Mei Hwei Chang

Summary

Affiliation: National Taiwan University
Country: Taiwan

Publications

  1. ncbi request reprint Breakthrough HBV infection in vaccinated children in Taiwan: surveillance for HBV mutants
    Mei Hwei Chang
    Department of Pediatrics and Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan
    Antivir Ther 15:463-9. 2010
  2. pmc Male germ cell-specific RNA binding protein RBMY: a new oncogene explaining male predominance in liver cancer
    Daw Jen Tsuei
    Department of Pediatrics, College of Medicine, National Taiwan University, National Taiwan University Hospital, Taipei, Taiwan
    PLoS ONE 6:e26948. 2011
  3. doi request reprint Weight-based policy of hepatitis B vaccination in very low birth weight infants in Taiwan: a retrospective cross-sectional study
    Chien Yi Chen
    Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    PLoS ONE 9:e92271. 2014
  4. doi request reprint Prediction of severe neonatal hyperbilirubinemia using cord blood hydrogen peroxide: a prospective study
    Hung Chieh Chou
    National Taiwan University College of Medicine Graduate Institute of Clinical Medicine, Taipei, Taiwan Department of Pediatrics, National Taiwan University Hospital, National Taiwan University, Medical College, Taipei, Taiwan
    PLoS ONE 9:e86797. 2014
  5. doi request reprint Paediatrics: Children need optimal management of chronic hepatitis B
    Mei Hwei Chang
    Department of Paediatrics and Hepatitis Research Centre, National Taiwan University Hospital, 8 Chung Shan South Road, Taipei, Taiwan
    Nat Rev Gastroenterol Hepatol 10:505-6. 2013
  6. doi request reprint Prevention of hepatitis B virus infection and liver cancer
    Mei Hwei Chang
    Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan
    Recent Results Cancer Res 193:75-95. 2014
  7. doi request reprint Hepatitis B virus and cancer prevention
    Mei Hwei Chang
    Department of Pediatrics and Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan
    Recent Results Cancer Res 188:75-84. 2011
  8. ncbi request reprint Decreased incidence of hepatocellular carcinoma in hepatitis B vaccinees: a 20-year follow-up study
    Mei Hwei Chang
    Department of Pediatrics, National Taiwan University Hospital, Chung Shan S Road, Taipei, Taiwan
    J Natl Cancer Inst 101:1348-55. 2009
  9. ncbi request reprint Cancer prevention by vaccination against hepatitis B
    Mei Hwei Chang
    National Taiwan University Hospital, Taipei
    Recent Results Cancer Res 181:85-94. 2009
  10. doi request reprint Hepatitis B vaccination: disease and cancer prevention-a Taiwanese experience
    Mei Hwei Chang
    Department of Pediatrics, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan
    Clin Liver Dis 14:521-30. 2010

Detail Information

Publications109 found, 100 shown here

  1. ncbi request reprint Breakthrough HBV infection in vaccinated children in Taiwan: surveillance for HBV mutants
    Mei Hwei Chang
    Department of Pediatrics and Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan
    Antivir Ther 15:463-9. 2010
    ..With limited evidence of spread, S gene mutants do not need to be incorporated into the HBV vaccine. Further studies are required to design better strategies to prevent breakthrough HBV infection of both wild-type and S gene mutants...
  2. pmc Male germ cell-specific RNA binding protein RBMY: a new oncogene explaining male predominance in liver cancer
    Daw Jen Tsuei
    Department of Pediatrics, College of Medicine, National Taiwan University, National Taiwan University Hospital, Taipei, Taiwan
    PLoS ONE 6:e26948. 2011
    ..Collectively, these findings suggest that Y chromosome-specific RBMY is likely involved in the regulation of androgen receptor activity and contributes to male predominance of HCC...
  3. doi request reprint Weight-based policy of hepatitis B vaccination in very low birth weight infants in Taiwan: a retrospective cross-sectional study
    Chien Yi Chen
    Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    PLoS ONE 9:e92271. 2014
    ..We use an alternative body-weight-based protocol, and evaluate its efficacy in an endemic area under a universal immunization program...
  4. doi request reprint Prediction of severe neonatal hyperbilirubinemia using cord blood hydrogen peroxide: a prospective study
    Hung Chieh Chou
    National Taiwan University College of Medicine Graduate Institute of Clinical Medicine, Taipei, Taiwan Department of Pediatrics, National Taiwan University Hospital, National Taiwan University, Medical College, Taipei, Taiwan
    PLoS ONE 9:e86797. 2014
    ..We hypothesized that cord blood hydrogen peroxide (H2O2) could be utilized to predict the severity of neonatal hyperbilirubinemia...
  5. doi request reprint Paediatrics: Children need optimal management of chronic hepatitis B
    Mei Hwei Chang
    Department of Paediatrics and Hepatitis Research Centre, National Taiwan University Hospital, 8 Chung Shan South Road, Taipei, Taiwan
    Nat Rev Gastroenterol Hepatol 10:505-6. 2013
    ..Children have the potential for a long lifespan and should be treated properly and early before complications develop...
  6. doi request reprint Prevention of hepatitis B virus infection and liver cancer
    Mei Hwei Chang
    Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan
    Recent Results Cancer Res 193:75-95. 2014
    ....
  7. doi request reprint Hepatitis B virus and cancer prevention
    Mei Hwei Chang
    Department of Pediatrics and Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan
    Recent Results Cancer Res 188:75-84. 2011
    ..Future strategies to increase the global coverage rate of HBV immunization and to interrupt mother-to- infant transmission may enhance the cancer prevention effect of HBV immunization...
