol Appl Pharmacol 222:315-26. 2007
    ..Cardiovascular death is the major cause of mortality worldwide, and a small increased risk may imply a large quantity of excess mortality...
  80. doi request reprint Urinary arsenic methylation capability and carotid atherosclerosis risk in subjects living in arsenicosis-hyperendemic areas in southwestern Taiwan
    Ya Li Huang
    Department of Public Health, School of Medicine, Taipei Medical University, Taipei, Taiwan
    Sci Total Environ 407:2608-14. 2009
    ..We conclude that individuals with greater exposure to arsenic and lower capacity to methylate inorganic arsenic may be at a higher risk to carotid atherosclerosis...
  81. ncbi request reprint Plasma folate level, urinary arsenic methylation profiles, and urothelial carcinoma susceptibility
    Yung Kai Huang
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Food Chem Toxicol 46:929-38. 2008
    ..The results of this study may identify the susceptible subpopulations and provide insight into the carcinogenic mechanisms of arsenic even at low arsenic exposure...
  82. doi request reprint Association of heme oxygenase-1 GT-repeat polymorphism with blood pressure phenotypes and its relevance to future cardiovascular mortality risk: an observation based on arsenic-exposed individuals
    Meei Maan Wu
    School of Public Health, Taipei Medical University, 250 Wu Hsing Street, Taipei 11031, Taiwan
    Atherosclerosis 219:704-8. 2011
    ..Here, we reported the association of GT-repeat polymorphism with blood pressure (BP) phenotypes, and their interaction on cardiovascular (CV) mortality risk in arsenic-exposed cohorts...
  83. ncbi request reprint Nationwide hepatitis B vaccination program in Taiwan: effectiveness in the 20 years after it was launched
    Yin Chu Chien
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    Epidemiol Rev 28:126-35. 2006
    ..In conclusion, since 1984, the national hepatitis B vaccination program has been successful in preventing acute and chronic liver diseases in Taiwan...
  84. ncbi request reprint Arsenic and diabetes and hypertension in human populations: a review
    Chien Jen Chen
    Genomics Research Center, Academia Sinica, 128 Academia Road Section 2, Nankang, Taipei 11529, Taiwan
    Toxicol Appl Pharmacol 222:298-304. 2007
    ..The dose-response relationship and toxicological mechanisms of arsenic-induced diabetes and hypertension need further elucidation...
  85. ncbi request reprint Clinicopathological significance of MMP-2 and TIMP-2 genotypes in gastric cancer
    Chun Ying Wu
    Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    Eur J Cancer 43:799-808. 2007
    ..We aim to elucidate the role of MMP-2 and TIMP-2 in clinicopathological manifestations of gastric cancer...
  86. ncbi request reprint Obesity and changes in body weight related to 10-year diabetes incidence in women in Taiwan
    Lee Ching Hwang
    Department of Family Medicine, Mackay Memorial Hospital, 92, Section 2, Chungshan North Road, Taipei, Taiwan
    Asia Pac J Clin Nutr 16:677-82. 2007
    ..This study indicated that obesity at young adult and weight gain appreciably increase risk for type 2 diabetes. Maintaining a lean weight throughout adulthood seems to be beneficial in the primary prevention of type 2 diabetes...
  87. ncbi request reprint Seropositivity of hepatitis B e antigen and hepatocellular carcinoma
    San Lin You
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, 1 Jen Ai Road, Section 1, Taipei 10018, Taiwan
    Ann Med 36:215-24. 2004
    ....
  88. ncbi request reprint Midlife risk factors for subtypes of dementia: a nested case-control study in Taiwan
    Chun Ju Chiang
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    Am J Geriatr Psychiatry 15:762-71. 2007
    ..To identify the midlife risk factors for subtypes of dementia newly developed later in life...
  89. doi request reprint Lifetime risk and sex difference of hepatocellular carcinoma among patients with chronic hepatitis B and C
    Yen Tsung Huang
    Harvard University, Boston, MA, USA
    J Clin Oncol 29:3643-50. 2011
    ..This study aimed to assess the lifetime risk and sex difference of HCC among patients with chronic HBV and/or HCV...
  90. ncbi request reprint Ultrasound screening and risk factors for death from hepatocellular carcinoma in a high risk group in Taiwan
    Tony Hsiu Hsi Chen
    Institute of Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
    Int J Cancer 98:257-61. 2002
    ..A randomized controlled trial would yield definitive evidence. Within the protocol of such a trial, a shorter interscreening interval for patients with liver cirrhosis is suggested...
