Ting Tsung Chang

Summary

Affiliation: National Cheng Kung University
Country: Taiwan

Publications

  1. pmc Hepatitis B virus X protein upregulates mTOR signaling through IKKβ to increase cell proliferation and VEGF production in hepatocellular carcinoma
    Chia Jui Yen
    Institute of Clinical Medicine, National Cheng Kung University College of Medicine and Hospital, Tainan, Taiwan
    PLoS ONE 7:e41931. 2012
  2. pmc Efficacy of telbivudine in Taiwanese chronic hepatitis B patients compared with GLOBE extension study and predicting treatment outcome by HBV DNA kinetics at week 24
    Chao Wei Hsu
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 199 Tung Hwa North Road, Taipei 105, Taiwan
    BMC Gastroenterol 12:178. 2012
  3. ncbi request reprint Results of up to 2 years of entecavir vs lamivudine therapy in nucleoside-naïve HBeAg-positive patients with chronic hepatitis B
    T T Chang
    National Cheng Kung University Medical College, Tainan, Taiwan
    J Viral Hepat 16:784-9. 2009
  4. pmc On-treatment monitoring of HBV DNA levels: predicting response and resistance to oral antiviral therapy at week 24 versus week 48
    Ting Tsung Chang
    Department of Medicine, National Cheng Kung University Hospital, Tainan, 70428, Taiwan
    Hepatol Int 3:16-23. 2009
  5. doi request reprint Entecavir treatment for up to 5 years in patients with hepatitis B e antigen-positive chronic hepatitis B
    Ting Tsung Chang
    Medical College, National Cheng Kung University, Tainan, Taiwan, ROC
    Hepatology 51:422-30. 2010
  6. doi request reprint Long-term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B
    Ting Tsung Chang
    Department of Internal Medicine, National Cheng Kung University Medical College, Tainan, Taiwan
    Hepatology 52:886-93. 2010
  7. ncbi request reprint A dose-ranging study of the efficacy and tolerability of entecavir in Lamivudine-refractory chronic hepatitis B patients
    Ting Tsung Chang
    National Cheng Kung University Medical College, Tainan, Taiwan
    Gastroenterology 129:1198-209. 2005
  8. ncbi request reprint A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B
    Ting Tsung Chang
    National Cheng Kung University Medical College, Tainan, Taiwan
    N Engl J Med 354:1001-10. 2006
  9. ncbi request reprint Four years of lamivudine treatment in Chinese patients with chronic hepatitis B
    Ting Tsung Chang
    Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
    J Gastroenterol Hepatol 19:1276-82. 2004
  10. pmc Existence of hepatitis C virus in Culex quinquefasciatus after ingestion of infected blood: experimental approach to evaluating transmission by mosquitoes
    T T Chang
    Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China
    J Clin Microbiol 39:3353-5. 2001

Collaborators

Detail Information

Publications65

  1. pmc Hepatitis B virus X protein upregulates mTOR signaling through IKKβ to increase cell proliferation and VEGF production in hepatocellular carcinoma
    Chia Jui Yen
    Institute of Clinical Medicine, National Cheng Kung University College of Medicine and Hospital, Tainan, Taiwan
    PLoS ONE 7:e41931. 2012
    ..Taken together, our findings demonstrate that HBx deregulates TSC1/mTOR signaling through IKKβ, which is crucially linked to HBV-associated HCC development...
  2. pmc Efficacy of telbivudine in Taiwanese chronic hepatitis B patients compared with GLOBE extension study and predicting treatment outcome by HBV DNA kinetics at week 24
    Chao Wei Hsu
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 199 Tung Hwa North Road, Taipei 105, Taiwan
    BMC Gastroenterol 12:178. 2012
    ..The aims of this study were to compare results from a Taiwanese sub-study of the GLOBE 2303 telbivudine study and evaluate the HBV DNA kinetics...
  3. ncbi request reprint Results of up to 2 years of entecavir vs lamivudine therapy in nucleoside-naïve HBeAg-positive patients with chronic hepatitis B
    T T Chang
    National Cheng Kung University Medical College, Tainan, Taiwan
    J Viral Hepat 16:784-9. 2009
    ..For patients who discontinued therapy because of nonresponse (nonresponders) and subsequently entered the rollover study ETV-901, follow-up results, including resistance profile, are provided...
