Luan Yin Chang

Summary

Affiliation: National Taiwan University
Country: Taiwan

Publications

  1. ncbi request reprint Enterovirus 71 in Taiwan
    Luan Yin Chang
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    Pediatr neonatol 49:103-12. 2008
  2. ncbi request reprint The correlation between the presence of viremia and clinical severity in patients with enterovirus 71 infection: a multi-center cohort study
    Hao Yuan Cheng
    Department of Pediatrics, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
    BMC Infect Dis 14:417. 2014
  3. pmc Adenovirus serotype 3 and 7 infection with acute respiratory failure in children in Taiwan, 2010-2011
    Chen Yin Lai
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    PLoS ONE 8:e53614. 2013
  4. pmc Atypical hand-foot-mouth disease in children: a hospital-based prospective cohort study
    Wen Chan Huang
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    Virol J 10:209. 2013
  5. pmc Epidemiological characteristics of varicella from 2000 to 2008 and the impact of nationwide immunization in Taiwan
    Luan Yin Chang
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    BMC Infect Dis 11:352. 2011
  6. ncbi request reprint Epidemiologic features of Kawasaki disease in Taiwan, 1996-2002
    Luan Yin Chang
    Division of Pediatric Infectious Diseases, Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    Pediatrics 114:e678-82. 2004
  7. ncbi request reprint Outcome of enterovirus 71 infections with or without stage-based management: 1998 to 2002
    Luan Yin Chang
    Divisions of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children s Hospital, Chang Gung University, 5 Fu Hsing Street, Kweishan, Taoyuan, Taiwan
    Pediatr Infect Dis J 23:327-32. 2004
  8. ncbi request reprint Neonatal enterovirus infections: emphasis on risk factors of severe and fatal infections
    Tzou Yien Lin
    Division of Pediatric Infecti ious Diseases, Department of Pediatrics, Chang Gung Children s Hospital, Taoyuan, Taiwan
    Pediatr Infect Dis J 22:889-94. 2003
  9. ncbi request reprint A community-derived outbreak of adenovirus type 3 in children in Taiwan between 2004 and 2005
    Sui Yuan Chang
    Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan
    J Med Virol 80:102-12. 2008
  10. ncbi request reprint Stenotrophomonas maltophilia bacteremia in pediatric patients-- a 10-year analysis
    Ping Sheng Wu
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    J Microbiol Immunol Infect 39:144-9. 2006

Detail Information

Publications102 found, 100 shown here

  1. ncbi request reprint Enterovirus 71 in Taiwan
    Luan Yin Chang
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    Pediatr neonatol 49:103-12. 2008
    ..Development of EV71-specific antiviral therapy, a novel class of imidazolidinones, and development of a vaccine are ongoing...
  2. ncbi request reprint The correlation between the presence of viremia and clinical severity in patients with enterovirus 71 infection: a multi-center cohort study
    Hao Yuan Cheng
    Department of Pediatrics, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
    BMC Infect Dis 14:417. 2014
    ..However, in recent decades, the pathogenesis of severe EV71 infection was not well understood. This study was aimed to investigate the correlation between the presence of viremia and the clinical severity of EV71 infection...
  3. pmc Adenovirus serotype 3 and 7 infection with acute respiratory failure in children in Taiwan, 2010-2011
    Chen Yin Lai
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    PLoS ONE 8:e53614. 2013
    ..We did this study to find the clinical characteristics and risk factors associated with severe adenovirus infection...
  4. pmc Atypical hand-foot-mouth disease in children: a hospital-based prospective cohort study
    Wen Chan Huang
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    Virol J 10:209. 2013
    ..Hyperpigmentation later developed as the bullous lesions crusted. Thus, we intended to study the etiology of the illness and the phylogeny of the pathogens...
  5. pmc Epidemiological characteristics of varicella from 2000 to 2008 and the impact of nationwide immunization in Taiwan
    Luan Yin Chang
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    BMC Infect Dis 11:352. 2011
    ..Varicella has an important impact on public health. Starting in 2004 in Taiwan, nationwide free varicella vaccinations were given to 1-year-old children...
  6. ncbi request reprint Epidemiologic features of Kawasaki disease in Taiwan, 1996-2002
    Luan Yin Chang
    Division of Pediatric Infectious Diseases, Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    Pediatrics 114:e678-82. 2004
    ..The incidence of KD varies among different countries, with Asian countries supposedly having higher incidences than Western countries. However, the incidence of KD in Taiwan has not been well investigated...
  7. ncbi request reprint Outcome of enterovirus 71 infections with or without stage-based management: 1998 to 2002
    Luan Yin Chang
    Divisions of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children s Hospital, Chang Gung University, 5 Fu Hsing Street, Kweishan, Taoyuan, Taiwan
    Pediatr Infect Dis J 23:327-32. 2004
    ..In Taiwan in 1998 almost all the EV71 patients with cardiopulmonary failure died. To improve clinical outcome of EV71 patients, we developed a stage-based management program in 2000...
  8. ncbi request reprint Neonatal enterovirus infections: emphasis on risk factors of severe and fatal infections
    Tzou Yien Lin
    Division of Pediatric Infecti ious Diseases, Department of Pediatrics, Chang Gung Children s Hospital, Taoyuan, Taiwan
    Pediatr Infect Dis J 22:889-94. 2003
    ..Neonatal enterovirus infections have diverse manifestations, from asymptomatic to fatal. An understanding of the risk factors associated with severe cases might help to reduce enterovirus-related morbidity and mortality...