  91. doi request reprint Body-mass index and progression of hepatitis B: a population-based cohort study in men
    Ming Whei Yu
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Room 522, No 17, Xuzhou Rd, Zhongzheng District, Taipei City 10055, Taiwan
    J Clin Oncol 26:5576-82. 2008
    ..To determine prospectively whether body-mass index (BMI) is associated with liver-related morbidity and mortality among male hepatitis B virus (HBV) carriers...
  92. ncbi request reprint Risk of carotid atherosclerosis associated with genetic polymorphisms of apolipoprotein E and inflammatory genes among arsenic exposed residents in Taiwan
    Yi Chen Hsieh
    School of Public Health, Taipei Medical University, Taipei, Taiwan
    Toxicol Appl Pharmacol 227:1-7. 2008
    ..22 mg/L-year would have strikingly highest risk of 10.3-fold and 15.7-fold, respectively, for the development carotid atherosclerosis, showing significant joint effect of arsenic exposure and risk genotypes of APOE and MCP-1...
  93. ncbi request reprint Cancer epidemiology and control in Taiwan: a brief review
    Chien Jen Chen
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    Jpn J Clin Oncol 32:S66-81. 2002
    ..Major fields of the research include cancer genomics, gene therapy, molecular epidemiology and DNA vaccine...
  94. doi request reprint Cancer trends in Taiwan
    Chun Ju Chiang
    Institute of Preventive Medicine, College of Public Health, National Taiwan University, Academia Sinica, Taipei, Taiwan
    Jpn J Clin Oncol 40:897-904. 2010
    ..This study presents for the first time the secular changes and age patterns in the incidence of childhood cancer using national cancer data...
  95. ncbi request reprint Interaction of collagen-related genes and susceptibility to betel quid-induced oral submucous fibrosis
    Chung Jung Chiu
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei 100, Taiwan
    Cancer Epidemiol Biomarkers Prev 11:646-53. 2002
    ..These results imply that susceptibility to OSF could involve multigenic mechanisms modified by the betel quid-exposure dose...
  96. doi request reprint Risk assessment of arsenic-induced internal cancer at long-term low dose exposure
    Chung Min Liao
    Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan ROC
    J Hazard Mater 165:652-63. 2009
    ....
  97. ncbi request reprint Urinary arsenic speciation in subjects with or without restriction from seafood dietary intake
    Yu Mei Hsueh
    Department of Public Health, School of Medicine, Taipei Medical University, No 250, Wu Hsin Street, 110, Taipei, Taiwan, ROC
    Toxicol Lett 133:83-91. 2002
    ..The frequencies of fish, shellfish and seaweed dietary intake were not significantly correlated with urinary arsenic species...
  98. doi request reprint Association of an EGFR intron 1 SNP with never-smoking female lung adenocarcinoma patients
    Yuh Shan Jou
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Lung Cancer 64:251-6. 2009
    ..81, 95% CI=1.02-7.77). Together, our results suggest that polymorphisms or haplotypes of the EGFR play an important role in the development of lung cancer in Taiwan, particularly in never-smoking female lung adenocarcinoma...
  99. doi request reprint Increased risk of QT prolongation associated with atherosclerotic diseases in arseniasis-endemic area in southwestern coast of Taiwan
    Chih Hao Wang
    Department of Cardiology, Cardinal Tien Hospital, College of Medicine, Fu Jen Catholic University, Taipei, Taiwan
    Toxicol Appl Pharmacol 239:320-4. 2009
    ..QTc prolongation might be suggested as an early biomarker for ischemic heart disease or carotid atherosclerosis in population with previous exposure to arsenic...
  100. ncbi request reprint Arsenic ingestion and increased microvascular disease risk: observations from the south-western arseniasis-endemic area in Taiwan
    Jeng Min Chiou
    Institute of Statistical Science, Academia Sinica, Taipei, Taiwan, R O C
    Int J Epidemiol 34:936-43. 2005
    ..We established the association between arsenic ingestion and increased risk of vascular diseases associated with diabetes. However, the specific microvascular diseases in relation to arsenic exposure level have not been well reported...
  101. ncbi request reprint Causes of increased mortality from hepatocellular carcinoma in high incidence country: Taiwan experience
    Chyi Feng Jan
    Department of Family Medicine, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan
    J Gastroenterol Hepatol 20:521-6. 2005
    ..The aim of the present study was to assess whether poor survival or excess incident cases pertaining to a cohort effect or a time-period effect accounted for such a rise...