  4. pmc On-treatment monitoring of HBV DNA levels: predicting response and resistance to oral antiviral therapy at week 24 versus week 48
    Ting Tsung Chang
    Department of Medicine, National Cheng Kung University Hospital, Tainan, 70428, Taiwan
    Hepatol Int 3:16-23. 2009
    ..This review discusses available data for appropriate predictors for long-term response and antiviral resistance for patients receiving specific oral NA antiviral therapy. Guidelines for on-treatment monitoring are also discussed...
  5. doi request reprint Entecavir treatment for up to 5 years in patients with hepatitis B e antigen-positive chronic hepatitis B
    Ting Tsung Chang
    Medical College, National Cheng Kung University, Tainan, Taiwan, ROC
    Hepatology 51:422-30. 2010
    ..4% (2/145) lost hepatitis B surface antigen (HBsAg) during study ETV-901. Through 5 years, entecavir resistance emerged in one patient. The safety profile of entecavir was consistent with previous reports...
  6. doi request reprint Long-term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B
    Ting Tsung Chang
    Department of Internal Medicine, National Cheng Kung University Medical College, Tainan, Taiwan
    Hepatology 52:886-93. 2010
    ....
  7. ncbi request reprint A dose-ranging study of the efficacy and tolerability of entecavir in Lamivudine-refractory chronic hepatitis B patients
    Ting Tsung Chang
    National Cheng Kung University Medical College, Tainan, Taiwan
    Gastroenterology 129:1198-209. 2005
    ..This randomized, dose-ranging, phase 2 study compared the efficacy and safety of entecavir with lamivudine in lamivudine-refractory patients...
  8. ncbi request reprint A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B
    Ting Tsung Chang
    National Cheng Kung University Medical College, Tainan, Taiwan
    N Engl J Med 354:1001-10. 2006
    ..Entecavir is a potent and selective guanosine analogue with significant activity against hepatitis B virus (HBV)...
  9. ncbi request reprint Four years of lamivudine treatment in Chinese patients with chronic hepatitis B
    Ting Tsung Chang
    Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
    J Gastroenterol Hepatol 19:1276-82. 2004
    ..This study assessed the efficacy and safety of up to 4 years of lamivudine treatment and the clinical relevance of the emergence of YMDD-variant hepatitis B virus (HBV)...
  10. pmc Existence of hepatitis C virus in Culex quinquefasciatus after ingestion of infected blood: experimental approach to evaluating transmission by mosquitoes
    T T Chang
    Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China
    J Clin Microbiol 39:3353-5. 2001
    ..HCV RNA was detectable under all three conditions, but it did not replicate in mosquitoes and was not detectably transmitted during feeding...
  11. pmc Current approaches for treating chronic hepatitis B: when to start, what to start with, and when to stop
    Ting Tsung Chang
    Department of Medicine, National Cheng Kung University, Medical College and Hospital, 138 Sheng Li Road, Tainan, 70428, Taiwan
    Hepatol Int 2:19-27. 2008
    ..Current approaches for treating CHB and new strategies for optimizing response to therapy are also discussed...
  12. ncbi request reprint Secular trends and geographic variations of hepatitis B virus and hepatitis C virus-associated hepatocellular carcinoma in Taiwan
    Sheng Nan Lu
    Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
    Int J Cancer 119:1946-52. 2006
    ..Prevention of new HCV infection and the treatment of chronic hepatitis C should be the primary goals, which will result in better control of HCC in the future, even in an HBV-endemic area like Taiwan...
  13. ncbi request reprint Do young hepatocellular carcinoma patients have worse prognosis? The paradox of age as a prognostic factor in the survival of hepatocellular carcinoma patients
    Chien Hung Chen
    Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Liver Int 26:766-73. 2006
    ..Thus, it seems that age has a paradoxical influence on the prognosis. To further clarify the issue of age on HCC prognosis, we initiated this study...
  14. ncbi request reprint Evaluation of predictive value of CLIP, Okuda, TNM and JIS staging systems for hepatocellular carcinoma patients undergoing surgery
    Yi Hsiang Huang
    Institute of Clinical Medicine, National Yang Ming University School of Medicine, Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    J Gastroenterol Hepatol 20:765-71. 2005
    ..The purpose of the present paper was to compare the CLIP, Okuda, TNM and JIS staging systems for HCC patients undergoing surgery...