  9. ncbi request reprint A community-derived outbreak of adenovirus type 3 in children in Taiwan between 2004 and 2005
    Sui Yuan Chang
    Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan
    J Med Virol 80:102-12. 2008
    ..001). In summary, our study demonstrated that Ad3 was the predominant serotype responsible for the respiratory adenovirus outbreak in northern Taiwan during 2004-2005 and was associated with severe infections in the outbreak period...
  10. ncbi request reprint Stenotrophomonas maltophilia bacteremia in pediatric patients-- a 10-year analysis
    Ping Sheng Wu
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    J Microbiol Immunol Infect 39:144-9. 2006
    ..Stenotrophomonas maltophilia bacteremia is an important cause of mortality among immunocompromised children. However, there has been little information concerning S. maltophilia bacteremia in the pediatric population...
  11. ncbi request reprint Lack of association between infection with a novel human coronavirus (HCoV), HCoV-NH, and Kawasaki disease in Taiwan
    Luan Yin Chang
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Infect Dis 193:283-6. 2006
    ..All PCR results were negative for both HCoV-NL63 and HCoV-NH; therefore, we did not find any association between HCoV-NH infection and KD in Taiwan...
  12. ncbi request reprint Epidemiology of respiratory syncytial virus infection in northern Taiwan, 2001-2005 -- seasonality, clinical characteristics, and disease burden
    Jian Te Lee
    Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Microbiol Immunol Infect 40:293-301. 2007
    ..However, there is limited epidemiological data about RSV infection in Taiwan. This study aimed to investigate the clinical, epidemiological, virological, and economical aspects of RSV infections in Taiwan...
  13. ncbi request reprint Transmission and clinical features of enterovirus 71 infections in household contacts in Taiwan
    Luan Yin Chang
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children s Hospital, Kweishan, Taiwan
    JAMA 291:222-7. 2004
    ..Although enterovirus 71 has caused epidemics associated with significant morbidity and mortality, its transmission has not been thoroughly investigated...
  14. ncbi request reprint Safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in Taiwanese infants
    Pei Lan Shao
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    J Formos Med Assoc 103:613-7. 2004
    ..The purpose of this study was to assess the safety and immunogenicity of heptavalent pneumococcal conjugate vaccine (serotypes 4, 6B, 9V, 14, 18C, 19F, 23F) in Taiwanese infants...
  15. doi request reprint An outbreak of coxsackievirus A16 infection: comparison with other enteroviruses in a preschool in Taipei
    Pei Chieh Wu
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, 7 Chung Shan South Road, Taipei, Taiwan
    J Microbiol Immunol Infect 43:271-7. 2010
    ..The transmission rate of enteroviruses in young children remains unclear. Therefore, we carried out active surveillance in preschool children to investigate the transmission rate and clinical manifestation of enteroviruses...
  16. ncbi request reprint Molecular and clinical characteristics of adenoviral infections in Taiwanese children in 2004-2005
    Chia Chi Cheng
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, No 7 Chung Shan South Road, Taipei, Taiwan, Republic of China
    Eur J Pediatr 167:633-40. 2008
    ..Patients with this genotype were significantly older, had a higher incidence of cough and family transmission, and had higher CRP levels than those with other genotypes...
  17. doi request reprint Epidemiological study of hospitalization associated with respiratory syncytial virus infection in Taiwanese children between 2004 and 2007
    Hsin Chi
    Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan
    J Formos Med Assoc 110:388-96. 2011
    ..The population-based burden of RSV hospitalization and the effect of potential risk factors on the severity of illness were evaluated in Taiwanese children...
  18. ncbi request reprint The epidemiology of hospitalized children with pneumococcal/lobar pneumonia and empyema from 1997 to 2004 in Taiwan
    Ping Sheng Wu
    Department of Pediatrics, Buddhist Tzu Chi General Hospital, Taipei Branch, Taipei, Taiwan
    Eur J Pediatr 169:861-6. 2010
    ..This population might benefit from a universal pneumococcal vaccination program which might cover about 70% of invasive pneumococcal diseases in Taiwanese children under 5 years old...
  19. ncbi request reprint Detection of human metapneumovirus in hospitalized children with acute respiratory tract infection using real-time RT-PCR in a hospital in northern Taiwan
    Pei Chun Chan
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Formos Med Assoc 106:16-24. 2007
    ..Human metapneumovirus (hMPV) is a newly discovered respiratory pathogen. This prospective hospital-based study investigated the clinical role and features of hMPV in Taiwan...
  20. ncbi request reprint Astrovirus gastroenteritis in children in Taipei
    Hsiao Chuan Lin
    Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan
    J Formos Med Assoc 107:295-303. 2008
    ..A prospective study was initiated to study astroviral infections in Taiwan...
  21. ncbi request reprint Neurodevelopment and cognition in children after enterovirus 71 infection
    Luan Yin Chang
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    N Engl J Med 356:1226-34. 2007
    ..Enterovirus 71 is a common cause of hand, foot, and mouth disease and encephalitis in Asia and elsewhere. The long-term neurologic and psychiatric effects of this viral infection on the central nervous system (CNS) are not well understood...
