Research Topics
Species | Ting Tsung ChangSummaryAffiliation: National Cheng Kung University Country: Taiwan Publications
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Detail Information
Publications
Existence of hepatitis C virus in Culex quinquefasciatus after ingestion of infected blood: experimental approach to evaluating transmission by mosquitoesT T Chang
Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China
J Clin Microbiol 39:3353-5. 2001..HCV RNA was detectable under all three conditions, but it did not replicate in mosquitoes and was not detectably transmitted during feeding...
Entecavir treatment for up to 5 years in patients with hepatitis B e antigen-positive chronic hepatitis BTing Tsung Chang
Medical College, National Cheng Kung University, Tainan, Taiwan, ROC
Hepatology 51:422-30. 2010..Additional patients also achieved HBeAg loss and seroconversion. Entecavir provides sustained viral suppression with minimal resistance during long-term treatment of HBeAg-positive CHB...- Current approaches for treating chronic hepatitis B: when to start, what to start with, and when to stopTing Tsung Chang
Department of Medicine, National Cheng Kung University, Medical College and Hospital, 138 Sheng Li Road, Tainan, 70428, Taiwan
Hepatol Int 2:19-27. 2008..Current approaches for treating CHB and new strategies for optimizing response to therapy are also discussed... 
Four years of lamivudine treatment in Chinese patients with chronic hepatitis BTing Tsung Chang
Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
J Gastroenterol Hepatol 19:1276-82. 2004..This study assessed the efficacy and safety of up to 4 years of lamivudine treatment and the clinical relevance of the emergence of YMDD-variant hepatitis B virus (HBV)...- On-treatment monitoring of HBV DNA levels: predicting response and resistance to oral antiviral therapy at week 24 versus week 48Ting Tsung Chang
Department of Medicine, National Cheng Kung University Hospital, Tainan, 70428, Taiwan
Hepatol Int 3:16-23. 2009..This review discusses available data for appropriate predictors for long-term response and antiviral resistance for patients receiving specific oral NA antiviral therapy. Guidelines for on-treatment monitoring are also discussed... - A dose-ranging study of the efficacy and tolerability of entecavir in Lamivudine-refractory chronic hepatitis B patientsTing Tsung Chang
National Cheng Kung University Medical College, Tainan, Taiwan
Gastroenterology 129:1198-209. 2005..This randomized, dose-ranging, phase 2 study compared the efficacy and safety of entecavir with lamivudine in lamivudine-refractory patients... - A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis BTing Tsung Chang
National Cheng Kung University Medical College, Tainan, Taiwan
N Engl J Med 354:1001-10. 2006..Entecavir is a potent and selective guanosine analogue with significant activity against hepatitis B virus (HBV)... - Results of up to 2 years of entecavir vs lamivudine therapy in nucleoside-naïve HBeAg-positive patients with chronic hepatitis BT T Chang
National Cheng Kung University Medical College, Tainan, Taiwan
J Viral Hepat 16:784-9. 2009..For patients who discontinued therapy because of nonresponse (nonresponders) and subsequently entered the rollover study ETV-901, follow-up results, including resistance profile, are provided... - Long-term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis BTing Tsung Chang
Department of Internal Medicine, National Cheng Kung University Medical College, Tainan, Taiwan
Hepatology 52:886-93. 2010..CONCLUSION: The majority of nucleoside-naive patients with CHB who were treated with entecavir in this long-term cohort achieved substantial histological improvement and regression of fibrosis or cirrhosis... - Characterization of viral kinetics in patients with hepatitis B e antigen-positive chronic hepatitis BI Chin Wu
Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
J Med Virol 79:663-9. 2007..8% and a specificity of 74.7%. In conclusion, different viral kinetic patterns in patients with chronic hepatitis B implicate distinct clinical significance and immunologic perspective... - A reverse-transcription competitive PCR assay based on chemiluminescence hybridization for detection and quantification of hepatitis C virus RNAKung Chia Young
Department of Medical Technology, Medical College, National Cheng Kung University, 70101, Tainan, Taiwan, ROC
J Virol Methods 103:27-39. 2002..In conclusion, the proposed chemiluminescence RT-cPCR method can detect quantitatively HCV RNA as accurately as the bDNA method and has sensitivity as high as nested RT-PCR... - Smoking and alanine aminotransferase levels in hepatitis C virus infection: implications for prevention of hepatitis C virus progressionChong Shan Wang