  15. ncbi request reprint Long-term trends and geographic variations in the survival of patients with hepatocellular carcinoma: analysis of 11,312 patients in Taiwan
    Chien Hung Chen
    Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    J Gastroenterol Hepatol 21:1561-6. 2006
    ..The survival rates of patients with hepatocellular carcinoma (HCC) were investigated over the past 20 years to clarify the long-term survival trend...
  16. doi request reprint Association of intrahepatic cccDNA reduction with the improvement of liver histology in chronic hepatitis B patients receiving oral antiviral agents
    Pin Nan Cheng
    Department of Internal Medicine, Medical College, National Cheng Kung University, Tainan, Taiwan
    J Med Virol 83:602-7. 2011
    ..Although one-year ETV or ADV treatment is insufficient for cccDNA eradication, oral antiviral therapies may improve liver histology, probably by suppressing intrahepatic cccDNA...
  17. ncbi request reprint Comparison of recurrence after hepatic resection in patients with hepatitis B vs. hepatitis C-related small hepatocellular carcinoma in hepatitis B virus endemic area
    Yi Hsiang Huang
    Institute of Clinical Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Liver Int 25:236-41. 2005
    ..The carcinogenic mechanism of HBV and HCV is considered to be different. It is interesting to compare the recurrence after hepatic resection in patients with small HCC who were infected with HBV or HCV...
  18. ncbi request reprint Characterization of viral kinetics in patients with hepatitis B e antigen-positive chronic hepatitis B
    I Chin Wu
    Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
    J Med Virol 79:663-9. 2007
    ..8% and a specificity of 74.7%. In conclusion, different viral kinetic patterns in patients with chronic hepatitis B implicate distinct clinical significance and immunologic perspective...
  19. doi request reprint Clinical significance of serum HBsAg levels and association with liver histology in HBeAg positive chronic hepatitis B
    Pin Nan Cheng
    Department of Internal Medicine, National Cheng Kung University Hospital, Taiwan
    J Clin Virol 57:323-30. 2013
    ..Despite its recognized role as a prognostic marker for antiviral treatment, the clinical significance of serum hepatitis B surface antigen (HBsAg) level in the immune-clearance stage of chronic hepatitis B remains unclear...
  20. ncbi request reprint Hepatitis B virus transmission and hepatocarcinogenesis: a 9 year retrospective cohort of 13676 relatives with hepatocellular carcinoma
    Chien Hung Chen
    Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, ROC
    J Hepatol 40:653-9. 2004
    ..The route of HBV transmission differs between the children and siblings of patients with HCC. This study examined the differences in HBV carrier rates and HCC-related mortality between two generations in HCC families...
  21. pmc Simultaneous quantification and genotyping of hepatitis B virus for genotypes A to G by real-time PCR and two-step melting curve analysis
    Wen Chun Liu
    Institute of Basic Medical Sciences, Department of Medicine, National Cheng Kung University, Tainan City 704, Taiwan, Republic of China, and Liver Unit, Hospital General Universitari Vall d Hebron, Barcelona, Spain
    J Clin Microbiol 44:4491-7. 2006
    ..3% of 441 samples were accurately genotyped by the current assay. The method should be useful for genotyping and quantification of HBV DNA in areas where all genotypes exist...
  22. ncbi request reprint High-dose interferon-alpha 2b plus ribavirin combination therapy for GB virus-C/hepatitis G virus infection--a study in patients with chronic hepatitis C
    Pin Nan Cheng
    Department of Internal Medicine, National Cheng Kung University Hospital, Taiwan, R O C
    Hepatogastroenterology 50:449-52. 2003
    ..We previously conducted a double-blind, placebo-controlled trial using high-dose interferon-alpha 2b with or without ribavirin for patients with interferon-alpha-relapsed chronic hepatitis C...
  23. doi request reprint Sustained hepatitis B e antigen seroconversion in patients with chronic hepatitis B after adefovir dipivoxil treatment: analysis of precore and basal core promoter mutants
    I Chin Wu
    Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China
    Clin Infect Dis 47:1305-11. 2008
    ..This study evaluated the persistence of hepatitis B e antigen (HBeAg) seroconversion (which is considered to be an important therapeutic end point) after adefovir dipivoxil treatment...
  24. ncbi request reprint The role of transcatheter arterial embolization in patients with resectable hepatocellular carcinoma: a nation-wide, multicenter study
    Yi Hsiang Huang
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    Liver Int 24:419-24. 2004
    ..The role of transcatheter arterial embolization (TAE) for patients with resectable hepatocellular carcinoma (HCC) is controversial. Analyzing a cohort of nation-wide data can delineate the beneficial effect of TAE for those patients...