  22. ncbi request reprint Control of an outbreak of pandrug-resistant Acinetobacter baumannii colonization and infection in a neonatal intensive care unit
    Pei Chun Chan
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Infect Control Hosp Epidemiol 28:423-9. 2007
    ..To investigate the potential reservoir and mode of transmission of pandrug-resistant (PDR) Acinetobacter baumannii in a 7-day-old neonate who developed PDR A. baumannii bacteremia that was presumed to be the iceberg of a potential outbreak...
  23. ncbi request reprint Clinical responses of patients with Kawasaki disease to different brands of intravenous immunoglobulin
    Ming Han Tsai
    Division of Pediatric Infectious Diseases, Division of Taipei Pediatrics, Department of Pediatrics, Chang Gung Children s Hospital, Taoyuan, Taiwan
    J Pediatr 148:38-43. 2006
    ..To determine whether different brands of intravenous immunoglobulin (IVIG) administered to children with Kawasaki disease (KD) result in different outcomes...
  24. pmc Serotype competence and penicillin resistance in Streptococcus pneumoniae
    Yu Chia Hsieh
    Taipei Municipal WanFang Hospital, Taipei, Taiwan
    Emerg Infect Dis 12:1709-14. 2006
    ..Under the 7-valent pneumococcal conjugate vaccine program, enhanced molecular surveillance of virulent clones with higher competence to detect serotype switching will become more important...
  25. ncbi request reprint Safety and immunogenicity of heptavalent pneumococcal conjugate vaccine booster in taiwanese toddlers
    Pei Lan Shao
    Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan
    J Formos Med Assoc 105:542-9. 2006
    ..This study evaluated the safety and immunogenicity of heptavalent pneumococcal conjugate (7VPnC) vaccine (serotypes 4, 6B, 9V, 14, 18C, 19F, 23F) booster dose administered at 15-20 months of age in Taiwanese toddlers...
  26. ncbi request reprint Status of cellular rather than humoral immunity is correlated with clinical outcome of enterovirus 71
    Luan Yin Chang
    Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100, Taiwan
    Pediatr Res 60:466-71. 2006
    ..Their titers of EV71 neutralizing antibodies demonstrated no difference among cases. These results suggest lower EV71-specific cellular response may be associated with immunopathogenesis of EV71-related pulmonary edema...
  27. ncbi request reprint Clinical management and outcome of childhood lung abscess: a 16-year experience
    Pei Chun Chan
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Microbiol Immunol Infect 38:183-8. 2005
    ..Oral anaerobes and S. aureus are the core pathogens in primary lung abscess and gram-negative pathogens should also be considered in secondary lung abscess...
  28. ncbi request reprint Clinical manifestations of human coronavirus NL63 infection in children in Taiwan
    Ping Sheng Wu
    Department of Pediatrics, Buddhist Tzu Chi General Hospital, Taipei Branch, Taipei, Taiwan
    Eur J Pediatr 167:75-80. 2008
    ..The odds ratio of croup in children infected with HCoV-NL63 was 43.4 (95% CI 8.1 approximately 233.1). In conclusion, HCoV-NL63 is an important respiratory tract pathogen as the main cause in children admitted to the hospital in Taiwan...
  29. doi request reprint Epidemiologic and clinical features of non-polio enteroviral infections in northern Taiwan in 2008
    Chien Hui Hsu
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Microbiol Immunol Infect 44:265-73. 2011
    ....
  30. ncbi request reprint The 1998 enterovirus 71 outbreak in Taiwan: pathogenesis and management
    Tzou Yien Lin
    Department of Pediatrics, Chang Gung Children s Hospital, Taoyuan, Taiwan
    Clin Infect Dis 34:S52-7. 2002
    ..After poliovirus is eradicated, EV71 will become the most important enterovirus that affects children, and development of a vaccine may be the only effective measure against it...
  31. ncbi request reprint Epidemiology of Haemophilus influenzae type b meningitis in Taiwan, 1997 and 2000
    Pei Lan Shao
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan, ROC
    J Microbiol Immunol Infect 37:164-8. 2004
    ..The availability of the NHIRD provides an extra tool for the epidemiological study of infectious diseases in Taiwan and can be valuable for similar studies...
  32. ncbi request reprint Clinical features and factors of unfavorable outcomes for non-polio enterovirus infection of the central nervous system in northern Taiwan, 1994-2003
    Tsou Tong Yang
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Microbiol Immunol Infect 38:417-24. 2005
    ..0009] and skin rash (p=0.005). Younger age and higher peak WBC were poor prognostic factors of severe enterovirus CNS infection. Death was related to neonatal enterovirus infection and enterovirus 71 infection in young children...
  33. ncbi request reprint Development of immunoglobulin G enzyme-linked immunosorbent assay for the serodiagnosis of severe acute respiratory syndrome
    Pei Lan Shao
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    J Biomed Sci 12:59-64. 2005
    ..The results suggest that the IgG ELISA using whole virus antigen of SARS-CoV has a high sensitivity and specificity in detecting SARS IgG antibodies. This IgG ELISA is a powerful tool for serodiagnosis of SARS...
  34. doi request reprint Viral load and clinical features in children infected with seasonal influenza B in 2006/2007
    Tsung Pei Tsou
    Research and Diagnostic Center, Centers for Disease Control, Taipei, Taiwan
    J Formos Med Assoc 111:83-7. 2012
    ..We conducted a study to assess the relationship between virus load and clinical features in children infected with influenza B, in the hope that clinical features could be used as surrogate markers of viral load to guide treatment...