National Yang Ming University, Institute of Public Health, Shih Pai, Taipei 112, Taiwan, Republic of China
Arch Intern Med 162:811-5. 2002..Alcohol consumption is a well-known risk factor for elevated ALT levels, but the role of cigarette smoking is unclear... - Association of intrahepatic cccDNA reduction with the improvement of liver histology in chronic hepatitis B patients receiving oral antiviral agentsPin Nan Cheng
Department of Internal Medicine, Medical College, National Cheng Kung University, Tainan, Taiwan
J Med Virol 83:602-7. 2011..Although one-year ETV or ADV treatment is insufficient for cccDNA eradication, oral antiviral therapies may improve liver histology, probably by suppressing intrahepatic cccDNA... - Sustained hepatitis B e antigen seroconversion in patients with chronic hepatitis B after adefovir dipivoxil treatment: analysis of precore and basal core promoter mutantsI Chin Wu
Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China
Clin Infect Dis 47:1305-11. 2008..This study evaluated the persistence of hepatitis B e antigen (HBeAg) seroconversion (which is considered to be an important therapeutic end point) after adefovir dipivoxil treatment... - Analysis of precore/core covariances associated with viral kinetics and genotypes in hepatitis B e antigen-positive chronic hepatitis B patientsChun Pei Cheng
Department of Computer Science and Information Engineering, National Cheng Kung University, Tainan, Taiwan
PLoS ONE 7:e32553. 2012..Moreover, representative covariances may benefit clinicians to prescribe a suitable treatment for patients even if they have no obvious symptoms at the early stage of HBV infection... - Efficacy of entecavir in chronic hepatitis B patients with mildly elevated alanine aminotransferase and biopsy-proven histological damageI Chin Wu
National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Hepatology 51:1185-9. 2010..However, HBeAg-positive patients with mildly elevated ALT responded less well to treatment with entecavir than did those with ALT greater than 2 x ULN... - Entecavir: a potent antiviral with minimal long-term resistance in nucleoside-naive chronic hepatitis B patientsPin Nan Cheng
National Cheng Kung University, Medical College and Hospital, Tainan, Taiwan, ROC
Expert Rev Anti Infect Ther 6:569-79. 2008..These data underscore the position of entecavir for first-line therapy and highlight its role in the long-term treatment of chronic hepatits B... - Very low-density lipoprotein/lipo-viro particles reverse lipoprotein lipase-mediated inhibition of hepatitis C virus infection via apolipoprotein C-IIIHung Yu Sun
College of Medicine, National Cheng Kung University, Tainan, Taiwan
Gut . 2012..CONCLUSION: This study reveals that LPL is an anti-HCV factor, and that apoC-III in VLDL and LVPs reduces the LPL-mediated inhibition of HCV infection... - Do young hepatocellular carcinoma patients have worse prognosis? The paradox of age as a prognostic factor in the survival of hepatocellular carcinoma patientsChien Hung Chen
Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
Liver Int 26:766-73. 2006..Thus, it seems that age has a paradoxical influence on the prognosis. To further clarify the issue of age on HCC prognosis, we initiated this study... - Variation of hepatitis C virus load, hypervariable region 1 quasispecies and CD81 hepatocyte expression in hepatocellular carcinoma and adjacent non-cancerous liverKung Chia Young
Departments of Medical Technology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China
J Med Virol 68:188-96. 2002..HCV-RNA quantity in both HCC and non-cancerous liver correlated with the number of HVR-1 quasispecies in the tissue, and distinct HVR-1 subclones existed... - Seroprevalence of hepatitis E virus infection among institutionalized psychiatric patients in TaiwanPin Nan Cheng
Department of Internal Medicine, National Cheng Kung University Hospital, Taipei, Taiwan, ROC
J Clin Virol 38:44-8. 2007..Hepatitis E virus infection (HEV) remains unclear in institutionalized psychiatric patients... - Novel nucleotide and amino acid covariation between the 5'UTR and the NS2/NS3 proteins of hepatitis C virus: bioinformatic and functional analysesHung Yu Sun
Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan
PLoS ONE 6:e25530. 2011..This unreported mechanism involving HCV replication possibly can be exploited in the development of advanced anti-HCV medication... - Five subgenotypes of hepatitis B virus genotype B with distinct geographic and virological characteristicsWen Chun Liu
Institute of Basic Medical Sciences, Medical College, National Cheng Kung University, Tainan, Taiwan, ROC
Virus Res 129:212-23. 2007..In conclusion, subgenotypes HBV/B(1)-B(5) exhibited distinct geographical distributions, virologic characteristics, and probable clinical implications... - Identification of hnRNPH1, NF45, and C14orf166 as novel host interacting partners of the mature hepatitis C virus core proteinJun Wei Lee