  25. doi request reprint Very low-density lipoprotein/lipo-viro particles reverse lipoprotein lipase-mediated inhibition of hepatitis C virus infection via apolipoprotein C-III
    Hung Yu Sun
    Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan
    Gut 62:1193-203. 2013
    ..This investigation considers the regulation of LPL by lipoproteins and LVPs, and their roles in the LPL-mediated anti-HCV function...
  26. pmc Analysis of precore/core covariances associated with viral kinetics and genotypes in hepatitis B e antigen-positive chronic hepatitis B patients
    Chun Pei Cheng
    Department of Computer Science and Information Engineering, National Cheng Kung University, Tainan, Taiwan
    PLoS ONE 7:e32553. 2012
    ..Moreover, representative covariances may benefit clinicians to prescribe a suitable treatment for patients even if they have no obvious symptoms at the early stage of HBV infection...
  27. doi request reprint Efficacy of entecavir in chronic hepatitis B patients with mildly elevated alanine aminotransferase and biopsy-proven histological damage
    I Chin Wu
    National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Hepatology 51:1185-9. 2010
    ..However, HBeAg-positive patients with mildly elevated ALT responded less well to treatment with entecavir than did those with ALT greater than 2 x ULN...
  28. ncbi request reprint Smoking and alanine aminotransferase levels in hepatitis C virus infection: implications for prevention of hepatitis C virus progression
    Chong Shan Wang
    National Yang Ming University, Institute of Public Health, Shih Pai, Taipei 112, Taiwan, Republic of China
    Arch Intern Med 162:811-5. 2002
    ..Alcohol consumption is a well-known risk factor for elevated ALT levels, but the role of cigarette smoking is unclear...
  29. pmc Novel nucleotide and amino acid covariation between the 5'UTR and the NS2/NS3 proteins of hepatitis C virus: bioinformatic and functional analyses
    Hung Yu Sun
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    PLoS ONE 6:e25530. 2011
    ..This unreported mechanism involving HCV replication possibly can be exploited in the development of advanced anti-HCV medication...
  30. doi request reprint Entecavir: a potent antiviral with minimal long-term resistance in nucleoside-naive chronic hepatitis B patients
    Pin Nan Cheng
    National Cheng Kung University, Medical College and Hospital, Tainan, Taiwan, ROC
    Expert Rev Anti Infect Ther 6:569-79. 2008
    ..These data underscore the position of entecavir for first-line therapy and highlight its role in the long-term treatment of chronic hepatits B...
  31. ncbi request reprint Variation of hepatitis C virus load, hypervariable region 1 quasispecies and CD81 hepatocyte expression in hepatocellular carcinoma and adjacent non-cancerous liver
    Kung Chia Young
    Departments of Medical Technology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China
    J Med Virol 68:188-96. 2002
    ..HCV-RNA quantity in both HCC and non-cancerous liver correlated with the number of HVR-1 quasispecies in the tissue, and distinct HVR-1 subclones existed...
  32. ncbi request reprint A reverse-transcription competitive PCR assay based on chemiluminescence hybridization for detection and quantification of hepatitis C virus RNA
    Kung Chia Young
    Department of Medical Technology, Medical College, National Cheng Kung University, 70101, Tainan, Taiwan, ROC
    J Virol Methods 103:27-39. 2002
    ..In conclusion, the proposed chemiluminescence RT-cPCR method can detect quantitatively HCV RNA as accurately as the bDNA method and has sensitivity as high as nested RT-PCR...
  33. ncbi request reprint Eight-year nationwide survival analysis in relatives of patients with hepatocellular carcinoma: role of viral infection
    Dar In Tai
    Liver Research Unit, Chang Gung Memorial Hospital, Kaohsiung, Taiwan, ROC
    J Gastroenterol Hepatol 17:682-9. 2002
    ..We determine the number of fatalities in relatives of HCC patients during an 8-year period to understand the risk and cause of HCC in relatives of patients with HCC...
  34. ncbi request reprint Five subgenotypes of hepatitis B virus genotype B with distinct geographic and virological characteristics
    Wen Chun Liu
    Institute of Basic Medical Sciences, Medical College, National Cheng Kung University, Tainan, Taiwan, ROC
    Virus Res 129:212-23. 2007
    ..In conclusion, subgenotypes HBV/B(1)-B(5) exhibited distinct geographical distributions, virologic characteristics, and probable clinical implications...