  35. ncbi request reprint Seroprevalence of enterovirus 71 and no evidence of crossprotection of enterovirus 71 antibody against the other enteroviruses in kindergarten children in Taipei city
    Wen Chan Huang
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Microbiol Immunol Infect 45:96-101. 2012
    ..This study is to investigate the seroprevalence and seroconversion of EV71, and the crossprotection of EV71 antibody against other enteroviruses among kindergarteners...
  36. doi request reprint Molecular detection and incidence of human papillomavirus in neonates: methodology and a pilot study in a medical center
    Chun Fu Tai
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan
    J Microbiol Immunol Infect 45:185-92. 2012
    ..Vertical transmission has been confirmed. This study aimed to establish a sensitive molecular diagnostic method and understand the incidence of the HPV-6 and HPV-11 in neonates with intubation...
  37. ncbi request reprint Attention-deficit/hyperactivity-related symptoms among children with enterovirus 71 infection of the central nervous system
    Susan Shur Fen Gau
    Department of Psychiatry, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
    Pediatrics 122:e452-8. 2008
    ..In this study we evaluated attention-deficit/hyperactivity disorder-related symptoms and internalizing problems as long-term sequelae resulting from enterovirus 71 central nervous system infection in children...
  38. pmc Disease burden and related medical costs of rotavirus infections in Taiwan
    Chun Yi Lu
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    BMC Infect Dis 6:176. 2006
    ..The disease burden and associated medical costs of rotavirus infections in inpatient and outpatient sectors in Taiwan were examined in anticipation of the availability of new rotavirus vaccines...
  39. ncbi request reprint Campylobacter enteritis in children in northern Taiwan--a 7-year experience
    Shu Chien Wang
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    J Microbiol Immunol Infect 41:408-13. 2008
    ..The clinical characteristics may vary in different countries. This study investigated the clinical manifestations of pediatric Campylobacter enteritis in a medical center in northern Taiwan...
  40. ncbi request reprint Risk factors of enterovirus 71 infection and associated hand, foot, and mouth disease/herpangina in children during an epidemic in Taiwan
    Luan Yin Chang
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children s Hospital, Chang Gung University, Taoyuan, Taiwan
    Pediatrics 109:e88. 2002
    ..We measured EV71 seroprevalence rates before and after the epidemic and investigated risk factors associated with EV71 infection and illness...
  41. pmc Clinical features and phylogenetic analysis of Coxsackievirus A9 in Northern Taiwan in 2011
    Yi Chuan Huang
    Division of Pediatric Infectious Disease, Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
    BMC Infect Dis 13:33. 2013
    ..After several patient series were reported in the 1960s and 1970s, few studies have focused on the clinical manifestations of CA9 infections. Our study explores and deepens the current understanding of CA9...
  42. ncbi request reprint Influenza in Taiwan: seasonality and vaccine strain match
    Yu Chia Hsieh
    Section of Infection, Department of Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
    J Microbiol Immunol Infect 38:238-43. 2005
    ....
  43. ncbi request reprint Clinical features and complications of viridans streptococci bloodstream infection in pediatric hemato-oncology patients
    Wan Ting Huang
    Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    J Microbiol Immunol Infect 40:349-54. 2007
    ..The clinical features, outcomes, and antibiotic susceptibilities of VS bloodstream infections in children with hemato-oncological diseases are reported in this study...
  44. ncbi request reprint Immunogenicity and reactogenicity of a reduced-antigen-content diphtheria-tetanus-acellular pertussis vaccine in healthy Taiwanese children and adolescents
    Li Min Huang
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    J Adolesc Health 37:517. 2005
    ....
  45. ncbi request reprint Invasive fungal infection in children with persistent febrile neutropenia
    Hsin Pao Lai
    Department of Pediatrics, God s Help Hospital, Taipei, Taiwan
    J Formos Med Assoc 104:174-9. 2005
    ..Children with persistent febrile neutropenia (fever > 96 hours) refractory to antibacterial therapy carry a high risk of invasive fungal infection (IFI). However, epidemiologic data in such patient populations is lacking in Taiwan...
  46. ncbi request reprint Risk factors of severe novel influenza A (H1N1) infections in hospitalized children
    Wei Hua Chen
    Division of Pediatric Infectious Diseases, Department of Pediatrics, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan
    J Formos Med Assoc 111:421-6. 2012
    ..We conducted a clinical study to identify clinical features and risk factors associated with severe novel H1N1 infections of children in Taiwan...
  47. doi request reprint Disease burden and epidemiology of herpes zoster in pre-vaccine Taiwan
    Yung Hsiu Lin
    Department of Pediatrics, Cardinal Tien Hospital, Yong Ho Branch, Taiwan
    Vaccine 28:1217-20. 2010
    ..In conclusion, about two-thirds of Taiwan's zoster cases occur in adults older than 40 years old and about one-third of the population would develop zoster within their lifetime...
  48. doi request reprint Severe bacterial infection in patients with heterotaxy syndrome
    Shuenn Nan Chiu
    Department of Pediatrics, National Taiwan University Hospital Medical College, National Taiwan University, Taipei, Taiwan
    J Pediatr 164:99-104.e1. 2014
    ..To determine the incidence of sepsis in patients with heterotaxy syndrome...