  8. ncbi request reprint Decreased incidence of hepatocellular carcinoma in hepatitis B vaccinees: a 20-year follow-up study
    Mei Hwei Chang
    Department of Pediatrics, National Taiwan University Hospital, Chung Shan S Road, Taipei, Taiwan
    J Natl Cancer Inst 101:1348-55. 2009
    ....
  9. ncbi request reprint Cancer prevention by vaccination against hepatitis B
    Mei Hwei Chang
    National Taiwan University Hospital, Taipei
    Recent Results Cancer Res 181:85-94. 2009
    ..Future efforts to reduce vaccine failure will improve the efficacy of liver cancer prevention by HBV vaccination. The experience of HCC prevention by HBV immunization may be applied to the prevention of other infection-related cancers...
  10. doi request reprint Hepatitis B vaccination: disease and cancer prevention-a Taiwanese experience
    Mei Hwei Chang
    Department of Pediatrics, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan
    Clin Liver Dis 14:521-30. 2010
    ..An effective decline in the incidence of HCC in adults is expected in the near future. The concept of a cancer preventive vaccine, using HBV as an example, can be applied further to other infectious agents and their related cancers...
  11. pmc Natural history and clinical management of chronic hepatitis B virus infection in children
    Mei Hwei Chang
    Division of Gastroenterology and Hepatology, Department of Pediatrics, National Taiwan University Hospital, No 7, Chung Shan S Road, Taipei, Taiwan
    Hepatol Int 2:28-36. 2008
    ..This article reviews current knowledge regarding the natural history and treatment of chronic hepatitis B in children. Factors that affect the natural history of HBV infection in children are also reviewed...
  12. ncbi request reprint Long-term follow-up of children with postnatal immunoprophylaxis failure who were infected with hepatitis B virus surface antigen gene mutant
    Hong Yuan Hsu
    Department of Pediatrics, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan
    J Infect Dis 207:1047-57. 2013
    ..The long-term evolution and outcomes of infection with a hepatitis B virus (HBV) surface antigen (HBsAg) gene mutant (hereafter, "HBsAg-mutant HBV") among immunized children remain unclear...
  13. doi request reprint Clinical course of de novo hepatitis B infection after pediatric liver transplantation
    Wei Ju Su
    Department of Pediatrics, National Taiwan University College of Medicine and Hospital, Taipei 100, Taiwan
    Liver Transpl 16:215-21. 2010
    ..In conclusion, surface mutants are frequent among pediatric liver transplant recipients with de novo HBV infections, but their clinical relevance requires further study...
  14. ncbi request reprint Lamivudine treatment in maternally transmitted chronic hepatitis B virus infection patients
    Yen Hsuan Ni
    Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan
    Pediatr Int 47:372-7. 2005
    ..Lamivudine treatment in chronic carriers who acquired hepatitis B virus through maternal transmission were investigated...
  15. doi request reprint Toll-like receptor and hepatitis B virus clearance in chronic infected patients: a long-term prospective cohort study in Taiwan
    Jia Feng Wu
    Department of Pediatrics, National Taiwan University Hospital, Taipei
    J Infect Dis 206:662-8. 2012
    ..We sought to elucidate the impacts of the Toll-like receptors (TLRs) on spontaneous hepatitis B virus (HBV) e antigen (HBeAg) and hepatitis B s antigen (HBsAg) seroconversion in chronic HBV-infected patients...
  16. doi request reprint 211 G to a variation of UDP-glucuronosyl transferase 1A1 gene and neonatal breastfeeding jaundice
    Hung Chieh Chou
    Departments of Pediatrics and Medical Genetics, Graduate Institute of Clinical Medicine, National Taiwan University Hospital, Taipei 100, Taiwan
    Pediatr Res 69:170-4. 2011
    ..This suggests that neonates who carry the nucleotide 211 GA or AA variation within coding region in UGT1A1 gene are more susceptible to develop early-onset neonatal breastfeeding jaundice...
  17. ncbi request reprint Pediatric fulminant hepatic failure in endemic areas of hepatitis B infection: 15 years after universal hepatitis B vaccination
    Huey Ling Chen
    Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei
    Hepatology 39:58-63. 2004
    ..HBV-positive FHF was prone to develop in infants born to HBeAg-negative, HBsAg-carrier mothers; these infants had not received hepatitis B immunoglobulin according to the vaccination program in place...
  18. ncbi request reprint Factors affecting the mortality of pediatric fulminant hepatic failure in relation to hepatitis B virus infection
    Pei Chun Chan
    Department of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
    J Gastroenterol Hepatol 20:1223-7. 2005
    ..To investigate the factors affecting the outcome of fulminant hepatic failure (FHF) in children in relation to hepatitis B virus (HBV) infection...
  19. doi request reprint Long-term effect of maternal HBeAg on delayed HBeAg seroconversion in offspring with chronic hepatitis B infection
    Yu Ru Tseng
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Liver Int 31:1373-80. 2011
    ..This cohort study investigated the long-term effect of maternal hepatitis B virus (HBV) sero-status on the spontaneous HBeAg seroconversion in offspring with chronic HBV infection...
  20. doi request reprint Human interleukin-10 genotypes are associated with different precore/core gene mutation patterns in children with chronic hepatitis B virus infection
    Jia Feng Wu
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    J Pediatr 158:808-13. 2011
    ..To elucidate the association between human interleukin-10 (IL-10) genotypes and hepatitis B virus (HBV) precore/core gene mutation in children with chronic HBV infection...
