Tsu Chung Chang


Affiliation: National Defense Medical Center
Country: Taiwan


  1. Chang P, Yen I, Tsai W, Chang T, Lee S. Protective Effects of Rhodiola Crenulata Extract on Hypoxia-Induced Endothelial Damage via Regulation of AMPK and ERK Pathways. Int J Mol Sci. 2018;19: pubmed publisher
    ..In summary, we showed that RCE protected endothelial cells from hypoxic insult and suggested that R. crenulata might be useful for the prevention of hypoxia-associated vascular dysfunction. ..
  2. Lee S, Lai F, Shi L, Chou Y, Yen I, Chang T. Rhodiola crenulata extract suppresses hepatic gluconeogenesis via activation of the AMPK pathway. Phytomedicine. 2015;22:477-86 pubmed publisher
    ..These findings provide evidence that Rhodiola crenulata may be helpful for the management of type II diabetes. ..
  3. Lee S, Chang W, Li Z, Kirkby N, Tsai W, Huang S, et al. Astragaloside VI and cycloastragenol-6-O-beta-D-glucoside promote wound healing in vitro and in vivo. Phytomedicine. 2018;38:183-191 pubmed publisher
    ..These findings indicate the therapeutic potential of AS-VI and CMG to accelerate wound healing; additionally, they suggest the mechanistic basis of this activity. ..
  4. Hsu S, Chang T, Wu Y, Lin K, Shi L, Lee S. Rhodiola crenulata extract counteracts the effect of hypobaric hypoxia in rat heart via redirection of the nitric oxide and arginase 1 pathway. BMC Complement Altern Med. 2017;17:29 pubmed publisher
    ..The findings provide evidence that the effects of Rhodiola crenulata against altitude illness are partially mediated by modulation of eNOS and Arg-1 pathways in the heart. ..
  5. Lee S, Tsai W, Lin J, Ahmetaj Shala B, Huang S, Chang W, et al. Astragaloside II promotes intestinal epithelial repair by enhancing L-arginine uptake and activating the mTOR pathway. Sci Rep. 2017;7:12302 pubmed publisher
    ..Similar results were also observed in vivo. Our findings indicate that AS II can contribute to epithelial barrier repair following intestinal injury, and may offer a therapeutic avenue in treating irritable bowel disease. ..