  35. ncbi request reprint Effects of multiple virus coinfections on disease progression in HIV-positive patients
    Biehuoy Shieh
    Department of Biochemistry, Chung Shan Medical University, Taichung, Taiwan, ROC
    Intervirology 46:105-13. 2003
    ....
  36. ncbi request reprint Molecular evidence for transmission of GB virus-C/Hepatitis G virus infection within family: close relationship between mother and child
    Pin Nan Cheng
    Department of Internal Medicine, National Cheng Kung University Hospital, Taiwan, ROC
    Hepatogastroenterology 50:151-6. 2003
    ..GBV-C/Hepatitis G virus (HGV) is transmitted parentally, but some of the transmitted routes are still unclear. This study was conducted to investigate the relationship of family members in the transmission of HGV...
  37. doi request reprint Effect of human leukocyte antigen class I and II alleles on hepatitis C viral load among chronic hepatitis C patients in Southern Taiwan
    Kuo Chih Tseng
    Department of Internal Medicine, Buddhist Dalin Tzu Chi General Hospital, Chia Yi, Taiwan School of Medicine, TzuChi University, Hualien, Taiwan
    Hum Immunol 74:978-82. 2013
    ..In conclusion, HLA-C(*)15 is an important host immunogenetic factor with an inverse association to HCV viral load in CHC patients in Taiwan. HCV genotype 1 is the viral factor that associated with high viral load...
  38. ncbi request reprint Tear function changes during interferon and ribavirin treatment in patients with chronic hepatitis C
    Fu Chin Huang
    Department of Ophthalmology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC
    Cornea 24:561-6. 2005
    ..To evaluate symptoms and changes in tear function and the ocular surface with interferon and ribavirin therapy for chronic hepatitis C...
  39. ncbi request reprint Peginterferon alfa-2a is associated with elevations in alanine aminotransferase at the end of treatment in chronic hepatitis C patients with sustained virologic response
    Chih Wei Tseng
    Department of Internal Medicine, Buddhist Dalin Tzu Chi General Hospital, Chia Yi, Taiwan Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan School of Medicine, National Yang Ming University, Taipei, Taiwan School of Medicine, TzuChi University, Hualien, Taiwan
    PLoS ONE 9:e100207. 2014
    ....
  40. pmc Lin28B is an oncofetal circulating cancer stem cell-like marker associated with recurrence of hepatocellular carcinoma
    Shu Wen Cheng
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    PLoS ONE 8:e80053. 2013
    ..Circulating Lin28B could refine early AJCC stages. Our finding supports the possible use of a TNMC (C for circulating tumor cells) staging system in HCC. ..
  41. ncbi request reprint Immune response to hepatitis B vaccine of subjects with isolated antibody to hepatitis B core antigen
    Kuo Chih Tseng
    Division of Gastroenterology, Department of Internal Medicine, Buddhist Dalin Tzu Chi General Hospital, Chia Yi, Taiwan
    Hepatogastroenterology 50:1474-7. 2003
    ..The aim of this study was to evaluate the clinical significance of isolated antibody to hepatitis B core antigen...
  42. ncbi request reprint Seroprevalence of hepatitis E virus infection among institutionalized psychiatric patients in Taiwan
    Pin Nan Cheng
    Department of Internal Medicine, National Cheng Kung University Hospital, Taipei, Taiwan, ROC
    J Clin Virol 38:44-8. 2007
    ..Hepatitis E virus infection (HEV) remains unclear in institutionalized psychiatric patients...
  43. doi request reprint Identification of hnRNPH1, NF45, and C14orf166 as novel host interacting partners of the mature hepatitis C virus core protein
    Jun Wei Lee
    Institute of Basic Medical Science, College of Medicine, National Cheng Kung University, Tainan 70401, Taiwan, Republic of China
    J Proteome Res 10:4522-34. 2011
    ..Collectively, our findings suggest that spatial interactions of hnRNPH1, NF45, and C14orf166 with HCVc174 likely modulate HCV or cellular functions during acute and chronic HCV infection...
  44. ncbi request reprint Serum tissue polypeptide specific antigen as a noninvasive prognostic indicator for early recurrence of hepatocellular carcinoma after curative resection
    Wei Jen Yao
    Department of Nuclear Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Cancer 95:112-8. 2002
    ..The objective of this study was to determine the usefulness of serum TPS as a noninvasive prognostic factor for early recurrence of hepatocellular carcinoma (HCC) after patients undergo curative resection...