  21. ncbi request reprint Genetic variants in GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals
    Yu Cheng Lin
    Department of Pediatrics, Far Eastern Memorial Hospital, Taipei, Taiwan Y CL and P FC the Departments of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan M HC and Y HN and the Oriental Institute of Technology, New Taipei City, Taiwan Y CL
    Am J Clin Nutr 99:869-74. 2014
    ....
  22. ncbi request reprint Hepatic steatosis and neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) in Taiwanese infants
    Jiun Nan Yeh
    Department of Pediatrics, Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan
    J Pediatr 148:642-6. 2006
    ..To explore the prevalence of hepatic steatosis and neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) in Taiwanese infants with idiopathic intrahepatic cholestasis...
  23. ncbi request reprint Differential integration rates of hepatitis B virus DNA in the liver of children with chronic hepatitis B virus infection and hepatocellular carcinoma
    Hsiang Po Huang
    Department of Pediatrics, College of Medicine, National Taiwan University, 10016 Taipei, Taiwan
    J Gastroenterol Hepatol 20:1206-14. 2005
    ..The aim of the present study was to determine the prevalence of HBV integration more accurately and to decide whether the integration rate varies at different stages of chronic HBV infection in children...
  24. doi request reprint Expression of hepatocyte transporters and nuclear receptors in children with early and late-stage biliary atresia
    Huey Ling Chen
    Department of Pediatrics, National Taiwan University College of Medicine and Hospital, Taipei, 10002 Taiwan
    Pediatr Res 63:667-73. 2008
    ..In conclusion, at long-term cholestasis, hepatocyte bile efflux was through sinusoidal and canalicular transporters, with FXR-BSEP levels maintained and PXR downregulated. Low PXR and CAR levels were associated with poor prognosis...
  25. ncbi request reprint Clinical relevance of hepatitis B virus genotype in children with chronic infection and hepatocellular carcinoma
    Yen Hsuan Ni
    Department of Pediatrics, College of Medicine, National Taiwan University, Taipei 100 Taiwan
    Gastroenterology 127:1733-8. 2004
    ..The aim of this study was to investigate the influence of hepatitis B virus (HBV) genotypes on the clinical outcome of chronic childhood HBV infection and hepatocellular carcinoma (HCC)...
  26. doi request reprint Secular trend of the viral genotype distribution in children with chronic hepatitis B virus infection after universal infant immunization
    Wan Hsin Wen
    Department of Pediatrics, College of Medicine and Hospital, National Taiwan University, Taipei, Taiwan
    Hepatology 53:429-36. 2011
    ..03, 95% CI = 1.62-5.65, P = 0.001). However, the increased genotype C to genotype B ratio was not seen in the HBsAg-carrier mother pool in the postimmunization era...
  27. ncbi request reprint Two decades of universal hepatitis B vaccination in taiwan: impact and implication for future strategies
    Yen Hsuan Ni
    Department of Pediatrics, Hospital and College of Medicine, National Taiwan University, Genomics Research Center, Taipei, Taiwan
    Gastroenterology 132:1287-93. 2007
    ....
  28. doi request reprint Effect of puberty onset on spontaneous hepatitis B virus e antigen seroconversion in men
    Jia Feng Wu
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Gastroenterology 138:942-8.e1. 2010
    ..Male predominance is a remarkable phenomenon in hepatitis B virus (HBV)-related liver disease. This study elucidated the effects of puberty on spontaneous hepatitis B virus e antigen (HBeAg) seroconversion in boys...
  29. ncbi request reprint Prevention of hepatocellular carcinoma by universal vaccination against hepatitis B virus: the effect and problems
    Mei Hwei Chang
    Department of Pediatrics, College of Medicine, National Taiwan University Hospital
    Clin Cancer Res 11:7953-7. 2005
    ..This study is aimed to investigate the problems in the HCC prevention in children...
  30. doi request reprint Tumour necrosis factor-α promoter region polymorphisms affect the course of spontaneous HBsAg clearance
    Pei Chi Kao
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Liver Int 30:1448-53. 2010
    ..This study aimed to investigate the roles of tumour necrosis factor-α (TNF-α) gene polymorphisms in the spontaneous clearance of HBsAg after a hepatitis B virus (HBV) infection...
  31. ncbi request reprint Waning immunity to plasma-derived hepatitis B vaccine and the need for boosters 15 years after neonatal vaccination
    Chun Yi Lu
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Hepatology 40:1415-20. 2004
    ..In conclusion, our findings suggest that one or more booster immunizations are needed in seronegative subjects by at least 15 years following neonatal immunization with plasma-derived HB vaccine...
  32. ncbi request reprint FIC1 and BSEP defects in Taiwanese patients with chronic intrahepatic cholestasis with low gamma-glutamyltranspeptidase levels
    Huey Ling Chen
    Department of Pediatrics, Pathology, and Clinical Medicine, National Taiwan University Hospital, Taipei
    J Pediatr 140:119-24. 2002
    ..BSEP mutations were found in 2 of the 3 patients in group 2, including 2 missense mutations and a 1-bp deletion. Phenotypic characterization is useful to differentiate FIC1- from BSEP-related disease...
  33. ncbi request reprint Development of autoantibodies after pediatric liver transplantation
    Ching Yi Chen
    Department of Pediatrics, College of Medicine and Children s Hospital, Taipei, Taiwan
    Pediatr Transplant 17:144-8. 2013
    ..The incidence of the development of autoantibodies was 75.0% in pediatric LT cases in this study. ASMA was the most commonly found autoantibody. Autoantibodies may not play a sentinel role for dn-AIH after LT...
