Research Topics

Bor Sen Chen

Summary

Affiliation: National Tsing Hua University
Country: Taiwan

Publications

  1. Chen B, Wang Y. On the attenuation and amplification of molecular noise in genetic regulatory networks. BMC Bioinformatics. 2006;7:52 pubmed
    ..This method will be potential for robust gene circuit design in future, on which a drug design could be based. ..
  2. Chen B, Chang C, Lee H. Robust synthetic biology design: stochastic game theory approach. Bioinformatics. 2009;25:1822-30 pubmed publisher
    ..Finally, an in silico example is given to illustrate the design procedure and to confirm the efficiency and efficacy of the proposed robust gene design method. http://www.ee.nthu.edu.tw/bschen/SyntheticBioDesign_supplement.pdf. ..
  3. Chen B, Wu C. A systematic design method for robust synthetic biology to satisfy design specifications. BMC Syst Biol. 2009;3:66 pubmed publisher
    ..Therefore, the proposed systematic design method has good potential for the robust synthetic gene network design. ..
  4. Chen B, Hsu C, Liou J. Robust design of biological circuits: evolutionary systems biology approach. J Biomed Biotechnol. 2011;2011:304236 pubmed publisher
    ..The result shows that the designed gene circuits can robustly track desired behaviors with minimal errors even with nontrivial intrinsic and external noise. ..
  5. Wong Y, Wu C, Wu J, Lai H, Chen K, Jheng B, et al. Temporal Genetic Modifications after Controlled Cortical Impact--Understanding Traumatic Brain Injury through a Systematic Network Approach. Int J Mol Sci. 2016;17:216 pubmed publisher
    ..The analytical results support some recent findings regarding TBI and provide additional guidance and directions for future research. ..
  6. Chen B, Li C. Constructing an integrated genetic and epigenetic cellular network for whole cellular mechanism using high-throughput next-generation sequencing data. BMC Syst Biol. 2016;10:18 pubmed publisher
    ....
  7. request reprint
    Wong Y, Chiu C, Lin C, Chen T, Jheng B, Lee Y, et al. A New Era for Cancer Target Therapies: Applying Systems Biology and Computer-Aided Drug Design to Cancer Therapies. Curr Pharm Biotechnol. 2016;17:1246-1267 pubmed
    ..We conclude with an example where we combined and applied systems biology and CADD to the core networks of four cancers and successfully developed a novel cocktail for drug therapy that treats multiple targets. ..
  8. Wu C, Chen B. Key Immune Events of the Pathomechanisms of Early Cardioembolic Stroke: Multi-Database Mining and Systems Biology Approach. Int J Mol Sci. 2016;17:305 pubmed publisher
    ..The results provide a more comprehensive understanding of stroke progression mechanisms from an immune perspective and shed light on acute stroke treatments. ..
  9. Chen B, Yeh C. Stochastic noncooperative and cooperative evolutionary game strategies of a population of biological networks under natural selection. Biosystems. 2017;162:90-118 pubmed publisher
    ....

Locale

Detail Information

Publications9

  1. Chen B, Wang Y. On the attenuation and amplification of molecular noise in genetic regulatory networks. BMC Bioinformatics. 2006;7:52 pubmed
    ..This method will be potential for robust gene circuit design in future, on which a drug design could be based. ..
  2. Chen B, Chang C, Lee H. Robust synthetic biology design: stochastic game theory approach. Bioinformatics. 2009;25:1822-30 pubmed publisher
    ..Finally, an in silico example is given to illustrate the design procedure and to confirm the efficiency and efficacy of the proposed robust gene design method. http://www.ee.nthu.edu.tw/bschen/SyntheticBioDesign_supplement.pdf. ..
  3. Chen B, Wu C. A systematic design method for robust synthetic biology to satisfy design specifications. BMC Syst Biol. 2009;3:66 pubmed publisher
    ..Therefore, the proposed systematic design method has good potential for the robust synthetic gene network design. ..
  4. Chen B, Hsu C, Liou J. Robust design of biological circuits: evolutionary systems biology approach. J Biomed Biotechnol. 2011;2011:304236 pubmed publisher
    ..The result shows that the designed gene circuits can robustly track desired behaviors with minimal errors even with nontrivial intrinsic and external noise. ..
  5. Wong Y, Wu C, Wu J, Lai H, Chen K, Jheng B, et al. Temporal Genetic Modifications after Controlled Cortical Impact--Understanding Traumatic Brain Injury through a Systematic Network Approach. Int J Mol Sci. 2016;17:216 pubmed publisher
    ..The analytical results support some recent findings regarding TBI and provide additional guidance and directions for future research. ..
  6. Chen B, Li C. Constructing an integrated genetic and epigenetic cellular network for whole cellular mechanism using high-throughput next-generation sequencing data. BMC Syst Biol. 2016;10:18 pubmed publisher
    ....
  7. request reprint
    Wong Y, Chiu C, Lin C, Chen T, Jheng B, Lee Y, et al. A New Era for Cancer Target Therapies: Applying Systems Biology and Computer-Aided Drug Design to Cancer Therapies. Curr Pharm Biotechnol. 2016;17:1246-1267 pubmed
    ..We conclude with an example where we combined and applied systems biology and CADD to the core networks of four cancers and successfully developed a novel cocktail for drug therapy that treats multiple targets. ..
  8. Wu C, Chen B. Key Immune Events of the Pathomechanisms of Early Cardioembolic Stroke: Multi-Database Mining and Systems Biology Approach. Int J Mol Sci. 2016;17:305 pubmed publisher
    ..The results provide a more comprehensive understanding of stroke progression mechanisms from an immune perspective and shed light on acute stroke treatments. ..
  9. Chen B, Yeh C. Stochastic noncooperative and cooperative evolutionary game strategies of a population of biological networks under natural selection. Biosystems. 2017;162:90-118 pubmed publisher
    ....