  49. ncbi request reprint Influenza pandemics: past, present and future
    Yu Chia Hsieh
    Section of Infection, Department of Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan, R O C
    J Formos Med Assoc 105:1-6. 2006
    ..Further investigations into how the virus interacts with the host's immune system will be helpful in guiding future therapeutic strategies in facing influenza pandemics...
  50. ncbi request reprint Childhood severe acute respiratory syndrome in Taiwan and how to differentiate it from childhood influenza infection
    Luan Yin Chang
    Departments of Pediatric, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei
    Arch Pediatr Adolesc Med 158:1037-42. 2004
    ..To investigate clinical features and outcomes of children in Taiwan with laboratory-confirmed severe acute respiratory syndrome (SARS) vs those of children with influenza to differentiate the 2 diseases...
  51. ncbi request reprint Hand, foot and mouth disease complicated with central nervous system involvement in Taiwan in 1980-1981
    Luan Yin Chang
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    J Formos Med Assoc 106:173-6. 2007
    ..Twenty years later, at least one male patient had sequelae of polio-like syndrome and was therefore exempted from military service. Clinical severity was comparable to the 1998 EV71 epidemic...
  52. pmc Inferring nonneutral evolution from contrasting patterns of polymorphisms and divergences in different protein coding regions of enterovirus 71 circulating in Taiwan during 1998-2003
    Hurng Yi Wang
    Institute of Clinical Medicine, National Taiwan University, Taipei, Taiwan
    BMC Evol Biol 10:294. 2010
    ..non-structural regions, and forces driving the evolution of EV71, are still not clear...
  53. doi request reprint Molecular diagnosis and clinical presentations of enteroviral infections in Taipei during the 2008 epidemic
    Min Hsiung Lee
    Department of Pediatrics, Cathay General Hospital, Taipei, Taiwan
    J Microbiol Immunol Infect 44:178-83. 2011
    ..To establish an early detection and effective management for children with EV71 infection, sensitive molecular diagnostic methods were applied from May to July 2008...
  54. doi request reprint Human bocavirus as an important cause of respiratory tract infection in Taiwanese children
    Chia Yunn Chuang
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Microbiol Immunol Infect 44:323-7. 2011
    ..However, only few reports provide the evidence for an association between HBoV and respiratory tract diseases. We conducted a prospective clinical and molecular study of HBoV in Taiwan...
  55. pmc Serologic status for pandemic (H1N1) 2009 virus, Taiwan
    Daniel Tsung Ning Huang
    Mackay Memorial Hospital, Taipei, Taiwan
    Emerg Infect Dis 17:76-8. 2011
    ..Seasonal influenza vaccines induced antibodies that did not protect against pandemic (H1N1) 2009 virus...
  56. doi request reprint Immune response to 2009 pandemic H1N1 influenza virus A monovalent vaccine in children with cancer
    Ting Yu Yen
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    Pediatr Blood Cancer 57:1154-8. 2011
    ..This study investigated the immune response to 2009 pandemic H1N1 influenza monovalent vaccine in children with cancer receiving chemotherapy...
  57. ncbi request reprint Epidemiology and treatment of Bell's palsy in children in northern Taiwan
    Han Sheng Tsai
    Department of Pediatrics, Department of Infectious Diseases, National Taiwan University Hospital, Taipei 100, Taiwan
    J Microbiol Immunol Infect 42:351-6. 2009
    ..Bell's palsy is not uncommon in children. This study was performed to evaluate the epidemiology of Bell's palsy in the northern Taiwanese pediatric population, and the effectiveness of corticosteroid treatment...
  58. ncbi request reprint Clinical characteristics of nosocomial rotavirus infection in children in Taiwan
    Jian Te Lee
    Department of Pediatrics, Yunlin Branch, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan
    J Formos Med Assoc 107:791-7. 2008
    ..The aim of this study was to determine the incidence and clinical characteristics of nosocomial rotavirus infection (NRI) among hospitalized children...
  59. doi request reprint Epidemiology and impacts of children hospitalized with pneumonia from 1997 to 2004 in Taiwan
    Ping Sheng Wu
    Department of Pediatrics, Buddhist Tzu Chi General Hospital, Taipei Branch, Taipei, Taiwan
    Pediatr Pulmonol 44:162-6. 2009
    ..Few studies have investigated the epidemiology and disease burden of childhood pneumonia in Taiwan, a middle-income country...
  60. doi request reprint Recommendations for rotavirus vaccine
    Ping Ing Lee
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Pediatr neonatol 54:355-9. 2013
    ....
  61. doi request reprint Epidemiology and clinical manifestations of children with macrolide-resistant Mycoplasma pneumoniae pneumonia in Taiwan
    Ping Sheng Wu
    Department of Pediatrics, Buddhist Tzu Chi General Hospital, Taipei Branch, Taiwan
    Pediatr Pulmonol 48:904-11. 2013
    ..In conclusion, 15% of CAP in children is caused by M. pneumoniae and the macrolide-resistance rate is 23% in Taiwan. Despite ineffective antibiotics, children with ML(r) M. pneumoniae pneumonia recover completely...
  62. ncbi request reprint Acute hematogenous osteomyelitis and septic arthritis in children
    Hui Chin Kao
    Department of Pediatrics, Li Shin Hospital, Taiwan, ROC
    J Microbiol Immunol Infect 36:260-5. 2003
    ..aureus as a cause of bone and joint infections has been increasing. Serum bactericidal titer is valuable for the management of patients receiving sequential therapy for acute hematogenous osteomyelitis and septic arthritis...