  34. doi request reprint A common variant in the peroxisome proliferator-activated receptor-γ coactivator-1α gene is associated with nonalcoholic fatty liver disease in obese children
    Yu Cheng Lin
    Department of Pediatrics, Far Eastern Memorial Hospital and Oriental Institute of Technology, New Taipei City, Taiwan
    Am J Clin Nutr 97:326-31. 2013
    ..The PPARGC1A gene encodes PGC-1α, which regulates cellular energy metabolism...
  35. doi request reprint Pre-S2 deletions of hepatitis B virus and hepatocellular carcinoma in children
    Hsiang Po Huang
    Department of Medical Research, National Taiwan University Hospital, Taipei 100, Taiwan
    Pediatr Res 67:90-4. 2010
    ....
  36. doi request reprint No increase in prevalence of hepatitis B surface antigen mutant in a population of children and adolescents who were fully covered by universal infant immunization
    Hong Yuan Hsu
    Department of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
    J Infect Dis 201:1192-200. 2010
    ..Mutants of the a determinant of hepatitis B surface antigen (HBsAg) can escape neutralization by vaccine-induced antibodies and prevail in an immunized population...
  37. ncbi request reprint Long-term prognosis of patients with biliary atresia: a 25 year summary
    Pei Yin Hung
    Department of Pediatrics, National Taiwan University Hospital, No 7 Chung Shan South Road, Taipei, Taiwan
    J Pediatr Gastroenterol Nutr 42:190-5. 2006
    ..The purpose of this study was to delineate the long-term prognosis of biliary atresia (BA) in Taiwan...
  38. ncbi request reprint Portal hemodynamic changes after hepatocyte transplantation in acute hepatic failure
    Chun Hsien Yu
    Graduate Institute of Clinical Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    J Biomed Sci 11:756-63. 2004
    ..Our studies provide critical insights into the delayed resolution of portal hemodynamics after hepatocyte transplantation in subjects with acute hepatic failure...
  39. doi request reprint Hepatocyte transplantation in bile salt export pump-deficient mice: selective growth advantage of donor hepatocytes under bile acid stress
    Huey Ling Chen
    Department of Pediatrics, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan
    J Cell Mol Med 16:2679-89. 2012
    ..This strategy changed the balance of the donor-recipient growth capacities and was critical for successful donor repopulation...
  40. ncbi request reprint Inadequate humoral immunogenicity to recombinant hepatitis B virus vaccine in biliary atresia children
    Jia Feng Wu
    Department of Pediatrics, National Taiwan University, Taipei 100, Taiwan, China
    Pediatr Res 64:100-4. 2008
    ..538). In conclusion, adequate primary humoral immunity after the standard doses of recombinant HBV vaccine in BA infants is hard to establish. However, once immunity is acquired, BA children have adequate anti-HBs titer in the long run...
  41. ncbi request reprint Screening for biliary atresia by infant stool color card in Taiwan
    Shan Ming Chen
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Pediatrics 117:1147-54. 2006
    ..We aimed to detect biliary atresia (BA) in early infancy to prevent additional liver damage because of the delay of referral and surgical treatment and to investigate the incidence rate of BA in Taiwan...
  42. ncbi request reprint Role of hepatitis B immunoglobulin in infants born to hepatitis B e antigen-negative carrier mothers in Taiwan
    Yao Jong Yang
    Department of Pediatrics, Institute of Clinical Medicine, College of Medicine, National Cheng Kung University and Hospital, Tainan, Taiwan
    Pediatr Infect Dis J 22:584-8. 2003
    ..The efficacy of hepatitis B immunoglobulin (HBIG) in infants of hepatitis B e antigen (HBeAg)-negative hepatitis B surface antigen (HBsAg) carrier mothers in Taiwan is not clear...
  43. ncbi request reprint Viremia profiles in children with chronic hepatitis B virus infection and spontaneous e antigen seroconversion
    Yen Hsuan Ni
    Department of Pediatrics, Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
    Gastroenterology 132:2340-5. 2007
    ..This study investigated the viremia profiles in children with chronic hepatitis B virus (HBV) infection and spontaneous hepatitis B e antigen (HBeAg) seroconversion...
  44. ncbi request reprint Prophylactic oral antibiotics in prevention of recurrent cholangitis after the Kasai portoenterostomy
    Ling Nan Bu
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    J Pediatr Surg 38:590-3. 2003
    ....
  45. doi request reprint Oral absorbable fat-soluble vitamin formulation in pediatric patients with cholestasis
    Yu Mei Shen
    Department of Pediatrics, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan
    J Pediatr Gastroenterol Nutr 55:587-91. 2012
    ..The aim of the present study was to evaluate the status of FSV deficiencies in patients under present practice and to test the effect of an oral, absorbable, fat-soluble vitamin formulation (OAFSV) in these patients...
  46. doi request reprint Minimization of hepatitis B infection by a 25-year universal vaccination program
    Yen Hsuan Ni
    Department of Pediatrics, Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
    J Hepatol 57:730-5. 2012
    ..Five previous seroepidemiologic surveys were conducted at 0, 5, 10, 15, and 20 years after the launch of the vaccination program...
  47. doi request reprint Effects of maternal screening and universal immunization to prevent mother-to-infant transmission of HBV
    Huey Ling Chen
    Department of Pediatrics, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan
    Gastroenterology 142:773-781.e2. 2012
    ..We analyzed the rate of HBV infection among children born to hepatitis B surface antigen (HBsAg)-positive mothers and whether HBIG administration reduces transmission...
