Bor Sen Chen
Affiliation: National Tsing Hua University
- Chen B, Wang Y. On the attenuation and amplification of molecular noise in genetic regulatory networks. BMC Bioinformatics. 2006;7:52 pubmed..This method will be potential for robust gene circuit design in future, on which a drug design could be based. ..
- Chen B, Chang C, Lee H. Robust synthetic biology design: stochastic game theory approach. Bioinformatics. 2009;25:1822-30 pubmed publisher..Finally, an in silico example is given to illustrate the design procedure and to confirm the efficiency and efficacy of the proposed robust gene design method. http://www.ee.nthu.edu.tw/bschen/SyntheticBioDesign_supplement.pdf. ..
- Chen B, Wu C. A systematic design method for robust synthetic biology to satisfy design specifications. BMC Syst Biol. 2009;3:66 pubmed publisher..Therefore, the proposed systematic design method has good potential for the robust synthetic gene network design. ..
- Chen B, Hsu C, Liou J. Robust design of biological circuits: evolutionary systems biology approach. J Biomed Biotechnol. 2011;2011:304236 pubmed publisher..The result shows that the designed gene circuits can robustly track desired behaviors with minimal errors even with nontrivial intrinsic and external noise. ..
- Wong Y, Wu C, Wu J, Lai H, Chen K, Jheng B, et al. Temporal Genetic Modifications after Controlled Cortical Impact--Understanding Traumatic Brain Injury through a Systematic Network Approach. Int J Mol Sci. 2016;17:216 pubmed publisher..The analytical results support some recent findings regarding TBI and provide additional guidance and directions for future research. ..
- Chen B, Li C. Constructing an integrated genetic and epigenetic cellular network for whole cellular mechanism using high-throughput next-generation sequencing data. BMC Syst Biol. 2016;10:18 pubmed publisher....
- Wong Y, Chiu C, Lin C, Chen T, Jheng B, Lee Y, et al. A New Era for Cancer Target Therapies: Applying Systems Biology and Computer-Aided Drug Design to Cancer Therapies. Curr Pharm Biotechnol. 2016;17:1246-1267 pubmed..We conclude with an example where we combined and applied systems biology and CADD to the core networks of four cancers and successfully developed a novel cocktail for drug therapy that treats multiple targets. ..
- Wu C, Chen B. Key Immune Events of the Pathomechanisms of Early Cardioembolic Stroke: Multi-Database Mining and Systems Biology Approach. Int J Mol Sci. 2016;17:305 pubmed publisher..The results provide a more comprehensive understanding of stroke progression mechanisms from an immune perspective and shed light on acute stroke treatments. ..
- Chen B, Yeh C. Stochastic noncooperative and cooperative evolutionary game strategies of a population of biological networks under natural selection. Biosystems. 2017;162:90-118 pubmed publisher....