Institute of Basic Medical Science, College of Medicine, National Cheng Kung University, Tainan 70401, Taiwan, Republic of China
J Proteome Res 10:4522-34. 2011..Collectively, our findings suggest that spatial interactions of hnRNPH1, NF45, and C14orf166 with HCVc174 likely modulate HCV or cellular functions during acute and chronic HCV infection... - Serum tissue polypeptide specific antigen as a noninvasive prognostic indicator for early recurrence of hepatocellular carcinoma after curative resectionWei Jen Yao
Department of Nuclear Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Cancer 95:112-8. 2002..The objective of this study was to determine the usefulness of serum TPS as a noninvasive prognostic factor for early recurrence of hepatocellular carcinoma (HCC) after patients undergo curative resection... - Secular trends and geographic variations of hepatitis B virus and hepatitis C virus-associated hepatocellular carcinoma in TaiwanSheng-Nan Lu
Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
Int J Cancer 119:1946-52. 2006..Prevention of new HCV infection and the treatment of chronic hepatitis C should be the primary goals, which will result in better control of HCC in the future, even in an HBV-endemic area like Taiwan... - HBV DNA level as an important determinant of E antigen seroconversion of chronic hepatitis B during adefovir dipivoxil therapyKuo Chih Tseng
Department of Internal Medicine, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan
Hepatogastroenterology 56:813-8. 2009..The study was to evaluate which clinical or virological variables correlate with endpoints (e.g. HBeAg seroconversion and HBV DNA <10(5) copies/mL) during Adefovir dipivoxil or placebo therapy... - Eight-year nationwide survival analysis in relatives of patients with hepatocellular carcinoma: role of viral infectionDar-In Tai
Liver Research Unit, Chang Gung Memorial Hospital, Kaohsiung, Taiwan, ROC
J Gastroenterol Hepatol 17:682-9. 2002..CONCLUSIONS: Chronic viral infection rather than a hereditary factor is the main cause of a familial tendency for HCC. Dual infection of hepatitis B and C virus increases the risk of HCC or decompensated liver diseases... - Hepatitis B virus transmission and hepatocarcinogenesis: a 9 year retrospective cohort of 13676 relatives with hepatocellular carcinomaChien-Hung Chen
Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, ROC
J Hepatol 40:653-9. 2004..These high prevalences indicated high maternal HBV replication status. CONCLUSIONS: Perinatal transmission and maternal viral load are important risk factors in hepatocarcinogenesis... - Effects of multiple virus coinfections on disease progression in HIV-positive patientsBiehuoy Shieh
Department of Biochemistry, Chung Shan Medical University, Taichung, Taiwan, ROC
Intervirology 46:105-13. 2003..CONCLUSION: This result confirmed that immune-suppressed persons are more vulnerable to common virus infections. Unlike hepatitis B or C virus, TTV seems to accelerate the progression of chronic hepatitis in HIV-infected patients... - Hepatitis B virus X protein upregulates mTOR signaling through IKKβ to increase cell proliferation and VEGF production in hepatocellular carcinomaChia Jui Yen
Institute of Clinical Medicine, National Cheng Kung University College of Medicine and Hospital, Tainan, Taiwan
PLoS ONE 7:e41931. 2012..Taken together, our findings demonstrate that HBx deregulates TSC1/mTOR signaling through IKKβ, which is crucially linked to HBV-associated HCC development... - Therapy with interferon-alpha and ribavirin for chronic hepatitis C virus infection upregulates membrane HLA-ABC, CD86, and CD28 on peripheral blood mononuclear cellsPin Nan Cheng
Department of Internal Medicine, Medical College, National Cheng Kung University, Tainan, Taiwan
J Med Virol 80:989-96. 2008..033). In conclusion, differential modulation of T-cell activation ISGs, such as HLA-ABC and CD86 might correlate with the outcome of interferon-alpha-based therapy in chronic hepatitis C patients... - Comparison of recurrence after hepatic resection in patients with hepatitis B vs. hepatitis C-related small hepatocellular carcinoma in hepatitis B virus endemic areaYi-Hsiang Huang
Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
Liver Int 25:236-41. 2005..CONCLUSIONS: HCV infection, as compared with HBV infection, had a higher cumulated recurrence after hepatic resection in patients with small HCC. Low serum albumin level was significantly associated with recurrence among these patients... - Long-term trends and geographic variations in the survival of patients with hepatocellular carcinoma: analysis of 11,312 patients in TaiwanChien-Hung Chen
Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
J Gastroenterol Hepatol 21:1561-6. 2006..CONCLUSIONS: There are geographic variations in the survival rates of patients with HCC. Survival has been improving gradually over the past 20 years, probably due to earlier detection of HCC or to improved patient care... - The role of transcatheter arterial embolization in patients with resectable hepatocellular carcinoma: a nation-wide, multicenter studyYi-Hsiang Huang
Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan
Liver Int 24:419-24. 2004..CONCLUSIONS: Surgery is superior to TAE for patients with resectable HCC. In patients who refuse surgery, TAE can be considered for selected patients whose tumors are in early stage... - Simultaneous quantification and genotyping of hepatitis B virus for genotypes A to G by real-time PCR and two-step melting curve analysisWen-Chun Liu
Institute of Basic Medical Sciences, Department of Medicine, National Cheng Kung University, Tainan City 704, Taiwan, Republic of China, and Liver Unit, Hospital General Universitari Vall d'Hebron, Barcelona, Spain
J Clin Microbiol 44:4491-7. 2006..3% of 441 samples were accurately genotyped by the current assay. The method should be useful for genotyping and quantification of HBV DNA in areas where all genotypes exist... - Comparative proteomic profiling of plasma very-low-density and low-density lipoproteinsHung Yu Sun
Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Clin Chim Acta 411:336-44. 2010..Low-density lipoprotein (LDL) is a natural metabolite of very-low-density lipoprotein (VLDL) in the circulation. Systematic investigation of total protein components and dynamics might provide insights into this normal metabolic process... - Geographic variations of predominantly hepatitis C virus associated male hepatocellular carcinoma townships in Taiwan: identification of potential high HCV endemic areasWei Wen Su
Department of Internal Medicine, Changhua Christian Hospital, No 135 Nanxiao, Changhua, Taiwan
Hepatol Int 3:537-43. 2009..It was not really due to an overall decrease in B-HCC but due to an increase in HCV-related HCC. The identification of potential HCV endemic areas in Taiwan has consequently become important... - Characteristics of hepatocellular carcinoma in a high arsenicism area in Taiwan: a case-control studySheng-Nan Lu
Division of Hepato-Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
J Occup Environ Med 46:437-41. 2004..No differences were observed between HCC patients or their tumors, from study and control areas... - Interspousal transmission of hepatitis C virus: application of comparing the variability of HVR1 nucleotide regionKuan-Wei Lai
Department of Internal Medicine, Chiayi Christian Hospital, Chiayi, Taiwan
Hepatogastroenterology 51:791-5. 2004..CONCLUSIONS: This study strongly suggests that sexual transmission does exist, which can be confirmed by comparing the variability of HVR1 nucleotide region of HCV... - Evaluation of predictive value of CLIP, Okuda, TNM and JIS staging systems for hepatocellular carcinoma patients undergoing surgeryYi-Hsiang Huang
Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
J Gastroenterol Hepatol 20:765-71. 2005..CONCLUSION: Both the Okuda and CLIP systems are not superior to TNM staging for HCC patients who undergo surgical resection. Whether JIS score is feasible for those patients with advanced HCC needs further evaluation... - Aeromonas spontaneous bacterial peritonitis: a highly fatal infectious disease in patients with advanced liver cirrhosisChi Jung Wu
Graduate Institute of Clinical Medicine, National Cheng Kung University, Medical College, Tainan, Taiwan
J Formos Med Assoc 108:293-300. 2009..The clinical manifestations and prognostic factors of Aeromonas spontaneous bacterial peritonitis (SBP) in patients with liver cirrhosis were investigated... - High-dose interferon-alpha 2b plus ribavirin combination therapy for GB virus-C/hepatitis G virus infection--a study in patients with chronic hepatitis CPin-Nan Cheng
Department of Internal Medicine, National Cheng Kung University Hospital, Taiwan, R.O.C
Hepatogastroenterology 50:449-52. 2003..Either interferon-alpha 2b alone or interferon-alpha 2b and ribavirin combination therapy achieved transient but not sustained virological response to hepatitis G virus viremia... - Tear function changes during interferon and ribavirin treatment in patients with chronic hepatitis CFu-Chin Huang
Department of Ophthalmology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC
Cornea 24:561-6. 2005..Symptoms of dry eye were mild and reversible; however, abnormalities in tear dynamics and the ocular surface persisted even 6 months after discontinuation of treatment... - Adefovir dipivoxil for the treatment of hepatitis B e antigen-negative chronic hepatitis BStephanos J Hadziyannis