  48. ncbi request reprint Response to booster hepatitis B vaccines in liver-transplanted children primarily vaccinated in infancy
    Yen Hsuan Ni
    Department of Pediatrics, College of Medicine and Hospital, National Taiwan University, Taipei, Taiwan
    Transplantation 86:1531-5. 2008
    ..Most of the children who received organ transplantation were primarily vaccinated before transplantation. This study investigated the efficacy of HBV vaccination and booster responses in children after liver transplantation (LT)...
  49. doi request reprint A common variant in the PNPLA3 gene is a risk factor for non-alcoholic fatty liver disease in obese Taiwanese children
    Yu Cheng Lin
    Department of Pediatrics, Far Eastern Memorial Hospital, Banqiao City, Taipei County, Taiwan
    J Pediatr 158:740-4. 2011
    ..To test the hypothesis that the presence of the PNPLA3 rs738409 G allele would increase the susceptibility of non-alcoholic fatty liver disease (NAFLD) in obese Taiwanese children...
  50. ncbi request reprint The development of hepatocellular carcinoma among prospectively followed children with chronic hepatitis B virus infection
    Wan Hsin Wen
    Department of Pediatrics, National Taiwan University Hospital, and the Department of Pediatrics, Cardinal Tien Hospital, Taipei, Taiwan
    J Pediatr 144:397-9. 2004
    ..Both had e antigen seroconversion in early childhood and cirrhosis. Early e antigen seroconversion and/or cirrhosis may be risk factors for hepatocellular carcinoma...
  51. ncbi request reprint Neonatal Dubin-Johnson syndrome: long-term follow-up and MRP2 mutations study
    Jyh Hong Lee
    Department of Pediatrics, National Taiwan University College of Medicine, Taipei, Taiwan
    Pediatr Res 59:584-9. 2006
    ....
  52. ncbi request reprint TT virus infection in healthy children, children after blood transfusion, and children with non-A to E hepatitis or other liver diseases in Taiwan
    Hong Yuan Hsu
    Department of Pediatrics, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan
    J Med Virol 69:66-71. 2003
    ..These results indicate that TTV infection in children was significantly associated with transfusion. TTV infection is highly prevalent in early childhood in Taiwan but plays a minimal role in the induction of hepatitis in children...
  53. ncbi request reprint Fecal elastase 1, serum amylase and lipase levels in children with cholestasis
    Wan Hsin Wen
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Pancreatology 5:432-7. 2005
    ..The aim of the study was to evaluate the exocrine pancreatic function and common pancreatic function tests in children with cholestatic disorders...
  54. doi request reprint Effects of the infant stool color card screening program on 5-year outcome of biliary atresia in Taiwan
    Tien Hau Lien
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Hepatology 53:202-8. 2011
    ..2%, respectively (P < 0.001). The 5-year jaundice-free survival rate with native liver was 27.3% in cohort A and 64.3% in cohort B (P < 0.001), and the 5-year overall survival rates were 55.7% and 89.3%, respectively (P < 0.001)...
  55. ncbi request reprint Time course of acylcarnitine elevation in neonatal intrahepatic cholestasis caused by citrin deficiency
    Ni Chung Lee
    Department of Medical Genetics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    J Inherit Metab Dis 29:551-5. 2006
    ..Although the rise of free carnitine and acylcarnitines seems to be a benign condition, the sequential changes of these metabolic derangements may give clues to the pathogenesis of this interesting disorder...
  56. ncbi request reprint Long-term immunogenicity and efficacy of universal hepatitis B virus vaccination in Taiwan
    Yu Cheng Lin
    Department of Pediatrics, National Taiwan University Hospital and National Taiwan University, College of Medicine, Taipei, Taiwan
    J Infect Dis 187:134-8. 2003
    ..The results suggest that routine booster vaccination may not be required to provide protection against chronic HBV infection before age 15 years...
  57. ncbi request reprint Post-transplantation lymphoproliferative disorders localizing to the gastrointestinal tract after liver transplantation: report of five pediatric cases
    Yi Chun Lai
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Pediatr Transplant 10:390-4. 2006
    ..In our series, each PTLD involved the GI tract. The mechanism of this phenomenon is unclear, but these five cases indicate the high incidence of PTLD in pediatric solid organ transplantation...
  58. ncbi request reprint Multiple intrahepatic biliary cysts in children with biliary atresia
    Ling Nan Bu
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    J Pediatr Surg 37:1183-7. 2002
    ..The aim of this study was to investigate the incidence, clinical course, and outcome of multiple intrahepatic biliary cysts in patients with biliary atresia...
  59. ncbi request reprint Ursodeoxycholic acid (UDCA) therapy in very-low-birth-weight infants with parenteral nutrition-associated cholestasis
    Chien Yi Chen
    Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, No 7 Chung Shan South Road, Taipei 100, Taiwan
    J Pediatr 145:317-21. 2004
    ..To determine the effect of ursodeoxycholic acid (UDCA) in very-low-birth-weight (VLBW) infants with parenteral nutrition-associated cholestasis (PNAC)...
  60. pmc Predictive effect of serial serum alanine aminotransferase levels on spontaneous HBeAg seroconversion in chronic genotype B and C HBV-infected children
    Jia Feng Wu
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    J Pediatr Gastroenterol Nutr 54:97-100. 2012
    ..The present study aimed to investigate the association between serial serum alanine aminotransferase (ALT) and spontaneous hepatitis B e antigen (HBeAg) seroconversion age in chronic hepatitis B virus (HBV)-infected children...