  63. ncbi request reprint Prognostic implications of myoclonic jerk in children with enterovirus infection
    Hsiao Kuo Lu
    Division of Infectious Diseases, Department of Pediatrics, Chang Gung Children s Hospital, Taoyuan, Taiwan, ROC
    J Microbiol Immunol Infect 37:82-7. 2004
    ..95 and 0.99, respectively. This study demonstrated that myoclonic jerk and EV71 infection are both independently associated with more severe disease and higher incidence of neurologic sequelae...
  64. ncbi request reprint Multidrug-resistant non-typhoid Salmonella infections in a medical center
    Chien Yu Lee
    Department of Pediatrics, Provincial Tao Yuan Hospital, Taiwan, ROC
    J Microbiol Immunol Infect 35:78-84. 2002
    ..choleraesuis found in this study indicate the importance of judicious use of antimicrobial agents in both humans and animals to reduce the selection and spread of resistant strains...
  65. ncbi request reprint Coxsackieviruses infection in northern Taiwan--epidemiology and clinical characteristics
    Feng Bin Yen
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    J Microbiol Immunol Infect 42:38-46. 2009
    ..The epidemiology of coxsackievirus has rarely been investigated in Taiwan. This study was performed to ascertain the epidemiological and clinical characteristics of coxsackievirus infections in Taiwan...
  66. ncbi request reprint Rapid-test sensitivity for novel swine-origin pandemic influenza A
    Chun Fu Tai
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Formos Med Assoc 111:427-30. 2012
    ..The QuickVue Influenza A+B test is one of the most common tests for rapid diagnosis of influenza. We evaluated the sensitivity and specificity of the test in children...
  67. ncbi request reprint Microbiology and epidemiology of brain abscess and subdural empyema in a medical center: a 10-year experience
    Tsung Pei Tsou
    Department of Pediatrics, National Taiwan University Hospital, and National Taiwan University College of Medicine, Taipei, Taiwan
    J Microbiol Immunol Infect 42:405-12. 2009
    ..Brain abscess and subdural empyema are the 2 most common forms of intracranial pyogenic infections. Predisposing factors and etiological agents may change with time. This study examined the epidemiological features of these conditions...
  68. ncbi request reprint HLA-A33 is associated with susceptibility to enterovirus 71 infection
    Luan Yin Chang
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, No 7, Chung Shan South Road, Taipei 10016, Taiwan
    Pediatrics 122:1271-6. 2008
    ..In this study, host genetic factors were investigated to link susceptibility to and clinical severity of enterovirus 71 infections...
  69. doi request reprint Immunogenicity and safety of a monovalent vaccine for the 2009 pandemic influenza virus A (H1N1) in children and adolescents
    Chun Yi Lu
    Department of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
    Vaccine 28:5864-70. 2010
    ..3% of adolescents aged 10-17 years generated protective antibodies. A second vaccination given 3 weeks later induced protective antibodies in 89.4% of all age groups. No severe adverse effects were found 6 weeks after vaccination...
  70. doi request reprint Comparison of acute lobar nephronia and uncomplicated urinary tract infection in children
    Ching Chi Yang
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Microbiol Immunol Infect 43:207-14. 2010
    ....
  71. pmc Longitudinal seroepidemiologic study of the 2009 pandemic influenza A (H1N1) infection among health care workers in a children's hospital
    Ting Yu Yen
    Department of Pediatrics, National Taiwan University Hospital, NO, 8, Chung Shan South Road, 10016 Taipei, Taiwan
    BMC Infect Dis 12:89. 2012
    ..To probe seroepidemiology of the 2009 pandemic influenza A (H1N1) among health care workers (HCWs) in a children's hospital...
  72. ncbi request reprint Disease burden and epidemiological characteristics of varicella in Taiwan from 2000 to 2005
    Yung Hsiu Lin
    Division of Infectious Diseases, Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Microbiol Immunol Infect 42:5-12. 2009
    ..This study investigated the epidemiological characteristics and disease burden of varicella during the introduction of the varicella vaccine for mass vaccination in Taiwan...
  73. doi request reprint Varicella breakthrough infection and vaccine effectiveness in Taiwan
    Wen Chan Huang
    Department of Pediatrics, National Taiwan University, Taipei, Taiwan
    Vaccine 29:2756-60. 2011
    ..001). The vaccine effectiveness against varicella was 82.6% and against varicella-related hospitalization was 85.4% from 2000 to 2005...
  74. ncbi request reprint Low seroprotection against preseasonal influenza local strains in children might predict the upcoming epidemic influenza strains
    Wei Ju Su
    Centers for Disease Control, Mackay Memorial Hospital, Taipei, Taiwan
    Clin Infect Dis 51:171-6. 2010
    ..A year-end preseasonal serological survey of children could provide valuable information about the possible circulating strain and tailor the disease-control strategy accordingly...
  75. doi request reprint Immunogenicity and reactogenicity of diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus and Haemophilus influenzae type B
    Pei Lan Shao
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    J Formos Med Assoc 110:336-41. 2011
    ..Combined vaccines, such as this pentavalent vaccine, minimize the number of injections and vaccination visits required to complete primary vaccination, and provide choice and flexibility for physicians and vaccine providers...