Department of Medicine and Hepatology, Henry Dunant Hospital, Athens, Greece
N Engl J Med 348:800-7. 2003..Adefovir dipivoxil, a nucleotide analogue, demonstrated clinically significant antiviral activity in patients with chronic hepatitis B in phase 1 and 2 clinical trials... - Strong association of hepatitis C virus (HCV) infection and thrombocytopenia: implications from a survey of a community with hyperendemic HCV infectionChong-Shan Wang
A-Lein Community Health Center, Kaohsiung County, Taipei, Taiwan
Clin Infect Dis 39:790-6. 2004..It is advisable to further check the hepatic condition of the patient, especially for HCV infection, if thrombocytopenia is present... - Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis BPatrick Marcellin
Service d Hepatologie, INSERM Unité 481, and Centre de Recherches Claude Bernard sur les Hépatites Virales, Hopital Beaujon, Clichy, France
N Engl J Med 348:808-16. 2003..In preclinical and phase 2 studies, adefovir dipivoxil demonstrated potent activity against hepatitis B virus (HBV), including lamivudine-resistant strains... - Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B for up to 5 yearsStephanos J Hadziyannis
Department of Medicine and Hepatology, Henry Dunant Hospital, Athens, Greece
Gastroenterology 131:1743-51. 2006..We investigated the efficacy, safety, and resistance profile of adefovir dipivoxil treatment for up to 240 weeks... - Hepatitis C virus infection and the development of type 2 diabetes in a community-based longitudinal studyChong Shan Wang
Community Medicine Research Center and Institute of Public Health, National Yang Ming University, Taipei, Taiwan
Am J Epidemiol 166:196-203. 2007..001). Results show that HCV infection is an independent predictor of diabetes, especially for anti-HCV+ persons who are younger or have a higher body mass index... - Cost-effectiveness of peginterferon alpha-2a compared to lamivudine treatment in patients with hepatitis B e antigen positive chronic hepatitis B in TaiwanSean D Sullivan
University of Washington, Seattle, Washington 98195, USA
J Gastroenterol Hepatol 22:1494-9. 2007.... - Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis BStephanos J Hadziyannis
Department of Medicine and Hepatology, Henry Dunant Hospital, Athens, Greece
N Engl J Med 352:2673-81. 2005..We evaluated the effect of continued therapy as compared with cessation of therapy... - Entecavir therapy for up to 96 weeks in patients with HBeAg-positive chronic hepatitis BRobert G Gish
Division of Hepatology and Complex GI, California Pacific Medical Center, San Francisco, California, USA
Gastroenterology 133:1437-44. 2007..We evaluated continued entecavir and lamivudine treatment through 96 weeks... - Long-term efficacy and safety of adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis BPatrick Marcellin
Hopital Beaujon, Paris, France
Hepatology 48:750-8. 2008..There were no serious adverse events related to ADV. CONCLUSION: Treatment with ADV beyond 48 weeks was well tolerated and produced long-term virological, biochemical, serological, and histological improvement... - Hepatitis B virus with primary resistance to adefovirTing-Tsung Chang
N Engl J Med 355:322-3; author reply 323. 2006 - Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis BChing Lung Lai
Queen Mary Hospital, Hong Kong, China
N Engl J Med 354:1011-20. 2006..Entecavir is a potent and selective antiviral agent that has demonstrated efficacy in phase 2 studies in patients with hepatitis B e antigen (HBeAg)-negative chronic hepatitis B... - Comparison of hepatitis B virus and hepatitis C virus prevalence and risk factors in a community-based studyChong-Shan Wang
A-Lein Community Health Center, Kaohsiung County, Taiwan
Am J Trop Med Hyg 66:389-93. 2002..Therefore, risk factors for HBsAg(+) and anti-HCV(+) were different in these Taiwanese communities. Safe medical injections and improved health education for high-risk groups are imperative for preventing HCV transmission... - Relationship of oral lichen planus to hepatitis C virus in southern TaiwanChing-Hung Chung
Graduate Institutes of Dental Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan
Kaohsiung J Med Sci 20:151-9. 2004..We concluded that OLP is significantly associated with HCV and DM in southern Taiwan, particularly in HCV patients with elevated serum ALT levels and atrophic-erosive OLP... - Community-based study of hepatitis C virus infection and type 2 diabetes: an association affected by age and hepatitis severity statusChong-Shan Wang
A-Lein Community Health Center, Kaohsiung County, Taiwan
Am J Epidemiol 158:1154-60. 2003..Data suggest that HCV infection is moderately associated with type 2 diabetes; the association was strongest for subjects aged 35-49 years and increased with severity of the liver condition...