  61. ncbi request reprint Characterization of integration patterns and flanking cellular sequences of hepatitis B virus in childhood hepatocellular carcinomas
    Daw Jen Tsuei
    Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Med Virol 68:513-21. 2002
    ..The results indicate that HBV integration and activation of RBMY gene expression in liver cells may be associated with the development of childhood HCC...
  62. doi request reprint Mother-to-infant transmission of hepatitis B virus infection: significance of maternal viral load and strategies for intervention
    Wan Hsin Wen
    Department of Pediatrics, Cardinal Tien Hospital, New Taipei City, Taiwan
    J Hepatol 59:24-30. 2013
    ..Immunoprophylaxis reduces but does not completely eradicate hepatitis B virus (HBV) transmission. This prospective study aims at assessing the rate and risk factors of maternally transmitted HBV infection...
  63. ncbi request reprint Viral infections and prolonged fever after liver transplantation in young children with inborn errors of metabolism
    Hsiang Po Huang
    Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    J Formos Med Assoc 104:623-9. 2005
    ..Liver transplantation could be a useful treatment for selected inborn errors of metabolism. This study evaluated the outcome and viral infections after liver transplantation in young children and infants with these diseases...
  64. pmc Long-term follow-up of Hepatitis B Surface antibody levels in subjects receiving universal Hepatitis B vaccination in infancy in an area of hyperendemicity: correlation between radioimmunoassay and enzyme immunoassay
    Ching Wen Wang
    Department of Pediatrics, Hepatitus Research Center, National Taiwan University Hospital, College of Medicine, Taipei 100, Taiwan
    Clin Diagn Lab Immunol 12:1442-7. 2005
    ..The anti-HBs titers measured by EIA correlate well with the S/N assayed by RIA. The annual decay rate of the log anti-HBs level may help in planning booster immunizations for hypo-responders or individuals at risk in adolescence...
  65. ncbi request reprint Longitudinal study on mutation profiles of core promoter and precore regions of the hepatitis B virus genome in children
    Yen Hsuan Ni
    Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taiwan
    Pediatr Res 56:396-9. 2004
    ....
  66. doi request reprint Contribution of mature hepatocytes to small hepatocyte-like progenitor cells in retrorsine-exposed rats with chimeric livers
    Ya Hui Chen
    Graduate Institute of Clinical Medicine, Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Hepatology 57:1215-24. 2013
    ..Extensive elimination of oval cell response by repeated administration of 4,4'-methylenedianiline (DAPM) to retrorsine-exposed rats impaired the emergence of SHPC clusters...
  67. doi request reprint A high serum interleukin-12p40 level prior to Kasai surgery predict a favourable outcome in children with biliary atresia
    Jia Feng Wu
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Liver Int 32:1557-63. 2012
    ..Biliary atresia (BA) is a paediatric cholestatic disease characterized by a progressive fibro-inflammation of the biliary tree. Current treatment of choice is to establish good bile flow via the Kasai operation...
  68. doi request reprint Suppression of furin by interferon-γ and the impact on hepatitis B virus antigen biosynthesis in human hepatocytes
    Jia Feng Wu
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Am J Pathol 181:19-25. 2012
    ....
  69. ncbi request reprint Stable seroepidemiology of hepatitis B after universal immunization in Taiwan: A 3-year study of national surveillance of primary school students
    Ching Yi Chen
    Department of Pediatrics, College of Medicine and Children s Hospital, National Taiwan University, Taipei 100, Taiwan
    Vaccine 28:5605-8. 2010
    ..This study is aimed to investigate if there was increased risk of HBV acquisition among first graders in Taiwan during a 3-year follow-up period...
  70. doi request reprint Hepatocyte transplantation and the differentiation fate of host oval cells in acute severe hepatic injury
    Chun Hsien Yu
    Graduate Institute of Clinical Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Cell Transplant 19:231-43. 2010
    ..We conclude that hepatocyte transplantation changes the mechanism of liver reconstitution and affects the differentiation fate of host oval cells in acute severe hepatic injury...
  71. doi request reprint Serum levels of interleukin-10 and interleukin-12 predict early, spontaneous hepatitis B virus e antigen seroconversion
    Jia Feng Wu
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Gastroenterology 138:165-72.e1-3. 2010
    ..This prospective cohort study aimed to determine the effect of cytokines on spontaneous hepatitis B e antigen (HBeAg) seroconversion in patients with chronic hepatitis B virus (HBV) infection...
  72. ncbi request reprint Pancreaticobiliary anomalies is the leading cause of childhood recurrent pancreatitis
    Wei Ju Su
    Department of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
    J Formos Med Assoc 106:119-25. 2007
    ..To explore the etiology, age and gender distribution, complications, and prognosis of recurrent pediatric pancreatitis...
  73. ncbi request reprint Attenuation of Kupffer cell function in acute on chronic liver injury enhanced engraftment of transplanted hepatocytes
    Ray Hwang Yuan
    Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    World J Surg 31:1270-7; discussion 1278-9. 2007
    ..The present study was designed to elucidate the relationship of engraftment efficiency of transplanted cells and Kupffer cell function in mice with acute on chronic liver injury and acute liver injury...
  74. doi request reprint Mutations of T-cell epitopes in the hepatitis B virus surface gene in children with chronic infection and hepatocellular carcinoma
    Yen Hsuan Ni
    Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Am J Gastroenterol 103:1004-9. 2008
    ..In this study, we aimed to investigate mutations of the human leukocyte antigen-A2-restricted T-cell epitope (TCE) in chronic HBV-infected children...
  75. ncbi request reprint Developmental expression of canalicular transporter genes in human liver
    Huey Ling Chen
    Department of Pediatrics, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei 100, Taiwan, ROC
    J Hepatol 43:472-7. 2005
    ..BSEP, MRP2, and MDR3 are major hepatic canalicular transporters mediating bile secretion. Their expression in human liver during development has not been reported...