  76. ncbi request reprint Epidemiologic features of Kawasaki disease in Taiwan, 2003-2006
    Wen Chan Huang
    Division of Pediatric Infectious Diseases, Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, No 7, Chung Shan South Road, Taipei 100, Taiwan
    Pediatrics 123:e401-5. 2009
    ..Kawasaki disease is the leading cause of acquired heart disease in children worldwide. This study characterizes the epidemiology of Kawasaki disease in Taiwan between 2003 and 2006...
  77. doi request reprint Breakthrough Streptococcus pneumoniae type 6B infection after adrenocorticotropic hormone therapy in a child vaccinated with pneumococcal conjugate vaccine
    Min Hsiung Lee
    Department of Pediatrics, Cathay General Hospital, Taipei, Taiwan
    J Formos Med Assoc 112:230-2. 2013
    ..Two months after ACTH therapy, she suffered from fever, cough, and decreased activity. Streptococcus pneumoniae, serotype 6B, was detected in blood culture. Vaccine failure could be possibly due to ACTH therapy...
  78. pmc An outbreak of coxsackievirus A6 hand, foot, and mouth disease associated with onychomadesis in Taiwan, 2010
    Sung Hsi Wei
    Taiwan Centers for Disease Control, Taipei, Taiwan
    BMC Infect Dis 11:346. 2011
    ..Therefore, we performed an epidemiological and molecular investigation to elucidate the characteristics of this outbreak...
  79. doi request reprint Disseminated candidemia refractory to caspofungin therapy in an infant with extremely low birth weight
    Meng Ju Li
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    J Formos Med Assoc 111:46-50. 2012
    ..As for the focal lesions, more aggressive treatments other than just parenteral antibiotics should be considered. The literature regarding caspofungin therapy for neonatal candidiasis is also reviewed...
  80. pmc Tuberculosis in children and adolescents, Taiwan, 1996-2003
    Pei Chun Chan
    National Taiwan University Hospital and College of Medicine, Taipei, Taiwan
    Emerg Infect Dis 13:1361-3. 2007
    ..61/100,000 person-years, biphasic, and age-relevant, with a major peak in persons slightly >12 years. Aboriginal children were 8.1-17.4x more likely to have TB than non-Aboriginal children...
  81. pmc Perinatal tuberculosis in a 73-day-old infant
    Hsin Chung Huang
    Division of Pediatric Infectious Diseases, Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, no 8, Chung Shan South Road, Taipei 100, Taiwan
    J Clin Microbiol 47:3785-6. 2009
    ..We emphasize that tuberculosis should be considered for neonates or infants with unresponsive pneumonia because delayed diagnosis is associated with a fatal outcome...
  82. ncbi request reprint Clinical manifestations and quantitative analysis of virus load in Taiwanese children with Epstein-Barr virus-associated infectious mononucleosis
    Chia Chi Cheng
    Department of Pediatrics, National Taiwan University Hospital College of Medicine, Taipei, Taiwan
    J Microbiol Immunol Infect 40:216-21. 2007
    ..To delineate the clinical manifestations in different age groups and to define the viral load in patients with Epstein-Barr virus-associated infectious mononucleosis (EBV-associated IM)...
  83. doi request reprint Lower prevalence of tuberculosis infection in BCG vaccinees: a cross-sectional study in adult prison inmates
    Pei Chun Chan
    Third Division, Centers for Disease Control, Taipei, Taiwan
    Thorax 68:263-8. 2013
    ..To address whether the effect of BCG vaccination against tuberculosis (TB) infection lasts to adulthood...
  84. doi request reprint Clinical characteristics of hepatosplenic fungal infection in pediatric patients
    Ting Yu Yen
    Department of Pediatric, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Microbiol Immunol Infect 44:296-302. 2011
    ..In this study, we investigated the clinical characteristics and outcomes of patients with HSF in childhood...
  85. doi request reprint A 6-year retrospective epidemiologic study of pediatric pneumococcal pneumonia in Taiwan
    Yi Chuan Huang
    Division of Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    J Formos Med Assoc 107:945-51. 2008
    ..The purpose of this study was to determine the epidemiology and morbidity of pneumococcal CAP (PCAP) in children hospitalized with pneumonia in Taiwan...
  86. pmc Household transmission of Pandemic (H1N1) 2009 Virus, Taiwan
    Luan Yin Chang
    National Taiwan University, Taipei, Taiwan
    Emerg Infect Dis 17:1928-31. 2011
    ..Overall, pandemic (H1N1) 2009 virus was transmitted to 60 (27%) of 223 household contacts. Transmission was 4× higher to children than to adults (61% vs. 15%; p<0.001)...
  87. ncbi request reprint Argonaute-2 enhances suppression of human cytomegalovirus replication by polycistronic short hairpin RNAs targeting UL46, UL70 and UL122
    Pei Lan Shao
    Department of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
    Antivir Ther 16:741-9. 2011
    ..The efficacy of anti-HCMV drugs such as ganciclovir, foscarnet and cidofovir is limited because of drug toxicities and frequent development of resistance. Here, we report an alternative anti-HCMV method using RNA silencing...
  88. ncbi request reprint Multidrug-resistant Acinetobacter baumannii isolates in pediatric patients of a university hospital in Taiwan
    Po Yang Chang
    Department of Pediatrics, Chang Bing Show Chwan Memorial Hospital, Lu Gang, Taiwan
    J Microbiol Immunol Infect 40:406-10. 2007
    ..baumannii (MDRAB) is a therapeutic problem. We describe the clinical characteristics and outcomes of MDRAB colonization/infection in pediatric patients at the National Taiwan University Hospital...