  45. ncbi request reprint Characteristics of hepatocellular carcinoma in a high arsenicism area in Taiwan: a case-control study
    Sheng Nan Lu
    Division of Hepato Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
    J Occup Environ Med 46:437-41. 2004
    ..No differences were observed between HCC patients or their tumors, from study and control areas...
  46. ncbi request reprint Interspousal transmission of hepatitis C virus: application of comparing the variability of HVR1 nucleotide region
    Kuan Wei Lai
    Department of Internal Medicine, Chiayi Christian Hospital, Chiayi, Taiwan
    Hepatogastroenterology 51:791-5. 2004
    ..We thus aim to investigate the possibility of HCV transmission between spouses by comparing the variability of HCV hypervariable region 1 (HVR1) between spouses and non-spouses...
  47. ncbi request reprint HBV DNA level as an important determinant of E antigen seroconversion of chronic hepatitis B during adefovir dipivoxil therapy
    Kuo Chih Tseng
    Department of Internal Medicine, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan
    Hepatogastroenterology 56:813-8. 2009
    ..The study was to evaluate which clinical or virological variables correlate with endpoints (e.g. HBeAg seroconversion and HBV DNA <10(5) copies/mL) during Adefovir dipivoxil or placebo therapy...
  48. pmc Geographic variations of predominantly hepatitis C virus associated male hepatocellular carcinoma townships in Taiwan: identification of potential high HCV endemic areas
    Wei Wen Su
    Department of Internal Medicine, Changhua Christian Hospital, No 135 Nanxiao, Changhua, Taiwan
    Hepatol Int 3:537-43. 2009
    ..It was not really due to an overall decrease in B-HCC but due to an increase in HCV-related HCC. The identification of potential HCV endemic areas in Taiwan has consequently become important...
  49. doi request reprint Therapy with interferon-alpha and ribavirin for chronic hepatitis C virus infection upregulates membrane HLA-ABC, CD86, and CD28 on peripheral blood mononuclear cells
    Pin Nan Cheng
    Department of Internal Medicine, Medical College, National Cheng Kung University, Tainan, Taiwan
    J Med Virol 80:989-96. 2008
    ..033). In conclusion, differential modulation of T-cell activation ISGs, such as HLA-ABC and CD86 might correlate with the outcome of interferon-alpha-based therapy in chronic hepatitis C patients...
  50. doi request reprint Comparative proteomic profiling of plasma very-low-density and low-density lipoproteins
    Hung Yu Sun
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Clin Chim Acta 411:336-44. 2010
    ..Low-density lipoprotein (LDL) is a natural metabolite of very-low-density lipoprotein (VLDL) in the circulation. Systematic investigation of total protein components and dynamics might provide insights into this normal metabolic process...
  51. doi request reprint Aeromonas spontaneous bacterial peritonitis: a highly fatal infectious disease in patients with advanced liver cirrhosis
    Chi Jung Wu
    Graduate Institute of Clinical Medicine, National Cheng Kung University, Medical College, Tainan, Taiwan
    J Formos Med Assoc 108:293-300. 2009
    ..The clinical manifestations and prognostic factors of Aeromonas spontaneous bacterial peritonitis (SBP) in patients with liver cirrhosis were investigated...
  52. ncbi request reprint Adefovir dipivoxil for the treatment of hepatitis B e antigen-negative chronic hepatitis B
    Stephanos J Hadziyannis
    Department of Medicine and Hepatology, Henry Dunant Hospital, Athens, Greece
    N Engl J Med 348:800-7. 2003
    ..Adefovir dipivoxil, a nucleotide analogue, demonstrated clinically significant antiviral activity in patients with chronic hepatitis B in phase 1 and 2 clinical trials...
  53. ncbi request reprint Comparison of hepatitis B virus and hepatitis C virus prevalence and risk factors in a community-based study
    Chong Shan Wang
    A Lein Community Health Center, Kaohsiung County, Taiwan
    Am J Trop Med Hyg 66:389-93. 2002
    ..Therefore, risk factors for HBsAg(+) and anti-HCV(+) were different in these Taiwanese communities. Safe medical injections and improved health education for high-risk groups are imperative for preventing HCV transmission...