  76. doi request reprint Prenatal diagnosis of progressive familial intrahepatic cholestasis type 2
    Szu Ta Chen
    Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    J Gastroenterol Hepatol 23:1390-3. 2008
    ..Mutations in ABCB11 are also associated with benign recurrent intrahepatic cholestasis type 2 and intrahepatic cholestasis of pregnancy in adult patients. We aimed to make the prenatal diagnosis of PFIC2...
  77. doi request reprint Diagnosis of neonatal intrahepatic cholestasis caused by citrin deficiency using high-resolution melting analysis and a clinical scoring system
    Szu Ta Chen
    Department of Pediatrics, National Taiwan University Hospital Yun Lin Branch, Yun Lin County, Taiwan
    J Pediatr 161:626-31.e2. 2012
    ..To assess the diagnosis of neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) by using high-resolution melting (HRM) analysis and a clinical scoring system...
  78. doi request reprint Decreasing rate of biliary atresia in Taiwan: a survey, 2004-2009
    Yi Chun Lin
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Pediatrics 128:e530-6. 2011
    ..The goals of this study were to identify BA incidence changes in Taiwan in 2004-2009 and to survey the factors that might influence incidence changes to elucidate the possible causes of BA...
  79. doi request reprint Persistent elevation of hepatocyte growth factor activator inhibitors in cholangiopathies affects liver fibrosis and differentiation
    Hsiang Po Huang
    Department of Medical Research, National Taiwan University Hospital, Taiwan
    Hepatology 55:161-72. 2012
    ..In addition, we showed that the hepatocyte growth factor activator, mitogen-activated protein kinase kinase 1, and phosphatidylinositol 3-kinase signaling pathways were involved in hepatic differentiation enhanced by HAI-2 knockdown...
  80. ncbi request reprint Mutation analysis of endothelin-B receptor gene in patients with Hirschsprung disease in Taiwan
    Yu Cheng Lin
    Department of Pediatrics, Far Eastern Memorial Hospital, Taiwan
    J Pediatr Gastroenterol Nutr 46:36-40. 2008
    ..Endothelin-B receptor (EDNRB) signaling pathway is associated for Hirschsprung disease (HSCR). The aim of this study was to investigate the EDNRB gene mutation in patients with HSCR in Taiwan and correlate the genotype and phenotype...
  81. doi request reprint Variants in the UGT1A1 gene and the risk of pediatric nonalcoholic fatty liver disease
    Yu Cheng Lin
    Department of Pediatrics, Far Eastern Memorial Hospital, Taipei, Taiwan
    Pediatrics 124:e1221-7. 2009
    ..Variants in the UGT1A1 gene contribute to increased bilirubin levels, and bilirubin can act as an antioxidant. We hypothesize that variant UGT1A1 genotypes reduce the risk for NAFLD development...
  82. doi request reprint Interferon-alpha treatment in children and young adults with chronic hepatitis B: a long-term follow-up study in Taiwan
    Hong Yuan Hsu
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Liver Int 28:1288-97. 2008
    ..The short- and long-term benefits of interferon (IFN)-alpha therapy in young patients with chronic hepatitis B (CHB) acquiring infection perinatally or during early childhood have been questioned...
  83. doi request reprint Characteristics and incidences of pediatric Crohn's disease in the decades before and after 2000
    Yu Mei Shen
    Department of Pediatrics, National Taiwan University Children s Hospital, National Taiwan University, Taipei, Taiwan
    Pediatr neonatol 52:317-20. 2011
    ..This study was conducted to delineate the trends of incidence during this period and clinical patterns of pediatric CD in Taiwan...
  84. doi request reprint Effect of age on the incidence of acute hepatitis B after 25 years of a universal newborn hepatitis B immunization program in Taiwan
    Wei Ju Su
    Centers for Disease Control, Department of Health, Taipei, Taiwan
    J Infect Dis 205:757-62. 2012
    ..Raising concerns about the waning immunity of cohorts receiving hepatitis B virus (HBV) vaccination in infancy persuaded us to identify the changing incidence of acute hepatitis B (AHB) in children and young adults...
  85. ncbi request reprint Screening for biliary atresia
    Mei Hwei Chang
    Department of Pediatrics, National Taiwan University Hospital, Taipei
    Chang Gung Med J 29:231-3. 2006
    ..The stool color card for infants has proved to be a sensitive and specific screening method for biliary atresia in infants younger than two months of age...
  86. ncbi request reprint Embryonic biliary atresia in a very-low-birth-weight premature infant
    Hung Wen Chen
    Department of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
    J Formos Med Assoc 106:78-81. 2007
    ..This case illustrates the poor outcome of embryonic biliary atresia and that early liver transplantation may be necessary to improve the prognosis...
  87. ncbi request reprint Decreasing incidence of hepatocellular carcinoma among children following universal hepatitis B immunization
    Mei Hwei Chang
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Liver Int 23:309-14. 2003
    ..This concept of cancer vaccine can be applied to other infectious agents and their related cancers...
  88. ncbi request reprint Characterization of cytokeratin 19-positive hepatocyte foci in the regenerating rat liver after 2-AAF/CCl4 injury
    Chien Chang Chiu
    The Graduate Institute of Applied Science and Engineering, Fu Jen Catholic University, No 510 Chung Cheng Rd, Hsinchuang, Taipei County, 24205, and Department of Internal Medicine, National Taiwan University Hospital, Taiwan
    Histochem Cell Biol 128:217-26. 2007
    ..In conclusions, oval cells appear to differentiate to CK-19+ foci and then to CK-19- foci in the high dose 2-AAF/CCl4 model...