  89. ncbi request reprint The transforming Streptococcus pneumoniae in the 21st century
    Yu Chia Hsieh
    Section of Infection, Department of Medicine, Taipei Medical University Wan Fang Hospital, Taipei, Taiwan, R O C
    Chang Gung Med J 31:117-24. 2008
    ..Development of cheaper, serotype-independent vaccines based on a combination of protein antigens should be pursued...
  90. doi request reprint Safety and immunogenicity of a tetravalent polysaccharide vaccine against meningococcal disease
    Pei Lan Shao
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    J Formos Med Assoc 108:539-47. 2009
    ..The purpose of this study was to evaluate the immunogenicity, safety and reactogenicity of a single dose of GlaxoSmithKline Biologicals' Mencevax ACWY vaccine in healthy Taiwanese subjects aged 2-30 years...
  91. pmc Pyogenic liver abscess as endemic disease, Taiwan
    Feng Chiao Tsai
    National Taiwan University Hospital, Taipei, Taiwan
    Emerg Infect Dis 14:1592-600. 2008
    ..Diabetes did not significantly change death rates for the 506 patients from the hospital...
  92. doi request reprint Etiology of community-acquired pneumonia in hospitalized children in northern Taiwan
    Chih Jung Chen
    Division of Pediatric Infectious Diseases, Chang Gung Memorial Hospital, Taiwan
    Pediatr Infect Dis J 31:e196-201. 2012
    ..There has been no comprehensive study of the etiology of childhood community-acquired pneumonia (CAP), either in the pre- or postpneumococcal conjugate vaccine era, in Taiwan...
  93. doi request reprint Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis
    Yi Ching Lee
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Nat Genet 44:522-5. 2012
    ..Our findings may lead to a better understanding of the role of immune activation and inflammation in Kawasaki disease pathogenesis...
  94. ncbi request reprint Humoral and cellular immune responses to a hepatitis B vaccine booster 15-18 years after neonatal immunization
    Chun Yi Lu
    Department of Pediatrics, National Taiwan University Hospital, Taiwan
    J Infect Dis 197:1419-26. 2008
    ..Whether hepatitis B (HB) vaccine-conferred immunity persists into adulthood is unknown. We aimed to investigate long-term HB immunity in adolescents...
  95. ncbi request reprint Survey of pertussis in patients with prolonged cough
    Jen Jan Hu
    Department of Pediatrics, Taiwan Adventist Hospital, Taipei, Taiwan
    J Microbiol Immunol Infect 39:54-8. 2006
    ..The incidence of pertussis in adolescents and adults has increased in many areas of the world. This study aimed to evaluate the etiologic role of B. pertussis in patients with prolonged cough in Taiwan...
  96. ncbi request reprint Nontyphoidal Salmonella bacteremia in previously healthy children: analysis of 199 episodes
    Ming Han Tsai
    Department of Pediatrics, Chang Gung Memorial Hospital, Keelung, Taiwan
    Pediatr Infect Dis J 26:909-13. 2007
    ..Nontyphoidal Salmonella (NTS) bacteremia is not rare in otherwise healthy children in Taiwan. Few studies described the clinical manifestations and outcomes of NTS bacteremia in previously healthy children...
  97. doi request reprint Novel swine-origin influenza virus A (H1N1): the first pandemic of the 21st century
    Luan Yin Chang
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Formos Med Assoc 108:526-32. 2009
    ..A breakthrough in vaccinology against influenza is needed to address the recurring influenza pandemic...
  98. ncbi request reprint Frequency and phenotypic analysis of CD4+CD25+ regulatory T cells in children with juvenile idiopathic arthritis
    Chih Ming Wei
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    J Microbiol Immunol Infect 41:78-87. 2008
    ....
  99. ncbi request reprint Auxological, clinical and MRI findings in Taiwanese children with growth hormone deficiency
    Fu Sung Lo
    Department of Pediatrics, National Taiwan University Hospital, Taiwan
    J Pediatr Endocrinol Metab 17:1519-26. 2004
    ..Meticulous evaluation of auxological, clinical and MRI findings can help evaluation of the severity of hypopituitarism and facilitate appropriate treatment in children with GHD...
  100. pmc Emerged HA and NA mutants of the pandemic influenza H1N1 viruses with increasing epidemiological significance in Taipei and Kaohsiung, Taiwan, 2009-10
    Chuan Liang Kao
    Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan, Republic of China
    PLoS ONE 7:e31162. 2012
    ..36% vs 23.40%, p<0.001). Future pre-vaccination public health efforts should monitor amino acids of HA and NA of pandemic influenza viruses isolated at exponential and peak phases in areas with high cluster cases...
  101. ncbi request reprint Infections of cefotaxime-resistant and cefmetazole-susceptible Escherichia coli and Klebsiella pneumoniae in children
    Tsung Zu Wu
    Department of Pediatrics, Women s and Children s Hospital, Taipei, Taiwan
    J Microbiol Immunol Infect 38:112-6. 2005
    ..8%). Except for 1 episode of pneumonia that ended in mortality, all of the infectious episodes were successfully treated. The mortality rate was 7.1%...