  54. ncbi request reprint Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B
    Patrick Marcellin
    Service d Hepatologie, INSERM Unité 481, and Centre de Recherches Claude Bernard sur les Hépatites Virales, Hopital Beaujon, Clichy, France
    N Engl J Med 348:808-16. 2003
    ..In preclinical and phase 2 studies, adefovir dipivoxil demonstrated potent activity against hepatitis B virus (HBV), including lamivudine-resistant strains...
  55. ncbi request reprint Strong association of hepatitis C virus (HCV) infection and thrombocytopenia: implications from a survey of a community with hyperendemic HCV infection
    Chong Shan Wang
    A Lein Community Health Center, Kaohsiung County, Taipei, Taiwan
    Clin Infect Dis 39:790-6. 2004
    ..Our aim was to study the association between HCV infection and thrombocytopenia in a community where hepatitis B virus (HBV) and HCV infections are hyperendemic...
  56. ncbi request reprint Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B
    Ching Lung Lai
    Queen Mary Hospital, Hong Kong, China
    N Engl J Med 354:1011-20. 2006
    ..Entecavir is a potent and selective antiviral agent that has demonstrated efficacy in phase 2 studies in patients with hepatitis B e antigen (HBeAg)-negative chronic hepatitis B...
  57. ncbi request reprint Hepatitis B virus with primary resistance to adefovir
    Ting Tsung Chang
    N Engl J Med 355:322-3; author reply 323. 2006
  58. ncbi request reprint Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B for up to 5 years
    Stephanos J Hadziyannis
    Department of Medicine and Hepatology, Henry Dunant Hospital, Athens, Greece
    Gastroenterology 131:1743-51. 2006
    ..We investigated the efficacy, safety, and resistance profile of adefovir dipivoxil treatment for up to 240 weeks...
  59. ncbi request reprint Hepatitis C virus infection and the development of type 2 diabetes in a community-based longitudinal study
    Chong Shan Wang
    Community Medicine Research Center and Institute of Public Health, National Yang Ming University, Taipei, Taiwan
    Am J Epidemiol 166:196-203. 2007
    ..001). Results show that HCV infection is an independent predictor of diabetes, especially for anti-HCV+ persons who are younger or have a higher body mass index...
  60. ncbi request reprint Cost-effectiveness of peginterferon alpha-2a compared to lamivudine treatment in patients with hepatitis B e antigen positive chronic hepatitis B in Taiwan
    Sean D Sullivan
    University of Washington, Seattle, Washington 98195, USA
    J Gastroenterol Hepatol 22:1494-9. 2007
    ....
  61. ncbi request reprint Entecavir therapy for up to 96 weeks in patients with HBeAg-positive chronic hepatitis B
    Robert G Gish
    Division of Hepatology and Complex GI, California Pacific Medical Center, San Francisco, California, USA
    Gastroenterology 133:1437-44. 2007
    ..We evaluated continued entecavir and lamivudine treatment through 96 weeks...
  62. ncbi request reprint Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B
    Stephanos J Hadziyannis
    Department of Medicine and Hepatology, Henry Dunant Hospital, Athens, Greece
    N Engl J Med 352:2673-81. 2005
    ..We evaluated the effect of continued therapy as compared with cessation of therapy...
  63. doi request reprint Long-term efficacy and safety of adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B
    Patrick Marcellin
    Hopital Beaujon, Paris, France
    Hepatology 48:750-8. 2008
    ..Adefovir resistance mutations A181V or N236T developed in 13 LTSES patients; the first observation was at study week 195. There were no serious adverse events related to ADV...
  64. ncbi request reprint Relationship of oral lichen planus to hepatitis C virus in southern Taiwan
    Ching Hung Chung
    Graduate Institutes of Dental Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan
    Kaohsiung J Med Sci 20:151-9. 2004
    ..We concluded that OLP is significantly associated with HCV and DM in southern Taiwan, particularly in HCV patients with elevated serum ALT levels and atrophic-erosive OLP...
  65. ncbi request reprint Community-based study of hepatitis C virus infection and type 2 diabetes: an association affected by age and hepatitis severity status
    Chong Shan Wang
    A Lein Community Health Center, Kaohsiung County, Taiwan
    Am J Epidemiol 158:1154-60. 2003
    ..Data suggest that HCV infection is moderately associated with type 2 diabetes; the association was strongest for subjects aged 35-49 years and increased with severity of the liver condition...