  89. ncbi request reprint Impact of hepatitis B vaccination on hepatitis B disease and nucleic acid testing in high-prevalence populations
    Mei Hwei Chang
    Department of Pediatrics, National Taiwan University Hospital, Taipei
    J Clin Virol 36:S45-50. 2006
    ..Systematic HBV DNA screening of a large population such as blood donors may be instrumental in following the long-term effect of the universal vaccination program on the incidence of silent HBV infection and vaccine escape mutants...
  90. ncbi request reprint RBMY, a male germ cell-specific RNA-binding protein, activated in human liver cancers and transforms rodent fibroblasts
    Daw Jen Tsuei
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taiwan
    Oncogene 23:5815-22. 2004
    ..The RBMY variant protein with deletion of C-terminal exons 9-12 was trapped in the cytoplasm and showed decreased tumorigenicity. Our results suggest that RBMY is a new candidate oncogene specific for male liver cancer...
  91. doi request reprint Timing of Epstein-Barr virus acquisition and the course of posttransplantation lymphoproliferative disorder in children
    Jia Feng Wu
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Transplantation 87:758-62. 2009
    ....
  92. ncbi request reprint Lactobacillus casei rhamnosus Lcr35 in children with chronic constipation
    Ling Nan Bu
    Department of Pediatrics, Keelung Hospital, Department of Health, The Executive Yuan, Keelung, Taiwan
    Pediatr Int 49:485-90. 2007
    ..The purpose of the present paper was to evaluate the efficacy of probiotics (Lactobacillus casei rhamnosus, Lcr35) for treating children with chronic constipation and to compare its effect with magnesium oxide (MgO) and placebo...
  93. ncbi request reprint Hepatitis B virus infection
    Mei Hwei Chang
    Department of Pediatrics, National Taiwan University Hospital, 7F, No 7 Chung Shan South Road, Taipei 100, Taiwan
    Semin Fetal Neonatal Med 12:160-7. 2007
    ..The first universal HBV immunisation programme in the world was launched in Taiwan 22 years ago. HBV infection rates, chronicity rates, incidence of HCC and incidence of fulminant hepatitis in children have been effectively reduced...
  94. doi request reprint Implication of early-onset biliary atresia and extrahepatic congenital anomalies
    Ming Chun Yang
    Children s Hospital, National Taiwan University, Taipei, Taiwan
    Pediatr Int 52:569-72. 2010
    ..The relationship between the timing of disease onset and congenital extrahepatic anomalies was also identified...
  95. ncbi request reprint Pediatric Crohn disease: clinical and genetic characteristics in Taiwan
    Cheng Hui Hsiao
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    J Pediatr Gastroenterol Nutr 44:342-6. 2007
    ..Because clinical and genetic data in Asian children with CD are lacking, the aim of this study was to elucidate the clinical and genetic characteristics of Taiwanese children with CD...
  96. doi request reprint Impaired hepatocyte regeneration in acute severe hepatic injury enhances effective repopulation by transplanted hepatocytes
    Chun Hsien Yu
    Graduate Institute of Clinical Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Cell Transplant 18:1081-92. 2009
    ..Impaired hepatocyte regeneration after acute severe hepatic injury may initiate serial compensatory repair mechanisms that facilitate the extensive repopulation by transplanted hepatocytes that enter early the hepatic plates...
  97. doi request reprint Clinical features and treatment responses of children with eosinophilic gastroenteritis
    Fu Mien Tien
    Department of Pediatrics, National Taiwan University Children s Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Pediatr neonatol 52:272-8. 2011
    ..This study aimed to evaluate the clinical manifestations and outcome of eosinophilic gastroenteritis in children of Asian background...
  98. pmc Distinct hepatitis B virus dynamics in the immunotolerant and early immunoclearance phases
    Hurng Yi Wang
    Department of Pediatrics, National Taiwan University Hospital, National Taiwan University, 7 Chung Shan South Road, Taipei 100, Taiwan
    J Virol 84:3454-63. 2010
    ..Different selective forces, including immune-mediated positive selection and virus-mediated negative selection, operate in tandem in shaping viral population dynamics within a host...
  99. doi request reprint Diagnosis of BSEP/ABCB11 mutations in Asian patients with cholestasis using denaturing high performance liquid chromatography
    Huey Ling Chen
    Department of Pediatrics, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan
    J Pediatr 153:825-32. 2008
    ..To determine if specific mutations were present in Asian patients with progressive familial intrahepatic cholestasis (PFIC) type 2 caused by defects in bile salt export pump (BSEP), encoded by ABCB11...
  100. doi request reprint Bone marrow transplantation results in donor-derived hepatocytes in an animal model of inherited cholestatic liver disease
    Huey Ling Chen
    Department of Pediatrics, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan, ROC
    J Biomed Sci 15:615-22. 2008
    ..Our results indicate that bone marrow cells could serve as a potential source for restoration of hepatic functions in chronic metabolic liver disease...
  101. doi request reprint Universal screening for biliary atresia using an infant stool color card in Taiwan
    Cheng Hui Hsiao
    Department of Pediatrics, Cardinal Tien Hospital Yung Ho Branch, Taipei, Taiwan
    Hepatology 47:1233-40. 2008
    ..002). Conclusion: Universal screening using the stool color cards can enhance earlier referral, which may ultimately lead to timely performance of the Kasai operation and better postoperative outcome in infants with biliary atresia...